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Condition: Hemorrhagic Stroke
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Total 196 results found since Jan 2013.

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research

Influence of the Intensive Care Unit Environment on the Reliability of the Montreal Cognitive Assessment
Conclusions: The reliability of the MoCA was excellent, independent from the testing environment being ICU or office. This finding is helpful for patient care and studies investigating the effect of therapeutic interventions on the neuropsychological outcome after SAH, stroke or traumatic brain injury.
Source: Frontiers in Neurology - July 2, 2019 Category: Neurology Source Type: research

One-Third of COVID-19 Survivors May Develop a Neuropsychiatric Disorder Within Months of Infection
One-third of individuals diagnosed with COVID-19 developed a psychiatric or neurological problem within six months of their diagnosis, according to astudy published Tuesday inThe Lancet Psychiatry. The prevalence of a post-COVID neurologic or psychiatric diagnosis was even greater among individuals with severe illness who had required hospitalization.“Given the size of the pandemic and the chronicity of many of the diagnoses and their consequences (for example, dementia, stroke, and intracranial hemorrhage), substantial effects on health and social care systems are likely to occur,” wrote Maxime Taque, Ph.D., of the Un...
Source: Psychiatr News - April 7, 2021 Category: Psychiatry Tags: anxiety COVID-19 electronic health records hospitalizations mood disorders neuropsychiatric disorders The Lancet Psychiatry Source Type: research

Behavioral Assessment of Sensory, Motor, Emotion, and Cognition in Rodent Models of Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is the second most common type of stroke and has one of the highest fatality rates of any disease. There are many clinical signs and symptoms after ICH due to brain cell injury and network disruption resulted from the rupture of a tiny artery and activation of inflammatory cells, such as motor dysfunction, sensory impairment, cognitive impairment, and emotional disturbance, etc. Thus, researchers have established many tests to evaluate behavioral changes in rodent ICH models, in order to achieve a better understanding and thus improvements in the prognosis for the clinical treatment of stroke...
Source: Frontiers in Neurology - June 17, 2021 Category: Neurology Source Type: research

Recent highlights in periopeative neurological disorders, from bench to bedside
CNS Neurosci Ther. 2022 Feb 11. doi: 10.1111/cns.13771. Online ahead of print.ABSTRACTPerioperative neurological disorders are important causes of postoperative disability and even perioperative death, bringing a huge challenge to the vulnerable and increasing aging population. Perioperative neurological disorders usually contain ischemic stroke, hemorrhagic stroke, and neurocognitive disorders during the perioperative period. Although a few prevention and treatment strategies have been developed for each disorder, there is still a lack of effective treatments and the underlying mechanisms are far from well-understood. Thi...
Source: CNS Neuroscience and Therapeutics - February 11, 2022 Category: Neuroscience Authors: Yunlu Guo Peiying Li Source Type: research

Radiomics-based prediction of hemorrhage expansion among patients with thrombolysis/thrombectomy related-hemorrhagic transformation using machine learning
CONCLUSIONS: The currently established NECT-based radiomic score is valuable in predicting hemorrhage expansion after HT among patients treated with reperfusion treatment after ischemic stroke, which may aid clinicians in determining patients with HT who are most likely to benefit from anti-expansion treatment.PMID:35173809 | PMC:PMC8842178 | DOI:10.1177/17562864211060029
Source: Adv Data - February 17, 2022 Category: Epidemiology Authors: Junfeng Liu Wendan Tao Zhetao Wang Xinyue Chen Bo Wu Ming Liu Source Type: research

Appropriate Use Criteria of Left Atrial Appendage Closure Devices: Latest Evidences
Expert Rev Med Devices. 2023 May 1. doi: 10.1080/17434440.2023.2208748. Online ahead of print.ABSTRACTAtrial fibrillation is the most common arrythmia and it is linked to an increased risk of stroke. Even if anticoagulation therapy reduces the rate of stroke the benefits of this therapy have to been balanced with the increased risk of hemorrhagic event. Left atrial appendage closure is a valid alternative to long term anticoagulation in patients with atrial fibrillation and high hemorrhagic risk. Actually new devices with different features have been tested and introduced progressively in the clinical practice. Improvement...
Source: Expert Review of Medical Devices - May 2, 2023 Category: Medical Devices Authors: Fabrizio Guarracini Eleonora Bonvicini Alberto Preda Marta Martin Simone Muraglia Giulia Casagranda Marianna Mochen Alessio Coser Silvia Quintarelli Stefano Branzoli Roberto Bonmassari Massimiliano Marini Patrizio Mazzone Source Type: research

Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage.
Abstract T-lymphocytes promote cerebral inflammation, thus aggravating neuronal injury after stroke. Fingolimod, a sphingosine 1-phosphate receptor analog, prevents the egress of lymphocytes from primary and secondary lymphoid organs. Based on these findings, we hypothesized fingolimod treatment would reduce the number of T-lymphocytes migrating into the brain, thereby ameliorating cerebral inflammation following experimental intracerebral hemorrhage (ICH). We investigated the effects of fingolimod in two well-established murine models of ICH, implementing intrastriatal infusions of either bacterial collagenase (c...
Source: Experimental Neurology - December 21, 2012 Category: Neurology Authors: Rolland WB, Lekic T, Krafft PR, Hasegawa Y, Altay O, Hartman R, Ostrowski R, Manaenko A, Tang J, Zhang JH Tags: Exp Neurol Source Type: research

Towards robust deconvolution of low-dose perfusion CT: Sparse perfusion deconvolution using online dictionary learning
Graphical abstract: Highlights: ► Dictionaries are learned from high-dose CTP data for low-dose CBF estimation. ► Temporal convolution model is combined with spatial dictionary mapping prior. ► Evaluation on in vivo aneurysmal subarachnoid hemorrhage and normal patients. ► Outperform existing methods in CBF estimation for low-dose CTP data. ► Improve the differentiation between ischemic and normal tissues in the brain.Abstract: Computed tomography perfusion (CTP) is an important functional imaging modality in the evaluation of cerebrovascular diseases, particularly in acute stroke and vasospasm. However, the post...
Source: Medical Image Analysis - March 7, 2013 Category: Radiology Authors: Ruogu Fang, Tsuhan Chen, Pina C. Sanelli Source Type: research

Prenatal cerebrovascular accidents diagnosed in the early infant stage: a series of 10 patients.
CONCLUSIONS. When CVA are not detected in the prenatal period, it is important in primary care to look for and detect the warning signs of the psychomotor development of the infant at an early stage in order to begin a study of the case and to undertake rehabilitation as early as possible. PMID: 23799595 [PubMed - in process]
Source: Revista de Neurologia - July 1, 2013 Category: Neurology Authors: Pina-Jover M, Martinez-Del Villar M, Lillo-Laguna L, Jadraque-Rodriguez R, Martinez-Pastor P, Jover-Cerda J, Gomez-Gosalvez F Tags: Rev Neurol Source Type: research

Estimation of individual-specific progression to impending cardiovascular instability using arterial waveforms
Trauma patients with "compensated" internal hemorrhage may not be identified with standard medical monitors until signs of shock appear, at which point it may be difficult or too late to pursue life-saving interventions. We tested the hypothesis that a novel machine-learning model called the compensatory reserve index (CRI) could differentiate tolerance to acute volume loss of individuals well in advance of changes in stroke volume (SV) or standard vital signs. Two hundred one healthy humans underwent progressive lower body negative pressure (LBNP) until the onset of hemodynamic instability (decompensation). Continuously m...
Source: Journal of Applied Physiology - October 15, 2013 Category: Physiology Authors: Convertino, V. A., Grudic, G., Mulligan, J., Moulton, S. Tags: INNOVATIVE METHODOLOGIES Source Type: research

Inhibition of the Sur1-Trpm4 Channel Reduces Neuroinflammation and Cognitive Impairment in Subarachnoid Hemorrhage Basic Sciences
Conclusions— Sur1-Trpm4 channels are upregulated in humans and rats with SAH. Channel inhibition with glibenclamide may reduce neuroinflammation and the severity of cognitive deficits after SAH.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Tosun, C., Kurland, D. B., Mehta, R., Castellani, R. J., deJong, J. L., Kwon, M. S., Woo, S. K., Gerzanich, V., Simard, J. M. Tags: Basic Sciences Source Type: research