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Nutrition: Potassium

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Total 378 results found since Jan 2013.

The Potassium SK Channel Activator NS309 Protects Against Experimental Traumatic Brain Injury Through Anti-Inflammatory and Immunomodulatory Mechanisms
Neuroinflammation plays important roles in neuronal cell death and functional deficits after TBI. Small conductance Ca2+-activated K+ channels (SK) have been shown to be potential therapeutic targets for treatment of neurological disorders, such as stroke and Parkinson’s disease (PD). The aim of the present study was to investigate the role of SK channels in an animal model of TBI induced by controlled cortical impact (CCI). The SK channels activator NS309 at a concentration of 2 mg/kg was administered by intraperitoneal injection, and no obviously organ-related toxicity of NS309 was found in Sprague-Dawley (SD) rats. Tr...
Source: Frontiers in Pharmacology - November 28, 2019 Category: Drugs & Pharmacology Source Type: research

Top 10 Health Questions America Asked Dr. Google In 2019
(CNN) — Google users in the United States had a lot of questions about blood pressure, the keto diet and hiccups in 2019. Those topics were among the 10 most-searched health-related questions on the search engine this year, according to new data from Google. The list was based on search terms collected between January and early December. Last year, the top health-related questions Googled by people in the US included what is amyotrophic lateral sclerosis, or ALS, what is endometriosis and how long does weed stay in your urine. In 2017, what is lupus, how long does the flu last and what causes hiccups were some of the...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 12, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Google Source Type: news

Admission glucose level was associated with increased short-term mortality and length-of-stay irrespective of diagnosis, treating medical specialty or concomitant laboratory values.
CONCLUSIONS: Short-term mortality increased substantially with admission hypo- and hyperglycemia for patients both with and without diabetes, irrespective of treating medical specialty, main discharge diagnosis, or concurrent laboratory values. Patients with diabetes (16%) were older, with higher glucose levels at admission, and with a different pattern of the association of admission glucose and mortality. PMID: 31982283 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - January 21, 2020 Category: Internal Medicine Authors: Björk M, Melin EO, Frisk T, Thunander M Tags: Eur J Intern Med Source Type: research

Synthesis, Molecular Modeling of Novel Substituted Pyridazinones and Their Vasorelaxant activities.
Abstract BACKGROUND: Hypertension, one of the most common cardiovascular diseases that can cause coronary disease, stroke, myocardial infarction and sudden death, it is the major contributor to cardiac failure as well as renal insufficiency. OBJECTIVES: As there are many cardio-active pyridazinone-base derivatives in clinical use, therefore, it we aimed to synthesize a new series of pyridazin-3-ones and evaluate their vasorelaxant activity. METHODS: The new series of synthesized compounds were carried out first by synthesis of 6-flouroarylpyridazinones by cyclization of 3-(4-flourobenzoyl) propionic acid...
Source: Medicinal Chemistry - March 26, 2020 Category: Chemistry Authors: Ismail M, Soliman D, Elmoniem MHA, Jaleel GARA Tags: Med Chem Source Type: research

Critical review of nutrition, blood pressure and risk of hypertension through the lifecycle: do B vitamins play a role?
Abstract Hypertension is the leading cause of preventable mortality worldwide, contributing to over 9 million deaths per annum, predominantly owing to cardiovascular disease. The association of obesity, physical inactivity and alcohol with elevated blood pressure (BP) is firmly established. Weight loss or other dietary strategies, such as the Dietary Approaches to Stop Hypertension (DASH) diet, have been shown to be effective in lowering BP. Additionally, specific nutrients are recognised to contribute to BP, with higher sodium intake linked with an increased risk of hypertension, while potassium is associated wit...
Source: Biochimie - April 10, 2020 Category: Biochemistry Authors: Psara E, Pentieva K, Ward M, McNulty H Tags: Biochimie Source Type: research

Potassium binders for chronic hyperkalaemia in people with chronic kidney disease.
CONCLUSIONS: Evidence supporting clinical decision-making for different potassium binders to treat chronic hyperkalaemia in adults with CKD is of low certainty; no studies were identified in children. Available studies have not been designed to measure treatment effects on clinical outcomes such as cardiac arrhythmias or major GI symptoms. This review suggests the need for a large, adequately powered study of potassium binders versus placebo that assesses clinical outcomes of relevance to patients, clinicians and policy-makers. This data could be used to assess cost-effectiveness, given the lack of definitive studies and t...
Source: Cochrane Database of Systematic Reviews - June 25, 2020 Category: General Medicine Authors: Natale P, Palmer SC, Ruospo M, Saglimbene VM, Strippoli GF Tags: Cochrane Database Syst Rev Source Type: research

Low serum potassium levels are associated with the risk of atrial fibrillation.
CONCLUSION: We found that low serum potassium levels of less than 3.5 mmol/l are associted with increased risk of AF. PMID: 32723154 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - July 30, 2020 Category: Cardiology Tags: Acta Cardiol Source Type: research

Sodium Fluctuations in Astroglia and Their Potential Impact on Astrocyte Function
Astrocytes are the main cell type responsible for the regulation of brain homeostasis, including the maintenance of ion gradients and neurotransmitter clearance. These processes are tightly coupled to changes in the intracellular sodium (Na+) concentration. While activation of the sodium-potassium-ATPase (NKA) in response to an elevation of extracellular K+ may decrease intracellular Na+, the cotransport of transmitters, such as glutamate, together with Na+ results in an increase in astrocytic Na+. This increase in intracellular Na+ can modulate, for instance, metabolic downstream pathways. Thereby, astrocytes are capable ...
Source: Frontiers in Physiology - August 11, 2020 Category: Physiology Source Type: research

Long Non-Coding KCNQ1OT1 Promotes Oxygen-Glucose-Deprivation/Reoxygenation-Induced Neurons Injury Through Regulating MIR-153-3p/FOXO3 Axis
In this study, we aimed to investigate the role of LncRNA-Potassium Voltage-Gated Channel Subfamily Q Member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) in cerebral I/R induced neuronal injury, and its underlying mechanisms. Methods: Primary mouse cerebral cortical neurons treated with oxygen-glucose deprivation and reoxygenation (OGD/R) in vitro and mice subjected to middle cerebral artery occlusion (MCAO) and reperfusion were used to mimic cerebral I/R injury.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2020 Category: Neurology Authors: Hua-Jun Wang, Xia-Lin Tang, Gan Huang, Ying-Bin Li, Rui-Huan Pan, Jie Zhan, Ye-Kun Wu, Jian-Feng Liang, Xiao-xin Bai, Jun Cai Source Type: research

Electrophysiological effects of non-vitamin K antagonist oral anticoagulants on atrial repolarizing potassium channels
Conclusion  Apixaban, dabigatran, edoxaban, and rivaroxaban did not exhibit direct functional interactions with human atrial K+ channels underlyingIKr,IKur,Ito,IK1, andIK2P currents that could account for beneficial clinical outcome associated with the drugs. Indirect or chronic effects and potential underlying signalling mechanisms remain to be investigated.
Source: Europace - July 17, 2020 Category: Cardiology Source Type: research

Neocortical in vivo focal and spreading potassium responses and the influence of astrocytic gap junctional coupling.
Abstract Raised extracellular potassium ion (K+) concentration is associated with several disorders including migraine, stroke, neurotrauma and epilepsy. K+ spatial buffering is a well-known mechanism for extracellular K+ regulation/distribution. Astrocytic gap junction-mediated buffering is a controversial candidate for K+ spatial buffering. To further investigate the existence of a K+ spatial buffering and to assess the involvement of astrocytic gap junctional coupling in K+ redistribution, we hypothesized that neocortical K+ and concomitant spreading depolarization (SD)-like responses are controlled by powerful...
Source: Neurobiology of Disease - November 2, 2020 Category: Neurology Authors: EbrahimAmini A, Bazzigaluppi P, Aquilino MS, Stefanovic B, Carlen PL Tags: Neurobiol Dis Source Type: research

Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood –Brain Barrier in vivo and in vitro
Ischemia/reperfusion injury is a major cause of acute kidney injury (AKI). AKI is characterized by a sudden decrease in kidney function, systemic inflammation, oxidative stress, and dysregulation of the sodium, potassium, and water channels. While AKI leads to uremic encephalopathy, epidemiological studies have shown that AKI is associated with a subsequent risk for developing stroke and dementia. To get more insights into kidney–brain crosstalk, we have created an in vitro co-culture model based on human kidney cells of the proximal tubule (HK-2) and brain microvascular endothelial cells (BMEC). The HK-2 cell line was g...
Source: Frontiers in Physiology - November 12, 2020 Category: Physiology Source Type: research

Network Pharmacology-Based Analysis of Xiao-Xu-Ming Decoction on the Treatment of Alzheimer ’s Disease
In conclusion, XXMD was found to have the potential to treat AD by targeting multiple AD-related targets and canonical pathways. Fangchinoline and dauricine might be the potential lead compounds in XXMD for the treatment of AD.
Source: Frontiers in Pharmacology - December 4, 2020 Category: Drugs & Pharmacology Source Type: research

Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling.
Authors: Fomina AF, Nguyen HM, Wulff H Abstract In the last 5 years inhibitors of the potassium channel KV1.3 have been shown to reduce neuroinflammation in rodent models of ischemic stroke, Alzheimer's disease, Parkinson's disease and traumatic brain injury. At the systemic level these beneficial actions are mediated by a reduction in microglia activation and a suppression of pro-inflammatory cytokine and nitric oxide production. However, the molecular mechanisms for the suppressive action of KV1.3 blockers on pro-inflammatory microglia functions was not known until our group recently demonstrated that KV1.3 chan...
Source: Channels - December 29, 2020 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

The KATP channel opener, nicorandil, ameliorates brain damage by modulating synaptogenesis after ischemic stroke
by Yuanzheng Zhao, Zhuoying Yang, Yuanhong He, Ruonan Sun, Heping Yuan With population growth and aging, more and more patients with cerebral infarction have varying degrees of disability. ATP-sensitive potassium (KATP) channels regulate many cellular functions by coupling metabolic status with cell membrane electrical activity. Nicorandil (N-(2-hydroxyethyl)-nicotin amide nitrate) is the first KATP channel opener approved for clinical use. It has been reported that it might exert protective effects on the cerebral infarction by increasing cerebral blood flow and reducing inflammation. However, only a few studies explored...
Source: PLoS One - January 26, 2021 Category: Biomedical Science Authors: Yuanzheng Zhao Source Type: research