Early mortality on continuous renal replacement therapy (CRRT): the prairie CRRT study
ConclusionPatients admitted to the ICU with AKI requiring CRRT have a high risk of early mortality. In these patients, vasopressor use and hypoxia were independently associated with adverse short-term survival. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - July 22, 2016 Category: Urology & Nephrology Source Type: research

Early mortality on continuous renal replacement therapy (CRRT): the prairie CRRT study
Conclusion Patients admitted to the ICU with AKI requiring CRRT have a high risk of early mortality. In these patients, vasopressor use and hypoxia were independently associated with adverse short-term survival. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - July 21, 2016 Category: Urology & Nephrology Source Type: research

The association between individual counselling and health behaviour change: the See Kidney Disease (SeeKD) targeted screening programme for chronic kidney disease
The objectives of this study are to determine the effectiveness of individual counselling sessions for eliciting behaviour change and to describe participant characteristics associated with behaviour change.DesignThis is a cross-sectional, descriptive study.SettingThe study setting is the National SeeKD targeted screening programme.PatientsThe participants are all ‘at risk’ patients who were screened for CKD and returned a follow-up health behaviour survey (n = 1129).MeasurementsHealth behaviour change was defined as a self-reported change in lifestyle, including dietary changes or medication adhe...
Source: Canadian Journal of Kidney Health and Disease - July 20, 2016 Category: Urology & Nephrology Source Type: research

The association between individual counselling and health behaviour change: the See Kidney Disease (SeeKD) targeted screening programme for chronic kidney disease
The objectives of this study are to determine the effectiveness of individual counselling sessions for eliciting behaviour change and to describe participant characteristics associated with behaviour change. Design This is a cross-sectional, descriptive study. Setting The study setting is the National SeeKD targeted screening programme. Patients The participants are all ‘at risk’ patients who were screened for CKD and returned a follow-up health behaviour survey (n = ...
Source: Canadian Journal of Kidney Health and Disease - July 19, 2016 Category: Urology & Nephrology Source Type: research

Recognizing IgG4-related tubulointerstitial nephritis
AbstractPurpose of the reviewImmunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder affecting nearly all organs, including the kidney. Tubulointerstitial nephritis (IgG4-TIN) is the most common form of IgG4-related kidney disease (IgG4-RKD) and is the focus of this concise review.ObjectiveThe study aims to describe when IgG4-TIN should be suspected and to summarize the diagnosis, treatment, and natural history of the disease.Sources of informationOvid MEDLINE, Google Scholar, and PubMed were searched for full-text English language articles up to January 2016. References included in the manuscr...
Source: Canadian Journal of Kidney Health and Disease - July 17, 2016 Category: Urology & Nephrology Source Type: research

Recognizing IgG4-related tubulointerstitial nephritis
Abstract Purpose of the review Immunoglobulin G4-related disease (IgG4-RD) is a systemic fibroinflammatory disorder affecting nearly all organs, including the kidney. Tubulointerstitial nephritis (IgG4-TIN) is the most common form of IgG4-related kidney disease (IgG4-RKD) and is the focus of this concise review. Objective The study aims to describe when IgG4-TIN should be suspected and to summarize the diagnosis, treatment, and natural history of the disease. Sources of information Ovid MEDLINE, Google S...
Source: Canadian Journal of Kidney Health and Disease - July 16, 2016 Category: Urology & Nephrology Source Type: research

Willingness to participate in a randomized trial comparing catheters to fistulas for vascular access in incident hemodialysis patients: an international survey of nephrologists
ConclusionsOur survey results suggest that nephrologists believe there is equipoise surrounding the optimal vascular access strategy and that a randomized controlled study should be undertaken, but restricted to those individuals with a high risk of primary fistula failure. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - July 13, 2016 Category: Urology & Nephrology Source Type: research

Willingness to participate in a randomized trial comparing catheters to fistulas for vascular access in incident hemodialysis patients: an international survey of nephrologists
Conclusions Our survey results suggest that nephrologists believe there is equipoise surrounding the optimal vascular access strategy and that a randomized controlled study should be undertaken, but restricted to those individuals with a high risk of primary fistula failure. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - July 12, 2016 Category: Urology & Nephrology Source Type: research

Perceptions of pediatric nephrologists regarding timing of dialysis initiation in children in Canada
ConclusionsVariability exists in Canada regarding the importance and threshold of eGFR guiding the decision as to when to start dialysis in children, whereas patient symptoms are almost universally important to pediatric nephrologists ’ decision-making. Additional studies evaluating outcomes of children starting dialysis earlier vs. later are needed to standardize decision-making and care for children with kidney failure. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - July 1, 2016 Category: Urology & Nephrology Source Type: research

Perceptions of pediatric nephrologists regarding timing of dialysis initiation in children in Canada
Conclusions Variability exists in Canada regarding the importance and threshold of eGFR guiding the decision as to when to start dialysis in children, whereas patient symptoms are almost universally important to pediatric nephrologists’ decision-making. Additional studies evaluating outcomes of children starting dialysis earlier vs. later are needed to standardize decision-making and care for children with kidney failure. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 30, 2016 Category: Urology & Nephrology Source Type: research

Needs assessment: towards a more responsive Canadian Society of Nephrology Annual General Meeting (CSN AGM) program
ConclusionsTo our knowledge, this is the first published example of a needs assessment for a nephrology CME event that considers both the perceived and unperceived needs of the membership. The results of this exercise are currently being used to assist in the development of a more responsive CME program. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 24, 2016 Category: Urology & Nephrology Source Type: research

Needs assessment: towards a more responsive Canadian Society of Nephrology Annual General Meeting (CSN AGM) program
Conclusions To our knowledge, this is the first published example of a needs assessment for a nephrology CME event that considers both the perceived and unperceived needs of the membership. The results of this exercise are currently being used to assist in the development of a more responsive CME program. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 23, 2016 Category: Urology & Nephrology Source Type: research

The WISHED Trial: implementation of an interactive health communication application for patients with chronic kidney disease
ConclusionsThis study will assess whether access to a website dedicated to supporting and promoting home-based dialysis therapies will increase the proportion of patients with CKD who initiate a home-based dialysis therapy.Trial registrationClinicalTrials.gov #NCT01403454, registration date: July 21, 2011. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 15, 2016 Category: Urology & Nephrology Source Type: research

The WISHED Trial: implementation of an interactive health communication application for patients with chronic kidney disease
Conclusions This study will assess whether access to a website dedicated to supporting and promoting home-based dialysis therapies will increase the proportion of patients with CKD who initiate a home-based dialysis therapy. Trial registration ClinicalTrials.gov #NCT01403454, registration date: July 21, 2011. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 14, 2016 Category: Urology & Nephrology Source Type: research

A retrospective review of the two-step tuberculin skin test in dialysis patients
ConclusionsThe TST has limited diagnostic and clinical utility for LTBI screening in patients on dialysis. Further research into the diagnostic accuracy of interferon-gamma release assays and a revision of LTBI screening guidelines in patients on dialysis should be considered. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 7, 2016 Category: Urology & Nephrology Source Type: research

A retrospective review of the two-step tuberculin skin test in dialysis patients
Conclusions The TST has limited diagnostic and clinical utility for LTBI screening in patients on dialysis. Further research into the diagnostic accuracy of interferon-gamma release assays and a revision of LTBI screening guidelines in patients on dialysis should be considered. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - June 6, 2016 Category: Urology & Nephrology Source Type: research

Conventional hemodialysis is associated with greater bone loss than nocturnal hemodialysis: a retrospective observational study of a convenience cohort
This study aims to determine whether there are differences in bone loss between frequent nocturnal hemodialysis and conventional hemodialysis.DesignThis is a retrospective observational study.SettingParticipants were selected from two teaching hospitals in downtown Toronto.ParticipantsThe study included 88 participants on dialysis for at least 6  months (52 patients on conventional hemodialysis and 36 patients converted from conventional hemodialysis to nocturnal hemodialysis). Patients on peritoneal dialysis and with previous renal transplants were excluded.MeasurementsWe obtained demographic variables and biochemica...
Source: Canadian Journal of Kidney Health and Disease - June 1, 2016 Category: Urology & Nephrology Source Type: research

Conventional hemodialysis is associated with greater bone loss than nocturnal hemodialysis: a retrospective observational study of a convenience cohort
This study aims to determine whether there are differences in bone loss between frequent nocturnal hemodialysis and conventional hemodialysis. Design This is a retrospective observational study. Setting Participants were selected from two teaching hospitals in downtown Toronto. Participants The study included 88 participants on dialysis for at least 6 months (52 patients on conventional hemodialysis and 36 patients converted from conventional hemodialysis to nocturnal hemodialysis). Patie...
Source: Canadian Journal of Kidney Health and Disease - May 31, 2016 Category: Urology & Nephrology Source Type: research

Results of the 2014 –2015 Canadian Society of Nephrology workforce survey
ConclusionsThis Canadian Society of Nephrology workforce survey demonstrated the current workforce demographics, individual nephrologist future workforce plans, and projected nephrology division requirements for the next 3 and 5  years. Further work will need to be done to refine Canadian nephrology workforce planning with the development of a robust strategy that encompasses both societal and nephrologists’ needs with the realities of employment. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - May 12, 2016 Category: Urology & Nephrology Source Type: research

Perspectives on optimizing care of patients in multidisciplinary chronic kidney disease clinics
This article summarizes the key concepts discussed at the symposium from a patient and physician perspectives. Key messages include (1) understanding patient values and preferences is important as it provides a framework as to what to prioritize in multidisciplinary CKD clinic and provincial renal program models, (2) barriers to effective communication and education are common in the elderly, and adaptive strategies to limit their influence are critical to improve adherence and facilitate shared decision-making, (3) the use of standardized operating procedures (SOPs) improves efficiency and minimizes practice variability a...
Source: Canadian Journal of Kidney Health and Disease - May 12, 2016 Category: Urology & Nephrology Source Type: research

Results of the 2014 –2015 Canadian Society of Nephrology workforce survey
Conclusions This Canadian Society of Nephrology workforce survey demonstrated the current workforce demographics, individual nephrologist future workforce plans, and projected nephrology division requirements for the next 3 and 5  years. Further work will need to be done to refine Canadian nephrology workforce planning with the development of a robust strategy that encompasses both societal and nephrologists’ needs with the realities of employment. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - May 11, 2016 Category: Urology & Nephrology Source Type: research

Perspectives on optimizing care of patients in multidisciplinary chronic kidney disease clinics
This article summarizes the key concepts discussed at the symposium from a patient and physician perspectives. Key messages include (1) understanding patient values and preferences is important as it provides a framework as to what to prioritize in multidisciplinary CKD clinic and provincial renal program models, (2) barriers to effective communication and education are common in the elderly, and adaptive strategies to limit their influence are critical to improve adherence and facilitate shared decision-making, (3) the use of standardized operating procedures (SOPs) improves efficiency and minimizes practice variability a...
Source: Canadian Journal of Kidney Health and Disease - May 11, 2016 Category: Urology & Nephrology Source Type: research

Results of the 2014–2015 Canadian Society of Nephrology workforce survey
Conclusions This Canadian Society of Nephrology workforce survey demonstrated the current workforce demographics, individual nephrologist future workforce plans, and projected nephrology division requirements for the next 3 and 5 years. Further work will need to be done to refine Canadian nephrology workforce planning with the development of a robust strategy that encompasses both societal and nephrologists’ needs with the realities of employment. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - May 11, 2016 Category: Urology & Nephrology Source Type: research

Cognitive impairment and depression in a population of patients with chronic kidney disease in Colombia: a prevalence study
ConclusionsCI and depression are prevalent conditions among patients with CKD stages 3 –4, with the greatest occurrence of CI, affecting half of the investigated Colombian patients with age ≥ 55 years. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - May 10, 2016 Category: Urology & Nephrology Source Type: research

Cognitive impairment and depression in a population of patients with chronic kidney disease in Colombia: a prevalence study
Conclusions CI and depression are prevalent conditions among patients with CKD stages 3–4, with the greatest occurrence of CI, affecting half of the investigated Colombian patients with age ≥ 55 years. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - May 9, 2016 Category: Urology & Nephrology Source Type: research

Catheter-related bloodstream infection in end-stage kidney disease: a Canadian narrative review
AbstractPurpose of the reviewPatients with end-stage renal disease (ESRD) are at a high risk of bacterial infection. We reviewed publications on risk factors, prevention, and treatment paradigms, as well as outcomes associated with bacterial infection in end-stage kidney disease. We focused in particular on studies conducted in Canada where rates of haemodialysis catheter use are high.Sources of informationWe included original research articles in English text identified from MEDLINE using search terms ‘chronic kidney failure’, ‘renal dialysis’, or ‘chronic renal insufficiency’, and &lsq...
Source: Canadian Journal of Kidney Health and Disease - May 5, 2016 Category: Urology & Nephrology Source Type: research

Catheter-related bloodstream infection in end-stage kidney disease: a Canadian narrative review
Abstract Purpose of the review Patients with end-stage renal disease (ESRD) are at a high risk of bacterial infection. We reviewed publications on risk factors, prevention, and treatment paradigms, as well as outcomes associated with bacterial infection in end-stage kidney disease. We focused in particular on studies conducted in Canada where rates of haemodialysis catheter use are high. Sources of information We included original research articles in English text identified from MEDLINE using search terms ‘chronic kidney failure’, &ls...
Source: Canadian Journal of Kidney Health and Disease - May 4, 2016 Category: Urology & Nephrology Source Type: research

Reduction in new-onset diabetes mellitus after renal transplant with erythropoietin-stimulating agents: a retrospective cohort study
The objective of this study is to examine the relationship between ESA exposure post-renal transplant and the development of NODAT.DesignWe performed a single center, retrospective cohort analysis.PatientsWe compared patients who received a first live or deceased donor renal allograft, with any exposure to an ESA vs. those without such exposure and who developed NODAT and who did not. Patients with a prior history of diabetes mellitus or multi-organ transplant, including a second renal transplant were excluded.Measurements and methodsNODAT was defined based on the 2008 Canadian Diabetes Association criteria. Multivariate l...
Source: Canadian Journal of Kidney Health and Disease - April 26, 2016 Category: Urology & Nephrology Source Type: research

Reduction in new-onset diabetes mellitus after renal transplant with erythropoietin-stimulating agents: a retrospective cohort study
The objective of this study is to examine the relationship between ESA exposure post-renal transplant and the development of NODAT. Design We performed a single center, retrospective cohort analysis. Patients We compared patients who received a first live or deceased donor renal allograft, with any exposure to an ESA vs. those without such exposure and who developed NODAT and who did not. Patients with a prior history of diabetes mellitus or multi-organ transplant, including a second renal transplant were excluded. ...
Source: Canadian Journal of Kidney Health and Disease - April 25, 2016 Category: Urology & Nephrology Source Type: research

Regional citrate anticoagulation in hemodialysis: an observational study of safety, efficacy, and effect on calcium balance during routine care
ConclusionsRegional citrate dialysis can be performed safely and effectively using a sparse plasma calcium sampling protocol. The calcium balance induced by this protocol is not different to that seen in standard heparin-anticoagulated dialysis, but in the absence of prospective studies, it is unknown whether this is optimal for patient care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 20, 2016 Category: Urology & Nephrology Source Type: research

Regional citrate anticoagulation in hemodialysis: an observational study of safety, efficacy, and effect on calcium balance during routine care
Conclusions Regional citrate dialysis can be performed safely and effectively using a sparse plasma calcium sampling protocol. The calcium balance induced by this protocol is not different to that seen in standard heparin-anticoagulated dialysis, but in the absence of prospective studies, it is unknown whether this is optimal for patient care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 19, 2016 Category: Urology & Nephrology Source Type: research

Atypical antipsychotic medications and hyponatremia in older adults: a population-based cohort study
ConclusionsIn this study, the use of an atypical antipsychotic was associated with a modest but statistically significant increase in the 30-day risk of a hospitalization with hyponatremia. The association was less pronounced than that described with other psychotropic drugs. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 11, 2016 Category: Urology & Nephrology Source Type: research

Atypical antipsychotic medications and hyponatremia in older adults: a population-based cohort study
Conclusions In this study, the use of an atypical antipsychotic was associated with a modest but statistically significant increase in the 30-day risk of a hospitalization with hyponatremia. The association was less pronounced than that described with other psychotropic drugs. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 10, 2016 Category: Urology & Nephrology Source Type: research

Validation of administrative database codes for acute kidney injury in kidney transplant recipients
The objective of this study is to determine the accuracy of AKI diagnostic codes in kidney transplant recipients. We hypothesized that the sensitivity of diagnostic codes would be significantly greater in the kidney transplant population since these patients are closely followed by nephrologists and are more likely to have serum creatinine measured.DesignThe design is a population-based retrospective cohort study using healthcare administrative and laboratory databases.SettingThe setting is in Southwestern Ontario and Ottawa, Ontario, Canada, from 2003 to 2012.PatientsWe included first-time kidney transplant recipients adm...
Source: Canadian Journal of Kidney Health and Disease - April 7, 2016 Category: Urology & Nephrology Source Type: research

Validation of administrative database codes for acute kidney injury in kidney transplant recipients
The objective of this study is to determine the accuracy of AKI diagnostic codes in kidney transplant recipients. We hypothesized that the sensitivity of diagnostic codes would be significantly greater in the kidney transplant population since these patients are closely followed by nephrologists and are more likely to have serum creatinine measured. Design The design is a population-based retrospective cohort study using healthcare administrative and laboratory databases. Setting The setting is in Southwestern Ontario and Ottawa, Ontari...
Source: Canadian Journal of Kidney Health and Disease - April 6, 2016 Category: Urology & Nephrology Source Type: research

Primary care physicians ’ perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study
ConclusionsThis work will inform development of clinical resources and tools for care of older adults with stage 5 CKD, to address barriers and enable facilitators to community-based conservative care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 4, 2016 Category: Urology & Nephrology Source Type: research

Primary care physicians ’ perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study
Conclusions This work will inform development of clinical resources and tools for care of older adults with stage 5 CKD, to address barriers and enable facilitators to community-based conservative care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 3, 2016 Category: Urology & Nephrology Source Type: research

Primary care physicians’ perceived barriers and facilitators to conservative care for older adults with chronic kidney disease: design of a mixed methods study
Conclusions This work will inform development of clinical resources and tools for care of older adults with stage 5 CKD, to address barriers and enable facilitators to community-based conservative care. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - April 3, 2016 Category: Urology & Nephrology Source Type: research

Reproducibility of carotid-femoral pulse wave velocity in end-stage renal disease patients: methodological considerations
AbstractBackgroundIn end-stage renal disease (ESRD) patients, increased arterial stiffness detected by carotid-femoral pulse wave velocity (cf-PWV) is associated with fatal cardiovascular events and all-cause mortality. Since cf-PWV is an operator-dependent technique, poor reproducibility may be a source of bias in the estimation of arterial stiffness.ObjectivesWe assessed the week-to-week reproducibility of cf-PWV and radial artery pulse wave analysis in healthy subjects and ESRD patients. We also determined the extent of patient eligibility, enrollment, acceptance, and comfort.MethodsIn a cohort study design, independent...
Source: Canadian Journal of Kidney Health and Disease - April 1, 2016 Category: Urology & Nephrology Source Type: research

Reproducibility of carotid-femoral pulse wave velocity in end-stage renal disease patients: methodological considerations
Abstract Background In end-stage renal disease (ESRD) patients, increased arterial stiffness detected by carotid-femoral pulse wave velocity (cf-PWV) is associated with fatal cardiovascular events and all-cause mortality. Since cf-PWV is an operator-dependent technique, poor reproducibility may be a source of bias in the estimation of arterial stiffness. Objectives We assessed the week-to-week reproducibility of cf-PWV and radial artery pulse wave analysis in healthy subjects and ESRD patients. We also determined the extent of patient eligibility,...
Source: Canadian Journal of Kidney Health and Disease - March 31, 2016 Category: Urology & Nephrology Source Type: research

Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review
AbstractPurpose of the reviewUremic pruritus (UP) is a common discomfort of dialysis-dependent end-stage renal disease. Some studies suggest a neuropathic cause of UP. Gabapentin, an anticonvulsant, has shown promising results as an emerging drug to treat this condition.ObjectiveAn updated qualitative systematic review was conducted to evaluate its efficacy and safety in hemodialysis patients.Source of informationOvid MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Clinicaltrials.gov, and Google Scholar through June 2015 were used as sources of information.PatientsPatients are adult hemodialysis patients r...
Source: Canadian Journal of Kidney Health and Disease - March 28, 2016 Category: Urology & Nephrology Source Type: research

Gabapentin for uremic pruritus in hemodialysis patients: a qualitative systematic review
Abstract Purpose of the review Uremic pruritus (UP) is a common discomfort of dialysis-dependent end-stage renal disease. Some studies suggest a neuropathic cause of UP. Gabapentin, an anticonvulsant, has shown promising results as an emerging drug to treat this condition. Objective An updated qualitative systematic review was conducted to evaluate its efficacy and safety in hemodialysis patients. Source of information Ovid MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Clinicaltrials.g...
Source: Canadian Journal of Kidney Health and Disease - March 27, 2016 Category: Urology & Nephrology Source Type: research

The Canadian experience using the expanded criteria donor classification for allocating deceased donor kidneys for transplantation
Conclusions The ECD classification identifies kidneys at increased risk for graft loss in Canadian patients. The performance of more granular measures of donor risk (e.g., Kidney Donor Risk Index) and its impact on organ allocation/utilization in Canadian patients requires further study. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - March 23, 2016 Category: Urology & Nephrology Source Type: research

Comparative effectiveness of home dialysis therapies: a matched cohort study
This study is an observational, propensity-matched, new-user cohort study. Setting Linked electronic data were from the United States Renal Data System (USRDS) and a large dialysis provider’s database. Patients The patients were adults receiving in-center hemodialysis in the USA between 2004 and 2011 and registered in the USRDS. Measurements Baseline comorbidities, demographics, and outcomes for both groups were ascertained from the United States Renal Data System. ...
Source: Canadian Journal of Kidney Health and Disease - March 19, 2016 Category: Urology & Nephrology Source Type: research

Parental attitudes to genetic testing differ by ethnicity and immigration in childhood nephrotic syndrome: a cross-sectional study
Conclusion While majority of parents were interested in genetic testing for their child, immigrants, particularly South Asians and East/Southeast Asians, were more likely to decline genetic testing. Genetic counseling needs to be tailored to address specific concerns in these parental groups to maximize informed decision-making in the clinical setting. Trial registration ClinicalTrials.gov, NCT01605266 (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - March 17, 2016 Category: Urology & Nephrology Source Type: research

Establishing a continuum of acute kidney injury – tracing AKI using data source linkage and long-term follow-up: Workgroup Statements from the 15th ADQI Consensus Conference
Conclusions We have identified minimal data elements and potential data sources necessary to trace the natural history of patients from onset of AKI to long-term outcome. Minimum infrastructure and key barriers to achieving these goals are outlined together with proposed solutions. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Impact of electronic-alerting of acute kidney injury: workgroup statements from the 15 th ADQI Consensus Conference
Abstract Purpose of the review Among hospitalized patients, acute kidney injury is common and associated with significant morbidity and risk for mortality. The use of electronic health records (EHR) for prediction and detection of this important clinical syndrome has grown in the past decade. The steering committee of the 15th Acute Dialysis Quality Initiative (ADQI) conference dedicated a workgroup with the task of identifying elements that may impact the course of events following Acute Kidney Injury (AKI) e-alert. Sources of information Followi...
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Utilizing electronic health records to predict acute kidney injury risk and outcomes: workgroup statements from the 15 th ADQI Consensus Conference
We describe AKI prediction targets, feature selection, model development, and data display. (Source: Canadian Journal of Kidney Health and Disease)
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Applications for detection of acute kidney injury using electronic medical records and clinical information systems: workgroup statements from the 15 th ADQI Consensus Conference
Abstract Electronic medical records and clinical information systems are increasingly used in hospitals and can be leveraged to improve recognition and care for acute kidney injury. This Acute Dialysis Quality Initiative (ADQI) workgroup was convened to develop consensus around principles for the design of automated AKI detection systems to produce real-time AKI alerts using electronic systems. AKI alerts were recognized by the workgroup as an opportunity to prompt earlier clinical evaluation, further testing and ultimately intervention, rather than as a diagnostic label. Workgroup members agreed with designing A...
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research

Optimizing administrative datasets to examine acute kidney injury in the era of big data: workgroup statement from the 15 th ADQI Consensus Conference
Abstract Purpose of review The purpose of this review is to report how administrative data have been used to study AKI, identify current limitations, and suggest how these data sources might be enhanced to address knowledge gaps in the field. Objectives 1) To review the existing evidence-base on how AKI is coded across administrative datasets, 2) To identify limitations, gaps in knowledge, and major barriers to scientific progress in AKI related to coding in administrative data, 3) To discuss how administrative data for AKI might be enhanced to en...
Source: Canadian Journal of Kidney Health and Disease - February 26, 2016 Category: Urology & Nephrology Source Type: research