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Condition: Autoimmune Disease

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Total 584 results found since Jan 2013.

A patient with MELAS syndrome combined with autoimmune abnormalities: a case report
ConclusionMitochondrial encephalomyopathy is a rare clinical condition; however, the association with autoimmune diseases is not yet clear and still needs further research and analysis.
Source: Frontiers in Neurology - August 24, 2023 Category: Neurology Source Type: research

Prophylactic dose fondaparinux for 6 weeks in superficial thrombophlebitis of the legs reduces the risk for symptomatic thromboembolic complications
Commentary on: Di Nisio M, Wichers IM, Middeldorp S. Treatment for superficial thrombophlebitis of the leg. Cochrane Database Syst Rev 2012;3:CD004982. Context Superficial thrombophlebitis (ST), an inflammatory-thrombotic disorder in a superficial vein, is relatively common and estimated to occur in 1 per 1000 persons.1 The classic symptoms include pain, oedema, erythema and occasionally a palpable cord in the area of the thrombosed vein. Risk factors for ST include surgery, pregnancy and puerperium, female hormones, malignancy, infection, varicose veins, autoimmune disorders and thrombophilia.2 ST is a risk factor for dee...
Source: Evidence-Based Medicine - January 17, 2013 Category: Internal Medicine Authors: DeSancho, M. T., Pastores, S. M. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Pain (neurology), Stroke, Pregnancy, Venous thromboembolism, Renal medicine, Pulmonary embolism, Drugs: musculoskeletal and joint diseases, Dermatology Therapeutics Source Type: research

The world pandemic of Vitamin D deficit could possibly be explained by cellular inflammatory response activity induced by the renin angiotensin system.
Abstract This review attempts to show that there may be a relationship between inflammatory processes induced by chronic overstimulation of the renin angiotensin system (RAS) and the worldwide vitamin D (VitD) deficiency, and probably both disorders are associated with environmental factors. Low VitD levels represent a risk factor for several apparently different diseases such as infectious, autoimmune, neurodegenerative, and cardiovascular diseases, as well as diabetes, osteoporosis, and cancer. Moreover, VitD insufficiency seems to predispose hypertension, metabolic syndrome, left ventricular hypertrophy, heart ...
Source: American Journal of Physiology. Cell Physiology - January 30, 2013 Category: Cytology Authors: Ferder M, Inserra F, Manucha W, Ferder L Tags: Am J Physiol Cell Physiol Source Type: research

A Case Report of Dihydroergotamine Administration for Status Migrainosus in a Patient on Longstanding Citalopram Causing a Fatal Reversible Cerebral Vasoconstriction Syndrome (RCVS) (P02.027)
CONCLUSIONS: We report this case report of fatal RCVS of a patient on long standing citalopram who developed this after being administered Dihydroergotamine for status migrainosus. As this is thought to be a self-limiting in terms of clinical features. However, some patients may have more severe focal neurologic symptoms and signs, including ischemic or hemorrhagic strokes as described in our patient.Disclosure: Dr. Asi has nothing to disclose. Dr. Gomes has nothing to disclose. Dr. Dani has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Asi, K., Gomes, J., Dani, D. Tags: P02 Cerebrovascular Disease II Source Type: research

Cystatin C as a Marker of Degeneration in Multiple Sclerosis (P03.241)
CONCLUSIONS: Cystatin C concentration decrease in RR form of MS could give evidence for high disease activity in this stage of the disease with high myelin damage and neurodegeneration.Supported by: Grant IGA MHCZ NT 12221-5/2010.Disclosure: Dr. Prikrylová Vranová has nothing to disclose. Dr. Sládková has nothing to disclose. Dr. Mares has nothing to disclose. Dr. Hlustík has nothing to disclose. Dr. Langová has nothing to disclose. Dr. Kanovsky has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Prikrylova Vranova, H., Sladkova, V., Mares, J., Hlustik, P., Langova, J., Kanovsky, P. Tags: P03 Multiple Sclerosis: Disease Biomarkers Source Type: research

Is the microbe-dementia hypothesis finally ready for a treatment trial?
Could infections really have something to do with disorders that cause dementia? Several chronic diseases, such as peptic ulcer, certain cancers, and autoimmune conditions, have established infectious etiologies, either bacterial or viral, but mainstream cognitive disorder research has not fully considered microbial involvement. Evidence is emerging,1 but the size of the problem—millions of patients with Alzheimer disease (AD) worldwide, and increasing—compels searching for clues in the dark, and not only below the streetlight, especially if established and safe treatments are available.
Source: Neurology - March 25, 2013 Category: Neurology Authors: Strandberg, T. E., Aiello, A. E. Tags: All Infections, All Cerebrovascular disease/Stroke, All Cognitive Disorders/Dementia EDITORIALS Source Type: research

Even 'light' smoking may raise women's arthritis risk
Conclusion This research indicates that a relatively low level of smoking (one to seven cigarettes per day) is associated with an increased risk of developing rheumatoid arthritis compared with women who had never smoked. This adds further knowledge to previous research that has suggested that cigarette smoking is directly linked to a higher risk of developing rheumatoid arthritis. While this study is relatively robust and its results believable, it does have limitations that should be considered. It was not clear how many women dropped out of the study. If this was a large proportion of the women who started, it could si...
Source: NHS News Feed - April 23, 2013 Category: Consumer Health News Tags: Cancer Heart/lungs Lifestyle/exercise Source Type: news

Serum vitamin D deficiency and its association with systemic disease in exfoliation syndrome.
Conclusions: Although vitamin D levels were similar between XFS and control subjects, the levels were found to be decreased in both groups. Patients with XFS had a significantly higher prevalence of cerebrovascular and cardiovascular disease as compared to controls independent of their 
serum 25(OH) D levels. Low vitamin D level does not appear to be linked to XFS in the studied population. PMID: 23564611 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - April 8, 2013 Category: Opthalmology Authors: Kocabeyoglu S, Mocan MC, Irkec M, Pinar A, Bozkurt B, Orhan M Tags: Eur J Ophthalmol Source Type: research

The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system
This review attempts to show that there may be a relationship between inflammatory processes induced by chronic overstimulation of the renin-angiotensin system (RAS) and the worldwide deficiency of vitamin D (VitD) and that both disorders are probably associated with environmental factors. Low VitD levels represent a risk factor for several apparently different diseases, such as infectious, autoimmune, neurodegenerative, and cardiovascular diseases, as well as diabetes, osteoporosis, and cancer. Moreover, VitD insufficiency seems to predispose to hypertension, metabolic syndrome, left ventricular hypertrophy, heart failure...
Source: AJP: Cell Physiology - June 1, 2013 Category: Cytology Authors: Ferder, M., Inserra, F., Manucha, W., Ferder, L. Tags: REVIEW Source Type: research

Moyamoya Disease in a Primarily White, Midwestern US Population: Increased Prevalence of Autoimmune Disease Brief Reports
Conclusions— This study of a unique, primarily white, Midwestern population of moyamoya patients demonstrates a significantly higher prevalence of autoimmune disease than in the general population. This supports a possible autoimmune component to the pathogenesis of moyamoya disease.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Bower, R. S., Mallory, G. W., Nwojo, M., Kudva, Y. C., Flemming, K. D., Meyer, F. B. Tags: Type 1 diabetes, Epidemiology, Other Vascular biology Brief Reports Source Type: research

Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4
by Harinder Manku, Carl D. Langefeld, Sandra G. Guerra, Talat H. Malik, Marta Alarcon-Riquelme, Juan-Manuel Anaya, Sang-Cheol Bae, Susan A. Boackle, Elizabeth E. Brown, Lindsey A. Criswell, Barry I. Freedman, Patrick M. Gaffney, Peter A. Gregersen, Joel M. Guthridge, Sang-Hoon Han, John B. Harley, Chaim O. Jacob, Judith A. James, Diane L. Kamen, Kenneth M. Kaufman, Jennifer A. Kelly, Javier Martin, Joan T. Merrill, Kathy L. Moser, Timothy B. Niewold, So-Yeon Park, Bernardo A. Pons-Estel, Amr H. Sawalha, R. Hal Scofield, Nan Shen, Anne M. Stevens, Celi Sun, Gary S. Gilkeson, Jeff C. Edberg, Robert P. Kimberly, Swapan K. Nat...
Source: PLoS Genetics - July 18, 2013 Category: Genetics & Stem Cells Authors: Harinder Manku et al. Source Type: research

Effect of Comorbidities and Psychosocial Conditions on HRQOL After Lumbar Spinal Fusion
To investigate the association between comorbidities and its impact on HRQOL scores following spinal fusion surgery. The SF-36, ODI and rating scales (0 to 10) for back and leg pain were administered prospectively to patients who had lumbar spine fusion. Data on 12 medical (diabetes, heart disease, DVT/PVD, hypertension, cancer, kidney disease, asthma, autoimmune diseases, osteoarthritis, osteoporosis, and stroke) and 5 psychosocial conditions (depression, anxiety, obesity, smoking status, and worker's compensation status) were collected. A Generalized Linear Model was created to test the impact of these comorbidities on ...
Source: Annals of Epidemiology - August 20, 2013 Category: Epidemiology Authors: N. Das, S.D. Glassman, M. Djurasovic, K.R. Bratcher, J.B. Nienhuis, L.Y. Carreon Tags: Abstracts Source Type: research

Crosstalk between platelets and the complement system in immune protection and disease.
Abstract Platelets have a central function in repairing vascular damage and stopping acute blood loss. They are equally central to thrombus formation in cardiovascular diseases such as myocardial infarction and ischaemic stroke. Beyond these classical prothrombotic diseases, immune mediated pathologies such as haemolytic uraemic syndrome (HUS) or paroxysmal nocturnal haemoglobinuria (PNH) also feature an increased tendency to form thrombi in various tissues. It has become increasingly clear that the complement system, part of the innate immune system, has an important role in the pathophysiology of these diseases....
Source: Thrombosis and Haemostasis - September 5, 2013 Category: Hematology Authors: Langer H, Verschoor A Tags: Thromb Haemost Source Type: research

The role of nutrition, nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension.
Abstract Macronutrient and micronutrient deficiencies are very common in the general population and may be even more common in patients with hypertension and cardiovascular disease due to genetic or environmental causes and prescription drug use. These deficiencies will have an enormous impact on present and future cardiovascular health and outcomes, such as hypertension, myocardial infarction, stroke and renal disease, and on overall health costs. The diagnosis and treatment of these nutrient deficiencies can reduce blood pressure; improve vascular health, endothelial dysfunction, and vascular biology; and decrea...
Source: Alternative Therapies in Health and Medicine - September 20, 2013 Category: Complementary Medicine Authors: Houston MC Tags: Altern Ther Health Med Source Type: research

Autoimmune gabab antibody encephalitis associated with non-malignant lung lesion
GABAb receptor autoimmune encephalitis is a potentially treatable disorder characterised by seizures, memory deficits, increased anxiety and mood dysregulation. In some patients it is associated with small–cell lung cancer and with other autoantibodies. We are presenting a case of GABAb receptor autoimmune encephalitis which was associated with non–malignant lung lesion, likely inflammatory in nature. A 62 year old woman presented with recent onset depression and tonic–clonic seizures. CT head showed patchy white matter changes particularly in the left frontal lobe. Initial treatment for suspected infecti...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Wysota, B., Teare, L., Karim, A., Jacob, S. Tags: Immunology (including allergy), Epilepsy and seizures, Infection (neurology), Stroke, Drugs: psychiatry, Memory disorders (psychiatry), Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics) Association of British Neurologists (AB Source Type: research