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Total 286 results found since Jan 2013.

Is Matrix Metalloproteinase-9 Associated with Post-Stroke Cognitive Impairment or Dementia?
CONCLUSIONS: MMP-9 level and MMP-9 rs3918242 polymorphism have an important role in the occurrence and development of post-stroke cognitive impairment or dementia (PSCID).PMID:36424752 | DOI:10.31083/j.jin2106160
Source: Journal of Integrative Neuroscience - November 25, 2022 Category: Neuroscience Authors: Jianhua Zhao Fangli Yang Xue Peng Qing Li Fan Wang Zhixiu Xu Ruiyan Cai Danxia Ji Jian Zhang Minghua Wang Qiong Li Sibei Ji Shaomin Li Source Type: research

Personalized and parametrized AVATAR for interacting with post-stroke action-perception loop during rehabilitation
Discussion – conclusion Using increased avatar allows to interfere with the action-perception loop, and make healthy and affected subjects bend their knee more than usual. We expect mirror neuron system to be involved in this spontaneous imitation mechanism. Experimentation dedicated to brain afferents is considered using an electroencephalogram to determine an optimum angle with stroke patients to generalize use of enhanced feedback during rehabilitation.
Source: Neurophysiologie Clinique - November 7, 2016 Category: Neuroscience Source Type: research

Increased functional connectivity one week after motor learning and tDCS in stroke patients
Publication date: 6 January 2017 Source:Neuroscience, Volume 340 Author(s): Stéphanie Lefebvre, Laurence Dricot, Patrice Laloux, Philippe Desfontaines, Frédéric Evrard, André Peeters, Jacques Jamart, Yves Vandermeeren Recent studies using resting-state functional magnetic resonance imaging (rs-fMRI) demonstrated that changes in functional connectivity (FC) after stroke correlate with recovery. The aim of this study was to explore whether combining motor learning to dual transcranial direct current stimulation (dual-tDCS, applied over both primary motor cortices (M1)) modulated FC in stroke patients. Twenty-two chronic...
Source: Neuroscience - November 25, 2016 Category: Neuroscience Source Type: research

A single session of anodal transcranial direct current stimulation applied over the affected primary motor cortex does not alter gait parameters in chronic stroke survivors
ConclusionA single session of a-tDCS delivered to the leg motor cortex did not immediately improve gait parameters in individuals with chronic stroke, regardless of their BDNF genotype.
Source: Neurophysiologie Clinique - July 31, 2019 Category: Neuroscience Source Type: research

Forced use of paretic leg induced by constraining the non-paretic leg leads to motor learning in individuals post-stroke.
Abstract The purpose of this study was to determine whether applying repetitive constraint forces to the non-paretic leg during walking would induce motor learning of enhanced use of the paretic leg in individuals post-stroke. Sixteen individuals post chronic (> 6 months) stroke were recruited in this study. Each subject was tested in two conditions, i.e., applying a constraint force to the non-paretic leg during treadmill walking and treadmill walking only. For the constraint condition, subjects walked on a treadmill with no force for 1 min (baseline), with force for 7 min (adaptation), and then without f...
Source: Experimental Brain Research - August 11, 2019 Category: Neuroscience Authors: Wu M, Hsu CJ, Kim J Tags: Exp Brain Res Source Type: research

Automated Segmentation of Acute Stroke Lesions Using a Data-driven Anomaly Detection on Diffusion Weighted MRI
ConclusionsThe current method is straightforward, fast, and shows good agreement with the lesions identified by human experts.
Source: Journal of Neuroscience Methods - January 3, 2020 Category: Neuroscience Source Type: research

Quantitative Assessment of Upper-Limb Motor Function for Post-Stroke Rehabilitation Based on Motor Synergy Analysis and Multi-Modality Fusion
Functional assessment is an essential part of rehabilitation protocols after stroke. Conventionally, the assessment process relies heavily on clinical experience and lacks quantitative analysis. In order to objectively quantify the upper-limb motor impairments in patients with post-stroke hemiparesis, this study proposes a novel assessment approach based on motor synergy quantification and multi-modality fusion. Fifteen post-stroke hemiparetic patients and fifteen age-matched healthy persons participated in this study. During different goal-directed tasks, kinematic data and surface electromyography(sEMG) signals were sync...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - March 31, 2020 Category: Neuroscience Source Type: research

Feasibility of Wearable Sensing for In-Home Finger Rehabilitation Early After Stroke
Wearable grip sensing shows potential for hand rehabilitation, but few studies have studied feasibility early after stroke. Here, we studied a wearable grip sensor integrated with a musical computer game (MusicGlove). Among the stroke patients admitted to a hospital without limiting complications, 13% had adequate hand function for system use. Eleven subjects used MusicGlove at home over three weeks with a goal of nine hours of use. On average they achieved 4.1 ± 3.2 (SD) hours of use and completed 8627 ± 7500 grips, an amount comparable to users in the chronic phase of stroke measured in a previous st...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - May 31, 2020 Category: Neuroscience Source Type: research

In-Bed Sensorimotor Rehabilitation in Early and Late Subacute Stroke Using a Wearable Elbow Robot: A Pilot Study
Conclusion: In-bed wearable elbow robotic rehabilitation is feasible and effective in improving biomechanical and clinical outcomes for early and late subacute stroke in-patients. Results from the pilot study suggested that patients with severe upper limb motor impairment may benefit more from the robot training compared to those with moderate impairment.
Source: Frontiers in Human Neuroscience - May 24, 2021 Category: Neuroscience Source Type: research

Intelligible Models for HealthCare: Predicting the Probability of 6-Month Unfavorable Outcome in Patients with Ischemic Stroke
AbstractEarly prediction of unfavorable outcome after ischemic stroke is significant for clinical management. Machine learning as a novel computational modeling technique could help clinicians to address the challenge. We aim to investigate the applicability of machine learning models for individualized prediction in ischemic stroke patients and demonstrate the utility of various model-agnostic explanation techniques for machine learning predictions. A total of 499 consecutive patients with Unfavorable [modified Rankin Scale (mRS) score 3 –6,n = 140] and favorable (mRS score 0–2,n = 359) outcome after 6-month f...
Source: Neuroinformatics - August 26, 2021 Category: Neuroscience Source Type: research

Enhanced error facilitates motor learning in weight shift and increases use of the paretic leg during walking at chronic stage after stroke
In conclusion, applying pelvis resistance forces to increase error signals may facilitate motor learning of weight shift toward the paretic side and enhance use of the paretic leg in chronic stroke survivors. Results from this study may be utilized to develop an intervention approach to improve walking in stroke survivors.PMID:34477919 | DOI:10.1007/s00221-021-06202-9
Source: Experimental Brain Research - September 3, 2021 Category: Neuroscience Authors: Seoung Hoon Park Chao-Jung Hsu Weena Dee Elliot J Roth William Z Rymer Ming Wu Source Type: research

An Intelligent Rehabilitation Assessment Method for Stroke Patients Based on Lower Limb Exoskeleton Robot
The 6-min walk distance (6MWD) and the Fugl-Meyer assessment lower-limb subscale (FMA-LE) of the stroke patients provide the critical evaluation standards for the effect of training and guidance of the training programs. However, gait assessment for stroke patients typically relies on manual observation and table scoring, which raises concerns about wasted manpower and subjective observation results. To address this issue, this paper proposes an intelligent rehabilitation assessment method (IRAM) for rehabilitation assessment of the stroke patients based on sensor data of the lower limb exoskeleton robot. Firstly, the feat...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - August 4, 2023 Category: Neuroscience Source Type: research

IS 27. Brain stimulation in stroke therapy
Non-invasive brain stimulation has shown its potential to modulate brain plasticity and enhance the effects of training in humans (Zimerman et al., Ann Neurol; 2012). Endeavour has been made to utilize brain stimulation in neurological diseases to enhance adaptive processes and prevent potential maladaptive ones. First studies presented evidence that non-invasive brain stimulation might not only transiently improve functions of the paretic hand, but can also modulate processes of learning (Zimerman et al., Stroke; 2012), a basis to achieve longer lasting effects. Based on this enhancement of functional recovery of both, se...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: F.C. Hummel Tags: Society Proceedings Source Type: research

P 155. Serial anodal tDCS over V1 induces long-term effects on colour discrimination in V4 measured in the unimpaired hemifield of patients with occipital stroke
Conclusion: Long-term modulation in colour perception following serial anodal tDCS may represent evidence of inducible long-term plasticity in distantly connected components of the visual system (V1 and V4) in patients with occipital stroke measured in the unimpaired hemifield. This builds on studies describing the immediate effects of tDCS in the visual system in healthy volunteers. The temporal dynamics of serial anodal tDCS seem to interact with learning processes, and may yield potential support for neuroplastic adaptation processes following cerebral lesions. Future studies should examine the long-term outcomes and dy...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: R. Dargie, M. Olma, J. Behrens, A. Kraft, K. Irlbacher, M. Fahle, S. Brandt Tags: Society Proceedings Source Type: research

P 168. TMS neurophysiology and interventional rTMS in children with perinatal stroke: Safety and tolerability in the PLASTIC CHAMPS trial
Introduction/Question: Perinatal stroke causes hemiplegic cerebral palsy and lifelong disability. TMS can define neurophysiology and central therapeutic targets while rTMS carries therapeutic potential in adult stroke but have not been applied to the more plastic developing brain. Ipsilateral projections from the unlesioned hemisphere to the affected hand are prominent in this population and the effects of non-lesioned inhibitory rTMS are unknown.Methods: PLASTIC CHAMPS is a randomized, blinded, factorial clinical trial of rTMS and constraint therapy (CIMT) to enhance upper extremity function in children (6–18years) with...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: T. Rajapakse, O. Kirton, J. Roe, A. Kirton Tags: Society Proceedings Source Type: research