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Total 253 results found since Jan 2013.

Pure OCD: a rude awakening
You mentally undress your friends, Tony Blair, the lollipop lady. Your thoughts are X-rated. You wonder if you're a paedophile – or just losing your mind. A sufferer describes the nightmare – and dark comedy – of living with pure OCDOn a spring night when I was 15 the mental image of a naked child entered my head and the corners of my world folded in. I put down my cutlery. My throat was closing over. Dad sat across from me, 10,000 miles away, and Mum was hunting draughts at the window.Stoned and smiling, my brother sat next to me, resting his elbows on teenage knees too high for the table. He looked sidelong at Mum ...
Source: Guardian Unlimited Science - August 31, 2013 Category: Science Tags: The Guardian Psychology Sexuality Mental health & wellbeing Society Features Obsessive-compulsive disorder Life and style Source Type: news

Mitochondrial Calcium Uniporter Opener Spermine Attenuates the Cerebral Protection of Diazoxide through Apoptosis in Rats
Conclusions: Results in our study suggested that diazoxide improved neurologic deficits, decreased infarct volume in cortex but not in subcortex, and apoptosis in cortex against ischemia/reperfusion injury is mediated by spermine.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Lei Zhang, Xiujuan Gao, Xin Yuan, Huanli Dong, Zongwang Zhang, Shilei Wang Tags: Original Articles Source Type: research

EHRA Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary
New oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with non-valvular atrial fibrillation (AF). Both physicians and patients will have to learn how to use these drugs effectively and safely in specific clinical situations. This text is an executive summary of a practical guide that the European Heart Rhythm Association (EHRA) has assembled to help physicians in the use of the different NOACs. The full text is being published in EP Europace. Practical answers have been formulated for 15 concrete clinical scenarios: (i) practical start-up and follow-up scheme for ...
Source: European Heart Journal - July 14, 2013 Category: Cardiology Authors: Heidbuchel, H., Verhamme, P., Alings, M., Antz, M., Hacke, W., Oldgren, J., Sinnaeve, P., Camm, A. J., Kirchhof, P. Tags: SPECIAL ARTICLE Source Type: research

Managing Bleeding in Anticoagulated Patients in the Emergency Care Setting
Conclusions: The introduction of alternative oral anticoagulants will require emergency procedures that differ in some respects from those currently in place for warfarin and it will be necessary for Emergency Medicine professionals to become familiar with these procedures. Clinical stabilization of the bleeding or at-risk patient remains the emergency physician’s priority.
Source: The Journal of Emergency Medicine - June 19, 2013 Category: Emergency Medicine Authors: Charles V. Pollack Tags: Clinical Reviews Source Type: research

Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database
DiscussionThe results of this study will help to establish the relative safety and balance of risks for different antidepressant drugs in people aged under 65.
Source: BMC Psychiatry - Latest articles - May 10, 2013 Category: Psychiatry Authors: Carol CouplandRichard MorrissAntony ArthurMichael MooreTrevor HillJulia Hippisley-Cox Source Type: research

European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation
New oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with non-valvular atrial fibrillation (AF). Both physicians and patients will have to learn how to use these drugs effectively and safely in clinical practice. Many unresolved questions on how to optimally use these drugs in specific clinical situations remain. The European Heart Rhythm Association set out to coordinate a unified way of informing physicians on the use of the different NOACs. A writing group listed 15 topics of concrete clinical scenarios and formulated as practical answers as possible based on ...
Source: Europace - April 26, 2013 Category: Cardiology Authors: Heidbuchel, H., Verhamme, P., Alings, M., Antz, M., Hacke, W., Oldgren, J., Sinnaeve, P., Camm, A. J., Kirchhof, P. Tags: EHRA PRACTICAL GUIDE Source Type: research

Case report: hemodialysis for dabigatran overdose
3 out of 5 stars Hemodialysis for the Treatment of Pulmonary Hemorrhage from Dabigatran Overdose. Chen BC et al. Am J Kidney Dis 2013 Apr 15 [Epub ahead of print] Abstract Dabigatran (Pradaxa) is a competitive direct thrombin inhibitor approved in the United States for stroke prophylaxis in patients with nonvalvular atrial fibrillation. Although dabigatran has certain advantages over coumadin related to issues of dosing and testing, there is no readily available test to measure its anticoagulation effect, and there is no antidote to reverse bleeding. Recommendations for treating a patient with dabigatran-associated hemorr...
Source: The Poison Review - April 24, 2013 Category: Toxicology Authors: Leon Tags: Medical dabigatran hemodialysis hemorrhage overdose Source Type: news

The Effect of Mitochondrial Calcium Uniporter Opener Spermine on Diazoxide against Focal Cerebral Ischemia—Reperfusion Injury in Rats
Conclusions: Our results suggested that diazoxide, which improved neurological deficits and decreased infarct volume and oxidative stress against ischemia–reperfusion injury, is mediated by spermine.
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2013 Category: Neurology Authors: Huanli Dong, Shilei Wang, Zongwang Zhang, Ailan Yu, Zhong Liu Tags: Original Articles Source Type: research

Tissue Plasminogen Activator Overdose in Acute Ischemic Stroke Patients Linked to Poorer Functional Outcomes
Conclusions: Our findings provide support for the practice of accurately weighing all acute ischemic stroke patients before thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - February 4, 2013 Category: Neurology Authors: Demetrios J. Sahlas, Linda Gould, Richard H. Swartz, Naufal Mohammed, Rhonda McNicoll-Whiteman, Fahd Naufal, Wieslaw Oczkowski Tags: Original Articles Source Type: research

Adderall® (Amphetamine-Dextroamphetamine) Toxicity
This article discusses our present understanding of Adderall® intoxication and examines 3 dogs presented to our practice after ingestion of large amounts of the drug.
Source: Topics in Companion Animal Medicine - February 1, 2013 Category: Veterinary Research Authors: Kevin T. Fitzgerald, Alvin C. Bronstein Source Type: research

Dabigatran, a Cause of Hematologic Emergency.
Abstract ABSTRACT:: Dabigatran etexilate, a direct thrombin inhibitor, has become an alternative to warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. There remains a concern about its overdose and life-threatening hemorrhage because of unavailability of appropriate coagulation tests to monitor and antidotes to reverse its effects. There are no clinical data about its safety in patients with fluctuating renal function. Multiple bleeding events reported with dabigatran have prompted the U.S. Food and Drug Administration to further investigate these reports. Four clinical cases with lif...
Source: The American Journal of the Medical Sciences - December 5, 2012 Category: Journals (General) Authors: Lal Y, Van Heukelom J Tags: Am J Med Sci Source Type: research