Long-term T cell responses in the brain after an ischemic stroke.
Long-term T cell responses in the brain after an ischemic stroke.
Discov Med. 2017 Dec;24(134):323-333
Authors: Selvaraj UM, Stowe AM
Abstract
Stroke, which occurs during a loss of blood flow to the brain, is a global disease that accounts for 10% of yearly mortality. But stroke is also a leading cause of long-term adult disability, with recovery continuing for months to years after initial stroke onset. This long-term functional recovery from stroke encompasses changes in neuronal structure and function, and occurs throughout the post-stroke brain. Much less understood is whether the adaptive immune cells that infiltrated the brain during acute post-stroke neuroinflammation remain long-term, and if their presence supports or hinders functional recovery. Studies show that T cell subsets and their derived cytokines exhibit diverse protective and detrimental effects in the immediate acute phase following stroke. Interestingly, T cells are also important in regulating physiological behavior, which hints at a potential role in functional recovery after stroke. Moreover, T cell egress into the post-stroke brain might actually peak weeks after stroke onset, suggesting a long-term role for the adaptive immune system in the injured CNS. However, the significance of T cells in the long-term functional and behavioral recovery and repair phase of stroke remains largely unexplored. We summarize here recent work in delineating the beneficial and ...
Source: Discovery Medicine - Category: Research Tags: Discov Med Source Type: research
More News: Brain | Disability | Gastroschisis Repair | Ischemic Stroke | Neurology | Research | Stroke | Study