Filtered By:
Specialty: Neuroscience
Education: Learning

This page shows you your search results in order of relevance. This is page number 9.

Order by Relevance | Date

Total 286 results found since Jan 2013.

Toward a better dexterity: Direction for future studies
Performing an accurate and adequate motor task is a key function in our daily living activities, and improvement of dexterity is a main concern especially in stroke survivors. Thus, the development of new strategies to improve motor learning and to promote stroke recovery is desirable.
Source: Clinical Neurophysiology - April 8, 2013 Category: Neuroscience Authors: Samar S. Ayache Tags: Editorials Source Type: research

S14-4. Possibility of a useful intervention of exercise induced by muscle fatigue to change excitabilities of corticospinal and cortico-cortical tracts for functional recovery in neurorehabilitation
Motor learning and synaptic plasticity in the cortex are enhanced by interventions that reduce the effectiveness of GABAergic intracortical inhibition. The disinhibition of SICI by muscle fatigue could enhance synaptic plasticity and improve the consolidation of motor learning. We found that the corticospinal excitability and SICI decrease after exhaustive muscle contraction or muscle fatigue. It seems possible that decreased SICI can enhance synaptic plasticity if motor learning or skill training is combined with muscle fatigue. Interestingly, fatigue in muscles on the opposite side of the body or in lower limb muscles re...
Source: Clinical Neurophysiology - July 16, 2013 Category: Neuroscience Authors: Atsuo Maruyama Tags: Society Proceedings Source Type: research

IS 39. Enhanced visuo-spatial and language learning with tDCS
Efficacy and effectiveness of training in conditions like chronic post-stroke aphasia or neglect, or neurodegenerative disorders like mild cognitive impairment (MCI) and Alzheimer’s disease, remain moderate only. Thus, novel strategies to enhance training success and overall behavioural outcome are urgently needed. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tool that is now being widely used in neuroscientific and clinical research in humans, modulating cortical excitability by application of weak electrical currents in the form of direct current brain polarization.In a series of st...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: A. Flöel, W. Suttorp, M. Meinzer, C. Breitenstein Tags: Society Proceedings Source Type: research

The effect of haptic guidance and visual feedback on learning a complex tennis task.
Abstract While haptic guidance can improve ongoing performance of a motor task, several studies have found that it ultimately impairs motor learning. However, some recent studies suggest that the haptic demonstration of optimal timing, rather than movement magnitude, enhances learning in subjects trained with haptic guidance. Timing of an action plays a crucial role in the proper accomplishment of many motor skills, such as hitting a moving object (discrete timing task) or learning a velocity profile (time-critical tracking task). The aim of the present study is to evaluate which feedback conditions-visual or hapt...
Source: Experimental Brain Research - September 8, 2013 Category: Neuroscience Authors: Marchal-Crespo L, van Raai M, Rauter G, Wolf P, Riener R Tags: Exp Brain Res Source Type: research

IS 39. Enhanced visuo-spatial and language learning with tDCS
Efficacy and effectiveness of training in conditions like chronic post-stroke aphasia or neglect, or neurodegenerative disorders like mild cognitive impairment (MCI) and Alzheimer’s disease, remain moderate only. Thus, novel strategies to enhance training success and overall behavioural outcome are urgently needed. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tool that is now being widely used in neuroscientific and clinical research in humans, modulating cortical excitability by application of weak electrical currents in the form of direct current brain polarization.In a series of st...
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: A. Flöel, W. Suttorp, M. Meinzer, C. Breitenstein Tags: Society Proceedings Source Type: research

Periodic Estrogen Receptor-Beta Activation: A Novel Approach to Prevent Ischemic Brain Damage.
Abstract In women, the risk for cerebral ischemia climbs rapidly after menopause. At menopause, production of ovarian hormones; i.e., progesterone and estrogen, slowly diminishes. Estrogen has been suggested to confer natural protection to premenopausal women from ischemic stroke and some of its debilitating consequences. This notion is also strongly supported by laboratory studies showing that a continuous chronic 17β-estradiol (E2; a potent estrogen) regimen protects brain from ischemic injury. However, concerns regarding the safety of the continuous intake of E2 were raised by the failed translation to the cli...
Source: Neurochemical Research - June 7, 2014 Category: Neuroscience Authors: Cue L, Diaz F, Briegel KJ, Patel HH, Raval AP Tags: Neurochem Res Source Type: research

Registration of challenging pre-clinical brain images
Publication date: 30 May 2013 Source:Journal of Neuroscience Methods, Volume 216, Issue 1 Author(s): William R. Crum , Michel Modo , Anthony C. Vernon , Gareth J. Barker , Steven C.R. Williams The size and complexity of brain imaging studies in pre-clinical populations are increasing, and automated image analysis pipelines are urgently required. Pre-clinical populations can be subjected to controlled interventions (e.g., targeted lesions), which significantly change the appearance of the brain obtained by imaging. Existing systems for registration (the systematic alignment of scans into a consistent anatomical coordinate...
Source: Journal of Neuroscience Methods - November 8, 2014 Category: Neuroscience Source Type: research

Features and models for human activity recognition
In this study, an Information Correlation Coefficient (ICC) analysis was carried out followed by a wrapper Feature Selection (FS) method on the reduced input space. Additionally, a novel HAR method is proposed for this specific problem of stroke early diagnosing, comprising an adaptation of the well-known Genetic Fuzzy Finite State Machine (GFFSM) method. To the best of the author׳s knowledge, this is the very first analysis of the feature space concerning all the previously published feature transformations on raw acceleration data. The main contributions of this study are the optimization of the sample rate, selection o...
Source: Neurocomputing - July 10, 2015 Category: Neuroscience Source Type: research

Learning from brain control: clinical application of brain–computer interfaces
In conclusion, clinical application of brain machine interfaces in well-defined and circumscribed neurological disorders have demonstrated surprisingly positive effects. The application of BCIs to psychiatric and clinical–psychological problems, however, at present did not result in substantial improvement of complex behavioral disorders.
Source: e-Neuroforum - October 6, 2015 Category: Neuroscience Source Type: research

Intravenous PEP-1-GDNF is protective after focal cerebral ischemia in rats
Publication date: 23 March 2016 Source:Neuroscience Letters, Volume 617 Author(s): Yaning Liu, Shangwu Wang, Shijian Luo, Zhendong Li, Fengyin Liang, Yanan Zhu, Zhong Pei, Ruxun Huang Glial cell line-derived neurotrophic factor (GDNF) is a potential therapeutic protein on a variety of central nervous system diseases including ischemic stroke. However, GDNF is a large molecule that cannot cross the blood–brain barrier (BBB), which is still intact in the early hours after stroke when neural rescue is possible. PEP-1 protein transduction domain can deliver protein cargo across the cell membrane and the BBB. In the...
Source: Neuroscience Letters - February 20, 2016 Category: Neuroscience Source Type: research

Reinforcement learning of self-regulated sensorimotor β-oscillations improves motor performance
Publication date: 1 July 2016 Source:NeuroImage, Volume 134 Author(s): G. Naros, I. Naros, F. Grimm, U. Ziemann, A. Gharabaghi Self-regulation of sensorimotor oscillations is currently researched in neurorehabilitation, e.g. for priming subsequent physiotherapy in stroke patients, and may be modulated by neurofeedback or transcranial brain stimulation. It has still to be demonstrated, however, whether and under which training conditions such brain self-regulation could also result in motor gains. Thirty-two right-handed, healthy subjects participated in a three-day intervention during which they performed 462 trials...
Source: NeuroImage - April 19, 2016 Category: Neuroscience Source Type: research

Learning from brain control: clinical application of brain –computer interfaces
In conclusion, clinical application of brain machine interfaces in well-defined and circumscribed neurological disorders have demonstrated surprisingly positive effects. The application of BCIs to psychiatric and clinical–psychological problems, however, at present did not result in substantial improvement of complex behavioral disord ers.
Source: e-Neuroforum - October 31, 2015 Category: Neuroscience Source Type: research

Effects of Dimeric PSD-95 Inhibition on Excitotoxic Cell Death and Outcome After Controlled Cortical Impact in Rats.
The objectives of the present study were to assess the effects of a dimeric inhibitor of PSD-95, UCCB01-144, on excitotoxic cell death in vitro and outcome after experimental TBI in rats in vivo. In addition, the pharmacokinetic parameters of UCCB01-144 were investigated in order to assess uptake of the drug into the central nervous system of rats. After a controlled cortical impact rats were randomized to receive a single injection of either saline or two different doses of UCCB01-144 (10 or 20 mg/kg IV) immediately after injury. Spatial learning and memory were assessed in a water maze at 2 weeks post-trauma, and at 4Â...
Source: Neurochemical Research - August 21, 2017 Category: Neuroscience Authors: Sommer JB, Bach A, Malá H, Gynther M, Bjerre AS, Gram MG, Marschner L, Strømgaard K, Mogensen J, Pickering DS Tags: Neurochem Res Source Type: research

CNS Summit 2017 Abstracts of Poster Presentations
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - November 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

Automated Evaluation of Upper-Limb Motor Function Impairment Using Fugl-Meyer Assessment
The Fugl-Meyer assessment (FMA) is the most popular instrument for evaluating upper extremity motor function in stroke patients. However, it is a labor-intensive and time-consuming method. This paper proposes a novel automated FMA system to overcome these limitations of the FMA. For automation, we used Kinect v2 and force sensing resistor sensors owing to their convenient installation as compared with body-worn sensors. Based on the linguistic guideline of the FMA, a rule-based binary logic classification algorithm was developed to assign FMA scores using the extracted features obtained from the sensors. The algorithm is a...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - January 1, 2018 Category: Neuroscience Source Type: research