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Total 1078 results found since Jan 2013.

How To Avoid China ’ s Medicine Monopoly
I want to share a shocking statistic with you… Around 80% of all the pharmaceuticals sold in America — both prescription and over-the-counter — are manufactured in China. I’m talking about drugs for Parkinson’s and Alzheimer’s, blood pressure and blood thinners, diuretics, aspirin, antibiotics, and a big chunk of the world’s insulin and diabetes drugs — just to name a few.1 We don’t even make penicillin anymore. The last penicillin plant in the U.S. closed its doors in 2004. Americans who rely on medicine are now almost entirely at the mercy of a country whose relations with the U.S. have become more ...
Source: Al Sears, MD Natural Remedies - September 19, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news

Solasodine protects rat brain against ischemia/reperfusion injury through its antioxidant activity.
Abstract Ischemic stroke is the second leading cause of death worldwide. The major limitation of stroke management is the lack of clinically effective therapy. Antioxidants have been demonstrated as potent neuroprotective agents by enhancing the defense mechanism(s), whereas reducing the oxidative stress in the ischemic stroke models. In the present study, we evaluated neuroprotective potential of solasodine, an antioxidant glycoalkaloid of Solanum species, against global model of ischemia in rats. Ischemia/reperfusion (I/R)-injury produced marked elevation in lipid peroxidation (LPO) and nitric oxide (NO), wherea...
Source: European Journal of Pharmacology - January 17, 2014 Category: Drugs & Pharmacology Authors: Tejas S, Vishal A, Nimesh P, Devendra V, Ranpariya V, Sheth N, Parmar S Tags: Eur J Pharmacol Source Type: research

Supplementation with different teas from Camellia sinensis prevents memory deficits and hippocampus oxidative stress in ischemia-reperfusion
Publication date: September 2017 Source:Neurochemistry International, Volume 108 Author(s): Alexandre Martins, Helen L. Schimidt, Alexandre Garcia, Caroline Dalla Colletta Altermann, Francielli W. Santos, Felipe P. Carpes, Weber Cláudio da Silva, Pâmela B. Mello-Carpes Memory and cognition impairments resultant of ischemic stroke could be minimized or avoided by antioxidant supplementation. In this regard, the neuroprotective potential of Green tea from Camellia sinensis has been investigated. However, there is a lack of information regarding the neuroprotective potential of others teas processed from the Camellia sinen...
Source: Neurochemistry International - July 13, 2017 Category: Neuroscience Source Type: research

Neuroprotective Effects of Grape Seed Procyanidin Extract on Ischemia-Reperfusion Brain Injury
Conclusion GSPE administration protects mice from ischemia-reperfusion brain injury through attenuating oxidative stress and apoptosis, promoting angiogenesis, and activating antioxidant enzyme GSH-Px. GSPE may represent a new therapeutical direction for the treatment of ischemia-reperfusion brain injury.
Source: Chinese Medical Sciences Journal - July 13, 2017 Category: General Medicine Source Type: research

Ferulic acid-loaded nanostructured lipid carriers: A promising nanoformulation against the ischemic neural injuries
Publication date: 15 January 2018 Source:Life Sciences, Volume 193 Author(s): Parichehr Hassanzadeh, Elham Arbabi, Fatemeh Atyabi, Rassoul Dinarvand Aims Treatment of the ischemic stroke has remained a major healthcare challenge. The phenolic compound, ferulic acid (FA), has shown promising antioxidant and neuroprotective effects, however, low bioavailability may negatively affect its efficiency. This, prompted us to incorporate FA into the nanostructured lipid carriers (FA-NLCs) and evaluate its therapeutic potential in in vitro and in vivo models of ischemic stroke. Main methods FA-NLCs were prepared by high-pressure ho...
Source: Life Sciences - December 22, 2017 Category: Biology Source Type: research

Poststroke Depressive Symptoms Are Associated With Increased Oxidative Deoxyribonucleic Acid Damage.
Authors: Chen CY, Chen CL, Yang YH, Ho CH, Tseng WC Abstract Poststroke depression is independently associated with poor health outcomes, such as increased mortality, disability, anxiety, and lower quality of life. Identifying the potential biomarkers and detailed mechanisms of poststroke depression may improve the effectiveness of therapeutic intervention. In this cross-sectional study, the authors recruited patients with subacute ischemic stroke who were consecutively admitted for neurorehabilitation. Depression was assessed with the Patient Health Questionnaire-9 (PHQ-9), with a cutoff based on a summed-items sc...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - January 27, 2018 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

Role of heme oxygenases in cardiovascular syndromes and co-morbidities.
CONCLUSIONS: Each of the six major categories of CVD exhibit features of pathogenesis that hold potential as future therapeutic targets, for modulated heme oxygenase activity. PMID: 30051777 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - July 26, 2018 Category: Drugs & Pharmacology Authors: Haines DD, Tosaki A Tags: Curr Pharm Des Source Type: research

Tyrosol attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation in in vitro oxygen glucose deprivation
Publication date: Available online 4 October 2018Source: Neurochemistry InternationalAuthor(s): Gang Luo, Yinuo Huang, Dapeng Mo, Ning Ma, Feng Gao, Ligang Song, Xuan Sun, Xiaotong Xu, Lian Liu, Xiaochuan Huo, Bo Wang, Xiaoqing Li, Baixue Jia, Yiming Deng, Xuelei Zhang, Alejandro Fernandez-Escobar, Guangge Peng, Zhongrong MiaoAbstractSubsequent inflammation in stroke plays an important role in the damage of neurons in the perilesional area. Therapeutic intervention targeting inflammation may be a promising complementary strategy to current treatments of stroke. Here, we explored the possible beneficial effects of tyrosol, ...
Source: Neurochemistry International - October 4, 2018 Category: Neuroscience Source Type: research

Neuroprotective effect of Paeoniae Radix Rubra on hippocampal CA1: region of mice induced by transient focal cerebral ischemia via anti-gliosis and anti-oxidant activity
Conclusion: PRR improved neuronal injuries that were induced by transient cerebral ischemia via inhibiting gliosis and elevating antioxidants.
Source: Chinese Herbal Medicines - October 29, 2018 Category: Complementary Medicine Source Type: research

Theaflavic acid from black tea protects PC12 cells against ROS-mediated mitochondrial apoptosis induced by OGD/R via activating Nrf2/ARE signaling pathway
AbstractCerebral ischemic stroke is a severe disease afflicting people worldwide. Phytochemicals play a pivotal role in the discovery of novel therapeutic approaches for the prevention of ischemic stroke. In our continual search for bioactive natural products for the treatment of ischemic stroke, we have evaluated the protective effects of theaflavic acid (TFA) from black tea using PC12 cells injured by oxygen and glucose deprivation/restoration (OGD/R), and investigated the possible mechanisms. The results showed that TFA can protect PC12 cells against OGD/R through increasing cell viability and decreasing intracellular l...
Source: Journal of Natural Medicines - June 20, 2019 Category: Drugs & Pharmacology Source Type: research

Moderate Protein Restriction Protects Against Focal Cerebral Ischemia in Mice by Mechanisms Involving Anti-inflammatory and Anti-oxidant Responses
AbstractFood composition influences stroke risk, but its effects on ischemic injury and neurological deficits are poorly examined. While severe reduction of protein content was found to aggravate neurological impairment and brain injury as a consequence of combined energy-protein malnutrition, moderate protein restriction not resulting in energy deprivation was recently suggested to protect against perinatal hypoxia-ischemia. Male C57BL6/j mice were exposed to moderate protein restriction by providing a normocaloric diet containing 8% protein (control: 20% protein) for 7, 14, or 30  days. Intraluminal middle cerebral arte...
Source: Molecular Neurobiology - June 30, 2019 Category: Neurology Source Type: research

Protective effects of hederagenic acid on PC12 cells against the OGD/R-induced apoptosis via activating Nrf2/ARE signaling pathway
AbstractCerebral ischemic stroke is a severe cause of disability and death among people worldwide. The occlusion of cerebral blood flow has resulted in the infarction due to the oxygen and glucose deprivation. Though timely reperfusion can reduce the infarct size, the oxidative stress triggered in ischemia and reperfusion will induce apoptosis of neurons in penumbra. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor regulating the expression of antioxidant enzymes through binding to antioxidant response elements (ARE). The activation of Nrf2/ARE pathway can protect neurons against oxidative stres...
Source: Medicinal Chemistry Research - October 31, 2019 Category: Chemistry Source Type: research

Phycocyanobilin reduces brain injury after endothelin-1- induced focal cerebral ischemia.
Abstract Pharmacological therapies for interrupting biochemical events of the ischemic cascade and protecting against stroke in humans are as yet unavailable. Up to now, the neuroprotective activity in cerebral ischemia of Phycocyanobilin (PCB), a tetrapyrrolic natural antioxidant, has not been fully examined. Here, we evaluated if PCB protects PC12 neuronal cells against oxygen and glucose deprivation plus reperfusion, and its protective effects in a rat model of endothelin-1-induced focal brain ischemia. PCB was purified from the cyanobacteria Spirulina platensis and characterized by spectrophotometric, liquid a...
Source: Clinical and Experimental Pharmacology and Physiology - November 14, 2019 Category: Drugs & Pharmacology Authors: Pavón-Fuentes N, Marín-Prida J, Llópiz-Arzuaga A, Falcón-Cama V, Campos-Mojena R, Cervantes-Llanos M, Piniella-Matamoros B, Pentón-Arias E, Pentón-Rol G Tags: Clin Exp Pharmacol Physiol Source Type: research

Study: Drinking Tea May Help You Live Longer, Especially If It ’ s Green
This study strengthens the body of evidence that habitual tea drinking is associated with lower rates of atherosclerotic cardiovascular disease, though it cannot prove that it’s definitely the tea that’s responsible,” Dr. Jenna Macciochi, a lecturer in immunology at the University of Sussex, told the SMC. However, she noted that “a body of evidence in nutrition suggests that whole diet patterns are more informative of diet-disease relationships than any isolated food or nutrient.” Dr. Duane Mellor, a registered dietitian and senior teaching fellow at Aston Medical School, Aston University, sai...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 10, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston CNN Green Tea Source Type: news

Oxidative stress in the pathogenesis of Alzheimer's disease and cerebrovascular disease with therapeutic implications.
Abstract The significant gain in life expectancy led to an increase in the incidence and prevalence of dementia. Although vascular risk factors have long and repeatedly been shown to increase the risk of Alzheimer's disease (AD), translating these findings into effective preventive measures has failed. In addition, the finding that incident ischemic stroke approximately doubles the risk of a patient to develop AD has been recently reinforced. Current knowledge and pathogenetic hypotheses of AD are discussed. The implication of oxidative stress in the development of AD is reviewed, with special emphasis on its sudd...
Source: CNS and Neurological Disorders Drug Targets - March 2, 2020 Category: Drugs & Pharmacology Authors: Jurcau A, Simion A Tags: CNS Neurol Disord Drug Targets Source Type: research