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Condition: Stroke
Procedure: Gastroschisis Repair

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Total 4990 results found since Jan 2013.

Strategies to improve recovery in acute ischemic stroke patients: Iberoamerican Stroke Group Consensus
Stroke is not only a leading cause of death worldwide but also a main cause of disability. In developing countries, its burden is increasing as a consequence of a higher life expectancy. Whereas stroke mortality has decreased in developed countries, in Latin America, stroke mortality rates continue to rise as well as its socioeconomic dramatic consequences. Therefore, it is necessary to implement stroke care and surveillance programs to better describe the epidemiology of stroke in these countries in order to improve therapeutic strategies. Advances in the understanding of the pathogenic processes of brain ischemia have re...
Source: International Journal of Stroke - June 29, 2013 Category: Neurology Authors: M Alonso de Leciñana, M Gutiérrez‐Fernández, M Romano, C Cantú‐Brito, A Arauz, LE Olmos, SF Ameriso, E Díez‐Tejedor, Tags: Review Source Type: research

VGF, Which Is Induced Transcriptionally in Stroke Brain, Enhances Neurite Extension and Confers Protection Against Ischemia In Vitro
Abstract Ischemic stroke is a devastating neural event as currently no therapies other than physical rehabilitation are available to enhance recovery after stroke. To identify endogenous mediators to repair stroke brain, we performed the expression profiling analysis of transcripts in the mouse photothrombotic stroke brain. Based on real-time PCR analysis, we found VGF, identified as a nerve growth factor (NGF)-regulated transcript, was induced transcriptionally in stroke brain at 1–7 days after insult. The immunoreactivites of VGF were observed in the neurons around the ischemic core of stroke brain. Experimen...
Source: Translational Stroke Research - April 29, 2015 Category: Neurology Source Type: research

Coherent neural oscillations predict future motor and language improvement after stroke
This study investigated whether the coherence of neural oscillations at language or motor nodes is associated with future clinical improvement. Twenty-four stroke patients underwent high-density EEG recordings and standardized motor and language tests at 2–3 weeks (T0) and 3 months (T1) after stroke onset. In addition, EEG and motor assessments were obtained from a second population of 18 stroke patients. The graph theoretical measure of weighted node degree at language and motor areas was computed as the sum of absolute imaginary coherence with all other brain regions and compared to the amount of clinical improveme...
Source: Brain - September 25, 2015 Category: Neurology Authors: Nicolo, P., Rizk, S., Magnin, C., Pietro, M. D., Schnider, A., Guggisberg, A. G. Tags: CNS Injury and Stroke Original Articles Source Type: research

Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke Basic Sciences
Conclusions— Our data suggest that DM exacerbates neurovascular damage and hinders brain repair processes, which likely contribute to the impairment of stroke recovery.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Zhang, L., Chopp, M., Zhang, Y., Xiong, Y., Li, C., Sadry, N., Rhaleb, I., Lu, M., Zhang, Z. G. Tags: Basic Science Research, Cognitive Impairment, Neurogenesis Basic Sciences Source Type: research

Endogenous Neural Stem Cell –induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
AbstractIschemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments include transplantation of exogenous stem cells but also stimulating endogenous neural ...
Source: Translational Stroke Research - September 3, 2022 Category: Neurology Source Type: research

Groin complications in endovascular mechanical thrombectomy for acute ischemic stroke: a 10-year single center experience
Conclusions These findings suggest that concerns for groin complications should not preclude the use of BGCs and large-bore sheaths in mechanical thrombectomy for acute ischemic stroke.
Source: Journal of NeuroInterventional Surgery - May 12, 2016 Category: Neurosurgery Authors: Shah, V. A., Martin, C. O., Hawkins, A. M., Holloway, W. E., Junna, S., Akhtar, N. Tags: Open access, Ischemic stroke Source Type: research

Poststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis Basic Sciences
Conclusions—These data confirm an important role for the hedgehog pathway in poststroke brain repair and functional recovery, suggesting a prolonged treatment window for potential treatment strategy to modulate sonic hedgehog pathway after stroke.
Source: Stroke - May 22, 2017 Category: Neurology Authors: Yongming Jin, Austin Barnett, Yifan Zhang, Xin Yu, Yu Luo Tags: Cerebrovascular Disease/Stroke, Cognitive Impairment, Ischemic Stroke, Neurogenesis Original Contributions Source Type: research

Role of Exosomes as a Treatment and Potential Biomarker for Stroke
AbstractApproximately, 16 million strokes occur worldwide each year, causing 6 million deaths and considerable disability, implying an enormous social, individual health, and economic burden. Due to this high incidence, strategies to promote stroke recovery are urgently needed. Research into new therapeutic approaches for stroke has determined that intravenous administration of mesenchymal stem cells (MSCs) is a good strategy to improve recovery by amplifying mechanisms implicated in brain plasticity. Recent studies have demonstrated the efficacy of MSCs in stroke, with no need for them to reach the area of brain injury. A...
Source: Translational Stroke Research - August 13, 2018 Category: Neurology Source Type: research

Neurogenesis After Stroke: A Therapeutic Perspective
AbstractStroke is a major cause of death and disability worldwide. Yet therapeutic strategies available to treat stroke are very limited. There is an urgent need to develop novel therapeutics that can effectively facilitate functional recovery. The injury that results from stroke is known to induce neurogenesis in penumbra of the infarct region. There is considerable interest in harnessing this response for therapeutic purposes. This review summarizes what is currently known about stroke-induced neurogenesis and the factors that have been identified to regulate it. Additionally, some key studies in this field have been hig...
Source: Translational Stroke Research - August 28, 2020 Category: Neurology Source Type: research

Zebrafish as a Model for In-Depth Mechanistic Study for Stroke
AbstractStroke is one of the world ’s leading causes of death and disability, posing enormous burden to the society. However, the pathogenesis and mechanisms that underlie brain injury and brain repair remain largely unknown. There’s an unmet need of in-depth mechanistic research in this field. Zebrafish (Danio rerio) is a powerful tool in brain science research mainly due to its small size and transparent body, high genome synteny with human, and similar nervous system structures. It can be used to establish both hemorrhagic and ischemic stroke models easily and effectively through different ways. After the establishm...
Source: Translational Stroke Research - May 29, 2021 Category: Neurology Source Type: research

2013 Thomas Willis Award Lecture: Causation and Collaboration for Stroke Research Special Report
The pathophysiology of stroke is complex. Adaptive and maladaptive signalling occurs between multiple cell types in the brain. There is crosstalk between central and systemic responses. And there are overlapping pathways during initial injury and subsequent repair. These numerous feed-forward and feed-back interactions have made it difficult to translate experimental discoveries into clinical applications. An emerging hypothesis in biomedical research now suggests that contrary to a traditional model, translation may not be efficiently obtained without a rigorous understanding of mechanisms. Hence, to optimize diagnostics ...
Source: Stroke - December 23, 2013 Category: Neurology Authors: Lo, E. H. Tags: Other Research Special Report Source Type: research

Stroke Induces Nuclear Shuttling of Histone Deacetylase 4 Basic Sciences
Conclusions— Our data show that stroke induces nuclear shuttling of HDAC4 in neurons in the peri-infarct cortex, and that increased nuclear HDAC4 is strongly associated with neuronal remodeling but not with neuronal cell death, suggesting a role for nuclear HDAC4 in promoting neuronal recovery after ischemic injury.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Kassis, H., Shehadah, A., Chopp, M., Roberts, C., Zhang, Z. G. Tags: Animal models of human disease Basic Sciences Source Type: research

A double‐tuned 1H/23Na resonator allows 1H‐guided 23Na‐MRI in ischemic stroke patients in one session
ConclusionsThe use of a double‐tuned 1H/23Na birdcage head coil in a clinical setting ‘allowed sodium intensity measurements’ in a justifiable time also for acute stroke patients, and heterogenous sodium signal intensity in the diffusion weighted imaging lesion might represent differences in tissue damage or repair.
Source: International Journal of Stroke - June 30, 2015 Category: Neurology Authors: Eva Neumaier‐Probst, Simon Konstandin, Judith Ssozi, Christoph Groden, Michael Hennerici, Lothar R. Schad, Marc Fatar Tags: Research Source Type: research

Translating G-CSF as an Adjunct Therapy to Stem Cell Transplantation for Stroke
Abstract Among recently investigated stroke therapies, stem cell treatment holds great promise by virtue of their putative ability to replace lost cells, promote endogenous neurogenesis, and produce behavioral and functional improvement through their “bystander effects.” Translating stem cell in the clinic, however, presents a number of technical difficulties. A strategy suggested to enhance therapeutic utility of stem cells is combination therapy, i.e., co-transplantation of stem cells or adjunct treatment with pharmacological agents and substrates, which is assumed to produce more profound therapeutic benefi...
Source: Translational Stroke Research - October 20, 2015 Category: Neurology Source Type: research

Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target
Ischaemic stroke is the leading cause of severe long-term disability yet lacks drug therapies that promote the repair phase of recovery. This repair phase of stroke occurs days to months after stroke onset and involves brain remapping and plasticity within the peri-infarct zone. Elucidating mechanisms that promote this plasticity is critical for the development of new therapeutics with a broad treatment window. Inhibiting tonic (extrasynaptic) GABA signalling during the repair phase was reported to enhance functional recovery in mice suggesting that GABA plays an important function in modulating brain repair. While tonic G...
Source: Brain - January 29, 2016 Category: Neurology Authors: Hiu, T., Farzampour, Z., Paz, J. T., Wang, E. H. J., Badgely, C., Olson, A., Micheva, K. D., Wang, G., Lemmens, R., Tran, K. V., Nishiyama, Y., Liang, X., Hamilton, S. A., ORourke, N., Smith, S. J., Huguenard, J. R., Bliss, T. M., Steinberg, G. K. Tags: CNS Injury and Stroke Original Articles Source Type: research