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Total 550 results found since Jan 2013.
Mystery of Retinal Vein Occlusion: Vasoactivity of the Vein and Possible Involvement of Endothelin-1.
Abstract
Retinal vein occlusion (RVO) is a common vascular disease of retina; however, the pathomechanism leading to RVO is not yet clear. In general, increasing age, hypertension, arteriosclerosis, diabetes mellitus, dyslipidemia, cardiovascular disorder, and cerebral stroke are systemic risk factors of RVO. However, RVO often occur in the unilateral eye and sometimes develop in young subjects who have no arteriosclerosis. In addition, RVO show different variations on the degrees of severity; some RVO are resolved without any treatment and others develop vision-threatening complications such as macular edema, com...
Source: Biomed Res - September 15, 2017 Category: Research Authors: Kida T Tags: Biomed Res Int Source Type: research
Epidemiology of a Rare Event
Retinal emboli are rare, with a prevalence in most of the relatively few studies on the subject, to my knowledge, of approximately 1 in 100 adults and an even smaller annual incidence. The study by Cheung et al in the present issue ofJAMA Ophthalmology involves the multiethnic population of Singapore and found that retinal emboli were present in only 88 of 9978 individuals who had retinal photographs (0.9%). This randomly selected sample of adults aged 40 to 80 years comprised, in almost equal numbers, of members of the 3 major ethnic groups residing in Singapore: Chinese, Malay, and Indian. Cheung et al provided data rele...
Source: JAMA Ophthalmology - October 1, 2017 Category: Opthalmology Source Type: research
E-088 Investigation of safety termination of antiplatelet therapy after lvis stent-assisted cerebral aneurysm coiling
Conclusion
Termination of AT at 3 months postoperatively did not result in ischemic events among patients who underwent LSAC. Neointimal formation of Lvis stent may be a criterion for termination of AT without increasing the risk of ischemic event.
Disclosures:
K. Takayama: None. K. Myouchin: None. T. Wada: None. S. Kurokawa: None. K. Kichikawa: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Takayama, K., Myouchin, K., Wada, T., Kurokawa, S., Kichikawa, K. Tags: Electronic Poster Abstracts Source Type: research
Not as Simple as Canker Sores
BY NANA P. MATSUMOTO, & DEREK MEEKS, DOA 16-year-old boy presented to a rural ED with a swollen jaw, painful blisters in the mouth, and earache for the past day. One week before, he had a fever with chills, sore throat, and dry coughs. He was not taking any medications, and his immunizations were up-to-date. He had a mild learning disorder but no significant past medical or surgical history.An apthous ulcer, the most common and one of the earliest signs of Behçet's disease.The patient's vital signs were within normal limits, and his physical examination revealed anterior cervical lymphadenopathy, sinus con...
Source: The Case Files - October 11, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes
AbstractImpaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5 –14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). ...
Source: Translational Stroke Research - November 8, 2017 Category: Neurology Source Type: research
The technique of superselective ophthalmic artery chemotherapy for retinoblastoma: The Garrahan Hospital experience.
Conclusion SOAC is a safe technique with a very low complication rate.
PMID: 29119878 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - November 10, 2017 Category: Radiology Tags: Interv Neuroradiol Source Type: research
Ocular Manifestations of Obstructive Sleep Apnea
Conclusions:Hypoxia induced by nightly cessation of breathing increases patients' risk of coronary artery disease, heart failure, stroke, and other conditions. As with many maladies detrimental to vascular health, obstructive sleep apnea affects the eye and ocular adnexa. This paper summarizes the current evidence implicating OSA in these ocular maladies and highlights their proposed mechanisms. The authors describe ocular pathology which sleep specialists may encounter. We encourage more aggressive attention to ocular symptoms in patients with sleep apnea to prevent vision-threatening complications. Further research shoul...
Source: Journal of Clinical Sleep Medicine : JCSM - November 14, 2017 Category: Sleep Medicine Source Type: research
Retinal Artery Occlusions.
Authors: Lang GE, Lang SJ
Abstract
Retinal artery occlusions are acute vascular diseases. Very often they are caused by an embolisation. Rarely a thrombosis is caused by an arteriitis. In the acute phase diagnosis in most of the cases can be made by ophthalmoscopy due to the whitish retinal edema and in central retinal artery occlusion the cherry red spot. Difficulties in making the diagnosis can occur in the chronic stage, especially after reperfusion of the retinal vessels, when the fundus colour returned to normal again. Several diagnostic procedures help to make the diagnosis. Unfortunately there is no generall...
Source: Klinische Monatsblatter fur Augenheilkunde - November 21, 2017 Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
Dietary patterns and retinal vessel caliber in the Irish Nun Eye Study
ConclusionIn this cohort of older women with a restricted lifestyle, an unhealthy DP was independently associated with an unfavorable retinal profile, namely a widening of retinal venules and narrowing of retinal arterioles. Key words: Dietary
Source: The Journal of Nutrition, Health and Aging - December 5, 2017 Category: Nutrition Source Type: research
Current treatment of central retinal artery occlusion: a national survey
ConclusionsThis survey shows that there is significant variability in treatment practices for acute CRAO in the US. Because of the high cerebrovascular and cardiovascular risk reported in this population of patients, it is notable that the approach to risk factor screening is also highly variable and many programs do not routinely refer patients to an emergency department for urgent evaluation. Finally, there appears to be equipoise among treatment teams regarding the efficacy of systemic fibrinolysis, as 53% of programs report a willingness to treat at least some patients with this modality.
Source: Journal of Neurology - December 13, 2017 Category: Neurology Source Type: research
Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1 ‐related stroke
ABSTRACT
Mutations in the α1 (COL4A1) or α2 (COL4A2) chains of collagen type IV, a major component of the vascular basement membrane, cause intracerebral haemorrhages with variable expressivity and reduced penetrance by mechanisms that remain poorly understood. Here we sought to investigate the cellular mechanisms of COL4A1‐related intracerebral haemorrhage and identify a marker for haemorrhage risk‐stratification. A combination of histological, immunohistochemical and electron microscopy analyses were used to analyse the brain parenchyma, cerebrovasculature, and retinal vessels of mice expressing the disease‐causi...
Source: The Journal of Pathology - December 20, 2017 Category: Pathology Authors: Julien Ratelade, Nicolas Mezouar, Val érie Domenga‐Denier, Ambre Rochey, Emmanuelle Plaisier, Anne Joutel Tags: Original Paper Source Type: research
Not as Simple as Canker Sores
BY NANA P. MATSUMOTO, & DEREK MEEKS, DOA 16-year-old boy presented to a rural ED with a swollen jaw, painful blisters in the mouth, and earache for the past day. One week before, he had a fever with chills, sore throat, and dry coughs. He was not taking any medications, and his immunizations were up-to-date. He had a mild learning disorder but no significant past medical or surgical history.An apthous ulcer, the most common and one of the earliest signs of Behçet's disease.The patient's vital signs were within normal limits, and his physical examination revealed anterior cervical lymphadenopathy, sinus con...
Source: The Case Files - October 11, 2017 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Follow-up Insufficient After Retinal Infarction Follow-up Insufficient After Retinal Infarction
Despite retinal infarction being a harbinger of subsequent stroke, patients with that condition don ' t receive proper risk factor evaluation and only 8% are referred to a neurologist, a new study shows.Medscape Medical News
Source: Medscape Medical News Headlines - February 7, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Perioperative Retinal Artery Occlusion: Incidence and Risk Factors in Spinal Fusion Surgery From the US National Inpatient Sample 1998–2013
Background:
Retinal artery occlusion (RAO) is a rare but devastating complication of spinal fusion surgery. We aimed to determine its incidence and associated risk factors.
Methods:
Hospitalizations involving spinal fusion surgery were identified by searching the National Inpatient Sample, a database of hospital discharges, from 1998 to 2013. RAO cases were identified using ICD-9-CM codes. Using the STROBE guidelines, postulated risk factors were chosen based on literature review and identified using ICD-9-CM codes. Multivariate logistic models with RAO as outcome, and risk factors, race, age, admission, and surgery t...
Source: Journal of Neuro-Ophthalmology - February 21, 2018 Category: Opthalmology Tags: Original Contribution Source Type: research
Proteomic analysis of plasma from children with sickle cell anemia and silent cerebral infarction.
Abstract
Silent cerebral infarction is the commonest neurological abnormality in children with sickle cell anemia, affecting 30-40% 14 year olds. There are no known biomarkers to identify children with silent cerebral infarcts and the pathological basis is also unknown. We used an unbiased proteomic discovery approach to identify plasma proteins differing in concentration between children with and without silent cerebral infarcts. Clinical parameters and plasma samples were analysed from 51 children (mean age 11.8 years, range 6-18) with sickle cell anemia (HbSS). 19 children had silent cerebral infarcts and 32 no...
Source: Haematologica - March 15, 2018 Category: Hematology Authors: Tewari S, Renney G, Brewin J, Gardner K, Kirkham F, Inusa B, Barrett JE, Menzel S, Thein SL, Ward M, Rees DC Tags: Haematologica Source Type: research
