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Nutrition: Antidoxidants

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Total 1078 results found since Jan 2013.

Neuroprotective effect of 2-hydroxy arachidonic acid in a rat model of transient middle cerebral artery occlusion
This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - July 4, 2017 Category: Biochemistry Source Type: research

Tetramethylpyrazine protects bone marrow-derived mesenchymal stem cells against hydrogen peroxide-induced apoptosis through PI3K/Akt and ERK1/2 pathways.
In conclusion, our results confirm that TMP protects BMSCs against H2O2-induced apoptosis by regulating the PI3K/Akt and ERK1/2 signaling pathways, suggesting that TMP may be used in combination with BMSCs to improve cell survival for the treatment of ischemic stroke. PMID: 28978811 [PubMed - as supplied by publisher]
Source: Biological and Pharmaceutical Bulletin - October 4, 2017 Category: Drugs & Pharmacology Authors: Fang Y, Chu L, Li L, Wang J, Yang Y, Gu J, Zhang J Tags: Biol Pharm Bull Source Type: research

Plasma Metal Concentrations and Incident Coronary Heart Disease in Chinese Adults: The Dongfeng-Tongji Cohort
Conclusions: Our study suggested that incident CHD was positively associated with plasma levels of titanium and arsenic, and inversely associated with selenium. Additional research is needed to confirm these findings in other populations. https://doi.org/10.1289/EHP1521 Received: 22 December 2016 Revised: 17 September 2017 Accepted: 19 September 2017 Published: 19 October 2017 Address correspondence to T. Wu, or A. Pan, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Rd., Wuhan 430030, Hubei, China. Telephone: +86-27-83692347. Email: wut@mails.tjmu.edu.cn or p...
Source: EHP Research - October 20, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

mfat ‐1 transgene protects cultured adult neural stem cells against cobalt chloride‐mediated hypoxic injury by activating Nrf2/ARE pathways
Abstract Ischemic stroke is a devastating neurological disorder and one of the leading causes of death and serious disability in adults. Adult neural stem cell (NSC) replacement therapy is a promising treatment for both structural and functional neurological recovery. However, for the treatment to work, adult NSCs must be protected against hypoxic‐ischemic damage in the ischemic penumbra. In the present study, we aimed to investigate the neuroprotective effects of the mfat‐1 transgene on cobalt chloride (CoCl2)‐induced hypoxic‐ischemic injury in cultured adult NSCs as well as its underlying mechanisms. The results ...
Source: Journal of Neuroscience Research - June 22, 2017 Category: Neuroscience Authors: Junfeng Yu, Haiyuan Yang, Bin Fang, Zhengwei Zhang, Ying Wang, Yifan Dai Tags: Research Article Source Type: research

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - February 16, 2018 Category: Neurology Authors: Matthew Houston Source Type: research

Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and Neurodegenerative Diseases: Regulation and Implication
AbstractNeurological diseases, including acute attacks (e.g., ischemic stroke) and chronic neurodegenerative diseases (e.g., Alzheimer ’s disease), have always been one of the leading cause of morbidity and mortality worldwide. These debilitating diseases represent an enormous disease burden, not only in terms of health suffering but also in economic costs. Although the clinical presentations differ for these diseases, a growing body of evidence suggests that oxidative stress and inflammatory responses in brain tissue significantly contribute to their pathology. However, therapies attempting to prevent oxidative damage o...
Source: Molecular Neurobiology - February 27, 2018 Category: Neurology Source Type: research

Serum albumin and cardiovascular diseases: A comprehensive review of the literature.
This article provides an overview of the physiological properties of serum albumin, the prevalence, causes, prognostic value and potential contribution to the emergence and aggravation of cardiovascular disease of hypoalbuminemia, as well as its clinical implications. PMID: 29544976 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - March 12, 2018 Category: Cardiology Authors: Arques S Tags: Ann Cardiol Angeiol (Paris) Source Type: research

Gualou Guizhi Granule Protects Against Oxidative Injury by Activating Nrf2/ARE Pathway in Rats and PC12 Cells.
The objective of this study is to investigate the protective effect of Gualou Guizhi granule (GLGZG) against oxidative stress and explore the protective mechanism of the Nrf2/ARE pathway. In vivo, administration of GLGZG in a rat model of focal cerebral ischemia significantly suppressed oxidative injury by increasing the activity of superoxide dismutase and glutathione level and decreasing reactive oxygen species and malondialdehyde levels. Western blot analysis showed that GLGZG induced nuclear translocation of Nrf2, and combined with real-time PCR results, which indicated that GLGZG up-regulated the Nrf2/ARE pathway. In ...
Source: Neurochemical Research - March 21, 2018 Category: Neuroscience Authors: Zhang Y, Fan L, Li H, Wang X, Xu W, Chu K, Lin Y Tags: Neurochem Res Source Type: research

Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2-VEGF Pathway.
In conclusion, administered XST for 7 days after stroke could significantly improve functional recovery and promote angiogenesis, that might be related to Nrf2 signaling pathway. These findings could provide scientific evidence for the use of XST in cerebral ischemic diseases and provide theoretical support for further studies. PMID: 29633164 [PubMed - as supplied by publisher]
Source: Neurochemical Research - April 9, 2018 Category: Neuroscience Authors: Guo H, Adah D, James PB, Liu Q, Li G, Ahmadu P, Chai L, Wang S, Liu Y, Hu L Tags: Neurochem Res Source Type: research

Human serum albumin in cardiovascular diseases.
Abstract Cardiovascular diseases are the leading cause of death worldwide. Endothelial dysfunction, inflammation and oxidative stress are at the forefront in the onset and development of atherosclerosis and many cardiovascular diseases. Epidemiological evidence is that low serum albumin levels are linked to incident ischemic heart disease, heart failure, atrial fibrillation, stroke and venous thromboembolism, independent of risk factors, body mass index and inflammation. Hypoalbuminemia has also emerged as an independent prognosticator in many cardiovascular diseases, such as coronary artery disease, heart failure...
Source: European Journal of Internal Medicine - April 18, 2018 Category: Internal Medicine Authors: Arques S Tags: Eur J Intern Med Source Type: research

Clinical benefits and pharmacology of Scutellarin: A comprehensive review
Publication date: Available online 6 May 2018 Source:Pharmacology & Therapeutics Author(s): Liping Wang, Qiang Ma Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. The current drug therapy of choice is to timely resupply the blood to the ischemic ti...
Source: Pharmacology and Therapeutics - May 6, 2018 Category: Drugs & Pharmacology Source Type: research

CTRP9 ameliorates cellular senescence via PGC ‑1α/AMPK signaling in mesenchymal stem cells.
CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells. Int J Mol Med. 2018 May 09;: Authors: Li Q, Zhu Z, Wang C, Cai L, Lu J, Wang Y, Xu J, Su Z, Zheng W, Chen X Abstract Stroke is the second most common cause of death worldwide, and thus, it imposes great financial burdens on both individuals and society. Mesenchymal stem cell (MSC) therapy is a promising approach for ischemic brain injury. However, MSC treatment potential is progressively reduced with age, limiting their therapeutic efficacy for brain repair post‑stroke. C1q and tumor necrosis factor‑relat...
Source: International Journal of Molecular Medicine - May 9, 2018 Category: Molecular Biology Authors: Li Q, Zhu Z, Wang C, Cai L, Lu J, Wang Y, Xu J, Su Z, Zheng W, Chen X Tags: Int J Mol Med Source Type: research

Serum Glutaredoxin Activity as a Marker of Oxidative Stress in Chronic Kidney Disease: A Pilot Study
Conclusion: Our pilot study indicates that Grx may be a useful marker for assessing the degree of oxidative stress in CKD, however this needs further investigation in a larger prospective patient cohort.Nephron
Source: Nephron - October 5, 2018 Category: Urology & Nephrology Source Type: research

Neuroprotective effect of Paeoniae Radix Rubra on hippocampal CA1 region of mice induced by transient focal cerebral ischemia via anti-gliosis and anti-oxidant activity
ConclusionPRR improved neuronal injuries that were induced by transient cerebral ischemia via inhibiting gliosis and elevating antioxidants.
Source: Chinese Herbal Medicines - November 15, 2018 Category: Complementary Medicine Source Type: research

ASAP New Quinolylnitrones for Stroke Therapy: Antioxidant and Neuroprotective ( < italic toggle="yes" > Z < /italic > )- < italic toggle="yes" > N < /italic > - < italic toggle="yes" > tert < /italic > -Butyl-1-(2-chloro-6-methoxyquinolin-3-yl)methanimine Oxide as a New Lead-Compound for Ischemic Stroke Treatment
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b01987
Source: Journal of Medicinal Chemistry - February 15, 2019 Category: Chemistry Authors: Mourad Chioua, Emma Mart ínez-Alonso, Rafael Gonzalo-Gobernado, Maria I. Ayuso, Alejandro Escobar-Peso, Lourdes Infantes, Dimitra Hadjipavlou-Litina, Juan J. Montoya, Joan Montaner, Alberto Alcázar, José Marco-Contelles Source Type: research