• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Do No Harm: Stories of Life, Death and Brain Surgery review
Patients see neurosurgeons as gods, but what is the reality? Henry Marsh has written a memoir of startling candourWe go to doctors for help and healing; we don't expect them to make us worse. Most people know the aphorism taught to medical students, attributed to the ancient Greek Hippocrates but timeless in its quiet sanity: "First, do no harm." But many medical treatments do cause harm: learning how to navigate the risks of drug therapies, as well as the catastrophic consequences of botched or inadvised surgical operations, is a big part of why training doctors takes so long. Even the simplest of therapies carries the ri...
Source: Guardian Unlimited Science - March 19, 2014 Category: Science Authors: Gavin Francis Tags: The Guardian Private healthcare Culture Society Reviews Books Neuroscience UK news Hospitals NHS Source Type: news

Single-Center Experience and Short-term Outcome With the JenaValve: A Second-Generation Transapical Transcatheter Aortic Valve Implantation Device
ConclusionsThis second-generation repositionable transcatheter aortic valve implantation device could safely and successfully be implanted with a fast learning curve, significant reduction in pressure gradients, overall clinical improvement at discharge, as well as an acceptable morbidity and mortality rate in this highest-risk patient cohort.
Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery - September 1, 2014 Category: Cardiovascular & Thoracic Surgery Tags: Original Articles Source Type: research

Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation.
CONCLUSIONS: -By identifying known drugs as potential therapeutics for CCM, we have decreased the time, cost, and risk of bringing treatments to patients. Each drug also prompts additional exploration of biomarkers of CCM disease. We further suggest that the structure-function screening platform presented here may be adapted and scaled to facilitate drug discovery for diverse loss-of-function genetic vascular disease. PMID: 25486933 [PubMed - as supplied by publisher]
Source: Circulation - December 8, 2014 Category: Cardiology Authors: Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY Tags: Circulation Source Type: research

Randomized Pilot Trial of Intensive Management of Blood Pressure or Volume Expansion in Subarachnoid Hemorrhage (IMPROVES)
CONCLUSION: This pilot study showed adequate feasibility and excellent retention to follow-up. Given the suggestion of possible worse neurobehavioral outcome with ABP, a larger trial to determine the optimal blood pressure management in this patient population is warranted. (ClinTrials.gov NCT01414894.) ABBREVIATIONS: ABP, augmented blood pressure CBP, conventional DCI, delayed cerebral ischemia GOSE, Glasgow Outcome Scale-Extended HV, volume expansion mRS, modified Rankin Scale NV, normovolemia PHQ-9, Patient Health Questionnaire RAVLT, Ray Auditory Verbal Learning Test SWLS, Satisfaction with Life scale TCD, transcranial...
Source: Neurosurgery - January 20, 2015 Category: Neurosurgery Tags: Research-Human-Clinical Trials Source Type: research

Blood pressure measurement in pregnancy
Key content Accurate blood pressure (BP) measurement is fundamental to early diagnosis of hypertensive disorders in pregnancy. Poor auscultatory technique and lack of training leads to inaccuracies in BP measurement using sphygmomanometry with mercury and aneroid devices. Automated devices limit user error but require validation of accuracy because they tend to underestimate BP in pre‐eclampsia. Systolic hypertension may better predict risk of adverse outcome (such as haemorrhagic stroke) than diastolic hypertension. Ambulatory/self‐monitoring increases the number of representative readings available on which to ...
Source: The Obstetrician and Gynaecologist - April 1, 2015 Category: OBGYN Authors: Hannah L Nathan, Kate Duhig, Natasha L Hezelgrave, Lucy C Chappell, Andrew H Shennan Tags: Review Source Type: research

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature
Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of a wide variety of species from locust to human. The depolarization spreads slowly at a rate of only millimeters per minute by way of grey matter contiguity, irrespective of functional or vascular divisions, and lasts up to a minute in otherwise normal tissue. As such, SD is a radically different breed of electrophysiological activity compared with everyday neural activity, such as action potentials and ...
Source: Physiological Reviews - July 1, 2015 Category: Physiology Authors: Ayata, C., Lauritzen, M. Tags: Reviews Source Type: research

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature.
Abstract Spreading depression (SD) is a transient wave of near-complete neuronal and glial depolarization associated with massive transmembrane ionic and water shifts. It is evolutionarily conserved in the central nervous systems of a wide variety of species from locust to human. The depolarization spreads slowly at a rate of only millimeters per minute by way of grey matter contiguity, irrespective of functional or vascular divisions, and lasts up to a minute in otherwise normal tissue. As such, SD is a radically different breed of electrophysiological activity compared with everyday neural activity, such as acti...
Source: Physiological Reviews - July 1, 2015 Category: Physiology Authors: Ayata C, Lauritzen M Tags: Physiol Rev Source Type: research

Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats Basic Sciences
Conclusions— Exogenous LXA4 inhibited inflammation by activating FPR2 and inhibiting p38 after SAH. LXA4 may serve as an alternative treatment to relieve early brain injury after SAH.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Guo, Z., Hu, Q., Xu, L., Guo, Z.-N., Ou, Y., He, Y., Yin, C., Sun, X., Tang, J., Zhang, J. H. Tags: Animal Models of Human Disease Basic Sciences Source Type: research

Compensatory Reserve Index Can Aid in Early Shock Detection
EARLY SHOCK DETECTION Convertino VA, Howard JT, Hinojosa-Laborde C. Individual-specific, beat-to-beat trending of significant human blood loss: The compensatory reserve. Shock. Jan. 6, 2015. [Epub ahead of print.] Hemorrhagic shock is the leading cause of death in trauma. The challenge is detecting shock early enough to intervene clinically. The human body is masterful at compensating with a variety of seemingly undetectable mechanisms, such as autonomic activity, vasoconstriction, increased stroke volume, improved cardiac filling and more efficient breathing. So by the time we see alterations in vital sign metrics, the p...
Source: JEMS Patient Care - August 10, 2015 Category: Emergency Medicine Authors: Alexander L. Trembley, NREMT P Tags: Resuscitation & Shock Special Topics Research Columns Patient Care Source Type: news

Comparison of Compensatory Reserve During Lower Body Negative Pressure and Hemorrhage in Non-human Primates.
Abstract Compensatory reserve was measured in baboons (n=13) during hemorrhage (Hem) and lower body negative pressure (LBNP) using a machine learning algorithm developed to estimate compensatory reserve by detecting reductions in central blood volume during LBNP. The algorithm calculates compensatory reserve index (CRI) from normovolemia (CRI=1) to cardiovascular decompensation (CRI=0). The hypothesis was that Hem and LBNP will elicit similar CRI values, and that CRI would have higher specificity than stroke volume (SV) in predicting decompensation. Blood was removed in four steps: 6.25%, 12.5%, 18.75%, and 25% of...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - March 29, 2016 Category: Physiology Authors: Hinojosa-Laborde C, Howard JT, Mulligan J, Grudic GZ, Convertino VA Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

The Utility of Factor VIII Infusion in a Rare Case of SHAM Syndrome (P4.343)
Conclusions: Genetic testing confirmed the presence of SHAM syndrome with an 83 kb deletion involving both F8 and BRCC3 genes responsible for severe hemophilia and Moyamoya disease respectively. This case illustrates the first phenotypically and genetically confirmed adult case of SHAM syndrome with intracerebral hemorrhage and highlights the utility/safety of factor VIII infusion in this case.Disclosure: Dr. Roh has nothing to disclose. Dr. Roth has nothing to disclose. Dr. Al-Mufti has nothing to disclose. Dr. Chung has nothing to disclose. Dr. Connolly has nothing to disclose. Dr. Eisenberger has nothing to disclose. Dr...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Roh, D., Roth, W., Al-Mufti, F., Chung, W., E. Sander, C., Eisenberger, A., Park, S., Claassen, J., Agarwal, S. Tags: Cerebrovascular Case Reports Source Type: research

Compensatory Reserve Index Can Aid in Early Shock Detection
EARLY SHOCK DETECTION Convertino VA, Howard JT, Hinojosa-Laborde C. Individual-specific, beat-to-beat trending of significant human blood loss: The compensatory reserve. Shock. Jan. 6, 2015. [Epub ahead of print.] Hemorrhagic shock is the leading cause of death in trauma. The challenge is detecting shock early enough to intervene clinically. The human body is masterful at compensating with a variety of seemingly undetectable mechanisms, such as autonomic activity, vasoconstriction, increased stroke volume, improved cardiac filling and more efficient breathing. So by the time we see alterations in vital sign metrics, the p...
Source: JEMS Special Topics - August 10, 2015 Category: Emergency Medicine Authors: Alexander L. Trembley, NREMT P Tags: Special Topics Cardiac & Resuscitation Columns Patient Care Source Type: news

Comparison of compensatory reserve during lower-body negative pressure and hemorrhage in nonhuman primates
Compensatory reserve was measured in baboons (n = 13) during hemorrhage (Hem) and lower-body negative pressure (LBNP) using a machine-learning algorithm developed to estimate compensatory reserve by detecting reductions in central blood volume during LBNP. The algorithm calculates compensatory reserve index (CRI) from normovolemia (CRI = 1) to cardiovascular decompensation (CRI = 0). The hypothesis was that Hem and LBNP will elicit similar CRI values and that CRI would have higher specificity than stroke volume (SV) in predicting decompensation. Blood was removed in four steps: 6.25%, 12.5%, 18.75%, and 25% of total blood ...
Source: AJP: Regulatory, Integrative and Comparative Physiology - May 31, 2016 Category: Physiology Authors: Hinojosa-Laborde, C., Howard, J. T., Mulligan, J., Grudic, G. Z., Convertino, V. A. Tags: Fluid and Electrolyte Homeostasis Source Type: research

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14