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Total 113 results found since Jan 2013.

Association Between Endogenous Testosterone and Cerebrovascular Disease in the ARIC Study (Atherosclerosis Risk in Communities) Clinical Sciences
Conclusions—After controlling for atherosclerotic risk factors, there was no association between endogenous testosterone and incident clinical stroke or ischemic brain changes in community-dwelling men.
Source: Stroke - October 23, 2016 Category: Neurology Authors: Srinath, R., Gottesman, R. F., Hill Golden, S., Carson, K. A., Dobs, A. Tags: Aging, Risk Factors, Ischemic Stroke Original Contributions Source Type: research

Early post-haemorrhagic stroke testosterone and oestradiol levels and long-term risk of death.
CONCLUSION: The testosterone/oestradiol ratio on day 7 after a haemorrhagic stroke is an independent predictor of mortality during later months. PMID: 28296530 [PubMed - in process]
Source: Brain Injury - March 19, 2017 Category: Neurology Tags: Brain Inj Source Type: research

Myocardial Infarction and Stroke Risk in Young Healthy Men Treated with Injectable Testosterone.
This study was conducted to examine the association between testosterone therapy and new myocardial infarction (MI) and stroke events in a series of patients treated at Low T Centers across the United States, consisting of mainly young (mean age = 46), otherwise, healthy men. Electronic medical records were queried between the years 2009 and 2014 to identify patients diagnosed with hypogonadism, MI, and stroke, as indicated by ICD-9 codes. The incidence of MI and stroke events was compared to community-based registries. 39,936 patients recruited from 40 Low T Centers across the United States were treated and 19,968 met eli...
Source: International Journal of Endocrinology - July 2, 2015 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Sex hormones and ischemic stroke: a prospective cohort study and meta-analyses.
CONCLUSIONS: Extreme low endogenous testosterone concentrations were associated with high risk of IS in men, a risk mediated in part by body mass index and hypertension. Whether or not low testosterone is a causal factor for IS or merely a biomarker of poor metabolic health is still not known. PMID: 26509870 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 28, 2015 Category: Endocrinology Authors: Holmegard HN, Nordestgaard BG, Jensen GB, Tybjærg-Hansen A, Benn M Tags: J Clin Endocrinol Metab Source Type: research

Risk factors: Very low endogenous testosterone in men is associated with high risk of ischaemic stroke
Nature Reviews Endocrinology 12, 6 (2016). doi:10.1038/nrendo.2015.208 Author: Robert Phillips A study of a Danish population has found that low testosterone is associated with increased risk of ischaemic stroke in men, but not in women. Levels of endogenous sex hormones were measured in 4,615 men and 4,724 women between 1981 and 1983. With up to
Source: Nature Reviews Endocrinology - November 20, 2015 Category: Endocrinology Authors: Robert Phillips Tags: Research Highlight Source Type: research

Impact Of Testosterone Replacement Therapy On Myocardial Infarction, Stroke, And Death In Men With Low Testosterone Concentrations In An Integrated Healthcare System
The aim of this study was to assess the effect of testosterone replacement therapy (TRT) on cardiovascular (CV) outcomes. Males (January 1, 1996-December 31, 2011) with a low initial total testosterone concentration, a subsequent testosterone level, and>3 years of follow-up were studied. Levels were correlated with testosterone supplement use. The primary outcome was major adverse cardiovascular events (MACE), defined as a composite of death, nonfatal myocardial infarction and stroke at 3 years.
Source: The American Journal of Cardiology - December 13, 2015 Category: Cardiology Authors: Jeffrey L. Anderson, Heidi T. May, Donald L. Lappé, Tami Bair, Viet Le, John F. Carlquist, Joseph B. Muhlestein Source Type: research

Low Testosterone Level as a Predictor of Poststroke Emotional Disturbances: Anger Proneness and Emotional Incontinence
The role of sex hormones in poststroke mood and emotional disturbances is unclear. We aimed to evaluate the impact of sex hormones on poststroke emotional disturbance, especially anger proneness (AP) and emotional incontinence (EI). We also investigated whether statins, which are widely used for stroke prevention, affect sex hormone levels or the presence of poststroke AP/EI based on the hypothesis that intensive treatment with statins would inhibit the synthesis of cholesterol, the preferred substrate of testosterone.
Source: Journal of Stroke and Cerebrovascular Diseases - September 6, 2018 Category: Neurology Authors: Mun Hee Choi, Tae Sung Lim, Bok Seon Yoon, Keoung Sun Son, Ji Man Hong, Jin Soo Lee Source Type: research

Testosterone replacement therapy (TRT) can increase men's risk of stroke and heart attack
(Elsevier) Aging men with low testosterone levels who take testosterone replacement therapy (TRT) are at a slightly greater risk of experiencing an ischemic stroke, transient ischemic attack (TIA), or myocardial infarction, especially during the first two years of use, reports a study appearing in The American Journal of Medicine, published by Elsevier. The findings confirm concerns voiced by many health agencies about the potential risks associated with the treatment.
Source: EurekAlert! - Medicine and Health - July 18, 2019 Category: International Medicine & Public Health Source Type: news

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Low testosterone - a risk marker rather than a risk factor for type 2 diabetes.
CONCLUSIONS: The observed negative associations of T and SHBG with T2D, but no association to LH and free T, indicates that low T in men who develop T2D is a marker of the disease rather than primary hypogonadism being a causal risk factor. PMID: 27285294 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 9, 2016 Category: Endocrinology Authors: Holmboe SA, Jensen TK, Linneberg A, Scheike T, Thuesen BH, Skakkebaek NE, Juul A, Andersson AM Tags: J Clin Endocrinol Metab Source Type: research

Sex Differences in Sex Hormone Profiles and Prediction of Consciousness Recovery After Severe Traumatic Brain Injury
Conclusion: These findings indicate that TBI differentially affects the levels of sex-steroid hormones in men and women patients. Plasma levels of testosterone could be a good candidate blood marker to predict recovery from unconsciousness after sTBI for male patients. Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide and is increasing in incidence (1). Patients with acute severe TBI (sTBI) often develop severe disorders of consciousness, i.e., coma, minimally conscious state or vegetative state. Although many patients may regain consciousness during the 1-month post-TBI p...
Source: Frontiers in Endocrinology - April 25, 2019 Category: Endocrinology Source Type: research

Testosterone Drugs May Be Overused, FDA Warns
WASHINGTON (AP) — The Food and Drug Administration is warning doctors against over-prescribing testosterone-boosting drugs for men, saying the popular treatments have not been established as safe or effective for common age-related issues like low libido and fatigue. The agency says drugmakers must clearly state in their labeling and promotions that the drugs, currently taken by millions of U.S. men, are only approved to treat low testosterone levels caused by disease or injury, not normal aging. Additionally, the FDA cautioned that the drugs may increase the risk of heart attack, stroke and other cardiovascular problem...
Source: Science - The Huffington Post - March 3, 2015 Category: Science Source Type: news

Major adverse cardiovascular events associated with testosterone treatment: a pharmacovigilance study of the FAERS database
Conclusion: For myocardial infarction and cardiomyopathy, TRT statistically tended to increase the risk of MACEs, while for cardiac arrhythmia, cardiac failure, and stroke, TRT demonstrated beneficial effects among the population with morbidities, such as testosterone deficiency (TD), diabetes mellitus (DM), and hypertension. MACEs were rare but led to serious outcomes including significant increase in death and disability. Since 2018, and before 2014, reports referring to TRT associated with MACEs were relatively scarce, which indicated that there might be a considerable number of cases that went unrecorded, due to neglec...
Source: Frontiers in Pharmacology - July 12, 2023 Category: Drugs & Pharmacology Source Type: research

Androgen activity, ischaemic heart disease and risk factors among men in NHANES III
ConclusionsAndrogen biomarkers had inconsistent associations with cardiovascular disease risk factors and ischaemic heart disease. Androstanediol glucuronide, rather than serum testosterone, had associations with cardiovascular disease risk factors more similar to those seen in randomized controlled trials of testosterone therapy, with corresponding implications for raising androgens.
Source: European Journal of Clinical Investigation - October 7, 2013 Category: Journals (General) Authors: C. Mary Schooling Tags: Original Article Source Type: research

Plasma testosterone, obesity, metabolic syndrome and diabetes.
Abstract The frequency of diabetes and/or metabolic syndrome rises concurrently with that of body mass index (BMI). In adult men, plasma testosterone level changes evolve inversely to that of BMI. Plasma total testosterone, sex hormone-binding globulin (SHBG) and free testosterone are significantly lower in adult men with a clinical and biological pattern of metabolic syndrome (MetS) than in those without such a pattern. After adjustment for confounding factors, diabetes type 2 (DT2) remains associated with a significant decrease of plasma testosterone level. The androgenic blockade, used as a treatment for dissem...
Source: Presse Medicale - November 21, 2013 Category: Journals (General) Authors: Prévost G, Eas F, Kuhn JM Tags: Presse Med Source Type: research