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Condition: Stroke
Procedure: Gastroschisis Repair

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Total 4990 results found since Jan 2013.

Gut microbiome plays a vital role in post-stroke injury repair by mediating neuroinflammation
In this study, we reviewed the role of the gut microbiome in cerebral stroke and the underlying mechanism of the AMPK signaling pathway in stroke. AMPK mediators in nerve repair and the regulation of intestinal microbial balance were also summarized.PMID:37031605 | DOI:10.1016/j.intimp.2023.110126
Source: International Immunopharmacology - April 9, 2023 Category: Allergy & Immunology Authors: Airu Huang Ling Ji Yamei Li Yufeng Li Qian Yu Source Type: research

A novel small-molecular CCR5 antagonist promotes neural repair after stroke
In this study we characterized the therapeutic potential of a novel CCR5 antagonist A14 in treating ischemic stroke mice. A14 was discovered in screening millions compounds in the Chemdiv library based on the molecular docking diagram of CCR5 and maraviroc. We found that A14 dose-dependently inhibited the CCR5 activity with an IC50 value of 4.29 μM. Pharmacodynamic studies showed that A14 treatment exerted protective effects against neuronal ischemic injury both in vitro and vivo. In a SH-SY5Y cell line overexpressing CCR5, A14 (0.1, 1 μM) significantly alleviated OGD/R-induced cell injury. We found that the expression o...
Source: Acta Pharmacologica Sinica - May 17, 2023 Category: Drugs & Pharmacology Authors: Qing-Lin Wu Li-Yuan Cui Wen-Yu Ma Sha-Sha Wang Zhao Zhang Zhong-Ping Feng Hong-Shuo Sun Shi-Feng Chu Wen-Bin He Nai-Hong Chen Source Type: research

Regulators of phagocytosis as pharmacologic targets for stroke treatment
Stroke, including ischemic and hemorrhagic stroke, causes massive cell death in the brain, which is followed by secondary inflammatory injury initiated by disease-associated molecular patterns released from dead cells. Phagocytosis, a cellular process of engulfment and digestion of dead cells, promotes the resolution of inflammation and repair following stroke. However, professional or non-professional phagocytes also phagocytose stressed but viable cells in the brain or excessively phagocytose myelin sheaths or prune synapses, consequently exacerbating brain injury and impairing repair following stroke. Phagocytosis inclu...
Source: Frontiers in Pharmacology - August 2, 2023 Category: Drugs & Pharmacology Source Type: research

Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1.
Abstract 3K3A-APC is a recombinant analog of activated protein C (APC) which is an endogenous protease with multiple functions in the body. Compared to APC, 3K3A-APC has reduced anticoagulant activity but preserved cell signaling activities. In the brain, 3K3A-APC exerts neuroprotective effects after an acute or chronic injury. 3K3A-APC is currently under clinical assessment as a neuroprotective agent following acute ischemic stroke. Whether 3K3A-APC can influence post-ischemic neurogenesis and improve neurological outcome by promoting brain repair remains unknown. Here we show that murine 3K3A-APC 0.8mg/kg intrap...
Source: Brain Research - February 21, 2013 Category: Neurology Authors: Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV Tags: Brain Res Source Type: research

Test-Retest Reliability of Portable Metabolic Monitoring After Disabling Stroke
Conclusions. Our results strongly support the reliability of the K4b2 for quantifying overground gait efficiency after stroke. Use of this device may enable researchers to study how varying poststroke rehabilitation interventions affect this central measure of health and function.
Source: Neurorehabilitation and Neural Repair - October 7, 2013 Category: Neurology Authors: Stookey, A. D., McCusker, M. G., Sorkin, J. D., Katzel, L. I., Shaughnessy, M., Macko, R. F., Ivey, F. M. Tags: Clinical Research Articles Source Type: research

Innate Inflammatory Responses in Stroke: Mechanisms and Potential Therapeutic Targets.
Abstract Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by ischemia due to occlusion of a cerebral artery. Inflammation is known to result as a result of ischemic injury, long thought to be involved in initiating the recovery and repair process. However, work over the past few decades indicates that aspects of this inflammatory response may in fact be detrimental to stroke outcome. Acutely, inflammation appears to have a detrimental effect, and anti-inflammatory treatments have been been ...
Source: Current Medicinal Chemistry - December 28, 2013 Category: Chemistry Authors: Kim JY, Kawabori M, Yenari MA Tags: Curr Med Chem Source Type: research

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke.
In conclusion, post-stroke chronic metformin treatment improved functional recovery following MCAO via AMPK-dependent M2 polarization. Modulation of microglia/macrophage polarization represents a novel therapeutic strategy for stroke. PMID: 24632338 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - March 12, 2014 Category: Neurology Authors: Jin Q, Cheng J, Liu Y, Wu J, Wang X, Wei S, Zhou X, Qin Z, Jia J, Zhen X Tags: Brain Behav Immun Source Type: research

Measuring Health-Related Quality Of Life (HRQOL) During Inpatient Stroke Rehabilitation (S21.002)
CONCLUSIONS: EQ-5 ratings converged between stroke survivors and clinicians, suggesting it is valid and reliable to measure moderate stroke survivor HRQOL in inpatient rehabilitation. EQ-5 and FIM improvement were poorly associated; HRQOL may independently complement functional outcome assessment in inpatient rehabilitation. Future studies could explore different areas of function to clarify the factor structure of improvement on these measures relative to HRQL.Study Supported by: NIH, Kessler FoundationDisclosure: Dr. Frisina has received personal compensation for activities with Kessler Institute for Rehabilitation as an...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Frisina, P., Kutlik, A., Hreha, K., Barrett, A. Tags: Neuro-rehabilitation and Neural Repair Source Type: research

Reducing Abnormal Muscle Coactivation After Stroke Using a Myoelectric-Computer Interface: A Pilot Study
Conclusions. These results suggest that the MCI was an effective tool in directly retraining muscle activation patterns following stroke.
Source: Neurorehabilitation and Neural Repair - May 22, 2014 Category: Neurology Authors: Wright, Z. A., Rymer, W. Z., Slutzky, M. W. Tags: Clinical Research Articles Source Type: research

Is the Recovery of Functional Balance and Mobility Accompanied by Physiological Recovery in People With Severe Impairments After Stroke?
Conclusions. During stroke rehabilitation, all participants improved functionally. Some patients improved physiologically, though near discharge, all participants remained very impaired. Future studies with larger sample sizes are needed to explore the capacity for physiological recovery in this population.
Source: Neurorehabilitation and Neural Repair - October 16, 2014 Category: Neurology Authors: Peters, S., Ivanova, T. D., Teasell, R., Garland, S. J. Tags: Clinical Research Articles Source Type: research

O-035 The Dotter Technique Revisited: Early Experience using this Technique for Treating Tandem Lesions in Acute Stroke
Conclusion The Dotter Stroke technique is a safe alternative to carotid stenting, and may be useful in patients at increased risk for haemorrhage. In this small series, a post-Dotter stenosis >75% is associated with re-occlusion, and stenting should be performed to prevent re-occlusion. No re-occlusion was identified at 30 days with post-Dotter stenosis <= 65%. Disclosures B. Woodward: None. E. Nyberg: None. S. Wegryn: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2014 Category: Neurosurgery Authors: Woodward, B., Nyberg, E., Wegryn, S. Tags: Oral abstracts Source Type: research

The Effect of Arm Support Combined With Rehabilitation Games on Upper-Extremity Function in Subacute Stroke: A Randomized Controlled Trial
Conclusions. AS training with computerized exercises is as effective as conventional therapy dedicated to the arm to improve arm function and activity in subacute stroke rehabilitation, when applied at the same dose.
Source: Neurorehabilitation and Neural Repair - December 24, 2014 Category: Neurology Authors: Prange, G. B., Kottink, A. I. R., Buurke, J. H., Eckhardt, M. M. E. M., van Keulen-Rouweler, B. J., Ribbers, G. M., Rietman, J. S. Tags: Clinical Research Articles Source Type: research