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Condition: Autoimmune Disease

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Total 584 results found since Jan 2013.

Distinct lesion features and underlying mechanisms in patients with acute multiple infarcts in multiple cerebral territories
CONCLUSION: The etiologies and mechanisms of patients with AMIMCT were more complex than those without AMIMCT. The distribution characteristics of infarct lesions might have important implications for the identification of etiology and mechanism in the future, which could further guide and optimize clinical diagnostic strategies.PMID:36726748 | PMC:PMC9885093 | DOI:10.3389/fneur.2022.1102505
Source: Atherosclerosis - February 2, 2023 Category: Cardiology Authors: Yuhui Sha Guangsong Han Yuehui Hong Juanjuan Wu Mingyu Tang Yicheng Zhu Lixin Zhou Jun Ni Source Type: research

Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population-based longitudinal follow-up study.
CONCLUSIONS: These findings suggest that DMS is associated with an increased risk of cardiovascular and cerebrovascular events. PMID: 23330740 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - January 21, 2013 Category: Dermatology Authors: Lai YT, Dai YS, Yen MF, Chen LS, Chen HH, Cooper RG, Pan SL Tags: Br J Dermatol Source Type: research

Lasting Relief from Chronic Pain after Cerebral Infarction (P02.005)
CONCLUSIONS: This patient's stroke appeared to produce the beneficial and persistent effect of dramatic pain relief, enabling him to discontinue all analgesic medications, including methadone. The alleviation of pain after ischemic infarction is highly unusual, and possible explanations include 1) damage to both anterior cingulate gyri producing apathy of such severity that the experience of pain was markedly blunted, and 2) bilateral injury to the nucleus accumbens abolishing a cerebral region critical for the appreciation of pain and opiate-related reward.Disclosure: Dr. Burke has nothing to disclose. Dr. Anderson's spou...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Burke, H., Anderson, C., Filley, C. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

Use of E-Selectin Tolerization as Treatment for Immunological and Vascular-Related Disorders
This technology relates to the mucosal delivery (e.g. intranasal) of an E-selectin fragment as a tolerization agent for the prevention and treatment of immunological and vascular-related disorders, including stroke and multiple sclerosis (MS) as well as rare or orphan diseases involving vascular modulated disorders. E-selectin is an adhesion molecule that is expressed on endothelial cells lining blood vessels in response to certain localized cytokines, making the endothelial surface pro-coagulant, pro-inflammatory and/or immunoreactive. Such changes on the endothelial surface have been linked to the development of vascula...
Source: NIH OTT Licensing Opportunities - April 1, 2001 Category: Research Authors: admin Source Type: research

Lupus patients 'at higher risk of developing other health conditions'
People with lupus are at a greater risk of developing other health conditions than members of the general population.This is according to a new study conducted by the University of Nottingham and the Arthritis Research UK Primary Care Centre at Keele University, which examined the frequency of comorbidities associated with systemic lupus erythematosus in the UK between 1999 and 2012.A broad UK study Published in the medical journal Arthritis Care & Research, the study drew upon data from the UK Clinical Practice Research Datalink, identifying cases of lupus and matching each one by age, gender and practice to four heal...
Source: Arthritis Research UK - May 26, 2016 Category: Rheumatology Source Type: news

Freiberg & #8217;s infarction as the first clinical presentation of Sneddon syndrome
Debopam Samanta, Sarah CobbJournal of Pediatric Neurosciences 2020 15(3):290-293Sneddon syndrome is a rare, non-inflammatory vasculopathy that generally occurs in the third to fourth decade of life but may rarely present in the pediatric population. It is characterized by the skin finding of livedo racemosa and recurrent ischemic strokes. Other common neurologic manifestations include migraine and early cognitive decline. It may be associated with systemic lupus erythematosus (SLE) and antiphospholipid antibodies, or as in our case, thrombophilia and autoimmune workup may be negative. Optimal treatment for Sneddon syndrome...
Source: Journal of Pediatric Neurosciences - November 6, 2020 Category: Neuroscience Authors: Debopam Samanta Sarah Cobb Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin
AbstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, and/or small vessel thrombosis, pregnancy morbidity, and persistently elevated levels of antiphospholipid antibodies (aPL). Cardiovascular disease (CVD) in APS can present as heart valvular disease (HVD), macro-micro-coronary artery disease (CAD), myocardial dysfunction, cardiac thrombi, or pulmonary hypertension. Brain disease presents as stroke or transient ischemic attack (TIA) and less frequently as cerebral venous thrombosis, seizures, cognitive dysfunction, multiple sclerosis (MS) −like syndrome, or chorea. Infarcts...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Cerebral venous thrombosis in patients with autoimmune disease, hematonosis or coronavirus disease 2019: Many familiar faces and some strangers
CONCLUSION: A systematic understanding of particular risk factors that should not be neglected when unconventional cerebral venous thrombosis occurs and for a scientific understanding of pathophysiological mechanisms, clinical diagnosis, and treatment, thus contributing to knowledge on special types of venous stroke.PMID:37365966 | DOI:10.1111/cns.14321
Source: CNS Neuroscience and Therapeutics - June 27, 2023 Category: Neuroscience Authors: Yifan Zhou Huimin Jiang Huimin Wei Xuechun Xiao Lu Liu Xunming Ji Chen Zhou Source Type: research

Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population‐based longitudinal follow‐up study
ConclusionsThese findings suggest that DMS is associated with an increased risk of cardiovascular and cerebrovascular events.
Source: British Journal of Dermatology - January 1, 2013 Category: Dermatology Authors: Y.‐T. Lai, Y.‐S. Dai, M.‐F. Yen, L.‐S. Chen, H.‐H. Chen, R.G. Cooper, S.‐L. Pan Tags: Original Article Source Type: research

Internal Carotid Artery Floating Thrombus in Relapsing Polychondritis
We present a 52‐year‐old man without any known risk factors for stroke, treated with prednisone and azathioprine for relapsing polychondritis, who presented a minor left hemisphere stroke. Ultrasound of the neck vessels revealed an isoechogenic thrombus in the left internal carotid artery superimposed on a smooth moderately stenosing isoechogenic atheroma of the carotid bulb. The patient was treated with high‐dose tinzaparin and was followed with serial ultrasound. After 16 days, the thrombus demonstrated a hypoechogenic core surrounded by a hyperechogenic rim and the following day it resolved completely. Thrombus fo...
Source: Journal of Neuroimaging - February 23, 2014 Category: Radiology Authors: Theodoros Karapanayiotides, Konstantinos Kouskouras, Panagiotis Ioannidis, Eleni Polychroniadou, Nikolaos Grigoriadis, Dimitrios Karacostas Tags: Case Report Source Type: research

Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection
Conclusions Antiviral treatment for HCV is associated with improved renal and circulatory outcomes, but unrelated to catastrophic autoimmune diseases.
Source: Gut - February 3, 2015 Category: Gastroenterology Authors: Hsu, Y.-C., Ho, H. J., Huang, Y.-T., Wang, H.-H., Wu, M.-S., Lin, J.-T., Wu, C.-Y. Tags: Hepatology Source Type: research