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Condition: Vitamin D Deficiency
Nutrition: Vitamins

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Total 182 results found since Jan 2013.

Is 25(OH)D Associated with Cognitive Impairment and Functional Improvement in Stroke? A Retrospective Clinical Study
In recent years, vitamin D deficiency has been suggested as a risk factor for ischemic stroke and stroke severity in both animal models and clinical studies. In this retrospective study, we investigated the relationship between 25-hydroxyvitamin D [25(OH)D] levels and functional outcomes in stroke patients during neurological rehabilitation program. We also investigated whether there is an association between 25(OH)D levels and cognitive impairment.
Source: Journal of Stroke and Cerebrovascular Diseases - April 24, 2015 Category: Neurology Authors: Seniz Akcay Yalbuzdag, Banu Sarifakioglu, Sevgi Ikbali Afsar, Canan Celik, Aslı Can, Tugba Yegin, Burcu Senturk, Aliye Yildirim Guzelant Source Type: research

Assessment of 25-hydroxy vitamin D in stroke patients based on severity and type: a cross-sectional study
This study showed that low 25(OH) vit D serum level is common in male but there was not any relation between serum level of 25(OH) vit D, type, and severity of stroke.
Source: Comparative Clinical Pathology - March 16, 2017 Category: Pathology Source Type: research

Vitamin D Status and Related Factors among Korean Stroke Survivors: A Nationwide Population-Based Study.
Authors: Lee JS, Kim YH Abstract The aim of this study was to investigate the vitamin D status and related factors in community-dwelling Korean stroke survivors. Data of 23,872 individuals ≥20 y who participated in the Korea National Health and Nutrition Examination Surveys (KNHANES) were analyzed. Participants who had ever been diagnosed with stroke by a doctor were defined as stroke survivors (n=431). The serum 25-hydroxyvitamin D (25(OH)D) level was measured by radioimmunoassay, and vitamin D deficiency was defined as 25(OH)D<20 ng/mL. The association between vitamin D and stroke status was analyzed using m...
Source: Journal of Nutritional Science and Vitaminology - May 2, 2020 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Genetic polymorphisms of vitamin D3 metabolizing CYP24A1 and CYP2R1 enzymes in Turkish patients with ischemic stroke.
Conclusion This is the first study conducted regarding the association of CYP24A1 rs927650 and CYP2R1 rs10741657 genetic polymorphisms and ischemic stroke risk. The polymorphic genotypes of these polymorphisms, together with hypertension, diabetes, smoking, and obesity, were found as significant risk factors for ischemic stroke. PMID: 29528271 [PubMed - as supplied by publisher]
Source: Neurological Research - March 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Vitamin D and Stroke: Effects on Incidence, Severity, and Outcome and the Potential Benefits of Supplementation
Vitamin D serum level has been positively associated with improved cardiovascular health, especially with reduction of stroke risk. This systemic review summarizes and synthesizes findings from studies relevant to the relationship between vitamin D and stroke risk, severity, and outcome; potential mechanisms explaining such a relationship; and outcomes from vitamin D supplementation. The literature shows that vitamin D deficiency is a significant risk factor for ischemic stroke, with sun exposure, sex, age, race, diabetes, and genetics playing a role as well. Stroke severity and short- and long-term outcomes also worsen wi...
Source: Frontiers in Neurology - June 9, 2020 Category: Neurology Source Type: research

Nutritional Supplementation of Naturally Occurring Vitamin D to Improve Hemorrhagic Stroke Outcomes
Vitamin D deficiency, if left untreated, is associated with bone disorders, cardiovascular damage, and an increased risk of ischemic stroke. While there are various nutritional options for the natural intake of vitamin D, we hope to elucidate the potential mechanisms dietary vitamin D may play in hemorrhagic stroke pathology. This scoping review outlines findings from studies relevant to the biochemical activity of vitamin D, the impact of vitamin D deficiency on hemorrhagic stroke outcomes, and the potential benefit of nutritional vitamin D on hemorrhagic stroke outcomes. Here, we analyze the relevant factors that can lea...
Source: Frontiers in Neurology - July 30, 2021 Category: Neurology Source Type: research

Vitamin D metabolites and fibroblast growth factor-23 in patients with left ventricular assist device implants: association with stroke and mortality risk
Conclusions In LVAD patients, deficient 25OHD levels are independently associated with high stroke and mortality risk. If confirmed in randomized controlled trials, preoperative correction of deficient vitamin D status could be a promising measure to reduce stroke and mortality risk in LVAD patients.
Source: European Journal of Nutrition - February 6, 2015 Category: Nutrition Source Type: research

Serum Vitamin D Status as a Predictor of Prognosis in Patients with Acute Ischemic Stroke
Background: Low 25-hydroxyvitamin D (25(OH)D) concentrations have been shown to predict risk of cardiovascular disease and all-cause mortality. Although the prevalence of 25(OH)D deficiency is high in patients with acute stroke, the prognostic value of 25(OH)D in stroke has not been clearly established. The purpose of this study was to determine whether the baseline serum 25(OH)D level was associated with the functional outcome in patients with acute ischemic stroke. Methods: From June 2011 to January 2014, consecutive patients with acute ischemic stroke within 7 days of symptom onset were enrolled in this study from a pro...
Source: Cerebrovascular Diseases - July 11, 2015 Category: Neurology Source Type: research

Serum 25 ‐hydroxyvitamin D deficiency predicts poor outcome amongst acute ischaemic stroke patients with low high density lipoprotein cholesterol
ConclusionsVitamin D deficiency may be merely an independent risk factor of poor prognosis in ischaemic stroke patients with low HDLC level.
Source: European Journal of Neurology - September 18, 2016 Category: Neurology Authors: T. Xu, C. Zhong, Y. Peng, C. ‐S. Chen, J. Wang, Z. Ju, Q. Li, D. Geng, Y. Sun, D. Zhang, Y. Zhang, J. Chen, T. Xu, Y. Zhang, J. He Tags: Original Article Source Type: research

Serum 25-hydroxyvitamin D deficiency predicts long-term poor prognosis among ischemic stroke patients without hyperglycaemia
Conclusion Serum 25(OH)D deficiency may be merely an independent risk factor of 1-year poor prognosis in ischemic stroke patients without hyperglycemia. Future studies about improving long-term prognosis of ischemic stroke by vitamin D supplementation could be first applied to these patients.
Source: Clinica Chimica Acta - May 22, 2017 Category: Laboratory Medicine Source Type: research

Vitamin D deficiency increases blood-brain barrier dysfunction after ischemic stroke in male rats.
Abstract Because vitamin D hormone deficiency (VDHdef) can worsen severity and outcome for ischemic stroke, we examined the role of VDH in maintaining blood-brain-barrier (BBB integrity) in a rat model of stroke. In most types of stroke, the BBB is markedly compromised, potentially leading to a cascade of injury processes and functional deficits, so we examined a number of biomarkers associated with BBB disruption to determine whether VDH deficiency would further compromise the BBB following a stroke. Male Wistar rats were randomly assigned to one of two diet cohorts, VDH-sufficient (VDHsuf) and VDHdef. The VDHsuf...
Source: Experimental Neurology - November 28, 2018 Category: Neurology Authors: Sayeed I, Turan N, Stein DG, Wali B Tags: Exp Neurol Source Type: research

What is the current role for vitamin D and the risk of stroke ?
Abstract Increasing evidence support the relationship between vitamin D and stroke. Vitamin D have now been proposed as a prognostic biomarker for also functional outcome in stroke patients. A revision of the data suggests that low vitamin D is associated more with ischemic than with haemorrhagic stroke, even if the role of optimal vitamin D levels for vascular wall is still unclear. Vitamin D deficiency induces with different mechanisms an alteration of vascular wall. However, to date, the research supporting the effectiveness of vitamin D supplementation in stroke and in post-stroke recovery is still inadequate ...
Source: Current Neurovascular Research - April 11, 2019 Category: Neurology Authors: Siniscalchi A, Lochner P, Anticoli S, Chirchiglia D, De Sarro G, Gallelli L Tags: Curr Neurovasc Res Source Type: research

Depressed serum 25-Hydroxyvitamin D levels increases hospital stay and alters glucose homeostasis in first ever ischemic stroke.
CONCLUSIONS: 25(OH)D levels are associated with glucose homeostasis ,25(OH) D contributes to increase the length of hospital stay. Low serum 25-OHD level is an independent predictor for hospital stay in first-ever ischemic stroke, Vitamin D deficiency did not predict functional outcome at 3 months. PMID: 31549956 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - September 23, 2019 Category: Neurology Authors: Wang Y, Wang Y, Zhang B, Lin Y, Tan S, Lu Z Tags: Curr Neurovasc Res Source Type: research

Stroke-Induced Peripheral Immune Dysfunction in Vitamin D –Deficient Conditions: Modulation by Progesterone and Vitamin D
AbstractVitamin D deficiency (Ddef) alters morphology and outcomes after a stroke. We investigated the interaction of Ddef following post-stroke systemic inflammation and evaluated whether administration of progesterone (P) or vitamin D (D) will improve outcomes. Ddef rats underwent stroke with lipopolysaccharide (LPS)-induced systemic inflammation. Rats were randomly divided into 9 groups and treated with P, D, or vehicle for 4 days. At day 4, rats were tested on different behavioral parameters. Markers of neuronal inflammation, endoplasmic reticulum stress, oxidative stress, white matter integrity, and apoptosis were mea...
Source: Molecular Neurobiology - February 11, 2021 Category: Neurology Source Type: research

Vitamin D status and its association with season, depression in stroke
ConclusionsVitamin D deficiency and insufficiency occur at high rates in acute stroke patients. Low serum vitamin D levels were associated with depression in patients with acute stroke as analyzed by both the absolute level of vitamin D and month-specific tertiles. Intervention studies are needed to determine the benefits of vitamin D supplementation for depression in poststroke patients.
Source: Neuroscience Letters - October 4, 2018 Category: Neuroscience Source Type: research