Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis

Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients with ICH, the 3-months poor functional outcome, mortality and morbidity are similar for the two sexes. The hematoma growth is higher in men, although their association with the functional poor outcome is not statistically significant. Microalbuminuria could be an early marker of hematoma growth, particularly in male patients with hypertensive ICH. Ethics Statement This research was carried out in accordance with the Declaration of Helsinki of the World Medical Association (2008) and approved by the Ethics Committee of the Servizo Galego de Saúde. Informed consent was obtained from each patient or their relatives after full explanation of the procedures. Author Contributions JC and RI-R participated in the design and coordination of the study, wrote the main manuscript text and analyzed the data. MR-Y, SA, MS, ER-C, and IL-D collected the data, have...
Source: Frontiers in Neurology - Category: Neurology Source Type: research