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Condition: Stroke
Procedure: Gastroschisis Repair

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Total 4990 results found since Jan 2013.

The Relationship of Astrocytes and Microglia with Different Stages of Ischemic Stroke
CONCLUSION: Understanding the details of astrocyte-microglia interaction processes will contribute to a better understanding of the mechanisms underlying ischemic stroke, contributing to the identification of new therapeutic interventions.PMID:37464832 | DOI:10.2174/1570159X21666230718104634
Source: Current Neuropharmacology - July 19, 2023 Category: Drugs & Pharmacology Authors: Zhen Liang Yingyue Lou Yulei Hao Hui Li Jiachun Feng Songyan Liu Source Type: research

Comparison of the Checkerboard P300 Speller vs. the Row-Column Speller in Normal Elderly and an Aphasic Stroke Population (S21.006)
CONCLUSION: Our study demonstrates that stroke patients with Broca’s aphasia can use a P300 visual speller to communicate. Our results also indicate that in the elderly population, CBP is a superior paradigm compared to RCP. Disclosure: Dr. Shih has received research support from Eisai Inc., and Visualase Inc. Dr. Townsend has nothing to disclose. Dr. Krusienski has nothing to disclose. Dr. Shih has nothing to disclose. Dr. Shih has nothing to disclose. Dr. Heggeli has nothing to disclose. Dr. Paris has nothing to disclose. Dr. Meschia has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shih, J., Townsend, G., Krusienski, D., Shih, K., Shih, R., Heggeli, K., Paris, T., Meschia, J. Tags: Neuro-rehabilitation and Neural Repair Source Type: research

NF-κB is involved in brain repair by stem cell factor and granulocyte-colony stimulating factor in chronic stroke.
Abstract Chronic stroke is the phase of brain recovery and repair generally beginning 3 months after stroke onset. No pharmaceutical approach is currently available to enhance brain repair in the chronic stroke. We have previously determined the therapeutic effects of stem cell factor (SCF) and granulocyte-colony stimulating factor (G-CSF) alone or in combination (SCF+G-CSF) in an animal model of chronic stroke and demonstrated that only SCF+G-CSF induces long-term functional recovery. However, the mechanism underlying the SCF+G-CSF-induced brain repair in chronic stroke remains largely elusive. In the present stu...
Source: Experimental Neurology - September 30, 2014 Category: Neurology Authors: Cui L, Duchamp NS, Boston DJ, Ren X, Zhang X, Hu H, Zhao LR Tags: Exp Neurol Source Type: research

Histone deacetylase expression in white matter oligodendrocytes after stroke
Publication date: November 2014 Source:Neurochemistry International, Volume 77 Author(s): Haifa Kassis , Michael Chopp , Xian Shuang Liu , Amjad Shehadah , Cynthia Roberts , Zheng Gang Zhang Histone deacetylases (HDACs) constitute a super-family of enzymes grouped into four major classes (Class I–IV) that deacetylate histone tails leading to chromatin condensation and gene repression. Whether stroke-induced oligodendrogenesis is related to the expression of individual HDACs in the oligodendrocyte lineage has not been investigated. We found that 2days after stroke, oligodendrocyte progenitor cells (OPCs) and mature olig...
Source: Neurochemistry International - November 4, 2014 Category: Neuroscience Source Type: research

The back and forth of axonal injury and repair after stroke
Purpose of review: The axon plays a central role in both the injury and repair phases after stroke. This review highlights emerging principles in the study of axonal injury in stroke and the role of the axon in neural repair after stroke. Recent findings: Ischemic stroke produces a rapid and significant loss of axons in the acute phase. This early loss of axons results from a primary ischemic injury that triggers a wave of calcium signaling, activating proteolytic mechanisms and downstream signaling cascades. A second progressive phase of axonal injury occurs during the subacute period and damages axons that survive the in...
Source: Current Opinion in Neurology - November 7, 2014 Category: Neurology Tags: TRAUMA AND REHABILITATION: Edited by S. Thomas Carmichael Source Type: research

Intranasal Delivery of Bone Marrow Mesenchymal Stem Cells Improved Neurovascular Regeneration and Rescued Neuropsychiatric Deficits after Neonatal Stroke in Rats.
Abstract Neonatal stroke is a major cause of mortality and long-term morbidity in infants and children. Currently very limited therapeutic strategies are available to protect the developing brain against ischemic damage and promote brain repairs for pediatric patients. Moreover, children who experienced neonatal stroke often have developmental social behavior problems. Cellular therapy using bone marrow mesenchymal stem cells (BMSCs) has emerged as a regenerative therapy after stroke. In the present investigation, neonatal stroke of postnatal day 7 (P7) rat pups was treated with non-invasive and brain specific int...
Source: Cell Transplantation - February 2, 2015 Category: Cytology Authors: Wei ZZ, Gu X, Ferdinand A, Lee JH, Ji X, Ji XM, Yu SP, Wei L Tags: Cell Transplant Source Type: research

Exploring the Evolution of Cortical Excitability Following Acute Stroke
Conclusions. The current study has demonstrated that evolution of intracortical excitability, particularly over the contralesional hemisphere, may vary between patients with differing baseline stroke and clinical characteristics, suggesting that ongoing contralesional network recruitment may be necessary for those patients who have significant disruptions to the integrity of ipsilesional motor pathways. Results from the present series have implications for the development of neuromodulatory brain stimulation protocols to harness and thereby facilitate stroke recovery.
Source: Neurorehabilitation and Neural Repair - February 12, 2016 Category: Neurology Authors: Huynh, W., Vucic, S., Krishnan, A. V., Lin, C. S.-Y., Kiernan, M. C. Tags: Clinical Research Articles Source Type: research

Proton magnetic resonance spectroscopy as a diagnostic biomarker in mild cognitive impairment following stroke in acute phase
To investigate proton magnetic resonance spectroscopy (1HMRS) as a diagnostic biomarker to identify mild cognitive impairment (MCI) following stroke in the acute phase. A total of 72 stroke patients were recruited in the acute phase of stroke from the Department of Neurology, including 36 stroke patients with MCI and 36 stroke patients without MCI. All patients underwent brain MRI/MRS examination on a 3.0 T scanner and a neuropsychological test in the acute phase of stroke. Single-voxel 1HMRS was performed to obtain hippocampal metabolism intensities and brain infarcts were assessed on MRI. Group difference in metabolite...
Source: NeuroReport - April 29, 2016 Category: Neurology Tags: Degeneration and Repair Source Type: research

Inflammatory Disequilibrium in Stroke.
Abstract Over the past several decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to the development of thrombolytic therapy as the cornerstone of current management of ischemic stroke, but there remains much to be learned about mechanisms of neuronal ischemic and reperfusion injury and associated inflammation. For ischemic stroke, novel therapeutic targets have continued to remain elusive. When considering modern molecular biological techniques, advanced translational stroke models, and clinical studies, a consi...
Source: Circulation Research - June 23, 2016 Category: Cardiology Authors: Petrovic-Djergovic D, Goonewardena SN, Pinsky DJ Tags: Circ Res Source Type: research

Compensatory Versus Noncompensatory Shoulder Movements Used for Reaching in Stroke
Conclusions. The upper-limb flexor synergy was used adaptively for reaching accuracy by patients with mild, but not moderate/severe stroke. The flexor synergy, as parameterized by the amount of arm-plane motion, can be used by clinicians to identify levels of motor recovery in patients with stroke.
Source: Neurorehabilitation and Neural Repair - July 10, 2016 Category: Neurology Authors: Levin, M. F., Liebermann, D. G., Parmet, Y., Berman, S. Tags: Clinical Research Articles Source Type: research

Heterogeneity of B  Cell Functions in Stroke-Related Risk, Prevention, Injury, and Repair
AbstractIt is well established that post-stroke inflammation contributes to neurovascular injury, blood –brain barrier disruption, and poor functional recovery in both animal and clinical studies. However, recent studies also suggest that several leukocyte subsets, activated during the post-stroke immune response, can exhibit both pro-injury and pro-recovery phenotypes. In accordance with these find ings, B lymphocytes, or B cells, play a heterogeneous role in the adaptive immune response to stroke. This review highlights what is currently understood about the various roles of B cells, with an emphasis on stroke risk fac...
Source: Neurotherapeutics - August 3, 2016 Category: Neurology Source Type: research

Effect of Combined Treatment with MLC601 (NeuroAiD < sup > TM < /sup > ) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMES-E Studies
Conclusions: More subjects on MLC601 improved to functional independence compared to placebo among subjects receiving persistent rehabilitation up to M3. The larger treatment effect of MLC601 was sustained over 2  years which supports the hypothesis that MLC601 combined with rehabilitation might have beneficial and sustained effects on neuro-repair processes after stroke. There is a need for more data on the effect of combining rehabilitation programs with stroke recovery treatments.Cerebrovasc Dis 2018;46:82 –88
Source: Cerebrovascular Diseases - September 7, 2018 Category: Neurology Source Type: research

Post-stroke neovascularization and functional outcomes differ in diabetes depending on severity of injury and sex: Potential link to hemorrhagic transformation.
Abstract Diabetes is associated with increased risk and worsened outcome of stroke. Previous studies showed that male diabetic animals had greater hemorrhagic transformation (HT), profound loss of cerebral vasculature, and poor behavioral outcomes after ischemic stroke induced by suture or embolic middle cerebral artery occlusion (MCAO). Females are protected from stroke until reaching the menopause age, but young females with diabetes have a higher risk of stroke and women account for the majority of stroke mortality. The current study postulated that diabetes is associated with greater vascular injury and exacer...
Source: Experimental Neurology - September 19, 2018 Category: Neurology Authors: Li W, Valenzuela JP, Ward R, Abdelbary M, Dong G, Fagan SC, Ergul A Tags: Exp Neurol Source Type: research

Effect of Combined Treatment with MLC601 (NeuroAiDTM) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMES-E Studies
Conclusions: More subjects on MLC601 improved to functional independence compared to placebo among subjects receiving persistent rehabilitation up to M3. The larger treatment effect of MLC601 was sustained over 2  years which supports the hypothesis that MLC601 combined with rehabilitation might have beneficial and sustained effects on neuro-repair processes after stroke. There is a need for more data on the effect of combining rehabilitation programs with stroke recovery treatments.Cerebrovasc Dis 2018;46:82 –88
Source: Cerebrovascular Diseases - October 5, 2018 Category: Neurology Source Type: research

Modulators of microglia activation and polarization in ischemic stroke (Review).
Authors: Jiang CT, Wu WF, Deng YH, Ge JW Abstract Ischemic stroke is one of the leading causes of mortality and disability worldwide. However, there is a current lack of effective therapies available. As the resident macrophages of the brain, microglia can monitor the microenvironment and initiate immune responses. In response to various brain injuries, such as ischemic stroke, microglia are activated and polarized into the proinflammatory M1 phenotype or the anti‑inflammatory M2 phenotype. The immunomodulatory molecules, such as cytokines and chemokines, generated by these microglia are closely associated with s...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research