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Total 6766 results found since Jan 2013.

Mediation effect of stroke recurrence in the association between post-stroke interleukin-6 and functional disability
CONCLUSIONS: Stroke recurrence mediates less than 20% of the association between IL-6 and functional outcome at 90 days among patients with acute ischemic stroke. In addition to typical secondary prevention strategies for preventing stroke recurrence, more attention should be paid to novel anti-inflammatory therapy to improve functional outcomes directly.PMID:37287421 | DOI:10.1111/cns.14289
Source: CNS Neuroscience and Therapeutics - June 8, 2023 Category: Neuroscience Authors: Hong-Qiu Gu Kai-Xuan Yang Jie-Jie Li Jin-Xi Lin Jing Jing Yun-Yun Xiong Xing-Quan Zhao Yi-Long Wang Li-Ping Liu Xia Meng Yong Jiang Hao Li Yong-Jun Wang Zi-Xiao Li Source Type: research

Gene expression profiling in whole blood stimulated ex vivo with lipopolysaccharide as a tool to predict post ‐stroke depressive symptoms: Proof‐of‐concept study
We studied if blood gene expression could facilitate identification of persons who will develop depression 3 months after ischemic stroke. Venous blood samples were collected on day 3 after stroke. Obtained blood was stimulated in vitro with lipopolysaccharide, a powerful inducer of gene expression. After stimulation, RNA was isolated and sequenced. Expression of 510 genes differed between patients who developed depression and those who had not depression after stroke. Bioinformatic analysis revealed that expression of 6 genes (PKM, PRRC2C, NUP188, CHMP3, H2AC8, NOP10) accurately predicted a risk of depression. Our finding...
Source: Journal of Neurochemistry - June 27, 2023 Category: Neuroscience Authors: Marcin Piechota, Dzesika Hoinkis, Michal Korostynski, Slawomir Golda, Joanna Pera, Tomasz Dziedzic Tags: ORIGINAL ARTICLE Source Type: research

Calcium/calmodulin ‐dependent protein kinase kinase β is neuroprotective in stroke in aged mice
This study demonstrates that CaMKK β is neuroprotective following stroke in aged mice. Inhibition of CaMKK β worsened stroke outcome by reducing expression of prosurvival factors, as well as the levels of proteins important for the integrity of blood–brain barrier, and increasing proinflammatory cytokines in the serum after stroke. Conversely, the overexpression of CaMKK β reduced infarcts and behavioral deficits in aged mice.
Source: European Journal of Neuroscience - August 16, 2016 Category: Neuroscience Authors: Lin Liu, Hui Yuan, Kyle Denton, Xue ‐jun Li, Louise McCullough, Jun Li Tags: Clinical and Translational Neuroscience Source Type: research

Mir363-3p improves ischemic stroke outcomes in female but not male rats
Publication date: Available online 20 October 2016 Source:Neurochemistry International Author(s): Amutha Selvamani, Farida Sohrabji With age, stroke prevalence is higher, and stroke outcome, worse, in women. Thus there is an urgent need to identify stroke neuroprotectants for this population. Using a preclinical stroke model, our studies focused on microRNAs (miRNAs), a class of translational repressors, as neuroprotectants. Analysis of circulating miRNA in the acute phase of stroke indicated potential neuroprotective capacity for miR363. Specifically, mir363 is elevated in serum of adult female rats that typically have s...
Source: Neurochemistry International - October 28, 2016 Category: Neuroscience Source Type: research

Stroke-Related Disease Comorbidity and Secondary Stroke Prevention Practices Among Young Stroke Survivors
Conclusions: Many young stroke survivors exhibit comorbid disease conditions that are similar to older stroke survivors. A large percentage are engaged in general chronic disease and secondary stroke prevention practices, yet less than two-thirds had seen a general doctor in the past 12 months. Primary care doctors and other health professionals are critical to the implementation of disease management strategies that consider their age, secondary stroke risk, expected life spans, and other issues that differ from older adult stroke survivors.
Source: Journal of Neuroscience Nursing - September 8, 2017 Category: Neuroscience Tags: Article Source Type: research

Bioinformatics Gene Analysis of Potential Biomarkers and Therapeutic Targets for Unstable Atherosclerotic Plaque-Related Stroke
AbstractAtherosclerotic plaque instability is a major cause of ischemic stroke. Researchers must develop novel strategies for the detection and treatment of unstable atherosclerotic plaque (UAP)-related stroke. We aimed to identify potential biomarkers and therapeutic targets of UAP-related stroke. Differentially expressed genes (DEGs) of UAP, ischemic stroke and smoking were identified by microarray analyses from the Gene Expression Omnibus. Gene Ontology (GO) and pathway functional enrichment analyses of DEGs were performed to analyze plaque destabilization and ischemic stroke physiopathology. An integrative analysis of ...
Source: Journal of Molecular Neuroscience - November 6, 2020 Category: Neuroscience Source Type: research

Elevated gamma-glutamyl transferase levels are associated with stroke recurrence after acute ischemic stroke or transient ischemic attack
CONCLUSION: This study demonstrated that elevated GGT levels were positively associated with an increased risk of stroke adverse outcomes, namely, recurrence, ischemic stroke, and combined vascular events.PMID:35789538 | DOI:10.1111/cns.13909
Source: CNS Neuroscience and Therapeutics - July 5, 2022 Category: Neuroscience Authors: Siqi Li Anxin Wang Xue Tian Yingting Zuo Xia Meng Yumei Zhang Source Type: research

Soluble lectin-like oxidized low-density Lipoproteinreceptor-1 and recurrent stroke: A nested case-control study
CONCLUSIONS: sLOX-1 was positively associated with the risk of recurrent stroke, which may be a candidate biomarker to improve risk stratification of recurrent stroke.PMID:35909324 | DOI:10.1111/cns.13932
Source: CNS Neuroscience and Therapeutics - August 1, 2022 Category: Neuroscience Authors: Anxin Wang Xue Tian Jie Xu Hao Li Qin Xu Pan Chen Xia Meng Yongjun Wang Source Type: research

Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines
AbstractPurpose of ReviewStroke is a leading cause of death and disability worldwide. The annual incidence of new or recurrent stroke is approximately 795,000 cases per year in the United States, of which 87% are ischemic in nature. In addition to the management of modifiable high-risk factors to reduce the risk of recurrent stroke, antithrombotic agents (antiplatelets and anticoagulants) play an important role in secondary stroke prevention. This review will discuss the published literature on the use of antiplatelets and anticoagulants in secondary prevention of acute ischemic stroke and transient ischemic attack (TIA), ...
Source: Current Neurology and Neuroscience Reports - April 11, 2023 Category: Neuroscience Source Type: research

8. Evolution and recovery of motor function post-stroke
Conclusion: Intracortical disinhibition occurs in both hemispheres immediately following acute stroke that likely represent functionally relevant changes supporting the recovery process in stroke. Whilst changes in the lesioned hemisphere persisted over the period of recovery in all patients, contralesional intracortical hyperexcitability persisted in patients with cortical strokes and those with more severe baseline functional impairment, suggesting that ongoing contralesional network recruitment may be necessary for those patients who have significant disruptions to the integrity of ipsilesional motor pathways. The study...
Source: Clinical Neurophysiology - March 3, 2014 Category: Neuroscience Authors: William Huynh, Steve Vucic, Arun V. Krishnan, Cindy S.-Y. Lin, Matthew C. Kiernan Tags: Society Proceedings Source Type: research

Targeting CD36-Mediated Inflammation Reduces Acute Brain Injury in Transient, but not Permanent, Ischemic Stroke.
CONCLUSION: The study revealed that targeting CD36 has a beneficial effect on transient but not permanent focal ischemic stroke. The study thus precludes a generalized strategy targeting CD36 in ischemic stroke and suggests careful consideration of types of stroke and associated pathology in developing stroke therapies. PMID: 25216018 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - September 12, 2014 Category: Neuroscience Authors: Kim E, Tolhurst AT, Szeto HH, Cho S Tags: CNS Neurosci Ther Source Type: research