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Total 3361 results found since Jan 2013.

Autologous bone marrow mononuclear cells intrathecal transplantation in chronic stroke.
This study demonstrates the potential of autologous BMMNCs intrathecal transplantation in improving the prognosis of functional recovery in chronic stage of stroke. Further clinical trials are recommended. This trial is registered with NCT02065778. PMID: 25126443 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Intravenous Bone Marrow Stem Cell Grafts Preferentially Migrate to Spleen and Abrogate Chronic Inflammation in Stroke Basic Sciences
Conclusions— hBMSC transplantation is therapeutic in chronic stroke possibly by abrogating the inflammation-plagued secondary cell death.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Acosta, S. A., Tajiri, N., Hoover, J., Kaneko, Y., Borlongan, C. V. Tags: Animal models of human disease, Pathology of Stroke, Other Stroke Treatment - Surgical Basic Sciences Source Type: research

Synergistic Effects of Transplanted Endothelial Progenitor Cells and RWJ 67657 in Diabetic Ischemic Stroke Models Basic Sciences
Conclusions— The combination of EPC transplantation and RWJ administration accelerated recovery from diabetic stroke, which might have been caused by increased levels of proangiogenic and neurotrophic factors.
Source: Stroke - June 22, 2015 Category: Neurology Authors: Bai, Y.-Y., Wang, L., Chang, D., Zhao, Z., Lu, C.-Q., Wang, G., Ju, S. Tags: Type 2 diabetes, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Bone Marrow Cell Transplantation Time-Dependently Abolishes Efficacy of Granulocyte Colony-Stimulating Factor After Stroke in Hypertensive Rats Basic Sciences
Conclusions— G-CSF improved functional recovery in spontaneously hypertensive rats, but this effect was abolished by cotransplantation of BM MNC after 48 hours. In the spleen, transplanted cells may hinder the clearance of granulocytes that were massively increased by G-CSF. Increased circulation and infiltration of granulocytes into the ischemic brain may be detrimental for stroke outcome.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Posel, C., Scheibe, J., Kranz, A., Bothe, V., Quente, E., Frohlich, W., Lange, F., Schabitz, W.-R., Minnerup, J., Boltze, J., Wagner, D.-C. Tags: Animal models of human disease, Acute Cerebral Infarction, Pathology of Stroke Basic Sciences Source Type: research

Delayed Pituitary Adenylate Cyclase-Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization Basic Sciences
Conclusions— Our results demonstrated that immunomodulatory strategies capable of redirecting the microglial response toward a neuroprotective M2 phenotype in the late phase of brain ischemia could represent attractive options for stroke treatment in a new and unexploited therapeutical window.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Brifault, C., Gras, M., Liot, D., May, V., Vaudry, D., Wurtz, O. Tags: Embolic stroke Basic Sciences Source Type: research

Human Muse Cells Reconstruct Neuronal Circuitry in Subacute Lacunar Stroke Model Basic Sciences
Conclusions—Transplantation at the delayed subacute phase showed muse cells differentiated into neural cells, facilitated neural reconstruction, improved functions, and displayed solid safety outcomes over prolonged graft maturation period, indicating their therapeutic potential for lacunar stroke.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Hiroki Uchida, Kuniyasu Niizuma, Yoshihiro Kushida, Shohei Wakao, Teiji Tominaga, Cesario V. Borlongan, Mari Dezawa Tags: Cell Therapy, Stem Cells, Translational Studies, Ischemic Stroke Original Contributions Source Type: research

Cerebrovascular Accidents During Mechanical Circulatory Support Clinical Sciences
Conclusions—Stroke is a major cause of morbidity and mortality in patients on LVAD support. Chronic obstructive pulmonary disease increases the risk of ischemic stroke, whereas dialysis may increase the risk of hemorrhagic stroke. Although any stroke increases mortality, post-LVAD hemorrhagic stroke was associated with higher mortality compared with ischemic stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Saef Izzy, Daniel B. Rubin, Firas S. Ahmed, Feras Akbik, Simone Renault, Katelyn W. Sylvester, Henrikas Vaitkevicius, Jennifer A. Smallwood, Michael M. Givertz, Steven K. Feske Tags: Heart Failure, Complications, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Intra‐arterial bone marrow mononuclear cells (BM‐MNCs) transplantation in acute ischemic stroke (IBIS trial): protocol of a phase II, randomized, dose‐finding, controlled multicenter trial
DiscussionThis is the first trial to explore efficacy of different doses of intra‐arterial bone marrow mononuclear cell in moderate‐to‐severe acute ischemic stroke patients. The trial is registered as NCT02178657.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Francisco Moniche, Irene Escudero, Elena Zapata‐Arriaza, María Usero‐Ruiz, María Prieto‐León, Javier Torre, Miguel‐Angel Gamero, Jose Antonio Tamayo, Juan‐José Ochoa‐Sepúlveda, José Maestre, Magdalena Carmona, Pilar Piñero, Cristina Cal Tags: Protocol Source Type: research

Vasculogenesis in Experimental Stroke After Human Cerebral Endothelial Cell Transplantation Basic Sciences
Conclusions— We found attenuation of behavioral and histological deficits coupled with robust vasculogenesis and neurogenesis in endothelial cell–transplanted stroke animals, suggesting that targeting vascular repair sets in motion a regenerative process in experimental stroke possibly via the VEGF pathway.
Source: Stroke - November 25, 2013 Category: Neurology Authors: Ishikawa, H., Tajiri, N., Shinozuka, K., Vasconcellos, J., Kaneko, Y., Lee, H. J., Mimura, O., Dezawa, M., Kim, S. U., Borlongan, C. V. Tags: Animal models of human disease Basic Sciences Source Type: research

Stroke versus non-stroke neurological complications after cardiac transplant (P4.299)
Conclusions:Neurological complications after CT in our population reach nearly a quarter of patients, similar to or even lower than in previous studies.4.3% of patients developed stroke, ischemic subtype.Pre- and perioperative variables do not differ between both groups, except from ischemic cardiomyopathy as the cause of heart failure being it more frequent in the stroke group.Disclosure: Dr. Vazquez has nothing to disclose. Dr. Thomson has nothing to disclose. Dr. Molina Melendres has nothing to disclose. Dr. Nadile has nothing to disclose. Dr. Gonzalez Toledo has nothing to disclose. Dr. Claverie has nothing to disclose...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Vazquez, G., Thomson, A., Melendres, J. M., Nadile, D., Toledo, M. E. G., Claverie, C. S., Thomson, A., Peradejordi, M., Couto, B., Favaloro, L. E., Favaloro, R., Bertolotti, A., Klein, F. Tags: In-Hospital Stroke Care Source Type: research

Neural Stem Cells Therapy for Ischemic Stroke: Progress and Challenges
AbstractIschemic stroke, with its high morbidity and mortality, is the most common cerebrovascular accident and results in severe neurological deficits. Despite advances in medical and surgical intervention, post-stroke therapies remain scarce, which seriously affects the quality of life of patients. Over the past decades, stem cell transplantation has been recognized as very promising therapy for neurological diseases. Neural stem cell (NSC) transplantation is the optimal choice for ischemic stroke as NSCs inherently reside in the brain and can potentially differentiate into a variety of cell types within the central nerv...
Source: Translational Stroke Research - January 15, 2022 Category: Neurology Source Type: research

Endogenous Neural Stem Cell –induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
AbstractIschemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments include transplantation of exogenous stem cells but also stimulating endogenous neural ...
Source: Translational Stroke Research - September 3, 2022 Category: Neurology Source Type: research

Survival and Differentiation of Transplanted Neural Stem Cells Derived from Human Induced Pluripotent Stem Cells in A Rat Stroke Model
Conclusions: To our knowledge, this is the first report of transplantation of NSCs derived from human iPSCs in a stroke model. Human iPSC-derived NSCs survived in the postischemic rat brain and appeared to differentiate, primarily into neurons. This cell transplantation approach for stroke appears to be feasible, but further optimization is needed.
Source: Journal of Stroke and Cerebrovascular Diseases - November 14, 2011 Category: Neurology Authors: Matthew B. Jensen, Hongmei Yan, Rajeev Krishnaney-Davison, Abdullah Al Sawaf, Su-Chun Zhang Tags: Original Articles Source Type: research

Mitochondrial Transfer as a Therapeutic Strategy Against Ischemic Stroke
AbstractStroke is a debilitating disease that remains the second leading cause of death and disability worldwide. Despite accumulating knowledge of the disease pathology, treatments for stroke are limited, and clinical translation of the neuroprotective agents has not been a complete success. Accumulating evidence links mitochondrial dysfunction to brain impairments after stroke. Recent studies have implicated the important roles of healthy mitochondria in neuroprotection and neural recovery following ischemic stroke. New and convincing studies have shown that mitochondrial transfer to the damaged cells can help revive cel...
Source: Translational Stroke Research - June 25, 2020 Category: Neurology Source Type: research

Translating G-CSF as an Adjunct Therapy to Stem Cell Transplantation for Stroke
Abstract Among recently investigated stroke therapies, stem cell treatment holds great promise by virtue of their putative ability to replace lost cells, promote endogenous neurogenesis, and produce behavioral and functional improvement through their “bystander effects.” Translating stem cell in the clinic, however, presents a number of technical difficulties. A strategy suggested to enhance therapeutic utility of stem cells is combination therapy, i.e., co-transplantation of stem cells or adjunct treatment with pharmacological agents and substrates, which is assumed to produce more profound therapeutic benefi...
Source: Translational Stroke Research - October 20, 2015 Category: Neurology Source Type: research