Angiotensin II receptor blockers are safe in patients with prior angioedema related to angiotensin converting enzyme inhibitors – a nation‐wide registry‐based cohort study
ConclusionsCompared with other antihypertensive drugs, AT2s do not increase the incidence of angioedema in patients with previous ACEi –related angioedema.This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 28, 2018 Category: Internal Medicine Authors: Eva Rye Rasmussen, Anton Potteg ård, Anette Bygum, Christian von Buchwald, Preben Homøe, Jesper Hallas Tags: Original Article Source Type: research

Is there a need for an emergency card in hypoparathyroidism?
ConclusionsThe majority answered that an acute card is highly needed or useful. Hospitalization for acute hypocalcemia was more common (44%) than for acute hypercalcemia (16%). As a result of this survey an emergency card will be distributed in three European countries to test its utility.This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 28, 2018 Category: Internal Medicine Authors: Marianne C. Astor, Wendy Zhu, Sigridur Bj örnsdottir, Jens Bollerslev, Olle Kämpe, Eystein S. Husebye Tags: Original Article Source Type: research

Head trauma in sports – clinical characteristics, epidemiology and biomarkers
This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 27, 2018 Category: Internal Medicine Authors: Henrik Zetterberg, Bengt Winblad, Charles Bernick, Kristine Yaffe, Marek Majdan, Gunilla Johansson, Virginia Newcombe, Lars Nyberg, David Sharp, Olli Tenovuo, Kaj Blennow Tags: Review ‐Symposium Source Type: research

Oxysterols in intestinal immunity and inflammation
AbstractCholesterol is an essential molecule for life. It is a component of the cell membrane, and it is a precursor molecule for bile acids, vitamin D and steroid hormones. Cholesterol is actively metabolized, but the impact of endogenous cholesterol metabolites on immune function, especially in the intestine, is poorly understood. In this review, I focus on oxysterols, hydroxylated forms of cholesterol, and their specialized functions in intestinal immunity. Oxysterols act through various intracellular and extracellular receptors and serve as key metabolic signals, coordinating immune activity and inflammation. Our recen...
Source: Journal of Internal Medicine - November 26, 2018 Category: Internal Medicine Authors: T. Willinger Tags: Review Source Type: research

MicroRNA detection in the pathogenesis of BAV ‐associated aortopathy‐mediated vascular remodelling through EndMT/EMT
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 26, 2018 Category: Internal Medicine Authors: S. A. Mohamed Tags: Editorial Comment Source Type: research

Morbidity and cause ‐specific mortality in first‐time myocardial infarction with nonobstructive coronary arteries
ConclusionsPatients with first ‐time MINOCA have a considerable risk of adverse events. This stresses the need for a comprehensive search of the cause of MINOCA, thorough treatment of underlying disease triggers and close follow‐up. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 25, 2018 Category: Internal Medicine Authors: K. M. Eggers, M. Hjort, T. Baron, T. Jernberg, A. M. Nordenskj öld, P. Tornvall, B. Lindahl Tags: Original Article Source Type: research

Anti ‐Inflammatory Therapy for Atherosclerosis:Interpreting Divergent Results from the CANTOS and CIRT Clinical Trials
AbstractOver the past 18 months, two multi ‐national clinical trials specifically designed to test the inflammation hypothesis of atherothrombosis have been presented. First, the 10,061 patient Canakinumab Anti‐inflammatory Thrombosis Outcomes Study (CANTOS) proved that specific targeting of interleukin‐1β can significantly reduce car diovascular event rates in the absence of lipid or blood pressure lowering. In CANTOS, canakinumab given at doses of either 150 or 300 mg SC once every three months lowered the inflammatory biomarkers interleukin‐6 and C‐reactive protein (hsCRP) by 35 to 40 percent when compare...
Source: Journal of Internal Medicine - November 25, 2018 Category: Internal Medicine Authors: Paul M Ridker Tags: Commentary Source Type: research

Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management
AbstractPostural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular autonomic disorder characterized by an excessive heart rate increase on standing and orthostatic intolerance. POTS affects  younger individuals 15–45 years old with a distinct female predominance (≈80%). The prevalence ranges between 0.2% and 1.0% in developed countries. The onset of POTS is typically precipitated by immunological stressors such as viral infection, vaccination, trauma, pregnancy, surgery or psycho social stress. The most common complaints are dizziness, weakness, rapid heartbeat and palpitation on ...
Source: Journal of Internal Medicine - November 23, 2018 Category: Internal Medicine Authors: A. Fedorowski Tags: Review Source Type: research

Iron deficiency anaemia due to proton pump inhibitors: clinical impact revealed
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 22, 2018 Category: Internal Medicine Authors: D. McCarthy Tags: Editorial Comment Source Type: research

Multimorbidity and functional impairment –bidirectional interplay, synergistic effects and common pathways
AbstractThis review discusses the interplay between multimorbidity (i.e. co ‐occurrence of more than one chronic health condition in an individual) and functional impairment (i.e. limitations in mobility, strength or cognition that may eventually hamper a person's ability to perform everyday tasks). On the one hand, diseases belonging to common patterns of multimorbidity may interact, curtailing compensatory mechanisms and resulting in physical and cognitive decline. On the other hand, physical and cognitive impairment impact the severity and burden of multimorbidity, contributing to the establishment of a vicious circle...
Source: Journal of Internal Medicine - November 22, 2018 Category: Internal Medicine Authors: A. Calder ón‐Larrañaga, D. L. Vetrano, L. Ferrucci, S. W. Mercer, A. Marengoni, G. Onder, M. Eriksdotter, L. Fratiglioni Tags: Review Symposium Source Type: research

Health consequences of androgenic anabolic steroid use
AbstractBackgroundThe lifetime prevalence of androgenic anabolic steroid abuse is estimated to be around 6% for men, but there is limited knowledge about the side effects of these drugs.ObjectiveTo investigate mortality and morbidity amongst users of androgenic anabolic steroids (AAS).MethodsIn this retrospective matched cohort study, 545 male subjects tested positive for AAS in Danish fitness centres during the period 3 January 2006 to 1 March 2018. Subjects were matched with 5450 male controls. In addition, 644 men who were sanctioned because they refused to submit to a doping test and 6440 controls were included as a re...
Source: Journal of Internal Medicine - November 20, 2018 Category: Internal Medicine Authors: H. Horwitz, J. T. Andersen, K. P. Dalhoff Tags: Original Article Source Type: research

SYMPOSIUM: Neuroendocrine interfaces in physiology and disease
Journal of Internal Medicine, Volume 284, Issue 6, Page 562-562, December 2018. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 19, 2018 Category: Internal Medicine Tags: Symposium Source Type: research

Issue Information
Journal of Internal Medicine, Volume 284, Issue 6, Page 561-561, December 2018. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 19, 2018 Category: Internal Medicine Tags: Issue Information Source Type: research

Anti ‐inflammatory diet to reduce mortality: is it time for a precision medicine approach?
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 18, 2018 Category: Internal Medicine Authors: M. Leggio, A. Fusco, A. Villano, G. Limongelli, A. Mazza Tags: Letter to the Editor Source Type: research

Systemic features of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: a monogenic small vessel disease
ConclusionsRetinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations is a rare, but likely underdiagnosed, systemic small vessel disease typically starting with vascular retinopathy, followed by multiple internal organ disease, progressive brain dysfunction, and ultimately premature death. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 8, 2018 Category: Internal Medicine Authors: N. Pelzer, E. S. Hoogeveen, J. Haan, R. Bunnik, C. C. Poot, E. W. van Zwet, A. Inderson, A. J. Fogteloo, M. E. J. Reinders, H. A. M. Middelkoop, M. C. Kruit, A. M. J. M. van den Maagdenberg, M. D. Ferrari, G. M. Terwindt Tags: Original Article Source Type: research

Precision medicine in Type 2 Diabetes
This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 7, 2018 Category: Internal Medicine Authors: Rashmi B Prasad, Leif Groop Tags: Review Source Type: research

Preventing anabolic steroid abuse; a long way to go
This article is protected by copyright. All rights reserved. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - November 7, 2018 Category: Internal Medicine Authors: Willem de Ronde Tags: Editorial Comment Source Type: research

Postural Orthostatic Tachycardia Syndrome: clinical presentation, aetiology, and management
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 29, 2018 Category: Internal Medicine Authors: Artur Fedorowski Source Type: research

Trends in patient outcome over the past two decades following allogeneic stem cell transplantation for acute myeloid leukemia. An ALWP/EBMT analysis
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 29, 2018 Category: Internal Medicine Authors: Jonathan Canaani, Eric Beohou, Myriam Labopin, Ardeshir Ghavamzadeh, Dietrich Beelen, Rose ‐Marie Hamladji, Dietger Niederwieser, Liisa Volin, Miroslaw Markiewicz, Renate Arnold, Ghulam Mufti, Gerhard Ehninger, Gerard Socié, Nicolaus Krög Source Type: research

Connecting the brain cholesterol and renin –angiotensin systems: potential role of statins and RAS‐modifying medications in dementia
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 29, 2018 Category: Internal Medicine Authors: B. Petek, M. Villa ‐Lopez, R. Loera‐Valencia, G. Gerenu, B. Winblad, M. G. Kramberger, M.‐A.‐M. Ismail, M. Eriksdotter, S. Garcia‐Ptacek Source Type: research

Superselective endovascular tissue access using trans ‐vessel wall technique: feasibility study for treatment applications in heart, pancreas and kidney in swine
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 29, 2018 Category: Internal Medicine Authors: R. Grankvist, M. Jensen ‐Urstad, J. Clarke, M. Lehtinen, P. Little, J. Lundberg, F. Arnberg, S. Jonsson, K. R. Chien, S. Holmin Source Type: research

Impact of comorbidity on disease characteristics, treatment intent and outcome in diffuse large B ‐cell lymphoma – a Swedish lymphoma register study
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 28, 2018 Category: Internal Medicine Authors: Tove W ästerlid, Mohammad Mohammadi, Karin E. Smedby, Ingrid Glimelius, Mats Jerkeman, Matteo Bottai, Sandra Eloranta Source Type: research

Synthetic surfactants with SP ‐B and SP‐C analogues to enable worldwide treatment of neonatal respiratory distress syndrome and other lung diseases
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 24, 2018 Category: Internal Medicine Authors: Jan Johansson, Tore Curstedt Source Type: research

Evidence supporting the best clinical management of patients with multimorbidity and polypharmacy: a systematic guideline review and expert consensus
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 24, 2018 Category: Internal Medicine Authors: Christiane Muth, Jeanet W. Blom, Susan M. Smith, Kristina Johnell, Ana Isabel Gonzalez ‐Gonzalez, Truc S. Nguyen, Maria‐Sophie Brueckle, Matteo Cesari, Mary E. Tinetti, Jose M. Valderas Source Type: research

Multimorbidity and functional impairment: bidirectional interplay, synergistic effects and common pathways
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 24, 2018 Category: Internal Medicine Authors: Amaia Calder ón‐Larrañaga, Davide L Vetrano, Luigi Ferrucci, Stewart W Mercer, Alessandra Marengoni, Graziano Onder, Maria Eriksdotter, Laura Fratiglioni Source Type: research

Iron deficiency anemia due to proton pump inhibitors: clinical impact revealed
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 24, 2018 Category: Internal Medicine Authors: Denis McCarthy Source Type: research

Primary hyperparathyroidism: should surgery be performed on all patients? Current evidence and residual uncertainties
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 24, 2018 Category: Internal Medicine Authors: I. ‐L Nilsson Source Type: research

SYMPOSIUM: 14th key symposium – metabolic complications of obesity
Journal of Internal Medicine,Volume 284, Issue 5, Page 446-446, November 2018. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 19, 2018 Category: Internal Medicine Source Type: research

Issue Information
Journal of Internal Medicine,Volume 284, Issue 5, Page 445-445, November 2018. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 19, 2018 Category: Internal Medicine Source Type: research

“Obesity‐associated metabolic complications, the second wave of the tsunami” 14th Key Symposium
Journal of Internal Medicine,Volume 284, Issue 5, Page 447-449, November 2018. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 19, 2018 Category: Internal Medicine Authors: A. Vidal ‐Puig, S. Enerback Source Type: research

Systemic bevacizumab for the treatment of chronic bleeding in hereditary haemorrhagic telangiectasia
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 9, 2018 Category: Internal Medicine Authors: H. Al ‐Samkari, A. Kritharis, J. M. Rodriguez‐Lopez, D. J. Kuter Source Type: research

Superselective Endovascular Tissue Access Using Trans ‐Vessel Wall Technique ‐ Feasibility Study for Treatment Applications in Heart, Pancreas, and Kidney in Swine
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 5, 2018 Category: Internal Medicine Authors: Rikard Grankvist, Mats Jensen ‐Urstad, Jonathan Clarke, Miia Lehtinen, Philip Little, Johan Lundberg, Fabian Arnberg, Stefan Jonsson, Kenneth R Chien, Staffan Holmin Source Type: research

Primary Hyperparathyroidism – Should Surgery be Performed on all Patients?
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 5, 2018 Category: Internal Medicine Authors: I.L Nilsson Source Type: research

The mir ‐200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 3, 2018 Category: Internal Medicine Authors: S. Maleki, K. A. Cottrill, F. ‐A. Poujade, A. Bhattachariya, O. Bergman, J. R. Gådin, N. Simon, K. Lundströmer, A. Franco‐Cereceda, H. M. Björck, S. Y. Chan, P. Eriksson Source Type: research

The new neuroendocrinology —a perspective
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - October 2, 2018 Category: Internal Medicine Authors: T. H ökfelt Source Type: research

Connecting the brain cholesterol and renin ‐angiotensin (RAS) systems. Potential role of statins and RAS‐modifying medications in dementia
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 28, 2018 Category: Internal Medicine Authors: B. Petek, M. Villa ‐Lopez, R. Loera‐Valencia, G. Gerenu, B. Winblad, M.G. Kramberger, M‐A‐M Ismail, M. Eriksdotter, S. Garcia‐Ptacek Source Type: research

Diagnosis and treatment of primary aldosteronism: practical clinical perspectives
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 26, 2018 Category: Internal Medicine Authors: W. F. Young Source Type: research

Issue Information
Journal of Internal Medicine,Volume 284, Issue 4, Page 331-331, October 2018. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 21, 2018 Category: Internal Medicine Source Type: research

Peptide ‐based multi‐agonists: a new paradigm in metabolic pharmacology
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 19, 2018 Category: Internal Medicine Authors: Sara J. Brandt , Timo D. M üller , Richard D. DiMarchi , Matthias H. Tschöp , Kerstin Stemmer Source Type: research

High ‐Dose Vitamin D: Without Benefit but Not Without Risk
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 19, 2018 Category: Internal Medicine Authors: Ian R Reid Source Type: research

Variations in maternal adenylate cyclase genes are associated with congenital Zika syndrome in a cohort from Northeast, Brazil
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 17, 2018 Category: Internal Medicine Authors: Á. D. Rossi , F. R. Faucz , A. Melo , P. Pezzuto , G. S. de Azevedo , B. L. F. Schamber‐Reis , J. S. Tavares , J. J. Mattapallil , A. Tanuri , R. S. Aguiar , C. C. Cardoso , C. A. Stratakis Source Type: research

Influence of anti ‐inflammatory diet and smoking on mortality and survival in men and women: two prospective cohort studies
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 13, 2018 Category: Internal Medicine Authors: J. Kaluza , N. H åkansson , H. R. Harris , N. Orsini , K. Michaëlsson , A. Wolk Source Type: research

Urinary Excretion of Homocysteine Thiolactone and the Risk of Acute Myocardial Infarction in Coronary Artery Disease Patients; the WENBIT Trial
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 7, 2018 Category: Internal Medicine Authors: Kamila Borowczyk , Justyna Piechocka , Rafa ł Głowacki , Indu Dhar , Øivind Midtun , Grethe S Tell , Per Magne Ueland , Ottar Nygård , Hieronim Jakubowski Source Type: research

Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 7, 2018 Category: Internal Medicine Authors: M. R. de Vries , L. Parma , H. A. B. Peters , A. Schepers , J. F. Hamming , J. W. Jukema , M. J. T. H. Goumans , L. Guo , A. V. Finn , R. Virmani , C. K. Ozaki , P. H. A. Quax Source Type: research

Systemic Bevacizumab for the Treatment of Chronic Bleeding in Hereditary Hemorrhagic Telangiectasia
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - September 7, 2018 Category: Internal Medicine Authors: Hanny Al ‐Samkari , Athena Kritharis , Josanna M. Rodriguez‐Lopez , David J. Kuter Source Type: research

Therapeutic value of stimulating the nitrate ‐nitrite‐nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - August 29, 2018 Category: Internal Medicine Authors: M. Carlstrom , M. F. Montenegro Source Type: research

A biomarker of collagen type I degradation is associated with cardiovascular events and mortality in patients with atherosclerosis
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - August 29, 2018 Category: Internal Medicine Authors: S. Holm Nielsen , C. Tengryd , A. Edsfeldt , S. Brix , F. Genovese , E. Bengtsson , M. Karsdal , D. J. Leeming , J. Nilsson , I. Goncalves Source Type: research

Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose ‐lowering therapy
Journal of Internal Medicine, EarlyView. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - August 28, 2018 Category: Internal Medicine Authors: A. Mahdi , O. K övamees , A. Checa , C. E. Wheelock , M. von Heijne , M. Alvarsson , J. Pernow Source Type: research

Genes that make you fat, but keep you healthy
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - August 24, 2018 Category: Internal Medicine Authors: Ruth J.F. Loos , Tuomas O. Kilpel äinen Source Type: research

“Obesity associated metabolic complications, the second wave of the tsunami” 14th Key Symposium
Journal of Internal Medicine,Volume 0, Issue ja, -Not available-. (Source: Journal of Internal Medicine)
Source: Journal of Internal Medicine - August 24, 2018 Category: Internal Medicine Authors: Antonio Vidal ‐Puig , Sven Enerback Source Type: research