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Condition: Autoimmune Disease

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Total 584 results found since Jan 2013.

Rheumatoid meningitis: A rare cause of aseptic meningitis with frequently stroke-like episodes
Conclusions RM is a rare manifestation of RA and often presents with stroke-like episodes. It is currently not implemented in the workup of aseptic meningitis in national guidelines. Crucial clues for diagnosis included recurrent stroke-like episodes refractory to antiepileptic treatment, headache and constitutional symptoms, meningeal enhancement on MRI, CSF pleocytosis, and positive serology findings for ACPA and RF. Prognosis is favorable with early immunosuppressive treatment.
Source: Neurology Clinical Practice - October 15, 2018 Category: Neurology Authors: Schuster, S., Braass, H., Iking-Konert, C., Schnoor, U., Matschke, J., Gerloff, C., Thomalla, G., Magnus, T. Tags: Autoimmune diseases, Meningitis, All Clinical Neurology Review Source Type: research

Stroke as Initial Manifestation of Adenosine Deaminase 2 Deficiency
Neuropediatrics DOI: 10.1055/s-0036-1597611Deficiency of adenosine deaminase 2 (ADA2) due to homozygous or compound heterozygous mutations in the cat eye syndrome chromosome region, candidate 1 (CECR1) gene causes an autoimmune phenotype with systemic vasculitis affecting the skin, inner organs, and the central nervous system. Typically, stroke has been reported to follow systemic inflammatory disease and predominantly affects posterior and central brain areas. Here, we describe one of the rare patients in whom acute mesencephalic stroke preceded systemic inflammation and presented as initial clinical symptom. Symptoms typ...
Source: Neuropediatrics - December 25, 2016 Category: Neurology Authors: Elbracht, Miriam Mull, Michael Wagner, Norbert Kuhl, Christiane Abicht, Angela Kurth, Ingo Tenbrock, Klaus H äusler, Martin Tags: Short Communication Source Type: research

Exacerbation of oxygen-glucose deprivation-induced blood brain barrier disruption: potential pathogenic role of interleukin 9 in ischemic stroke
Interleukin (IL) -9 exerts a variety of functions in autoimmune diseases. However, its role in ischemic brain injury remains unknown. The present study explored the biological effects of IL-9 in ischemic stroke. We recruited 42 patients newly diagnosed with ischemic stroke and 22 age- and sex-matched healthy controls. The expression levels of IL-9 and percentages of IL-9-producing T cells, including CD3+CD4+IL-9+ and CD3+CD8+IL-9+ cells, were determined in peripheral blood mononuclear cells (PBMCs) obtained from patients and control individuals. We also investigated the effects of IL-9 on the blood brain barrier (BBB) foll...
Source: Clinical Science - May 26, 2017 Category: Biomedical Science Authors: Tan, S., Shan, Y., Wang, Y., Lin, Y., Liao, S., Deng, Z., Zhou, L., Cai, W., Zeng, Q., Zhang, L., Zhang, B., Men, X., Li, H., Hu, X., Wu, C., Peng, L., Lu, Z. Tags: PublishAheadOfPrint Source Type: research

Was Antiphospholipid Syndrome a Risk Factor of Stroke? A Systemic Review and Meta-Analysis of Cohort Studies
Dis Markers. 2021 Dec 16;2021:4431907. doi: 10.1155/2021/4431907. eCollection 2021.ABSTRACTAntiphospholipid syndrome (APS) is characterized by thrombosis. This systemic review and meta-analysis was to verify the hypothesis that APS might increase the risk of stroke. Studies were identified after literature searching of PubMed, Embase, and Cochrane. Newcastle-Ottawa Quality Assessment Scale Cohort Studies (NOQAS-C) was used to assess the quality of studies. The pooled effect with 95% confidence interval (95% CI) was calculated by random-effect model. I-square (I 2) was used to test heterogeneity. Funnel plot was used to eva...
Source: Disease Markers - December 27, 2021 Category: Laboratory Medicine Authors: Kai Zhao Ping Zhou Ling Xu Ruili Li Jincai Yang Qiang Zhang Mingfei Yang Xiaoxing Wei Source Type: research

Myasthenia Gravis and Ischemic Stroke: A Bidirectional Mendelian Randomization Study
CONCLUSION: Bidirectional MR analysis did not provide evidence to support a causal relationship between genetically predicted MG and IS, although observational studies have found such a potential link.PMID:37403387 | DOI:10.2174/1567202620666230703122140
Source: Current Neurovascular Research - July 5, 2023 Category: Neurology Authors: Chen Liu Chengyuan Mao Shen Li Yun Su Hongbing Liu Xin Wang Weishi Liu Jiawei Zhao Xuyang Liu Yuming Xu Source Type: research

Plasma levels of neuron specific enolase quantifies the extent of neuronal injury in murine models of ischemic stroke and multiple sclerosis.
CONCLUSIONS: Plasma NSE is a valid and simple experimental biomarker that allows quantifying the degree of neuronal injury in a non-invasive approach. PMID: 23932916 [PubMed - as supplied by publisher]
Source: Neurobiology of Disease - August 8, 2013 Category: Neurology Authors: Gelderblom M, Daehn T, Schattling B, Ludewig P, Bernreuther C, Arunachalam P, Matschke J, Glatzel M, Gerloff C, Friese MA, Magnus T Tags: Neurobiol Dis Source Type: research

Stroke Due To Extracranial Internal Carotid Artery Dissection After Roller Coaster Rides In A 4-Year-Old Boy (P7.343)
CONCLUSIONS: To our knowledge this is the youngest patient with stroke secondary to ICA dissection following roller-coaster rides. Although the exact mechanism of injury leading to ICA dissection in the setting of sudden linear acceleration, deceleration and rotational forces such as those experienced while riding a roller coaster is not fully understood, these injuries have been attributed to brief sustained excessive gravitational forces likely augmented among predisposed individuals. Children may be at higher risk due to the immature anatomy of their cervical spine. Alterations to roller coaster ride dynamics and use of...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Nouh, A., Vela-Duarte, D., Grobelny, T., Hoganson, G., Pasquale, D., Biller, J. Tags: Child Neurology and Developmental Neurology VI Source Type: research

Chronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and Stroke: A Population-Based Cohort Study.
CONCLUSIONS: -The risk of cardiovascular diseases and T2DM is increased across a range of organ-specific and multi-system chronic inflammatory disorders with evidence that risk is associated with severity of inflammation. Clinical management of patients with chronic inflammatory disorders should aim to reduce cardiovascular risk. PMID: 24970784 [PubMed - as supplied by publisher]
Source: Circulation - June 26, 2014 Category: Cardiology Authors: Dregan A, Charlton J, Chowienczyk P, Gulliford MC Tags: Circulation Source Type: research

Correspondence Infectious causes of stroke
We read with great interest the excellent Review by Jennifer Fugate and colleagues1 about the infectious causes of stroke. Their Review is useful for daily practice, since physicians often focus excessively on autoimmune causes of central nervous system vasculitis causing stroke, while forgetting about infectious causes. However, we think that apart from neurosyphilis, which is mentioned in great detail, an additional comment on stroke caused by another spirochetal disease, Lyme neuroborreliosis, is needed.
Source: The Lancet Infectious Diseases - May 18, 2015 Category: Infectious Diseases Authors: Adam Garkowski, Joanna Zajkowska, Anna Moniuszko, Piotr Czupryna, Sławomir Pancewicz Tags: Correspondence Source Type: research

Vasculitic neuropathy following exposure to minocycline
Conclusions: Our findings suggest that the typical neuropathy associated with minocycline use is painful single or multiple mononeuropathy due to peripheral nerve vasculitis, which may also be accompanied by presumed CNS vasculitis (presenting as stroke).
Source: Neurology Neuroimmunology and Neuroinflammation - November 12, 2015 Category: Neurology Authors: Baratta, J. M., Dyck, P. J. B., Brand, P., Thaisetthawatkul, P., Dyck, P. J., Engelstad, J. K., Goodman, B., Karam, C. Tags: All Cerebrovascular disease/Stroke, Other cerebrovascular disease/ Stroke, All Immunology, Autoimmune diseases, Vasculitis Article Source Type: research

Intracranial Fibromuscular Dysplasia in a Middle-Aged Woman with Recurrent Ischemic Stroke (P4.388)
Conclusions: FMD is a rare disease and has very rarely been described in the intracranial arteries. This case illustrates the natural history and progression of FMD in this patient and elucidates the limited treatment options for preventing disease progression and secondary complications. FMD most predominantly affects younger to middle-aged females and if the disease process goes unrecognized it can have devastating consequences. It is important to continue research endeavors into the genetic and biologic determinants of FMD in order to develop better prevention and therapeutic strategies for this condition.Disclosure: Dr...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Beaton, N., Malik, A., Maque-Acosta, Y., Koch, S. Tags: Non-Atherosclerotic Arteriopathies Source Type: research

A rare cause of ischemic stroke: cardiac myxoma. Case report and review of literature.
Authors: Mustafa ER, Tudoraşcu DR, Giucă A, Toader DM, Foarfă MC, Puiu I, Istrate-Ofiţeru AM Abstract A 46-year-old female diagnosed several years ago with arterial hypertension and an ischemic stroke with significant recovery was admitted for dyspnea on usual physical activity and fatigue. Physical examination revealed signs of heart failure with crackles on both lung bases, distented jugular veins, accentuated pulmonic valve closure (P2) and tricuspid regurgitation murmur. Echocardiography identified a large tumor in the left atrium, suggestive of atrial myxoma, which caused a severe functional mitral stenosi...
Source: Romanian Journal of Morphology and Embryology - December 13, 2018 Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research