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Nutrition: Antidoxidants
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Total 1078 results found since Jan 2013.
Gut Flora Mediates the Rapid Tolerance of Electroacupuncture on Ischemic Stroke by Activating Melatonin Receptor through Regulating Indole-3-Propionic Acid
This study aimed to clarify the mechanisms of action of treatments of cerebral ischemic stroke from the perspective of gut microecology. We used a mouse model and cell cultures to investigate the effects of EA on the intestinal microflora in mice models of middle cerebral artery occlusion (MCAO) and the mechanisms underlying the antioxidant activities of metabolites. Fecal microbiota transplantation (FMT) was used to validate the roles of gut microbiota. Metabolomic analysis was performed to characterize the metabolic profile differences between the mice in the EA + MCAO and MCAO groups. Gavaging with feces relieved brain ...
Source: The American Journal of Chinese Medicine - April 27, 2022 Category: Complementary Medicine Authors: Shan Li Xiaoyong Zhao Feihong Lin Xuqing Ni Xia Liu Chang Kong Xinyu Yao Yunchang Mo Qinxue Dai Junlu Wang Source Type: research
Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke
Biomaterials. 2022 Nov 10;291:121904. doi: 10.1016/j.biomaterials.2022.121904. Online ahead of print.ABSTRACTOxidative stress and mitochondrial damage are the main mechanisms of ischemia-reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free radical scavenging ability were used as carriers to load dl-3-n-butylphthalide (NBP-CeO2 NPs) for the combined treatment of ischemic stroke. NBP-CeO2 NPs could eliminate reactive oxygen species (ROS) in mouse brain microvascular endothelial cells and hippocampal neurons after oxygen-glucose deprivation/reoxygenation (OGD/R), and also save mitochond...
Source: Biomaterials - November 20, 2022 Category: Materials Science Authors: Xiang Li Zhihui Han Tianyi Wang Cheng Ma Haiying Li Huali Lei Yuqi Yang Yuanjie Wang Zifan Pei Zhuang Liu Liang Cheng Gang Chen Source Type: research
A Bioinspired Manganese-Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant Enzymes
Adv Sci (Weinh). 2023 May 2:e2206854. doi: 10.1002/advs.202206854. Online ahead of print.ABSTRACTFollowing stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients. Nanozyme-based antioxidants are emerging to treat stroke through scavenging excessive ROS. However, most of nanozymes cannot efficiently scavenge ROS in neuronal cytosol and mitochondria, due to low-uptake abilities of neurons and barriers of organelle membranes, significantly limiting nanozymes' neuroprotective effects. To overcome this limitation, a man...
Source: Adv Data - May 2, 2023 Category: Epidemiology Authors: Jian Wang Yang Wang Xiakeerzhati Xiaohalati Qiangfei Su Jingwei Liu Bo Cai Wen Yang Zheng Wang Lin Wang Source Type: research
Association between dietary antioxidant capacity and atherosclerotic carotid stenosis in patients with ischemic stroke
CONCLUSIONS: DTAC may influence the initiation and development of atherosclerosis, and, therefore, the risk of ischemic stroke.PMID:37210776 | DOI:10.1016/j.jstrokecerebrovasdis.2023.107148
Source: Atherosclerosis - May 21, 2023 Category: Cardiology Authors: Jizi Ma Xuerong Jia Yaqian Xia Min Peng Yantong Chen Jingjing Cai Xinfeng Liu Gelin Xu Source Type: research
Dietary Flavonoid Intake and Carotid Calcification in Patients with Ischemic Stroke
CONCLUSION: Dietary flavonoid intake is associated with carotid calcification, and, therefore, may influence the risk of stroke occurrence and recurrence.PMID:37524067 | DOI:10.1159/000532117
Source: Atherosclerosis - July 31, 2023 Category: Cardiology Authors: Tao Mou Xuerong Jia Min Peng Xiang Li Yaqian Xia Yantong Chen Qing Wang Xiaoke Wang Xinfeng Liu Gelin Xu Source Type: research
Naringenin prevents ischemic stroke damage via anti-apoptotic and anti-oxidant effects.
This study aimed to investigate the anti-apoptotic and anti-oxidant effects of naringenin on ischemic stroke. In vitro, cortical neuron cells isolated from the brains of neonatal Sprague-Dawley rats were randomly divided into control, oxygen and glucose deprivation/reperfusion (OGD/Rep), NAR-L, NAR-M and NAR-H groups. MTT and RT-PCR were used for cell proliferation and apoptosis-related proteins analyses. The effects of NAR on the Nrf2 signaling pathway were investigated using transfection approaches. Differences in mitochondrial dysfunction were analyzed by flow cytometry. In vivo, middle cerebral artery occlusion (MCAO) ...
Source: Pharmacological Reports - April 28, 2017 Category: Drugs & Pharmacology Authors: Wang K, Chen Z, Huang J, Huang L, Luo N, Liang X, Liang M, Xie W Tags: Clin Exp Pharmacol Physiol Source Type: research
Correlation of Serum Nitric Oxide (NO) with Glasgow Coma Scale (GCS) in Acute Ischemic Stroke Patient: A Study in North India
AbstractNitric oxide (NO) is one of the key players in the pathogenesis of ischemic stroke. Limited reports are available about the serum level of NO and their correlation with Glasgow Coma Scale (GCS) score in acute (<24 h) ischemic stroke (AIS) patients. A hospital based, cross sectional study was done in North Indian population to find out correlation of serum NO and GCS in AIS patients. 50 patients of AIS and 25 healthy controls were chosen for the study. Serum NO level was measured by ELISA and GCS scores were assessed by a neurologist. Pearson correlation coefficients were analyzed to look for the relationship b...
Source: Indian Journal of Clinical Biochemistry - July 5, 2017 Category: Biochemistry Source Type: research
