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CNS Summit 2017 Abstracts of Poster Presentations

Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky D Affiliation: CSO, Caprion Biosciences, Inc., Montreal, Quebec, Canada Background/Objective: Early detection markers are critical for neurodegenerative diseases since substantial, irreversible damage to the brain occurs by the time of clinical diagnosis. Markers of disease progression are also important, as established clinical assessment tools can require a year or more to detect changes. Current efforts in our laboratory include developing such markers in Alzheimer’s, Parkinson’s, and Huntington’s diseases. Design: Candidate biomarkers were identified in the literature for each disease, and targeted metabolic response modifiers (MRM) mass spectrometry assays were assembled. In the case of Huntington’s disease, very few candidate markers were known in the literature, so a label-free liquid chromatography–tandem mass spectrom...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research

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Authors: Tavares Paes Barreto AC, Rangel da Rocha Paschoal AC, Barbosa Farias C, Gomes Nogueira Borges PS, Gonelli Albanez da Cunha Andrade R, de Orange FA Abstract INTRODUCTION: Anesthesia emergence delirium (AED) is a self-limiting clinical phenomenon very common in children. Although pathophysiology is still uncertain, some factors seem to be involved, such as rapid awakening in an unknown environment, agitation during anesthetic induction, preoperative anxiety, environmental disorders, use of preanesthetic medication, use of inhalational anesthetics, and postoperative pain. OBJECTIVE: To determine the preva...
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
CONCLUSIONS: Among ischemic stroke patients, higher omentin-1 levels were inversely associated with carotid plaque instability, but not associated with moderate-severe carotid stenosis or occlusion. Omentin-1 may represent a biomarker for predicting carotid plaque instability of acute ischemic stroke patients. PMID: 29225325 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
CONCLUSIONS: Cilnidipine promoted the regression of common carotid IMT in post-stroke hypertensive patients, especially in the thick group. Cilnidipine also reduced the IAD in both normal and thick groups. PMID: 29225324 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
THE GRIEVING parents of a six-year-old boy who died from Meningitis B are calling for all children to be vaccinated against the deadly strain of the disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Under the leadership of Professor Bart De Strooper, the UK Dementia Research Institute aims to revolutionise the way we diagnose and treat dementia and improve quality of life for everyone affected.
Source: Alzheimers Society - Category: Geriatrics Source Type: news
To the Editor: We read with interest the letter by Drago et  al1 responding to our article on alcohol intake and increased risk for rosacea.2 On the basis of the positive association between rosacea and small intestinal bacterial overgrowth (SIBO) in their prior study, Drago et al examined alcohol intake as a risk factor for SIBO in rosacea patients in a c ase-control study.1 The authors propose that ethanol causes achlorhydria and decreased intestinal motility, which favor the proliferation of luminal bacteria, leading to SIBO.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD online Source Type: research
The objective of the study was to compare the vasodilator efficacy of topical 10% nifedipine versus 5% sildenafil in subjects with secondary RP associated with connective tissue disease. A prospective study was performed including 10 patients with secondary RP. We excluded tobacco smokers, patients with primary RP, hypotension, hypertension, myocardial infarction, stroke, or arrhythmia.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
This study aimed to perform a systematic review and meta-analysis on the association between vitamin D levels and AA.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
Subcision is a commonly performed procedure for depressed rolling scars of acne.1 Breaking up the fibrotic strands mechanically with a blade or needle leads to neocollagenosis and hematoma formation, resulting in elevation of the depressed scars. However, the excessive mechanical force often leads to trauma to the surrounding tissue, excessive bleeding, and large hematoma formation and fibrosis.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: JAAD online Source Type: research
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