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Condition: Overdose
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Total 253 results found since Jan 2013.
Pure motor monoparesis of the leg after carbon monoxide intoxication
A woman in her late 40s with no medical history presented as comatose (Glasgow Coma Scale (GCS) score, 8) after a suicide attempt, where she inhaled the fumes of burning charcoal for approximately 4 h. On admission, her blood pressure was 108/70 mm Hg, and her heart rate was 118 bpm. Her carbon monoxide (CO)–haemoglobin concentration was 34%. Blood examinations did not show any evidence of drug overdose. Supportive mechanical ventilation was employed, and she became alert after 48 h. A physical examination revealed no abnormal findings except for left leg weakness, and a neurological examinat...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 17, 2014 Category: Neurosurgery Authors: Tajima, Y., Satoh, C., Yaguchi, H., Mito, Y. Tags: Coma and raised intracranial pressure, Neurological injury, Stroke, Trauma CNS / PNS, Hypertension, Unwanted effects / adverse reactions, Drugs misuse (including addiction), Suicide (psychiatry), Radiology, Adult intensive care, Mechanical ventilation, Me Source Type: research
Seizures after heart transplantation - two cases of non-immunosuppressant drug interactions in young patients.
Conclusions We conclude that theophylline overdose combined with metoclopramide may provoke new-onset seizures, especially in young patients following heart transplantation.
PMID: 25152323 [PubMed - in process]
Source: Annals of Transplantation - August 27, 2014 Category: Transplant Surgery Authors: Urbanowicz T, Pawłowska M, Buczkowski P, Perek B, Baszyńska-Wachowiak H, Straburzyńska-Migaj E, Jemielity M Tags: Ann Transplant Source Type: research
Dabigatran: patient management in specific clinical settings.
Abstract
Dabigatran, a direct thrombin inhibitor, is licensed for the prevention of venous thromboembolism after knee and hip replacement, the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and for the treatment of acute venous thromboembolism. As dabigatran has a favourable benefit-risk profile, it is being increasingly used. Dabigatran differs from vitamin K antagonists as regards its pharmacological characteristics and its impact on certain laboratory tests, and also in the lack of a direct antagonist that can reverse dabigatran-induced anticoagulation. In emergency...
Source: Wiener Klinische Wochenschrift - August 20, 2014 Category: Journals (General) Authors: Kyrle PA, Binder K, Eichinger S, Függer R, Gollackner B, Hiesmayr JM, Huber K, Lang W, Perger P, Quehenberger P, Roithinger FX, Schmaldienst S, Weltermann A, Domanovits H Tags: Wien Klin Wochenschr Source Type: research
Monitoring the anticoagulant effect after a massive rivaroxaban overdose
We report the case of a 42‐year‐old man who took an overdose of 1400 mg of rivaroxaban and describe how resolution of the anticoagulant effect was monitored using readily available coagulation assays.
Source: Journal of Thrombosis and Haemostasis - August 11, 2014 Category: Hematology Authors: L.‐A. Linkins, K. Moffat Tags: Case of the Month Source Type: research
Impaired renal function and bleeding in elderly treated with dabigatran
Advantages of dabigatran, a thrombin inhibitor, for stroke prevention in patients with atrial fibrillation are numerous. Elderly patients with impaired renal function are at high risk of bleeding. Recommendations about the renal monitoring in elderly patients are not precise enough. The hemoclot direct thrombin inhibitor (HTI) assay measures accurately the dabigatran activity. Both could help managing serious bleeding events in selected populations. Four elderly patients recently treated with appropriate doses of dabigatran were hospitalized for major bleeding. Three patients were very elderly (> 80 years) and three had im...
Source: Blood Coagulation and Fibrinolysis - August 5, 2014 Category: Hematology Tags: Case Reports Source Type: research
Case Report: Monitoring the Anticoagulant Effect After a Massive Rivaroxaban Overdose.
This article is protected by copyright. All rights reserved.
PMID: 25040104 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 17, 2014 Category: Hematology Authors: Linkins LA, Moffat K Tags: J Thromb Haemost Source Type: research
Unilateral hippocampal infarction associated with an attempted suicide: a case report - Nishiyori Y, Nishida M, Shioda K, Suda S, Kato S.
INTRODUCTION: In our case report we describe the case of a patient who experienced a stroke in her left hippocampus that was found following an attempted suicide via glyphosate overdose. To the best of our knowledge this is the first case report to describ...
Source: SafetyLit: All (Unduplicated) - July 1, 2014 Category: Global & Universal Tags: Suicide and Self-Harm Source Type: news
Case Report: Monitoring the Anticoagulant Effect After a Massive Rivaroxaban Overdose
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - July 1, 2014 Category: Hematology Authors: Lori‐Ann Linkins, Karen Moffat Tags: Case Report Source Type: research
Re-evaluating Brain Death: The Potential for Treatment and Recovery after Brain Injury (P4.285)
Conclusions: Treatment-induced reversal of BD was evidenced by functional recovery across several domains. ACP neuromodulation optimizes cerebral functioning: electrical stimulation increases metabolic coupling; nutraceuticals promote healing, repair and neurotransmitter production while attenuating inflammatory cascades and free-radical damage. BD may not be definitively irreversible and deserves therapeutic consideration.Disclosure: Dr. Defina has nothing to disclose. Dr. Zakrzewski has nothing to disclose. Dr. Prestigiacomo has nothing to disclose. Dr. Machado has nothing to disclose. Dr. Bernad has nothing to disclose....
Source: Neurology - April 9, 2014 Category: Neurology Authors: Defina, P., Zakrzewski, C., Prestigiacomo, C., Machado, C., Bernad, P., Halper, J., Fellus, J. Tags: Practice, Policy, and Ethics: Stroke, Critical Care, and Other Source Type: research
Akinetic Mutism And Parkinsonian Features Progressing To Coma Following A Hypoxic Event With Extended Lucid Interval: Manifestations Of Delayed Post-Hypoxic Leukoencephalopathy (P4.033)
CONCLUSIONS: Clinical anticipation and recognition of DPHL should lead to earlier diagnosis and higher-value care.Disclosure: Dr. Doerner Rinaldi has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Czeisler has nothing to disclose. Dr. Willey has nothing to disclose. Dr. John has nothing to disclose. Dr. Claassen has nothing to disclose. Dr. Mayer has received personal compensation for activities with Actelion, Baxter, Biogen Idec, Codman/Johnson & Johnson Company, CSL Behring, Cornerstone Therapeutics, CR Bard, Novartis, Orsan Technologies, Pfizer Inc, Sage Therapeutics, and Stryker. Dr. Mayer has receive...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Doerner Rinaldi, A. P., Miller, E., Czeisler, B., Willey, J., John, C., Claassen, J., Mayer, S., Agarwal, S. Tags: General Neurology III Source Type: research
Maybe Pradaxa (dabigatran) does need blood monitoring after all
2.5 out of 5 stars
The Effect of Dabigatran Plasma Concentrations and Patient Characteristics on the Frequency of Ischemic Stroke and Major Bleeding in Atrial Fibrillation Patients. Reilly PA et al. J Am Coll Cardiol 2014 Feb 4;63:321-8.
Abstract
A must-read article in yesterday’s New York Times described the internal battle at Boehringer Ingelheim, the maker of Pradaxa (dabiagtran etexilate), concerning the publication of this study.
A major marketing point posited in favor of dabigatran over warfarin for the prevention of stroke in patients with atrial fibrillation was that it did not require monitoring with reg...
Source: The Poison Review - February 7, 2014 Category: Toxicology Authors: Leon Tags: Medical bleeding blood testing boehringer ingelheim dabigatran pradaxa stroke Source Type: news
The acute management of haemorrhage, surgery and overdose in patients receiving dabigatran
Dabigatran is an oral direct thrombin inhibitor (DTI) licensed for stroke prevention in atrial fibrillation and likely to be soon approved in Europe for treatment of venous thrombosis. Predictable pharmacokinetics and a reduced risk of intracranial haemorrhage do not negate the potential risk of haemorrhage. Unlike warfarin, there is no reversal agent and measurement of the anticoagulant effect is not ‘routine’. The prothrombin time/international normalised ratio response to dabigatran is inconsistent and should not be measured when assessing a patient who is bleeding or needs emergency surgery. The activated p...
Source: Emergency Medicine Journal - January 15, 2014 Category: Emergency Medicine Authors: Alikhan, R., Rayment, R., Keeling, D., Baglin, T., Benson, G., Green, L., Marshall, S., Patel, R., Pavord, S., Rose, P., Tait, C. Tags: Poisoning/Injestion, Open access, Drugs: cardiovascular system, Stroke, Poisoning Review Source Type: research
No pain, no gain? Getting the most out of exercise
Staying in shape has all sorts of benefits, from maintaining heart health to warding off dementia and cancerInactivity – fuelled by cars and a sedentary work life – has been dubbed the biggest public health problem of the 21st century, a global pandemic with dramatic impact on peoples wellbeing. The latest reports suggest that around the world it was responsible for 5.3 million deaths in 2008 – around one in 10 – more deaths than smoking.Not only does exercise make you fitter, it can also ward off numerous and often unexpected diseases, from heart attacks, to diabetes, some forms of cancer and dementia. There are t...
Source: Guardian Unlimited Science - January 13, 2014 Category: Science Authors: Catherine de Lange Tags: Cycling Fitness Sport Running Transport Yoga Weightlifting Features UK news Life and style Cycle hire schemes The Observer Swimming Science Source Type: news
Patient with acute renal injury presenting dabigatran overdose: Hemodialysis for surgery.
We report a case of an 80-year-old man presenting hemorrhage with dabigatran overdose caused by obstructive acute renal failure. Before nephrostomy, several hemodialysis sessions were necessary to remove dabigatran probably because of its large volume of distribution.
PMID: 24378048 [PubMed - as supplied by publisher]
Source: Annales Francaises d'Anesthesie et de Reanimation - December 27, 2013 Category: Anesthesiology Authors: Bachellerie B, Ruiz S, Conil JM, Crognier L, Seguin T, Georges B, Fourcade O Tags: Ann Fr Anesth Reanim Source Type: research
Response to “Effect of Tissue Plasminogen Activator Dose and Interval on Stroke Severity”
We read with interest the comments on our recent study “Tissue Plasminogen Activator Overdose in Acute Ischemic Stroke Patients Linked to Poorer Functional Outcomes” by Nedelman and Glenn, and would like to address the points that were raised.
Source: Journal of Stroke and Cerebrovascular Diseases - December 2, 2013 Category: Neurology Authors: Demetrios J. Sahlas, Linda Gould, Richard Swartz, Naufal Mohammed, Rhonda McNicoll-Whiteman, Fahd Naufal, Wieslaw Oczkowski Tags: Letters to the Editor Source Type: research
