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Condition: Autoimmune Disease

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Total 584 results found since Jan 2013.

Beyond vascular inflammation-recent advances in understanding atherosclerosis.
Abstract Atherosclerosis is the most life-threatening pathology worldwide. Its major clinical complications, stroke, myocardial infarction, and heart failure, are on the rise in many regions of the world-despite considerable progress in understanding cause, progression, and consequences of atherosclerosis. Originally perceived as a lipid-storage disease of the arterial wall (Die cellularpathologie in ihrer begründung auf physiologische und pathologische gewebelehre. August Hirschwald Verlag Berlin, [1871]), atherosclerosis was recognized as a chronic inflammatory disease in 1986 (New Engl J Med 314:488-500, 1986)...
Source: Cellular and Molecular Life Sciences : CMLS - June 23, 2015 Category: Cytology Authors: Wolf D, Zirlik A, Ley K Tags: Cell Mol Life Sci Source Type: research

Gardasil HPV Vaccine Safety Assessed In Most Comprehensive Study To Date
The largest review of the available evidence on the quadrivalent, or four-strain, HPV vaccine Gardasil, has found no evidence of any serious short-term or long-term safety issues. Bringing together the findings from clinical trials, post-licensure studies and data presented at scientific meetings but not yet published, the researchers focused particularly on autoimmune diseases, nervous system disorders, anaphylaxis, blood clots and stroke – but none of them is caused by the vaccine, they found.
Source: Forbes.com Healthcare News - July 15, 2015 Category: Pharmaceuticals Authors: Tara Haelle Source Type: news

An Overview of Quadrivalent Human Papillomavirus Vaccine Safety: 2006 to 2015
Conclusions: These results, along with the safety data from the prelicensure clinical trials, confirm that the HPV4 vaccine has a favorable safety profile. Key policy, medical and regulatory organizations around the world have independently reviewed these data and continue to recommend routine HPV vaccination.
Source: The Pediatric Infectious Disease Journal - August 14, 2015 Category: Infectious Diseases Tags: Vaccine Reports Source Type: research

Bullous pemphigoid and neurodegenerative diseases: a study in a setting of a Central European university dermatology department.
Abstract Bullous pemphigoid (BP) is an autoimmune blistering dermatosis of the elderly mediated by IgG and IgE antibodies to skin hemidesmosomal proteins, BP180 and/or BP230, that occur physiologically also in neuronal tissue. It was reported that BP is associated with neurodegenerative diseases (ND). We performed a retrospective study in a setting of a Central European university dermatology department on prevalence of ND in 94 BP patients. 26 out of 94 BP patients had at least one ND. ND included: Parkinson's disease, dementia, stroke, hear loss, tinnitus, blindness, vertigo, neurosyphilis, systemic sclerosis, a...
Source: Aging Clinical and Experimental Research - September 29, 2015 Category: Geriatrics Authors: Pietkiewicz P, Gornowicz-Porowska J, Bowszyc-Dmochowska M, Bartkiewicz P, Dmochowski M Tags: Aging Clin Exp Res Source Type: research

Depression as a Microglial Disease.
Abstract Despite decades of intensive research, the biological mechanisms that causally underlie depression are still unclear, and therefore the development of novel effective antidepressant treatments is hindered. Recent studies indicate that impairment of the normal structure and function of microglia, caused by either intense inflammatory activation (e.g., following infections, trauma, stroke, short-term stress, autoimmune or neurodegenerative diseases) or by decline and senescence of these cells (e.g., during aging, Alzheimer's disease, or chronic unpredictable stress exposure), can lead to depression and asso...
Source: Trends in Neurosciences - October 1, 2015 Category: Neuroscience Authors: Yirmiya R, Rimmerman N, Reshef R Tags: Trends Neurosci Source Type: research

Increased activity of factor VIII causing acute intestinal ischemic disorder with recurrent and multiple arterial thromboses
We present the case of a 52-year-old man with hypercoagulability-induced acute arterial occlusive mesenteric ischemia. The patient suffered from arterial occlusive mesenteric ischemia, recent ischemic stroke, and previous renal infarction. He had no history of atrial fibrillation, atherosclerosis, vascular diseases, autoimmune diseases, malignancy, liver diseases, copper deficiency, or other risk factors for arterial thromboembolism. Segmental resection of the gangrenous bowel with primary end-to-end anastomosis was performed. A pathological examination revealed multiple thrombi within the mesenteric arteries of the infarc...
Source: Formosan Journal of Surgery - November 17, 2015 Category: Surgery Source Type: research

Study of the lipidemic profile of diabetic patients. Negative correlation of cholesterol levels of diabetes type I patients with serum amylase concentration.
Authors: Eleftheriou P, Tseka E, Varaga E, Nasiou M, Sampanis C, Zografou I, Oulorgia J, Damontsidou K, Zaimi T, Markou HI, Varsamidis K, Petrou C, Limberaki E, Ganou CJ Abstract Diabetes Mellitus type I (DM1) and II (DM2) share the common characteristic of high blood glucose concentration and the health complications resulting from uncontrolled hyperglycemia such as hyperlipidemia, cardiovascular problems, stroke, ketoacidosis, kidney failure and blindness but have different etiology. DM1 is practically an autoimmune disease. Genetic susceptibility together with environmental factors leads to disease development. ...
Source: Hellenic Journal of Nuclear Medicine - November 18, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Women still at risk long after CV event
Risk of further events 10 times higher in decades after heart attack or stroke Related items from OnMedicaSurvivors of childhood cancer more prone to autoimmune diseasesMacrolides linked to increased cardiovascular riskHeart disease research needs £500m boostStress in childhood linked to disease risk in adulthoodHuge variations in cardiovascular death rates across Europe
Source: OnMedica Latest News - November 24, 2015 Category: UK Health Source Type: news

Bullous pemphigoid: What's ahead?
Abstract Bullous pemphigoid (BP) is an autoimmune subepidermal blistering skin disease mainly affecting older individuals. Pathogenic autoantibodies preferentially target the non‐collagenous 16A domain of collagen XVII (also called BP antigen 2, BPAG2) present in hemidesmosomes. The pathogenic anti‐BPAG2 antibodies cause the dermal–epidermal separation in neonatal and adult mice as well as in cryosections of human skin. These experimental BP models stress a pivotal role for neutrophils and the Fcγ receptor of immunoglobulins. Mice that have been genetically manipulated in the pathogenic domain of BPAG2 spontaneously...
Source: The Journal of Dermatology - November 25, 2015 Category: Dermatology Authors: Masutaka Furue, Takafumi Kadono Tags: Review Article Source Type: research

Statistical methods for studying disease subtype heterogeneity
A fundamental goal of epidemiologic research is to investigate the relationship between exposures and disease risk. Cases of the disease are often considered a single outcome and assumed to share a common etiology. However, evidence indicates that many human diseases arise and evolve through a range of heterogeneous molecular pathologic processes, influenced by diverse exposures. Pathogenic heterogeneity has been considered in various neoplasms such as colorectal, lung, prostate, and breast cancers, leukemia and lymphoma, and non‐neoplastic diseases, including obesity, type II diabetes, glaucoma, stroke, cardiovascular d...
Source: Statistics in Medicine - December 1, 2015 Category: Statistics Authors: Molin Wang, Donna Spiegelman, Aya Kuchiba, Paul Lochhead, Sehee Kim, Andrew T. Chan, Elizabeth M. Poole, Rulla Tamimi, Shelley S. Tworoger, Edward Giovannucci, Bernard Rosner, Shuji Ogino Tags: Tutorial in Biostatistics Source Type: research

Sjogren's syndrome with acute cerebellar ataxia and massive lymphadenopathy : a case report.
DISCUSSION: For patients with acute acquired cerebellar ataxia, immune-mediated cerebellar ataxia should be an important differential diagnosis aside from the more common causes like stroke or drugs. PMID: 24030041 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Multiple cerebral and cerebellar infarcts as the first clinical manifestation in a patient with Churg-Strauss syndrome: case report and literature review.
CONCLUSION: Symptoms and signs of central nervous system can be the initial neurological manifestation of CSS patients. CSS should be considered while patients have stroke and hypereosinophilia. In our patient, there is a good response to timely steroid, immunosuppressant and anticoagulant therapies. PMID: 23329548 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Low prevalence of patients with mitochondrial disease in the German/Austrian DPV diabetes registry
Conclusion: Primary mitochondrial disorders are a rare cause of juvenile diabetes and likely to be underdiagnosed. As there is clinical overlap with T1D and T2D, dyslipidemia and low body weight may help to identify further DMO cases. What is Known: • In adults diabetes of mitochondrial origin (DMO) is a rare cause of non-autoimmune diabetes, affecting about 0.8 % of diabetes cases. • Common features are a maternal family history of diabetes, hearing loss and neurological abnorma...
Source: European Journal of Pediatrics - December 15, 2015 Category: Pediatrics Source Type: research

Nudging Oligodendrocyte Intrinsic Signaling to Remyelinate and Repair: Estrogen Receptor Ligand Effects
Publication date: Available online 14 January 2016 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Anna J. Khalaj, Jonathan Hasselmann, Catherine Augello, Spencer Moore, Seema K. Tiwari-Woodruff Demyelination in multiple sclerosis (MS) leads to significant, progressive axonal and neuronal degeneration. Currently existing immunosuppressive and immunomodulatory therapies alleviate MS symptoms and slow, but fail to prevent or reverse, disease progression. Restoration of damaged myelin sheath by replenishment of mature oligodendrocytes (OLs) should not only restore saltatory axon conduction, ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 15, 2016 Category: Biochemistry Source Type: research

Multiple Sclerosis, Jamie-Lynn Sigler's Autoimmune Disease, Explained
In a People magazine interview on this week, Jamie-Lynn Sigler revealed that she has had multiple sclerosis, an autoimmune disease, for the past 15 years.  "You'd think that after all these years, somebody would be settled with something like this." Sigler told People. "It's still hard to accept." What is multiple sclerosis? MS is a degenerative nervous system disease, in which the immune system attacks it's own nerve cells, slowing down messages between the brain and the rest of the body. No one knows what causes MS, but symptoms -- which differ from person to person, but typically include muscle weakness, coordinati...
Source: Healthy Living - The Huffington Post - January 21, 2016 Category: Consumer Health News Source Type: news