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Total 253 results found since Jan 2013.

Dalfampridine in chronic sensorimotor deficits after ischemic stroke: A proof of concept study.
CONCLUSIONS: D-ER was generally well tolerated in participants with chronic stroke deficits. Potential drug activity on lower extremity sensorimotor function, with an improvement in walking speed, was seen. PMID: 26540083 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - November 7, 2015 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Overdose death risk for discharged drug users
GPs, users and families must be made aware of risks and take precautionsRelated items from OnMedicaMarijuana users are more likely to have stroke caused by stenosisMake chemsex public health priority, urge expertsEmergency staff ‘playing catch-up’ in battle against legal highs'Skunk’ causes a quarter of new cases of psychosis Overdose antidote drug in safety alert
Source: OnMedica Latest News - November 6, 2015 Category: UK Health Source Type: news

Updated European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvular atrial fibrillation
The current manuscript is an update of the original Practical Guide, published in June 2013[Heidbuchel H, Verhamme P, Alings M, Antz M, Hacke W, Oldgren J, et al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation. Europace 2013;15:625–51; Heidbuchel H, Verhamme P, Alings M, Antz M, Hacke W, Oldgren J, et al. EHRA practical guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation: executive summary. Eur Heart J 2013;34:2094–106]. Non-vitamin K antagonist oral anticoagulants (NOACs) are an ...
Source: Europace - October 23, 2015 Category: Cardiology Authors: Heidbuchel, H., Verhamme, P., Alings, M., Antz, M., Diener, H.-C., Hacke, W., Oldgren, J., Sinnaeve, P., Camm, A. J., Kirchhof, P., Advisors:, Ahmad, Heinrich-Nols, Hess, Muller, Munzel, Schwertfeger, Van Eickels, Richard-Lordereau, Document reviewers:, L Tags: EHRA PRACTICAL GUIDE Source Type: research

Predicting Heart Rate at the Ventilatory Threshold for Aerobic Exercise Prescription in Persons With Chronic Stroke
Conclusions: Derived regression equations, 80% HRpeak and 62% HRRpeak, provide a specific target intensity for initial aerobic exercise prescription that should minimize underdosing and overdosing for persons with chronic stroke. The specificity of these methods may lead to more efficient and effective treatment for poststroke deconditioning. Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A114 ).
Source: Journal of Neurologic Physical Therapy - September 21, 2015 Category: Physiotherapy Tags: Research Articles Source Type: research

Predicting Heart Rate at the Ventilatory Threshold for Aerobic Exercise Prescription in Persons With Chronic Stroke.
CONCLUSIONS: Derived regression equations, 80% HRpeak and 62% HRRpeak, provide a specific target intensity for initial aerobic exercise prescription that should minimize underdosing and overdosing for persons with chronic stroke. The specificity of these methods may lead to more efficient and effective treatment for poststroke deconditioning.Video Abstract available for more insights from the authors (see Supplemental Digital Content 1, http://links.lww.com/JNPT/A114). PMID: 26371532 [PubMed - in process]
Source: Physical Therapy - September 18, 2015 Category: Physiotherapy Authors: Boyne P, Buhr S, Rockwell B, Khoury J, Carl D, Gerson M, Kissela B, Dunning K Tags: J Neurol Phys Ther Source Type: research

Even Milk Chocolate Is Good For You, According To New Study
Chocolate is good for your heart — sort of, maybe. Eating up to 3.5 ounces (100 grams) of chocolate daily is linked with lowered risks of heart disease and stroke, scientists reported today (June 15) in the journal Heart. That amount of chocolate is equal to about 22 Hershey's Kisses, two Hershey bars or two bags of M&M's, depending on how you want to divvy up this good news. "There does not appear to be any evidence to say that chocolate should be avoided in those who are concerned about cardiovascular risk," the researchers concluded in their paper. Their new study is based on a meta-analysis of eight previously pu...
Source: Science - The Huffington Post - June 16, 2015 Category: Science Source Type: news

The Great Pot Experiment
Barcott is a journalist who has contributed to the New York Times, National Geographic and other publications. Scherer is TIME’s Washington bureau chief. Portions of this article were adapted from Barcott’s new book “Weed the People, the Future of Legal Marijuana in America,” from TIME Books, is now available wherever books are sold, including Amazon.com, Barnes & Noble and Indiebound. Yasmin Hurd raises rats on the Upper East Side of Manhattan that will blow your mind. Though they look normal, their lives are anything but, and not just because of the pricey real estate they call home on the 10t...
Source: TIME.com: Top Science and Health Stories - May 14, 2015 Category: Consumer Health News Authors: Megan Gibson Tags: Uncategorized Drugs Source Type: news

Predictors of Poor Outcome in Neuroleptic Malignant Syndrome: Retrospective Analysis of Nationwide Inpatient Sample (S32.006)
CONCLUSIONS: In patients admitted for neuroleptic malignant syndrome, every decade increment in age, acute kidney injury, seizures and respiratory failure were positive predictors of poor outcome. Every calendar year increase was a negative predictor of poor outcome. Study Supported by:Disclosure: Dr. Modi has nothing to disclose. Dr. Dharaiya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Modi, S., Dharaiya, D. Tags: Movement Disorders: Tremor, Ataxia, and More Platform Blitz Source Type: research

7 Ways to Permanently Banish Belly Fat
Sixty-nine percent of Americans adults are overweight, and over 35 percent are obese. Obesity increases your risk for numerous conditions including heart disease, stroke, Type 2 diabetes, high blood pressure, and cancer. Sadly, about 3.4 million adults die each year from being overweight or obese. Globally obesity now kills about the same as tobacco and all wars, terrorism and violence. Nearly all people who are overweight already have "pre-diabetes" and have significant risks of disease and death. They just don't know it. When you begin to put on weight, especially lethal belly fat, your biology shifts out of balance, v...
Source: Healthy Living - The Huffington Post - February 27, 2015 Category: Consumer Health News Source Type: news

Dabigatran overdose: case report of laboratory coagulation parameters and hemodialysis of an 85-year-old man
Dabigatran is an oral direct inhibitor indicated for stroke prevention in patients with atrial fibrillation. Unlike warfarin, dabigatran's observed therapeutic window and minimal drug-to-drug interaction suggest that laboratory test and dose adjustments are not necessary; nevertheless, circumstances of excessive anticoagulation, decreased kidney function, and instances of significant bleeding and thrombosis require laboratory assessment. In order to gather experience in the management of global [activated partial thromboplastin time (APTT) and thrombin time (TT) with extended endpoint] and specific [ecarin chromogenic assa...
Source: Blood Coagulation and Fibrinolysis - January 30, 2015 Category: Hematology Tags: Case Reports Source Type: research

Management of dabigatran-induced bleeding with continuous venovenous hemodialysis.
Abstract Dabigatran, a direct thrombin inhibitor, is increasingly used for stroke prevention in patients with non-valvular atrial fibrillation. Dabigatran has a stable pharmacokinetic profile with minimum drug interactions, and requires no routine laboratory evaluation to measure level of anticoagulation. This provides a huge advantage over warfarin, and has the potential to improve patient compliance. The disadvantages of dabigatran are the lack of a reversal agent to counter dabigatran-related bleeding and the absence of a widely available laboratory test that can quantify the extent of coagulopathy in dabigatr...
Source: International Journal of Hematology - January 30, 2015 Category: Hematology Authors: Paul S, Hamouda D, Prashar R, Mbaso C, Khan A, Ali A, Shah S, Assaly R Tags: Int J Hematol Source Type: research

Epinephrine in Anaphylaxis: Higher Risk of Cardiovascular Complications and Overdose After Administration of Intravenous Bolus Epinephrine Compared with Intramuscular Epinephrine
Conclusion The risk of overdose and adverse CV events is significantly higher with IV bolus epinephrine administration. Analysis of the data supports the safety of IM epinephrine and a need for extreme caution and further education about IV bolus epinephrine in anaphylaxis.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 7, 2015 Category: Allergy & Immunology Source Type: research

CDC's Mission: Protecting the Health of Americans
There is no doubt Ebola will rank as the biggest public health story of 2014, both here in the United States and around the world: more people sickened by Ebola than ever before in history, more people dying, and more understanding of how the health of one nation affects the health of us all. Today, more than 170 of CDC's top health professionals are in West Africa working to stop the current Ebola epidemic and leave behind stronger public health systems. Many hundreds more support their work at home. Leaving behind better capacities to find, stop, and prevent health threats in affected countries will help prevent the ...
Source: Healthy Living - The Huffington Post - December 24, 2014 Category: Consumer Health News Source Type: news

Prescription opioid use is associated with increased mortality in the reasons for geographic and racial differences in stroke study
Aims: Prescription opioid use (POU) for chronic non-malignant pain has increased in the US over the last decade. Previous research has demonstrated increased mortality related to POU overdose or abuse but population-based studies have not examined the relationship between POU and all cause mortality (ACM), adjusting for a variety of underlying chronic conditions as well as levels of chronic pain, which was the purpose of this study.
Source: Drug and Alcohol Dependence - December 18, 2014 Category: Addiction Authors: Yulia Khodneva, Paul Muntner, Stefan Kertesz, George Howard, Monika Safford Source Type: research

Measurement of non-VKA oral anticoagulants versus classic ones: the appropriate use of hemostasis assays
This article aims at providing guidance on laboratory testing of classic anticoagulants and NOACs.
Source: Thrombosis Journal - November 4, 2014 Category: Hematology Authors: Jonathan DouxfilsAnne TamigniauBernard ChatelainCatherine GoffinetJean-Michel DognéFrançois Mullier Source Type: research