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Condition: Hemorrhagic Stroke
Education: Learning

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Total 196 results found since Jan 2013.

Ifenprodil Improves Long-Term Neurologic Deficits Through Antagonizing Glutamate-Induced Excitotoxicity After Experimental Subarachnoid Hemorrhage
AbstractExcessive glutamate leading to excitotoxicity worsens brain damage after SAH and contributes to long-term neurological deficits. The drug ifenprodil is a non-competitive antagonist of GluN1-GluN2B N-methyl-d-aspartate (NMDA) receptor, which mediates excitotoxic damage in vitro and in vivo. Here, we show that cerebrospinal fluid (CSF) glutamate level within 48  h was significantly elevated in aSAH patients who later developed poor outcome. In rat SAH model, ifenprodil can improve long-term sensorimotor and spatial learning deficits. Ifenprodil attenuates experimental SAH-induced neuronal death of basal cortex and h...
Source: Translational Stroke Research - March 12, 2021 Category: Neurology Source Type: research

A journey through clinic and research
I started to study Medicine at the University of Genoa, Italy more than 20 years ago and I now realize that I was quite far from understanding what ‘Medicine’ really means. After weeks and weeks spent on books during the first year, I understood that becoming a MD not only requires the willingness to help people with health problems, but also strong motivation and dedication to learn a huge amount of notions. In Italy, as it is the case for several other countries, the University courses last 6 years, during which the MD student is fully engaged by individual study, lessons and seminars, exercises, and internships. Wit...
Source: European Heart Journal - March 29, 2021 Category: Cardiology Source Type: research

Machine Learning-Enabled Determination of Diffuseness of Brain Arteriovenous Malformations from Magnetic Resonance Angiography
AbstractThe diffuseness of brain arteriovenous malformations (bAVMs) is a significant factor in surgical outcome evaluation and hemorrhagic risk prediction. However, there are still predicaments in identifying diffuseness, such as the judging variety resulting from different experience and difficulties in quantification. The purpose of this study was to develop a machine learning (ML) model to automatically identify the diffuseness of bAVM niduses using three-dimensional (3D) time-of-flight magnetic resonance angiography (TOF-MRA) images. A total of 635 patients with bAVMs who underwent TOF-MRA imaging were enrolled. Three...
Source: Translational Stroke Research - August 12, 2021 Category: Neurology Source Type: research

Intracerebral Hemorrhage
This article summarizes the basic pathophysiology, classification, and management of ICH and discusses the available evidence on therapy for hematoma, hematoma expansion, and perihematomal edema. RECENT FINDINGS Current available data on potential therapeutic options for ICH are promising, although none of the trials have shown improvement in mortality rate. The literature available on reversal of anticoagulation and antiplatelet agents after an ICH and resumption of these medications is also increasing. SUMMARY ICH continues to have high morbidity and mortality. Advances in therapeutic options to target seco...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2021 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Acute Neurologic Manifestations of Respiratory Viruses
This article describes the most common respiratory viruses that have neurologic manifestations, with a focus on SARS-CoV-2 and COVID-19. RECENT FINDINGS In vitro and in vivo studies have better elucidated the neurotropism of various respiratory viruses. Understanding host cell receptors that mediate viral binding and entry not only demonstrates how viruses enter host cells but also provides possible mechanisms for therapeutic interventions. Elucidation of SARS-CoV-2 binding and fusion with host cells expressing the angiotensin-converting enzyme 2 (ACE2) receptor may also provide greater insights into its systemic an...
Source: CONTINUUM: Lifelong Learning in Neurology - October 1, 2021 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

CT radiomics helps predict spontaneous intracerebral hemorrhage
CT radiomics and a machine-learning model can predict hematoma expansion i...Read more on AuntMinnie.comRelated Reading: Portable MRI helps clarify stroke symptoms more quickly MIDRC offers support for COVID-19 AI AI detection of intracranial hemorrhage saves lives Study confirms viability of low-field MRI for ICH AI software bests Chinese physicians in contest
Source: AuntMinnie.com Headlines - October 18, 2021 Category: Radiology Source Type: news

Identifying risk factors of intracerebral hemorrhage stability using explainable attention model
AbstractSegmentation of intracerebral hemorrhage (ICH) helps improve the quality of diagnosis, draft the desired treatment methods, and clinically observe the variations with healthy patients. The clinical utilization of various ICH progression scoring systems has limitations due to the systems ’ modest predictive value. This paper proposes a single pipeline of a multi-task model for end-to-end hemorrhage segmentation and risk estimation. We introduce a 3D spatial attention unit and integrate it into the state-of-the-art segmentation architecture, UNet, to enhance the accuracy by bootstr apping the global spatial represe...
Source: Medical and Biological Engineering and Computing - December 2, 2021 Category: Biomedical Engineering Source Type: research

What are Some Risk Factors for Hypoxic-Ischemic Encephalopathy Outcomes?
Discussion “Neonatal encephalopathy, manifesting as altered responsiveness, seizures, apnea and abnormal muscle tone and reflexes, resulting from hypoxic-ischemic injury is termed hypoxic-ischemic encephalopathy (HIE).” Neonatal encephalopathy can be associated with other problems including stroke, hemorrhage, infection, pre-term brain injury and hypoglycemia as some examples. Sometimes more than one of these entities occurs simultaneously such as hypoglycemia and HIE. HIE can result in long-term neurological problems including motor, behavioral, and cognitive problems that can become apparent even years later....
Source: PediatricEducation.org - December 13, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Central Hypovolemia Detection During Environmental Stress —A Role for Artificial Intelligence?
The first step to exercise is preceded by the required assumption of the upright body position, which itself involves physical activity. The gravitational displacement of blood from the chest to the lower parts of the body elicits a fall in central blood volume (CBV), which corresponds to the fraction of thoracic blood volume directly available to the left ventricle. The reduction in CBV and stroke volume (SV) in response to postural stress, post-exercise, or to blood loss results in reduced left ventricular filling, which may manifest as orthostatic intolerance. When termination of exercise removes the leg muscle pump fun...
Source: Frontiers in Physiology - December 15, 2021 Category: Physiology Source Type: research

Machine Learning Models Prognosticate Functional Outcomes Better than Clinical Scores in Spontaneous Intracerebral Haemorrhage
Spontaneous intracerebral haemorrhage (SICH) was associated with an overall incidence of 24.6 per 100,000 person-years worldwide and was most common in Asians, with an incidence of 51.8 per 100,000 person-years.1 SICH is a major cause of mortality and morbidity, with a case fatality of 40.4% at one month, one-year mortality rate of 54.0% and only 12 to 39% of patients leading an independent life on follow up.1,2 Current management for SICH remains supportive, and includes outcome prediction and rehabilitation.
Source: Journal of Stroke and Cerebrovascular Diseases - December 10, 2021 Category: Neurology Authors: Mervyn Jun Rui Lim, Raphael Hao Chong Quek, Kai Jie Ng, Ne-Hooi Will Loh, Sein Lwin, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo, Mehul Motani Source Type: research

Sutureless Valve in Bicuspid Aortic Stenosis: Modified Technique and Midterm Outcome
Conclusions The sutureless valve can achieve satisfactory outcomes in BAV without paravalvular leakage and excellent hemodynamics. It may serve as the benchmark for transcatheter aortic valve implantation in this unique population. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: The Thoracic and Cardiovascular Surgeon - February 10, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Li, Han-Yan Tsai, Feng-Chun Lu, Cheng-Hui Chou, An-Hsun Huang, Huei-Chiun Gersak, Borut Tags: Original Cardiovascular Source Type: research

Subarachnoid Hemorrhage Induces Sub-acute and Early Chronic Impairment in Learning and Memory in Mice
AbstractSubarachnoid hemorrhage (SAH) leads to significant long-term cognitive deficits, so-called the post-SAH syndrome. Existing neurological scales used to assess outcomes of SAH are focused on sensory-motor functions. To better evaluate short-term and chronic consequences of SAH, we explored and validated a battery of neurobehavioral tests to gauge the functional outcomes in mice after the circle of Willis perforation-induced SAH. The 18-point Garcia scale, applied up to 4  days, detected impairment only at 24-h time point and showed no significant difference between the Sham and SAH group. A decrease in locomotion wa...
Source: Translational Stroke Research - March 8, 2022 Category: Neurology Source Type: research