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Total 253 results found since Jan 2013.

Stroke due to Left Atrial Appendage Thrombus after Pulmonary Vein Isolation despite Novel Oral Anticoagulant: A Case Report
We report on a patient with atrial fibrillation undergoing catheter ablation and cardioversion suffering from ischemic stroke despite being under oral anticoagulation. It turned out that the drug activity of the NOACs used was repeatedly insufficient in spite of regular intake and adequate dosing. In sum, drug activity controls should be taken into consideration in patients with thrombotic events despite oral anticoagulation with NOACs.Case Rep Neurol 2021;13:225 –232
Source: Case Reports in Neurology - April 12, 2021 Category: Neurology Source Type: research

Overdose Receiving Centers - An Idea Whose Time Has Come?
Authors: Hern HG, Goldstein D, Tzvieli O, Mercer M, Sporer K, Herring AA Abstract Drug overdose deaths have been the leading cause of accidental death in the United States with two thirds involving opioids. Strong evidence supports the efficacy of medications for addiction treatment such as buprenorphine and harm reduction strategies such as naloxone distribution. While emergency medical service (EMS) systems have defined specialty centers for the treatment of many significant life threatening disease (trauma, stroke, myocardial infarction) implementation of opioid use disorder systems of care that integrate EMS ar...
Source: Prehospital Emergency Care - January 30, 2021 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

Non-Vitamin K Antagonist Oral Anticoagulants (NOACs) Versus Warfarin in Patients with Atrial Fibrillation and (Morbid) Obesity or Low Body Weight: a Systematic Review and Meta-Analysis
ConclusionThe benefit-risk profile of NOACs seems preserved in (morbidly) obese AF patients and patients with low body weight. However, more data are needed on underweight AF patients (BMI<  18.5 kg/m2) and on differences between NOACs in these patients.
Source: Cardiovascular Drugs and Therapy - January 11, 2021 Category: Cardiology Source Type: research

High Fluctuation Between Anticoagulants, Frequent Off-Label Dosing, and No Difference Concerning Outcomes: Results of a Real-Life Cohort Study
Recently published studies indicated a high proportion of patients taking direct oral anticoagulants (DOACs) are off-label under- or overdosed. The present study aimed at investigating whether off-label dosages are corrected over time and whether off-label doses are associated with differences in bleeding rates, ischemic stroke, or venous thromboembolism.
Source: The American Journal of Medicine - October 24, 2020 Category: General Medicine Authors: Corinne M. Eschler, Ana Antelo, Georg-Christian Funk, Aristomenis K. Exadaktylos, Gregor Lindner Tags: Clinical Research Study Source Type: research

Drug-Induced Arrhythmias: A Scientific Statement From the American Heart Association.
Abstract Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as well as a growing list of drugs from other therapeutic classes (neurological drugs, anticancer agents, and many others), can prolong the QT interval and provoke torsades de pointes. Perhaps less familiar to clinicians is the fact that drugs can also trigger other arrhythmias, including bradyarrhythmias, atrial fibrillation/atrial flutter, atrial tachycardia, atrioventricular nodal reentrant tachycardia, monomorphic ventricular tachy...
Source: Circulation - September 14, 2020 Category: Cardiology Authors: Tisdale JE, Chung MK, Campbell KB, Hammadah M, Joglar JA, Leclerc J, Rajagopalan B, American Heart Association Clinical Pharmacology Committee of the Council on Clinical Cardiology and Council on Cardiovascular and Stroke Nursing Tags: Circulation Source Type: research

The Difficulty Of Counting the COVID-19 Pandemic ’s Full Death Toll
Sara Wittner had seemingly gotten her life back under control. After a December relapse in her battle with drug addiction, the 32-year-old completed a 30-day detox program and started taking a monthly injection to block her cravings for opioids. She was engaged to be married, working for a local health advocacy group in Colorado, and counseling others about drug addiction. Then the COVID-19 pandemic hit. The virus knocked down all the supports she had carefully built around her: no more in-person Narcotics Anonymous meetings, no talks over coffee with trusted friends or her addiction recovery sponsor. As the virus stressed...
Source: TIME: Health - June 22, 2020 Category: Consumer Health News Authors: Markian Hawryluk / Kaiser Health News Tags: Uncategorized COVID-19 Source Type: news

Intravenous Fat Emulsion Does Not Significantly Alter Clotting Markers in Dabigatran-Treated Blood
AbstractDabigatran etexilate is an oral direct thrombin (Factor IIa) inhibitor approved for patients with atrial fibrillation and for management of risk of deep vein thrombosis and pulmonary embolism. Dabigatran offers advantages over treatment with warfarin, including limited laboratory monitoring. It is equivalent in prevention of stroke and deep vein thrombosis with essentially equivalent complication rates. In contrast to warfarin, reversal of the anticoagulation is less well established. Idarucizumab is available for reversal, however supporting research is mixed; the agent also happens to be quite expensive making av...
Source: Indian Journal of Hematology and Blood Transfusion - June 21, 2020 Category: Hematology Source Type: research

Right drug, wrong dosage: insights from the PAVE-AF antithrombotic study in older patients with atrial fibrillation
AbstractOptimal antithrombotic treatment of older patients is usually impeded by several prevailing misconceptions. The aim of our study was to assess the type, dosage and predictors of antithrombotic therapy in older patients with non-valvular atrial fibrillation (NVAF). PAVE-AF was a prospective, cross-sectional study, including NVAF patients ≥ 80 years from 30 participating centers. Demographic data, comorbidities and treatment patterns were documented in a single visit. Patients treated with non-vitamin K oral anticoagulants (NOACs) were further classified into three dosing categories (recommended, underdosing and o...
Source: Journal of Thrombosis and Thrombolysis - June 8, 2020 Category: Hematology Source Type: research

Effect of Donor Death by Drug Intoxication Combined with Chronic Drug Abuse on Lung Transplantation: A Single Center Study
In the field of lung transplantation, there is a high wait list mortality. Broader use of extended criteria donors would provide additional organs for transplantation. An increasing number of organ donors are dying from drug overdose. These donors are often considered “high risk” because of their exposure to infectious diseases such as HIV and Hepatitis B and C. However, these organ donors are often younger and healthier than those that die from stroke or cardiac arrest. Successful use of lung donors who have a history of drug abuse may serve to provide addit ional organs for those patients on the wait list.
Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: E.C. Klipsch, T. Hathaway, R.S. Mangus Tags: (330) Source Type: research

Ischemic stroke and dose adjustment of oral Factor Xa inhibitors in patients with atrial fibrillation
ConclusionOne in three patients with ischemic stroke during treatment with oral Xa inhibitors used inappropriate dose regimens. Underdosing was associated with lower functional plasma levels, higher clinical stroke severity and worse functional outcome.
Source: Journal of Neurology - March 22, 2020 Category: Neurology Source Type: research

Degree of bystander-patient relationship and prehospital care for opioid overdose - McCann MK, Jusko TA, Jones CMC, Seplaki CL, Cushman JT.
BackgroundAcross the spectrum of patient care for opioid overdose, an important, yet frequently overlooked feature is the bystander, or witness to the overdose event. For other acute medical events such as cardiac arrest and stroke, research supports that ...
Source: SafetyLit - February 24, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Degree of Bystander-Patient Relationship and Prehospital Care for Opioid Overdose.
ConclusionPresence of a proximal bystander during an overdose event is associated with dispatch codes indicative of an overdose and shorter times to naloxone administration compared with those with distal bystanders. These findings offer opportunities for public education and engagement of overdose harm reduction strategies. PMID: 32073921 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - February 21, 2020 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research

For the First Time in Four Years, the U.S. Life Expectancy Rose a Little
(NEW YORK) — Life expectancy in the United States is up for the first time in four years. The increase is small — just a month — but marks at least a temporary halt to a downward trend. The rise is due to lower death rates for cancer and drug overdoses. “Let’s just hope it continues,” said Robert Anderson, who oversees the report released Thursday by the Centers for Disease Control and Prevention. The latest calculation is for 2018 and factors in current death trends and other issues. On average, an infant born that year is expected to live about 78 years and 8 months, the CDC said. For...
Source: TIME: Health - January 30, 2020 Category: Consumer Health News Authors: Associated Press Tags: Uncategorized health onetime overnight Source Type: news

Possible Interaction between Dabigatran and Ranolazine in Patients with Renal Failure.
Abstract Dabigatran etexilate is a direct oral anticoagulant (thrombin inhibitor) used for the prevention of stroke and systemic thromboembolic events in patients with permanent atrial fibrillation; prevention of venous thromboembolic events and deep veins thrombosis; treatment and prevention of pulmonary embolism. Dabigatran is a relatively new drug, and as a result, its interactions with other medications and their significance are not fully known. A 72 years old male, having a medical history of heart and renal failure, was hospitalized for pneumonia treatment. The patient was taking several drugs, including da...
Source: Medicina (Kaunas) - December 28, 2019 Category: Universities & Medical Training Authors: Gumbrevičius G, Damulevičienė G, Galaunė V, Gumbrevičiūtė M Tags: Medicina (Kaunas) Source Type: research

Gender differences in association of prescription opioid use and mortality: a propensity-matched analysis from the REasons for Geographic And Racial Differences in Stroke (REGARDS) prospective cohort - Khodneva Y, Richman J, Kertesz S, Safford MM.
Background: Prescription opioids (PO) have been widely used for chronic non-cancer pain, with commensurate concerns for overdose. The long-term effect of these medications on non-overdose mortality in the general population remains poorly understood...
Source: SafetyLit - December 23, 2019 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news