Filtered By:
Condition: Stroke
Procedure: Gastroschisis Repair

This page shows you your search results in order of relevance. This is page number 6.

Order by Relevance | Date

Total 4990 results found since Jan 2013.

Discovery could lead to better recovery after stroke
UCLA researchers have identified a molecule that, after a stroke, signals brain tissue to form new connections to compensate for the damage and initiate repairs to the brain. The finding could eventually lead to a new treatment to promote brain repair and functional recovery in people who have suffered a stroke, which is the leading cause of serious long-term disability in adults. The five-year study, performed in an animal model, was the first to identify growth differentiation factor 10, or GDF10, a molecule that previously had no known role in the adult brain, said Dr. S. Thomas Carmichael, the study’s senior author ...
Source: UCLA Newsroom: Health Sciences - October 26, 2015 Category: Universities & Medical Training Source Type: news

Age at stroke determines post-stroke language lateralization.
CONCLUSION: As expected, the age of stroke occurrence affects subsequent verb generation lateralization. Greater cortical plasticity is observed in earlier stroke while later stroke is associated with reliance on the repair of the previously damaged left-hemispheric networks. PMID: 25159870 [PubMed - indexed for MEDLINE]
Source: Restorative Neurology and Neuroscience - January 25, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Long-term T cell responses in the brain after an ischemic stroke.
Authors: Selvaraj UM, Stowe AM Abstract Stroke, which occurs during a loss of blood flow to the brain, is a global disease that accounts for 10% of yearly mortality. But stroke is also a leading cause of long-term adult disability, with recovery continuing for months to years after initial stroke onset. This long-term functional recovery from stroke encompasses changes in neuronal structure and function, and occurs throughout the post-stroke brain. Much less understood is whether the adaptive immune cells that infiltrated the brain during acute post-stroke neuroinflammation remain long-term, and if their presence s...
Source: Discovery Medicine - January 28, 2018 Category: Research Tags: Discov Med Source Type: research

Enhancing endogenous capacity to repair a stroke-damaged brain: an evolving field for stroke research
Publication date: Available online 21 February 2018 Source:Progress in Neurobiology Author(s): Li-Ru Zhao, Alison Willing Stroke represents a severe medical condition that causes stroke survivors to suffer from long-term and even lifelong disability. Over the past several decades, a vast majority of stroke research targets neuroprotection in the acute phase, while little work has been done to enhance stroke recovery at the later stage. Through reviewing current understanding of brain plasticity, stroke pathology, and emerging preclinical and clinical restorative approaches, this review aims to provide new insights to adva...
Source: Progress in Neurobiology - March 2, 2018 Category: Neuroscience Source Type: research

Enhancing endogenous capacity to repair a stroke-damaged brain: An evolving field for stroke research
Publication date: April–May 2018Source: Progress in Neurobiology, Volumes 163–164Author(s): Li-Ru Zhao, Alison WillingAbstractStroke represents a severe medical condition that causes stroke survivors to suffer from long-term and even lifelong disability. Over the past several decades, a vast majority of stroke research targets neuroprotection in the acute phase, while little work has been done to enhance stroke recovery at the later stage. Through reviewing current understanding of brain plasticity, stroke pathology, and emerging preclinical and clinical restorative approaches, this review aims to provide new insights ...
Source: Progress in Neurobiology - July 5, 2018 Category: Neuroscience Source Type: research

Temporal Patterning of Neurofilament Light as a Blood-Based Biomarker for Stroke: A Systematic Review and Meta-Analysis
Damage to axons is a core feature of ischemic stroke and cerebrovascular disease. The burden of axonal injury is correlated with the acute clinical deficits, the underlying burden of ischemic brain injury, the prognosis of recovery, and may be a meaningful therapeutic target for brain repair. Neurofilament light chain (NfL) has been identified as a blood-based biomarker that reflects neuroaxonal damage resulting from stroke. However, the utility of NfL as a blood-based biomarker in stroke is confounded by studies examining different temporal windows and patient populations. We conducted a systematic review and meta-analysi...
Source: Frontiers in Neurology - May 16, 2022 Category: Neurology Source Type: research

Immune responses in stroke: How the immune system contributes to damage and healing after stroke and how this knowledge could be translated to better cures?
This article is protected by copyright. All rights reserved. PMID: 29494762 [PubMed - as supplied by publisher]
Source: Immunology - March 1, 2018 Category: Allergy & Immunology Authors: Rayasam A, Hsu M, Kijak JA, Kissel L, Hernandez G, Sandor M, Fabry Z Tags: Immunology Source Type: research

Technical improvements in carotid revascularization based on the mechanism of procedural stroke.
In conclusion, this review provides an overview of the pathophysiological mechanism of stroke following carotid revascularization (both CAS and CEA) and of the technical improvements that have contributed to reducing this stroke risk. PMID: 30827087 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - February 28, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Fassaert LM, de Borst GJ Tags: J Cardiovasc Surg (Torino) Source Type: research

Paradoxical Motor Recovery From a First Stroke After Induction of a Second Stroke: Reopening a Postischemic Sensitive Period
Conclusions. New ischemia can reopen a sensitive period of heightened responsiveness to training and mediate full recovery from a previous stroke.
Source: Neurorehabilitation and Neural Repair - August 8, 2016 Category: Neurology Authors: Zeiler, S. R., Hubbard, R., Gibson, E. M., Zheng, T., Ng, K., OBrien, R., Krakauer, J. W. Tags: Basic Science Article Source Type: research

Biomaterial developed at UCLA helps regrow brain tissue after stroke in mice
A new stroke-healing gel created by UCLA researchers helped regrow neurons and blood vessels in mice whose brains had been damaged by strokes.The finding is reported May 21 in Nature Materials.“We tested this in laboratory mice to determine if it would repair the brain and lead to recovery in a model of stroke,” said Dr. S. Thomas Carmichael, professor of neurology at theDavid Geffen School of Medicine at UCLA. “The study indicated that new brain tissue can be regenerated in what was previously just an inactive brain scar after stroke.”The results suggest that such an approach could some day be used to treat people...
Source: UCLA Newsroom: Health Sciences - May 22, 2018 Category: Universities & Medical Training Source Type: news

Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice
AbstractIschemic stroke remains a serious threat to human life. Generation of neuronal and vascular cells is an endogenous regenerative mechanism in the adult brain, which may contribute to tissue repair after stroke. However, the regenerative activity is typically insufficient for significant therapeutic effects after brain injuries. Pyruvate kinase isoform M2 (PKM2) is a key regulator for energy metabolism. PKM2 also has nonmetabolic roles involving regulations of gene expression, cell proliferation, and migration in cancer cells as well as noncancerous cells. In a focal ischemic stroke mouse model, recombinant PKM2 (rPK...
Source: Neurotherapeutics - June 4, 2018 Category: Neurology Source Type: research

Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons
Type 2 diabetes (T2D) hampers stroke recovery though largely undetermined mechanisms. Few preclinical studies have investigated the effect of genetic/toxin-induced diabetes on long-term stroke recovery. However, the effects of obesity-induced T2D are mostly unknown. We aimed to investigate whether obesity-induced T2D worsens long-term stroke recovery through the impairment of brain's self-repair mechanisms - stroke-induced neurogenesis and parvalbumin (PV)+ interneurons-mediated neuroplasticity. To mimic obesity-induced T2D in the middle-age, C57bl/6j mice were fed 12 months with high-fat diet and subjected to transient mi...
Source: Clinical Science - June 23, 2019 Category: Biomedical Science Authors: Pintana, H., Lietzau, G., Augestad, I. L., Chiazza, F., Nystrom, T., Patrone, C., Darsalia, V. Tags: PublishAheadOfPrint Source Type: research

Peripheral and central smell regions in patients with stroke: an MRI evaluation
ConclusionBoth central and peripheral odor pathways were affected, and left OB in the peripheral odor pathways was even more affected in case of longer duration of the stroke. Changes in central and peripheral olfactory pathways in patients with stroke may not be aimed at neuroplasticity and repair, but rather may be a reflection of inflammation and degenerative changes in stroke.
Source: Neurological Sciences - February 19, 2022 Category: Neurology Source Type: research

How Can You Mend a Broken Brain? - Neurorestorative Approaches to Stroke Recovery
Background: Stroke is a devastating disorder that strikes approximately 15 million people worldwide. While most patients survive stroke, many are left with lifelong impairments, thereby making stroke the leading cause of permanent neurological disability. Despite this, there are a few options for treatment of acute stroke. Restoration of blood flow using clot-dissolving drugs has produced impressive benefits in some patients. However, for these drugs to be effective, they must be given soon after stroke onset and relatively only a few stroke patients reach hospital within this time. Side effects of these compounds further ...
Source: Cerebrovascular Diseases - November 12, 2014 Category: Neurology Source Type: research