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Total 6766 results found since Jan 2013.
Stroke biomarkers in clinical practice: A critical appraisal
Publication date: Available online 11 January 2017 Source:Neurochemistry International Author(s): Geelyn J.L. Ng, Amy M.L. Quek, Christine Cheung, Thiruma V. Arumugam, Raymond C.S. Seet Biomarkers provide critical mechanistic insights to key biologic processes that occur during cerebral ischemia which, when carefully applied, can improve clinical decision-making in acute stroke management. The translation of a blood-based biomarker in ischemic stroke to clinical practice is challenging, in part, due to the complexity of ischemic stroke pathogenesis and the presence of a blood-brain barrier that restricts the release of br...
Source: Neurochemistry International - January 11, 2017 Category: Neuroscience Source Type: research
Association of GWAS-Reported Variant rs11196288 near HABP2 with Ischemic Stroke in Chinese Han Population
AbstractA recent genome-wide association analysis identified a novel single nucleotide polymorphism locus on chromosome 10q25.3 (rs11196288, nearHABP2) associated with the risk of early-onset ischemic stroke (IS) in European population, but not with late-onset IS. However, the role of this genome-wide association study (GWAS)-reported variant in ischemic stroke in Chinese Han population remained unknown. In our study, 389 adult ischemic stroke patients with an age of onset<60 years and 389 matched healthy controls were enrolled to investigate association of rs11196288 genotypes with early-onset ischemic stroke and its...
Source: Journal of Molecular Neuroscience - May 13, 2017 Category: Neuroscience Source Type: research
Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis
AbstractSeveral brain imaging markers have been studied in the development of post-stroke depression (PSD) and post-stroke apathy (PSA), but inconsistent associations have been reported. This systematic review and meta-analysis aims to provide a comprehensive and up-to-date evaluation of imaging markers associated with PSD and PSA. Databases (Medline, Embase, PsycINFO, CINAHL, and Cochrane Database of Systematic Reviews) were searched from inception to July 21, 2016. Observational studies describing imaging markers of PSD and PSA were included. Pooled odds ratios (OR) and 95% confidence intervals (CI) were calculated to ex...
Source: Neuropsychology Review - August 22, 2017 Category: Neuroscience Source Type: research
Changes in structure and perfusion of grey matter tissues during recovery from Ischaemic subcortical stroke: a longitudinal MRI study
This study provides the imaging evidence of structural and vascular plasticity after stroke and expands our understanding of neurobiology of stroke recovery.
Source: European Journal of Neuroscience - September 4, 2017 Category: Neuroscience Authors: Xinfeng Yu, Linglin Yang, Ruirui Song, Yerfan Jiaerken, Jun Yang, Min Lou, Quan Jiang, Minming Zhang Tags: Research Report Source Type: research
Visual field impairment predicts recurrent stroke after acute posterior circulation stroke and transient ischemic attack.
CONCLUSIONS: VFI is an independent predictor of recurrent VB stroke and TIA.
PMID: 29293287 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 2, 2018 Category: Neuroscience Authors: Deng YM, Chen DD, Wang LY, Gao F, Sun X, Liu L, Lei K, Wang SR, Mo DP, Ma N, Song LG, Huo XC, Xu XT, Yan TY, Miao ZR Tags: CNS Neurosci Ther Source Type: research
Sleep-Wake Disorders in Stroke —Increased Stroke Risk and Deteriorated Recovery? An Evaluation on the Necessity for Prevention and Treatment
AbstractPurpose of ReviewSleep-wake disorders (SWD) are common not only in the general population but also in stroke patients, in whom SWD may be pre-existent or appear “de novo” as a consequence of brain damage. Despite increasing evidence of a negative impact of SWD on cardiocerebrovascular risk, cognitive functions, and quality of life, SWD are insufficiently considered in the prevention and management of patients with stroke. This narrative review aims at s ummarizing the current data on the bidirectional link between SWD and stroke.Recent FindingsSeveral studies have demonstrated that sleep-disordered breathing (S...
Source: Current Neurology and Neuroscience Reports - September 7, 2018 Category: Neuroscience Source Type: research
The effect of age, sex and strains on the performance and outcome in animal models of stroke
Publication date: Available online 3 October 2018Source: Neurochemistry InternationalAuthor(s): Hongxia Zhang, Siyang Lin, Xudong Chen, Lei Gu, Xiaohong Zhu, Yinuo Zhang, Kassandra Reyes, Brain Wang, Kunlin JinAbstractStroke is one of the leading causes of death worldwide, and the majority of cerebral stroke is caused by occlusion of cerebral circulation, which eventually leads to brain infarction. Although stroke occurs mainly in the aged population, most animal models for experimental stroke in vivo almost universally rely on young-adult rodents for the evaluation of neuropathological, neurological, or behavioral outcome...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research
HDAC9 Polymorphisms Predict Susceptibility, Severity, and Short-Term Outcome of Large Artery Atherosclerotic Stroke in Chinese Population
This study aimed to investigate whether these two polymorphisms were associated with susceptibility, severity, and short-term outcome of LAA stroke in a southern Chinese Han population. rs2074633 and rs28688791 were genotyped using SNPscan technology in 1011 LAA stroke patients and 1121 healthy controls. Stroke severity on admission and short-term outcome were, respectively, assessed by the National Institute of Health Stroke Scale (NIHSS) score on admission and modified Rankin Scale score at 3 months after stroke onset. rs2074633 (P = 0.039) and rs28688791 (P = 0.025) were associated with risk of LAA stroke. In ...
Source: Journal of Molecular Neuroscience - December 18, 2018 Category: Neuroscience Source Type: research
Timeliness of Nursing Care Delivered by Stroke Certified Registered Nurses as Compared to Non–Stroke Certified Registered Nurses to Hyperacute Stroke Patients
In this retrospective, nonexperimental, comparative descriptive design using convenience sampling, the timeliness of care delivered by 11 Stroke Certified Registered Nurses (SCRNs) to 95 hyperacute stroke patients (last known well of 4.5 hours or less) on the acute stroke protocol set by Target: Stroke Phase II Campaign Manual was compared with that of 13 non-SCRNs in a small, rural, level III stroke facility in the southwestern region of the United States. There was statistical significance in the total timeliness of care delivered by SCRNs to hyperacute stroke patients as compared with the non-SCRNs (t = −4.109, P = .0...
Source: Journal of Neuroscience Nursing - January 8, 2019 Category: Neuroscience Tags: Article Source Type: research
A troponin study on patients with ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage: Type II myocardial infarction is significantly associated with stroke severity, discharge disposition and mortality
Publication date: Available online 20 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ayham M. Alkhachroum, Benjamin Miller, Tarek Chami, Curtis Tatsuoka, Cathy SilaAbstractTroponin elevations due to Type II myocardial infarction (T2MI) are associated with hemorrhagic and ischemic strokes but there is little data on stroke severity, troponin elevation and outcome. We studied 1655 patients from a tertiary medical center between 1/2013-4/2015 using multivariate regression analysis for demographics, vascular risk factors, admission stroke severity, laboratory tests, echocardiogram results and discharge dispositio...
Source: Journal of Clinical Neuroscience - April 21, 2019 Category: Neuroscience Source Type: research
Association Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis
AbstractIschemic stroke is a disease that affects people’s health and quality of life. Cystatin C has been found as a new biomarker of cardiovascular disease. We performed this meta-analysis to assess the relationship between cystatin C and the risk of ischemic stroke. The studies on looking at the association between cystatin C and ischemic stroke were identified from inception to November 18, 2018. We performed a random-effects meta-analysis using mean difference. Nine studies with a total of 3773 ischemic stroke patients were included into the meta-analysis. Our results showed that patients with ischemic stroke had si...
Source: Journal of Molecular Neuroscience - July 16, 2019 Category: Neuroscience Source Type: research
Epidemiologic features and risk factors of sepsis in ischemic stroke patients admitted to intensive care: A prospective cohort study
ConclusionsThis study showed that ICU patients with severe ischemic stroke were more susceptible to sepsis during the hospital course.
Source: Journal of Clinical Neuroscience - September 20, 2019 Category: Neuroscience Source Type: research
Two Novel SNPs in the PLCL2 Gene Associated with Large Artery Atherosclerotic Stroke Identified by Fine-Mapping
AbstractA genome-wide association study (GWAS) reported that the single nucleotide polymorphism (SNP) rs4618210 in thePLCL2 gene is related to myocardial infarction (MI) in the Japanese population, but no study has examined the correlation ofPLCL2 with ischemic stroke (IS). The present study was designed to investigate whether the genetic variation inPLCL2 is associated with large artery atherosclerotic (LAA) stroke in a Han Chinese population. Tagging SNPs (tSNPs) of thePLCL2 gene were determined by a fine-mapping strategy and were genotyped by improved multiplex ligation detection reaction (iMLDR) technology in 669 LAA s...
Source: Journal of Molecular Neuroscience - January 21, 2020 Category: Neuroscience Source Type: research
Cardiac Imaging After Ischemic Stroke or Transient Ischemic Attack
This article summarizes the latest research on this topic and provides an approach to clinical practice to use cardiac imaging after stroke.Recent FindingsEchocardiography remains the primary imaging method for cardiac work-up after stroke. Recent echocardiography studies further demonstrated promising results regarding the prediction of non-permanent atrial fibrillation after ischemic stroke. Cardiac magnetic resonance imaging and computed tomography have been tested for their diagnostic value, in particular in patients with cryptogenic stroke, and can be considered as second line methods, providing complementary informat...
Source: Current Neurology and Neuroscience Reports - June 29, 2020 Category: Neuroscience Source Type: research
