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Total 129 results found since Jan 2013.

Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke Basic Sciences
Conclusions— Thus, cholinergic pathways play a pivotal role in the development of pulmonary infections after acute central nervous system injury.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Engel, O., Akyuz, L., da Costa Goncalves, A. C., Winek, K., Dames, C., Thielke, M., Herold, S., Bottcher, C., Priller, J., Volk, H. D., Dirnagl, U., Meisel, C., Meisel, A. Tags: Animal models of human disease, Pulmonary biology and circulation, Acute Cerebral Infarction Basic Sciences Source Type: research

Delayed Varenicline Administration Reduces Inflammation and Improves Forelimb Use Following Experimental Stroke
Pharmacological activation of the cholinergic anti-inflammatory pathway (CAP), specifically by activating α7 nicotinic acetylcholine receptors, has been shown to confer short-term improvements in outcome. Most studies have investigated administration within 24 hours of stroke, and few have investigated drugs approved for use in human patients. We investigated whether delayed administration of varenicli ne, a high-affinity agonist at α7 nicotinic receptors and an established therapy for nicotine addiction, decreased brain inflammation and improved functional performance in a mouse model of experimental stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - August 7, 2017 Category: Neurology Authors: Siyi Chen, Laura Bennet, Ailsa L. McGregor Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Organized Post-Stroke Care through Case Management on the Basis of a Standardized Treatment Pathway : Results of a Single-Centre Pilot Study.
CONCLUSIONS: Our pilot data demonstrate that case management-based post-stroke care is feasible and may contribute to effective secondary prevention of stroke. PMID: 27072795 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - April 11, 2016 Category: Neurology Authors: Barlinn J, Barlinn K, Helbig U, Siepmann T, Pallesen LP, Urban H, Pütz V, Schmitt J, Reichmann H, Bodechtel U Tags: Nervenarzt Source Type: research

An association between electronic nicotine delivery systems use and a history of stroke using the 2016 behavioral risk factor surveillance system
This study aims to assess, using a survey representative of the USA general population, if an association exists between a history of ENDS use and a history of stroke. This cross-sectional study was a secondary data analysis using the 2016 behavioral risk factor surveillance system survey. The main exposure variable of the study was a self-reported history of ENDS use. The main outcome was a self-reported history of stroke. Covariates included sex, race, traditional cigarette use, smokeless tobacco use, chronic kidney disease, diabetes, myocardial infarction, and coronary artery disease. Unadjusted and adjusted logistic...
Source: Medicine - September 10, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Snus (Swedish smokeless tobacco) use and risk of stroke: Pooled Analyses of Incidence and Survival
ConclusionUse of snus was not associated with the risk of stroke. Hence, nicotine is unlikely to contribute importantly to the pathophysiology of stroke. However, case fatality was increased in snus users, compared to non‐users, but further studies are needed to determine any possible causal mechanisms.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - February 1, 2014 Category: Internal Medicine Authors: Jenny Hansson, Maria Rosaria Galanti, Maria‐Pia Hergens, Peeter Fredlund, Anders Ahlbom, Lars Alfredsson, Rino Bellocco, Gunnar Engström, Marie Eriksson, Johan Hallqvist, Bo Hedblad, Jan‐Håkan Jansson, Nancy L Pedersen, Ylva Trolle Lagerros, Per‐O Tags: Original Article Source Type: research

Pharmacological interventions for unilateral spatial neglect after stroke.
CONCLUSIONS: The quality of the evidence from available RCTs was very low. The effectiveness and safety of pharmacological interventions for USN after stroke are therefore uncertain. Additional large RCTs are needed to evaluate these treatments. PMID: 26544542 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - November 6, 2015 Category: Journals (General) Authors: Luvizutto GJ, Bazan R, Braga GP, Resende LA, Bazan SG, El Dib R Tags: Cochrane Database Syst Rev Source Type: research

Association between electronic nicotine delivery systems use and risk of stroke: a meta-analysis of 1,024,401 participants
CONCLUSIONS: The ENDS usage appears to be associated with a higher risk of stroke compared to non-use, whereas there was no association between former ENDS use and the risk of stroke.PMID:37732043 | PMC:PMC10507757 | DOI:10.5114/aoms/171473
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Kamal Awad Maged Mohammed Seth S Martin Maciej Banach Source Type: research

Call for human contact and support: an interview study exploring patients' experiences with inpatient stroke rehabilitation and their perception of nurses' and nurse assistants' roles and functions.
CONCLUSION: The findings deepen our understanding of how patients experience inpatient rehabilitation. The patients struggled with existential thoughts and concerns about the future and therefore called for human contact and support from the nursing staff. They perceived the nursing staff as mostly polite and helpful, but were unclear about the nursing staff's function in rehabilitation which, in the patients' perspective, equals physical training. Implications for Rehabilitation Nursing staff need to pay attention to the patients' needs, existential thoughts and concerns during inpatient rehabilitation. Meaningful goals f...
Source: Disability and Rehabilitation - October 24, 2017 Category: Rehabilitation Authors: Loft MI, Martinsen Woythal B, Esbensen BA, Mathiesen LL, Iversen HK, Poulsen I Tags: Disabil Rehabil Source Type: research

Middle Cerebral Artery Velocities Are Inversely Related to Hemoglobin Levels and Acutely Drop in Response to RBC Transfusion: Implications for Stroke Screening in SCD
DiscussionThese data show a striking relationship between anemia and TCD velocity, and that RBC transfusion can alter MCA velocity. Even an 11% increase in hemoglobin such as that seen in the low-responder in Figure 3 could change a patient classification from high-risk to conditional TCD. These data also show the significant sensitivity of MCA velocity to the depth of measurement (Figure 2 & 3). The investigators in the STOP study went to extreme ends to standardize these measurements. Nonetheless, TCD measures may not be done with such rigor in clinical settings. It is clear that standard TCD screening has been of tr...
Source: Blood - November 21, 2018 Category: Hematology Authors: Perumbeti, A., Carreras, O., Detterich, J. A., Shah, P., Sunwoo, J., Khoo, M., Wood, J. C., Coates, T. D. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster II Source Type: research

Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?
In this study we provide additional in vivo evidence showing that MF can effectively reduce the oxidative and inflammatory risk for stroke and attenuate post-ischemic brain injury promoted by TS and e-Cig vaping. Our data also suggest that MF administration could be extended as prophylactic care during the time window required for the renormalization of the risk levels of stroke following smoking cessation thus further studies in that direction are warrated. Graphical abstract
Source: Redox Biology - June 22, 2017 Category: Biology Source Type: research

Factors associated with post-stroke suicidal death
Conclusions The risk of suicidal death is approximately 2 times higher than that in the general population. Depression, diabetes, and large lesions in specific locations should be considered in the implementation of suicide prevention strategies in stroke patients.
Source: Journal of Psychiatric Research - October 14, 2017 Category: Psychiatry Source Type: research

FES for abnormal movement of upper limb during walking in post-stroke subjects.
CONCLUSIONS: The present study showed that a traditional foot drop functional electrical stimulator providing stimulation also to the patient's upper limbs, while being triggered by a foot switch under his or her heel, can help the patient to swing the arms and reduce the foot drop. The method has significant effect on traditional foot drop therapy. The subjects' high degree of acceptance and willingness to commit to long-term use showed that the method is indeed worthy of further research. PMID: 24934709 [PubMed - as supplied by publisher]
Source: Technology and Health Care - June 16, 2014 Category: Medical Equipment Authors: Chou CH, Hwang YS, Chen CC, Chen SC, Lai CH, Chen YL Tags: Technol Health Care Source Type: research