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Total 286 results found since Jan 2013.

The right uncinate fasciculus supports verbal short-term memory in aphasia
Brain Struct Funct. 2023 Apr 2. doi: 10.1007/s00429-023-02628-9. Online ahead of print.ABSTRACTVerbal short-term memory (STM) deficits are associated with language processing impairments in people with aphasia. Importantly, the integrity of STM can predict word learning ability and anomia therapy gains in aphasia. While the recruitment of perilesional and contralesional homologous brain regions has been proposed as a possible mechanism for aphasia recovery, little is known about the white-matter pathways that support verbal STM in post-stroke aphasia. Here, we investigated the relationships between the language-related whi...
Source: Brain Structure and Function - April 3, 2023 Category: Neuroscience Authors: Guillem Oliv é Claudia Pe ñaloza Luc ía Vaquero Matti Laine Nadine Martin Antoni Rodriguez-Fornells Source Type: research

IS 15. Flashes of insight: Non-conventional NIBS reveals novel ways to stimulate the brain
Conclusion: These non-conventional NIBS techniques may thus be opening new research domains for influencing brain activity and to treat neurological and psychiatric disorders in a non-invasive way.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: A. Antal, L. Chaieb, G.G. Ambrus, W. Paulus Tags: Society Proceedings Source Type: research

IS 45. Brain stimulation-enhanced therapy for visual neglect
Conclusions: This is the first proof-of-principle demonstration that a single-shot, simple behavioural procedure combined with TDCS can remediate treatment-unresponsive chronic visual neglect. TDCS provoked a positive therapeutic response in patients who did not otherwise respond to the behavioural therapy. By enhancing the consolidation of prism therapy, TDCS increased both the gain and longevity of therapeutic response, yielding large, long-lasting improvements in visual neglect.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: J. O’Shea, P. Revol, H. Cousijn, J. Near, C. Stagg, G. Rode, Y. Rossetti Tags: Society Proceedings Source Type: research

P 171. Bihemispheric motor cortex stimulation in older adults induces modulations of resting state and task-related activity
Bihemispheric transcranial direct current stimulation (“dual” tDCS) of primary motor cortices has been described to enhance motor learning in healthy subjects and to facilitate motor recovery after stroke. In order to investigate the neural correlates of its mode of action, we compared different tDCS montages in a group of healthy older adults in a cross-over design (‘dual’ vs. ‘anodal’ vs. ‘sham’).20 subjects (mean age 68.7±4.7years, all right-handed) underwent tDCS and simultaneous MRI at 3T, including resting state fMRI and a choice reaction time task. In the task, subjects were presented with different...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: R. Lindenberg, L. Nachtigall, M. Meinzer, M.M. Sieg, A. Flöel Tags: Society Proceedings Source Type: research

A Robotic Platform to Assess, Guide and Perturb Rat Forelimb Movements
Animal models are widely used to explore the mechanisms underlying sensorimotor control and learning. However, current experimental paradigms allow only limited control over task difficulty and cannot provide detailed information on forelimb kinematics and dynamics. Here we propose a novel robotic device for use in motor learning investigations with rats. The compact, highly transparent, three degree-of-freedom manipulandum is capable of rendering nominal forces of 2 N to guide or perturb rat forelimb movements, while providing objective and quantitative assessments of endpoint motor performance in a $50times 30~{hbox{mm}}...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - September 1, 2013 Category: Neuroscience Source Type: research

IS 15. Flashes of insight: Non-conventional NIBS reveals novel ways to stimulate the brain
Conclusion: These non-conventional NIBS techniques may thus be opening new research domains for influencing brain activity and to treat neurological and psychiatric disorders in a non-invasive way.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: A. Antal, L. Chaieb, G.G. Ambrus, W. Paulus Tags: Society Proceedings Source Type: research

IS 45. Brain stimulation-enhanced therapy for visual neglect
Conclusions: This is the first proof-of-principle demonstration that a single-shot, simple behavioural procedure combined with TDCS can remediate treatment-unresponsive chronic visual neglect. TDCS provoked a positive therapeutic response in patients who did not otherwise respond to the behavioural therapy. By enhancing the consolidation of prism therapy, TDCS increased both the gain and longevity of therapeutic response, yielding large, long-lasting improvements in visual neglect.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: J. O’Shea, P. Revol, H. Cousijn, J. Near, C. Stagg, G. Rode, Y. Rossetti Tags: Society Proceedings Source Type: research

P 171. Bihemispheric motor cortex stimulation in older adults induces modulations of resting state and task-related activity
Bihemispheric transcranial direct current stimulation (“dual” tDCS) of primary motor cortices has been described to enhance motor learning in healthy subjects and to facilitate motor recovery after stroke. In order to investigate the neural correlates of its mode of action, we compared different tDCS montages in a group of healthy older adults in a cross-over design (‘dual’ vs. ‘anodal’ vs. ‘sham’).20 subjects (mean age 68.7±4.7years, all right-handed) underwent tDCS and simultaneous MRI at 3T, including resting state fMRI and a choice reaction time task. In the task, subjects were presented with different...
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: R. Lindenberg, L. Nachtigall, M. Meinzer, M.M. Sieg, A. Flöel Tags: Society Proceedings Source Type: research

59. Alterations of the electroencephalographic rhythms in children with Sickle Cell disease (SCD): Source analysis with LORETA
Sickle Cell Disease (SCD) is a congenital familial pathology of the haemoglobin and it is classified as the most common genetic disease in the world.Neurological complications are very frequent: symptomatic stroke occurs in 11% of the SCD patients before they reach 20years of age, while 35% of the patients shows silent damages at the RMN with cognitive impairments and learning disabilities. The aim of this study is to verify the hypothesis that a different cerebral maturation between children with SCD and healthy controls exists. This has been achieved with the spectral analysis of electroencephalographic (EEG) rhythms and...
Source: Clinical Neurophysiology - October 21, 2013 Category: Neuroscience Authors: A. Bertoldo, P. Rampazzo, R. Manara, R. Colombatti, L. Sainati, M. Ermani Tags: Society Proceedings Source Type: research

Glun2b N‐methyl‐D‐aspartic acid receptor subunit mediates atorvastatin‐Induced neuroprotection after focal cerebral ischemia
This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and GluN2B subunits of the N‐methyl‐D‐aspartic acid receptor in the somatosensory cerebral cortex at short and long periods following ischemia. Sham and ischemic male Wistar rats received 10 mg/kg of ATV or placebo by gavage every 24 hr for 3 consecutive days. The first dose was administered 6 hr after ischemia–reperfusion or the sham operation. ATV treatment resulted in faster recovery of neurological scores than placebo, prevented the appearance of pyknotic neurons, and restored microtubule‐associated protein 2 and neuronal nuclei stain...
Source: Journal of Neuroscience Research - June 17, 2014 Category: Neuroscience Authors: Johanna Andrea Gutierrez‐Vargas, Juan Ignacio Muñoz‐Manco, Luis Miguel Garcia‐Segura, Gloria Patricia Cardona‐Gómez Tags: Research Article Source Type: research

Cerebellum Tunes the Excitability of the Motor System: Evidence from Peripheral Motor Axons.
Abstract Cerebellum is highly connected with the contralateral cerebral cortex. So far, the motor deficits observed in acute focal cerebellar lesions in human have been mainly explained on the basis of a disruption of the cerebello-thalamo-cortical projections. Cerebellar circuits have also numerous anatomical and functional interactions with brainstem nuclei and projects also directly to the spinal cord. Cerebellar lesions alter the excitability of peripheral motor axons as demonstrated by peripheral motor threshold-tracking techniques in cerebellar stroke. The biophysical changes are correlated with the function...
Source: Cerebellum - June 25, 2014 Category: Neuroscience Authors: Nodera H, Manto M Tags: Cerebellum Source Type: research

Neurorehabilitation: From sensorimotor adaptation to motor learning, or the opposite?
In a recent editorial, Vasudevan (2014) argued that amplifying movement errors through sensorimotor adaptation can be an interesting way to improve walking post-stroke and more generally to develop new approach in neurorehabilitation. I would like to comment further this idea and to raise some key issues that should be addressed to complete this discussion.
Source: Clinical Neurophysiology - February 5, 2014 Category: Neuroscience Authors: François Bonnetblanc Tags: Letters to the Editor Source Type: research

The Dance Between The Immune System and Stem Cells
We named it the  immunoLinkTM We have been testing a growing number of Clients with our Quantibody Arrays. Many of of these clients have Autoimmune Disorder Diseases. These range from Rheumatoid Arthritis to Multiple Sclerosis.These arrays are designed to precisely measure factors or markers (proteins) that are dysregulated by these diseases. We measure the levels of these biomarkers in our Clients' Blood serum. The arrays have also been used to measure the levels of markers in plasma and cell culture supernatants.Based on results, we are finding links between immune system and stem cell health. We call this the ...
Source: Neuromics - September 30, 2014 Category: Neuroscience Tags: autoimmune disease G-CSF GM-CSF Human Mesenchymal Stem Cells immune response immunoLink Neural Progenitor Cells Neural Stem Cell Markers Source Type: news

Understanding and Modulating Motor Learning with Cerebellar Stimulation.
Abstract Non-invasive brain stimulation techniques are a powerful approach to investigate the physiology and function of the central nervous system. Recent years have seen numerous investigations delivering transcranial magnetic stimulation (TMS) and or transcranial direct current stimulation (tDCS) to the cerebellum to determine its role in motor, cognitive and emotional behaviours. Early studies have shown that it is possible to assess cerebellar-motor cortex (CB-M1) connectivity using a paired-pulse TMS paradigm called cerebellar inhibition (CBI), and indirectly infer the state of cerebellar excitability. Thus,...
Source: Cerebellum - October 5, 2014 Category: Neuroscience Authors: Celnik P Tags: Cerebellum Source Type: research