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Relationship Between Cerebral Blood Flow and Blood Pressure in Long-Term Heart Transplant Recipients Cerebral Blood Flow
Heart transplant recipients are at an increased risk for cerebral hemorrhage and ischemic stroke; yet, the exact mechanism for this derangement remains unclear. We hypothesized that alterations in cerebrovascular regulation is principally involved. To test this hypothesis, we studied cerebral pressure-flow dynamics in 8 clinically stable male heart transplant recipients (62±8 years of age and 9±7 years post transplant, mean±SD), 9 male age-matched controls (63±8 years), and 10 male donor controls (27±5 years). To increase blood pressure variability and improve assessment of the pressure-f...
Source: Hypertension - November 12, 2014 Category: Cardiology Authors: Smirl, J. D., Haykowsky, M. J., Nelson, M. D., Tzeng, Y.-C., Marsden, K. R., Jones, H., Ainslie, P. N. Tags: Doppler ultrasound, Transcranial Doppler etc. Cerebral Blood Flow Source Type: research

Hypertension care in Aseer region, Saudi Arabia: Barriers and solutions.
This study revealed that HTN patients received insufficient care, which could be attributed to many different barriers. In order to improve the quality of HTN care for HTN, these barriers should be overcome by implementation of the recommendations. PMID: 25394461 [PubMed - in process]
Source: Saudi Journal of Kidney Diseases and Transplantation - November 1, 2014 Category: Urology & Nephrology Authors: Al-Saleem SA, Al-Shahrani A, Al-Khaldi YM Tags: Saudi J Kidney Dis Transpl Source Type: research

Quantitative computed tomography of pulmonary emphysema and ventricular function in chronic obstructive pulmonary disease patients with pulmonary hypertension.
CONCLUSION: The study revealed that percent emphysema is correlated with RV dysfunction among COPD patients with PH. Based on our findings, percent emphysema can be considered for use as an indicator to predict the severity of right ventricular dysfunction among COPD patients. PMID: 25469102 [PubMed - in process]
Source: Korean Journal of Radiology - December 6, 2014 Category: Radiology Tags: Korean J Radiol Source Type: research

RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension
Conclusions The adequacy of RV functional adaptation to afterload predicts survival in patients referred for PH. Whether this can simply be evaluated using RV volumetric imaging will require additional confirmation.
Source: Heart - December 12, 2014 Category: Cardiology Authors: Vanderpool, R. R., Pinsky, M. R., Naeije, R., Deible, C., Kosaraju, V., Bunner, C., Mathier, M. A., Lacomis, J., Champion, H. C., Simon, M. A. Tags: Hypertension Pulmonary vascular disease Source Type: research

Hemodynamic effects of different vasodilators in patients with type II pulmonary hypertension (PH)
Conclusions. Inhaled Iloprost causes favorable changes in preload and afterload of the impaired LV and increases its performance in patients with PH associated with LV systolic dysfunction.
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bautin, A., Tashkhanov, D., Datsenko, S., Fedotov, P., Iakovlev, A., Moiseeva, O., Sitnikova, M. Tags: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Epigenetic regulation of smooth muscle cell plasticity
This article is part of a Special Issue entitled: Stress as a fundamental theme in cell plasticity.
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 19, 2015 Category: Genetics & Stem Cells Source Type: research

Has Brazil found the way to better health care?
Under Brazil’s family health program, when a woman learns that she is pregnant, she contacts her local community health agent, who often is a neighbor. Typically, the agent visits her home to arrange an appointment with the neighborhood’s family health team, and the woman visits the health center for an assessment by a nurse assistant and a physician. During the pregnancy, if she misses a prenatal care appointment, the agent checks in on her at home and helps her reschedule her visit. Any prenatal medications she needs are provided free of charge. Brazil — home to the world’s fifth-largest population and seventh-l...
Source: UCLA Newsroom: Health Sciences - June 5, 2015 Category: Universities & Medical Training Source Type: news

Pre-existing diabetes and risks of morbidity and mortality after liver transplantation: A nationwide database study in an Asian population.
CONCLUSION: DM is associated with elevated risk of 90-day post-LTx. Moreover, DM patients with coexisting renal manifestations exhibited an increased postoperative risk of mortality after LTx. PMID: 26048000 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - June 2, 2015 Category: Internal Medicine Authors: Tsai MS, Wang YC, Wang HH, Lee PH, Jeng LB, Kao CH Tags: Eur J Intern Med Source Type: research

Hemodynamic monitoring during liver transplantation: A state of the art review.
Authors: Rudnick MR, Marchi LD, Plotkin JS Abstract Orthotopic liver transplantation can be marked by significant hemodynamic instability requiring the use of a variety of hemodynamic monitors to aide in intraoperative management. Invasive blood pressure monitoring is essential, but the accuracy of peripheral readings in comparison to central measurements has been questioned. When discrepancies exist, central mean arterial pressure, usually measured at the femoral artery, is considered more indicative of adequate perfusion than those measured peripherally. The traditional pulmonary artery catheter is less frequentl...
Source: World Journal of Hepatology - June 10, 2015 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Frequency of Cardiovascular Events and Effect on Survival in Liver Transplant Recipients for Cirrhosis Due to Alcoholic or Nonalcoholic Steatohepatitis.
CONCLUSIONS: Cardiovascular events occurred with similar frequency in transplant recipients for nonalcoholic steatohepatitis or alcoholic cirrhosis. Patient survival was affected in both groups, but male patients with concomitant hepatitis C virus infection remained at higher risk for a cardiovascular event after liver transplant. Development of a cardiac evaluation protocol for liver transplant recipients could help monitor these patients. PMID: 26581602 [PubMed - as supplied by publisher]
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 17, 2015 Category: Transplant Surgery Authors: Piazza NA, Singal AK Tags: Exp Clin Transplant Source Type: research

Novel 24-h ovine model of brain death to study the profile of the endothelin axis during cardiopulmonary injury
Conclusions: This novel, clinically relevant, ovine model of brain death demonstrated that increased pulmonary artery pressures are observed after brain death. This may contribute to right ventricular dysfunction and pulmonary injury. The development of this model will allow for further investigation of therapeutic strategies to minimise the deleterious effects of brain death on potentially transplantable organs.
Source: Intensive Care Medicine Experimental - November 24, 2015 Category: Surgery Authors: Ryan WattsIzabela BilskaSara DiabKimble DunsterAndrew BulmerAdrian BarnettJohn Fraser Source Type: research

The Safety of Erythropoiesis-Stimulating Agents for the Treatment of Anemia Resulting from Chronic Kidney Disease
Abstract Chronic kidney disease (CKD) anemia treatment was revolutionized in the late 1980s with the introduction of recombinant human erythropoietin. This and related erythropoiesis-stimulating agents (ESAs) greatly benefited patients by decreasing debilitating symptoms, improving their quality of life, and freeing them from dependence on blood transfusions with their associated complications such as infections, sensitization impeding transplantation, and secondary iron overload. However, even in the initial studies, untoward effects were noted in patients receiving ESAs, including worsening hypertension, seizure...
Source: Clinical Drug Investigation - February 19, 2016 Category: Drugs & Pharmacology Source Type: research

Metabolic Syndrome After Hematopoietic Cell Transplantation: At the Intersection of Treatment Toxicity and Immune Dysfunction
Hematopoietic cell transplantation (HCT) survivors face a multitude of short- and long-term health complications in the years following treatment. One important health complication that is associated with significant morbidity is metabolic syndrome (MetSyn). This constellation of findings, including obesity, glucose and lipid dysmetabolism, and hypertension, place affected individuals at increased risk for type 2 diabetes mellitus, cardiovascular complications and stroke. Previous studies have linked MetSyn in HCT survivors to prior treatment; however, few have addressed the potential roles of systemic inflammation and imm...
Source: Biology of Blood and Marrow Transplantation - March 21, 2016 Category: Hematology Authors: Lucie M. Turcotte, Ashley Yingst, Michael R. Verneris Source Type: research

The Canadian experience using the expanded criteria donor classification for allocating deceased donor kidneys for transplantation
Conclusions The ECD classification identifies kidneys at increased risk for graft loss in Canadian patients. The performance of more granular measures of donor risk (e.g., Kidney Donor Risk Index) and its impact on organ allocation/utilization in Canadian patients requires further study.
Source: Canadian Journal of Kidney Health and Disease - March 23, 2016 Category: Urology & Nephrology Source Type: research

Hypertensive emergency in kidney transplant recipient with autosomal dominant polycystic kidney disease
We report a case of kidney transplant recipient with autosomal dominant polycystic kidney disease (ADPKD) presenting with diplopia and hypertensive emergency complicated by cerebral aneurysmal rupture.
Source: Journal of the American Society of Hypertension - March 31, 2016 Category: Cardiology Authors: Ekamol Tantisattamo, Attasit Chokechanachaisakul, Siwadon Pitukweerakul, Praveen Ratanasrimetha, Pritika Shrivastava, Dilip Samarapungavan, Shaun P. Healy Tags: Stroke Source Type: research

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