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Nutrition: Antidoxidants

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Total 1078 results found since Jan 2013.

Heme oxygenase-1: clinical relevance in ischemic stroke.
Abstract Stroke is the second-leading cause of death and a leading cause of serious long-term disability worldwide, with an icreasing global burden due to the growing and aging population. However, strict eligibility criteria for current treatment opportunities make novel therapeutic apporaches desirable. Oxidative stress plays a pivotal role during cerebral ischemia, eventually leading to neuronal injury and cell death. The significant correlation between redox imbalance and ischemic stroke has led to various treatment strategies targeting the endogenous antioxidant system in order to ameliorate the adverse progn...
Source: Current Pharmaceutical Design - July 16, 2018 Category: Drugs & Pharmacology Authors: Bereczki D, Balla J, Bereczki D Tags: Curr Pharm Des Source Type: research

Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke
Publication date: Available online 7 November 2018Source: Life SciencesAuthor(s): Kanta Pravalika, Deepaneeta Sarmah, Harpreet Kaur, Kanchan Vats, Jackson Saraf, Madhuri Wanve, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Kunjan R. Dave, Pallab BhattacharyaAbstractAimStroke is devastating with a limited choice of intervention. Many pharmacological entities are available but none of them have evolved successfully in counteracting the multifaceted molecular alterations following stroke. Myeloperoxidase (MPO) has been reported to play an important role in neuroinflammation following neurodegenerative diseases. Therefore, usi...
Source: Life Sciences - November 8, 2018 Category: Biology Source Type: research

Baihui Point Laser Acupuncture Ameliorates Cognitive Impairment, Motor Deficit, and Neuronal Loss Partly via Antioxidant and Anti-Inflammatory Effects in an Animal Model of Focal Ischemic Stroke.
In conclusion, Baihui point laser acupuncture alleviates cognitive impairment and motor deficits via antioxidant and anti-inflammatory effects in focal ischemic rats. Further study is warranted to investigate other possible mechanisms of action. PMID: 30915140 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - March 29, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Calcitriol protects the Blood-Brain Barrier integrity against ischemic stroke and reduces vasogenic brain edema via antioxidant and antiapoptotic actions in rats.
CONCLUSION: Calcitriol may reduce brain injury and attenuate vasogenic edema by upregulating antioxidant enzymes activities, reducing cell apoptosis and increasing BDNF protein in the brain tissue in a rat model of ischemic stroke. PMID: 31220552 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - June 16, 2019 Category: Neurology Authors: Sadeghian N, Shadman J, Moradi A, Ghasem Golmohammadi M, Panahpour H Tags: Brain Res Bull Source Type: research

Central Application of Aliskiren, a Renin Inhibitor, Improves Outcome After Experimental Stroke Independent of Its Blood Pressure Lowering Effect
Epidemiological studies suggest that pharmacological reduction of systemic hypertension lowers incidence and severity of stroke. However, whether the reduction of blood pressure per se or the compounds used to reduce hypertension are responsible for this effect received little attention. In the current study we therefore aimed to investigate whether Aliskiren, a renin-inhibitor used to treat arterial hypertension, may improve outcome in a mouse model of ischemic stroke when applied centrally and in a dose not affecting blood pressure. Male C57BL/6 mice received 0.6, 2.0, or 6.0 µg Aliskiren or vehicle by intracerebroven...
Source: Frontiers in Neurology - September 3, 2019 Category: Neurology Source Type: research

Serum Uric Acid and Risk of Hemorrhagic Transformation in Patients with Acute Ischemic Stroke
AbstractUric acid (UA) is an antioxidant with neuroprotective effects in experimental stroke models. Whether serum UA plays a role in hemorrhagic transformation (HT) remains unclear. We aimed to explore the association between serum UA and HT in patients with acute ischemic stroke (AIS). AIS patients within 7  days after stroke onset were consecutively enrolled between January 2016 and October 2017. Patients were categorized into three groups according to serum UA tertiles by sex. HT was detected by follow-up CT or MRI within 7 days after admission. The multivariate logistic analysis was performed to a ssess the associat...
Source: Journal of Molecular Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Attenuating effect of α‐pinene on neurobehavioural deficit, oxidative damage and inflammatory response following focal ischaemic stroke in rat
ConclusionsIt was ultimately attainted that α‐pinene exerts neuroprotective effect in ischaemic stroke in rat through the restoration of antioxidant enzymes activity, attenuation of lipid peroxidation and reduction of inflammation in the ischaemic brains.
Source: Journal of Pharmacy and Pharmacology - September 15, 2019 Category: Drugs & Pharmacology Authors: Mahdieh Khoshnazar, Mohammad Reza Bigdeli, Siavash Parvardeh, Ramin Pouriran Tags: Research Paper Source Type: research

Improvement of a novel proposal for antioxidant treatment against brain damage occurring in ischemic stroke patients.
Abstract The underlying mechanism of cerebral injury occurring in patients with acute ischemic stroke involves a key pathophysiological role of oxidative stress. Thus, reactive oxygen species are related to the development of brain edema, calcium overload, mitochondrial dysfunction, excitotoxicity, iron release and inflammation. Nevertheless, although experimental studies have tested the use of antioxidants as an adjuvant therapy in this setting, clinical data and randomized trials are still lacking. Current approved pharmacological therapy is aimed at reperfusion strategies; however, the therapeutic window is lim...
Source: CNS and Neurological Disorders Drug Targets - September 9, 2020 Category: Drugs & Pharmacology Authors: Orellana-Urzúa S, Claps G, Rodrigo R Tags: CNS Neurol Disord Drug Targets Source Type: research

Protective effect of grape seed extract and orlistat co-treatment against stroke: Effect on oxidative stress and energy failure.
Abstract Ischemic stroke is a major health concern and a leading cause of mortality worldwide. Oxidative stress is an early event in the course of stroke inducing neuro-inflammation and cell death. Grape seed extract (GSE) is a natural phytochemical mixture exhibiting antioxidant, anti-inflammatory and neuroprotective properties. Orlistat (ORL) is an anti-obesity agent and a gastro-intestinal lipase inhibitor which showed recently beneficial effects on brain lipotoxicity. Recent studies reported the increase of lipase activity upon stroke which led us to investigate the neuroprotective effect of ORL on rat brain I...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 20, 2021 Category: Drugs & Pharmacology Authors: Kadri S, El Ayed M, Kadri A, Limam F, Aouani E, Mokni M Tags: Biomed Pharmacother Source Type: research

Licochalcone B attenuates neuronal injury through anti-oxidant effect and enhancement of Nrf2 pathway in MCAO rat model of stroke
CONCLUSIONS: The present study revealed the neuroprotective effects of Lico B in MCAO rats. Importantly, we proposed a potential mechanism that Lico B activated the Nrf2 pathway, thereby acting as anti-oxidant to attenuate neuronal injury and apoptosis after stroke. The proposed mechanism provided an encouraging possibility for anti-oxidant therapy of stroke.PMID:34454290 | DOI:10.1016/j.intimp.2021.108073
Source: International Immunopharmacology - August 28, 2021 Category: Allergy & Immunology Authors: Baosheng Zhou Honglin Wang Bo Zhang Lianlian Zhang Source Type: research

Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke
In conclusion, Fos acts as an important link between hypertension and IS. Furthermore, Fos can be used as a potential biomarker for target therapy in the prevention of stroke among hypertensive patients and also potential treatment targeting apoptosis and oxidative stress after its onset.
Source: Frontiers in Neurology - October 21, 2021 Category: Neurology Source Type: research

Gut Flora Mediates the Rapid Tolerance of Electroacupuncture on Ischemic Stroke by Activating Melatonin Receptor through Regulating Indole-3-Propionic Acid
This study aimed to clarify the mechanisms of action of treatments of cerebral ischemic stroke from the perspective of gut microecology. We used a mouse model and cell cultures to investigate the effects of EA on the intestinal microflora in mice models of middle cerebral artery occlusion (MCAO) and the mechanisms underlying the antioxidant activities of metabolites. Fecal microbiota transplantation (FMT) was used to validate the roles of gut microbiota. Metabolomic analysis was performed to characterize the metabolic profile differences between the mice in the EA + MCAO and MCAO groups. Gavaging with feces relieved brain ...
Source: The American Journal of Chinese Medicine - April 27, 2022 Category: Complementary Medicine Authors: Shan Li Xiaoyong Zhao Feihong Lin Xuqing Ni Xia Liu Chang Kong Xinyu Yao Yunchang Mo Qinxue Dai Junlu Wang Source Type: research