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Condition: Stroke
Procedure: Gastroschisis Repair

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Total 4990 results found since Jan 2013.

Impact of BDNF -196 g≯a and BDNF -270 c≯t polymorphisms on stroke rehabilitation outcome: sex and age differences.
Conclusions:BDNF -196 G≯A polymorphism might affect functional outcome of stroke rehabilitation, but this hypothesis needs further verification. PMID: 24722042 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - April 17, 2014 Category: Neurology Authors: Mirowska-Guzel D, Gromadzka G, Mendel T, Janus-Laszuk B, Dzierka J, Sarzynska-Dlugosz I, Czlonkowski A, Czlonkowska A Tags: Top Stroke Rehabil Source Type: research

Low Circulating Acute Brain-Derived Neurotrophic Factor Levels Are Associated With Poor Long-Term Functional Outcome After Ischemic Stroke Brief Reports
Conclusions— Circulating concentrations of BDNF protein are lowered in the acute phase of ischemic stroke, and low levels are associated with poor long-term functional outcome. Further studies are necessary to confirm these associations and to determine the predictive value of BDNF in stroke outcomes.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Stanne, T. M., Aberg, N. D., Nilsson, S., Jood, K., Blomstrand, C., Andreasson, U., Blennow, K., Zetterberg, H., Isgaard, J., Svensson, J., Jern, C. Tags: Biomarkers, Etiology, Ischemic Stroke Brief Reports Source Type: research

Vascularization Pattern After Ischemic Stroke is Different in Control Versus Diabetic Rats: Relevance to Stroke Recovery Basic Sciences
Conclusions— Diabetes mellitus impairs poststroke reparative neovascularization and impedes the recovery. Glycemic control after stroke can improve neurovascular repair and improve functional outcome.
Source: Stroke - September 23, 2013 Category: Neurology Authors: Prakash, R., Li, W., Qu, Z., Johnson, M. A., Fagan, S. C., Ergul, A. Tags: Type 2 diabetes, Behavioral Changes and Stroke, Other imaging, Other Vascular biology Basic Sciences Source Type: research

Emerging molecular targets for brain repair after stroke.
Authors: Krupinski J, Slevin M Abstract The field of neuroprotection generated consistent preclinical findings of mechanisms of cell death but these failed to be translated into clinics. The approaches that combine the modulation of the inhibitory environment together with the promotion of intrinsic axonal outgrowth needs further work before combined therapeutic strategies will be transferable to clinic trials. It is likely that only when some answers have been found to these issues will our therapeutic efforts meet our expectations. Stroke is a clinically heterogeneous disease and combinatorial treatments require ...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models Basic Sciences
Conclusions— The combination of EPC transplantation and RWJ administration accelerated recovery from diabetic stroke, which might have been caused by increased levels of proangiogenic and neurotrophic factors.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Bai, Y.-Y., Wang, L., Chang, D., Zhao, Z., Lu, C.-Q., Wang, G., Ju, S. Tags: Type 2 diabetes, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Age-Dependent Exacerbation of White Matter Stroke Outcomes: A Role for Oxidative Damage and Inflammatory Mediators Basic Sciences
Conclusions— Age has a profound effect on the outcome of WMS, with more prolonged cell death and oxidative damage, increased inflammation, greater secondary white matter atrophy, and a worse behavioral effect in aged versus young-adult mice.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Rosenzweig, S., Carmichael, S. T. Tags: Animal models of human disease, Acute Cerebral Infarction, Behavioral Changes and Stroke Basic Sciences Source Type: research

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke Basic Sciences
Conclusions—Systemic poststroke administration of hAECs elicits marked neuroprotection and facilitates mechanisms of repair and recovery.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Megan A. Evans, Rebecca Lim, Hyun Ah Kim, Hannah X. Chu, Chantelle V. Gardiner-Mann, Kimberly W.E. Taylor, Christopher T. Chan, Vanessa H. Brait, Seyoung Lee, Quynh Nhu Dinh, Antony Vinh, Thanh G. Phan, Velandai K. Srikanth, Henry Ma, Thiruma V. Arumugam, Tags: Animal Models of Human Disease, Cell Therapy, Stem Cells, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model Basic Sciences
Conclusions—Transplantation at the delayed subacute phase showed muse cells differentiated into neural cells, facilitated neural reconstruction, improved functions, and displayed solid safety outcomes over prolonged graft maturation period, indicating their therapeutic potential for lacunar stroke.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Hiroki Uchida, Kuniyasu Niizuma, Yoshihiro Kushida, Shohei Wakao, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Cell Therapy, Stem Cells, Translational Studies, Ischemic Stroke Original Contributions Source Type: research

Endoglin Deficiency Impairs Stroke Recovery Basic Sciences
Conclusions— Endoglin deficiency impairs brain injury recovery. Reduced angiogenesis, impaired macrophage homing, and delayed inflammation resolution could be the underlying mechanism.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Shen, F., Degos, V., Chu, P.-L., Han, Z., Westbroek, E. M., Choi, E.-J., Marchuk, D., Kim, H., Lawton, M. T., Maze, M., Young, W. L., Su, H. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Genetically altered mice, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Basic Sciences Source Type: research

Stroke Induces Mesenchymal Stem Cell Migration to Infarcted Brain Areas Via CXCR4 and C-Met Signaling
AbstractMesenchymal stem cells circulate between organs to repair and maintain tissues. Mesenchymal stem cells cultured with fetal bovine serum have therapeutic effects when intravenously administered after stroke. However, only a small number of mesenchymal stem cells reach the brain. We hypothesized that the serum from stroke patients increases mesenchymal stem cells trophism toward the infarcted brain area. Mesenchymal stem cells were grown in fetal bovine serum, normal serum from normal rats, or stroke serum from ischemic stroke rats. Compared to the fetal bovine serum group, the stroke serum group but not the normal s...
Source: Translational Stroke Research - May 25, 2017 Category: Neurology Source Type: research

Perlecan Domain-V Enhances Neurogenic Brain Repair After Stroke in Mice
AbstractThe extracellular matrix fragment perlecan domain V is neuroprotective and functionally restorative following experimental stroke. As neurogenesis is an important component of chronic post-stroke repair, and previous studies have implicated perlecan in developmental neurogenesis, we hypothesized that domain V could have a broad therapeutic window by enhancing neurogenesis after stroke. We demonstrated that domain V is chronically increased in the brains of human stroke patients, suggesting that it is present during post-stroke neurogenic periods. Furthermore, perlecan deficient mice had significantly less neuroblas...
Source: Translational Stroke Research - April 6, 2020 Category: Neurology Source Type: research

Delayed rFGF21 Administration Improves Cerebrovascular Remodeling and White Matter Repair After Focal Stroke in Diabetic Mice
This study aims to evaluate the potential effects of rFGF21 on cerebrovascular remodeling after T2DM stroke. Permanent distal middle cerebral artery occlusion was performed in heterozygous non-diabetic db/  + and homozygous diabetic db/db mice. Daily rFGF21 administration was initiated 1 week after stroke induction and maintained for up to 2 weeks thereafter. Multiple markers associated with post-stroke recovery, including angiogenesis, oligodendrogenesis, white matter integrity, and neurogenesi s, were assessed up to 3 weeks after stroke. Our results showed an impairment in post-stroke vascular remodeling under T2D...
Source: Translational Stroke Research - March 14, 2022 Category: Neurology Source Type: research

Vascular Endothelial Growth Factor Augments the Tolerance Towards Cerebral Stroke by Enhancing Neurovascular Repair Mechanism
We report that the transgenic overexpression of VEGF (GOF) prior to the stroke stabilizes the vasculature and prevents blood–brain barrier disruption in young and aged animals after stroke. Whereas inhibition of signals for endogenous VEGF (LOF) prior to stroke results in bigger infarction with massive brain swelling and enhanced BBB permeability, furthermore, activating or blocking VEGF signaling after ischemic stroke onset had comparable effects on BBB repair an d cerebral edema. VEGF can function as an anti-permeability factor, and a VEGF-based therapy in the context of stroke prevention and recovery has an enormous potential.
Source: Translational Stroke Research - February 17, 2022 Category: Neurology Source Type: research

Vasculogenesis in Experimental Stroke After Human Cerebral Endothelial Cell Transplantation Basic Sciences
Conclusions— We found attenuation of behavioral and histological deficits coupled with robust vasculogenesis and neurogenesis in endothelial cell–transplanted stroke animals, suggesting that targeting vascular repair sets in motion a regenerative process in experimental stroke possibly via the VEGF pathway.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Ishikawa, H., Tajiri, N., Shinozuka, K., Vasconcellos, J., Kaneko, Y., Lee, H. J., Mimura, O., Dezawa, M., Kim, S. U., Borlongan, C. V. Tags: Animal models of human disease Basic Sciences Source Type: research

Critical Role of the Sphingolipid Pathway in Stroke: a Review of Current Utility and Potential Therapeutic Targets
Abstract Sphingolipids are a series of cell membrane-derived lipids which act as signaling molecules and play a critical role in cell death and survival, proliferation, recognition, and migration. Sphingosine-1-phosphate acts as a key signaling molecule and regulates lymphocyte trafficking, glial cell activation, vasoconstriction, endothelial barrier function, and neuronal death pathways which plays a critical role in numerous neurological conditions. Stroke is a second leading cause of death all over the world and effective therapies are still in great demand, including ischemic stroke and hemorrhagic stroke as w...
Source: Translational Stroke Research - June 23, 2016 Category: Neurology Source Type: research