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Non-vitamin-K oral anticoagulants reduce mortality, stroke and intracranial haemorrhage when compared with warfarin in randomised trials of patients with non-valvular atrial fibrillation
Commentary on: Ruff CT, Giugliano RP, Braunwald E, et al.. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet 2014;383:955–62. Context Historically, the standard medication for stroke prevention in atrial fibrillation (AF) has been a vitamin-K antagonist (warfarin). However, several non-vitamin-K oral anticoagulants (NOACs) have been developed and shown to be at least as effective as dose-adjusted warfarin in their respective phase-3 clinical trials.1–4 These include the direct thrombin inhibitor dabig...
Source: Evidence-Based Medicine - September 15, 2014 Category: Internal Medicine Authors: Steinberg, B. A. Tags: Epidemiologic studies, Drugs: cardiovascular system, Stroke, Ischaemic heart disease, Connective tissue disease, Musculoskeletal syndromes, Diabetes, Arrhythmias Therapeutics Source Type: research

Knowledge Regarding Oral Anticoagulation Therapy among Patients with Stroke and Those at High Risk of Thromboembolic Events
Apart from atrial fibrillation, indications for oral anticoagulation common in our clinical practice include rheumatic heart disease and mechanical heart valve replacement. Evaluation of current patient knowledge regarding oral anticoagulation therapy (OAT) is the first step in improving the quality of anticoagulation therapy and patient care. The aim of the present study was to assess the knowledge regarding OAT among patients with stroke and those at high risk of thromboembolic events in a tertiary care hospital in India.
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2015 Category: Neurology Authors: Annu Alphonsa, Kamlesh K. Sharma, Gautam Sharma, Rohit Bhatia Source Type: research

Too much sleep could increase chance of a stroke
A new study suggests that sleeping more than eight hours a night could triple the risk of a stroke, among those with high blood pressure
Source: Telegraph Health - May 15, 2015 Category: Consumer Health News Tags: .stroke blood pressure heart disease NHS sleep sleeping Source Type: news

Homocysteine, Ischemic Stroke, and Coronary Heart Disease in Hypertensive Patients: A Population-Based, Prospective Cohort Study Clinical Sciences
Conclusions— Hyperhomocysteinemia in Chinese hypertensive patients is significantly associated with IS risk but not coronary heart disease susceptibility, and folic acid supplementation can efficiently reduce tHcy levels.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Han, L., Wu, Q., Wang, C., Hao, Y., Zhao, J., Zhang, L., Fan, R., Liu, Y., Li, R., Chen, Z., Zhang, T., Chen, S., Ma, J., Liu, S., Peng, X., Duan, S. Tags: Myocardial cardiomyopathy disease, Valvular heart disease, Clinical Studies, Acute Cerebral Hemorrhage, Cerebral Venous Thrombosis Clinical Sciences Source Type: research

Medical News Today: Longer working hours linked to greater stroke risk
A new study reveals how individuals working 55 hours or more per week are putting their health at risk by increasing their likelihood of stroke and heart disease.
Source: Health News from Medical News Today - August 20, 2015 Category: Consumer Health News Tags: Stroke Source Type: news

Predictors of Ischemic Stroke in Rheumatic Heart Disease
Studies on predictors of ischemic strokes caused by rheumatic heart disease (RHD) are sparse and extremely important for identifying high-risk cases to direct future therapeutic trials for prevention of ischemic stroke in this population.
Source: Journal of Stroke and Cerebrovascular Diseases - September 22, 2015 Category: Neurology Authors: Anirban Gupta, Rohit Bhatia, Gautam Sharma, Kameshwar Prasad, Mamta Bhushan Singh, Deepti Vibha Source Type: research

Combined effects of hypertension and heart rate on the risk of stroke and coronary heart disease: a population-based prospective cohort study among Inner Mongolians in China
n & Yonghong Zhang
Source: Hypertension Research - December 7, 2015 Category: Cardiology Authors: Chongke ZhongXiaoyan ZhongTian XuHao PengHongmei LiMingzhi ZhangAili WangTan XuYingxian SunYonghong Zhang Tags: cohort study coronary heart disease heart rate stroke Source Type: research

Admission Heart Rate Predicts Poor Outcomes in Acute Intracerebral Hemorrhage: The Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial Studies Clinical Sciences
Conclusions— Higher admission heart rate is independently associated with death and poor functional outcome after acute intracerebral hemorrhage. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Qiu, M., Sato, S., Zheng, D., Wang, X., Carcel, C., Hirakawa, Y., Sandset, E. C., Delcourt, C., Arima, H., Wang, J., Chalmers, J., Anderson, C. S., for the INTERACT Investigators* Tags: Mortality/Survival, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage Clinical Sciences Source Type: research

Inhibitory Effects of P2Y12 Receptor Antagonist on PAR1- and PAR4-AP-Induced Platelet Aggregation in Patients with Stroke or TIA
Platelet aggregation is a key stage in the formation of arterial thrombi, which cause thrombotic events such as stroke or acute coronary syndrome, and is thus employed to evaluate platelet function and reactivity.1-3 Individual differences in platelet aggregation have been reported.4-10 Ethnic differences in platelet aggregation could explain differences in the incidences and outcomes of ischemic heart disease,2 but platelet aggregation has been associated with coronary heart disease in some epidemiological studies,3 whereas not in others.
Source: Journal of Stroke and Cerebrovascular Diseases - December 22, 2020 Category: Neurology Authors: Asami Kamada, Mie Shimizu, Kazumasa Oura, Makiko Yoshida, Keisuke Tsuda, Kiyotaka Oi, Yoko Ishigaku, Tatsunori Natori, Shinsuke Narumi, Ryo Itabashi, Tetsuya Maeda, Yasuo Terayama Source Type: research

Sleep apnoea greatly increases risk of stroke, US scientists find
Stanford study shows that people with the common sleep disorder are also five times more likely to develop atrial fibrillationSnoring loudly and feeling tired even after a full night ’s sleep could leave people at an increased risk of a stroke, a study has shown.Hundreds of millions of people globally have sleep apnoea, a disorder with symptoms including stopping and starting breathing, making snorting noises, waking up a lot and loud snoring. Many have the condition but are undiagnosed.Continue reading...
Source: Guardian Unlimited Science - August 25, 2023 Category: Science Authors: Andrew Gregory Health editor in Amsterdam Tags: Stroke Sleep apnoea Medical research Heart disease Science Society Source Type: news

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Age- and Sex-Associated Impacts of Body Mass Index on Stroke Type Risk: A 27-Year Prospective Cohort Study in a Low-Income Population in China
Conclusions Being overweight increased the risk of both ischemic and hemorrhagic strokes; obesity was only associated with an increased risk of IS. Additionally, the positive association between BMI and stroke risk was only observed in participants aged <65 years and the associations differed between men and women. Being overweight increased the risk of both ischemic and hemorrhagic strokes in men and being underweight increased their risk of hemorrhagic stroke. In women, being overweight increased the hemorrhagic stroke risk, whereas obesity increased their IS risks. The high prevalence of hypertension and elevat...
Source: Frontiers in Neurology - April 30, 2019 Category: Neurology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Platelet Count Predicts Adverse Clinical Outcomes After Ischemic Stroke or TIA: Subgroup Analysis of CNSR II
Conclusion: In ischemic stroke or TIA patients with platelet count within normal range, platelet count may be a qualified predictor for long-term recurrent stroke, mortality, and poor functional outcome. Introduction Platelets exert a critical role in the pathogenesis of atherosclerotic complications of cardio-cerebrovascular disease, contributing to thrombus formation, and embolism (1, 2). Previous literature reported that platelets of various size and density are produced by megakaryocytes of different size and stages of maturation in different clinical conditions, suggesting various platelet patterns in differen...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research