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Nutrition: Potassium

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Total 378 results found since Jan 2013.

Analysis of the clinical features and risk factors of kidney injury in patients with chronic heart failure-a retrospective cohort study
CONCLUSIONS: Kidney injury occurred in more than half of the patients with CHF during hospitalization. The independent risk factors for kidney injury in the CHF patients included sex (male), hypertension, and stroke. Kidney injury was positively correlated with age and serum potassium, and negatively correlated with serum albumin, hemoglobin concentration, LVEF, and ARB application.PMID:37559657 | PMC:PMC10407521 | DOI:10.21037/jtd-23-1016
Source: Journal of Thoracic Disease - August 10, 2023 Category: Respiratory Medicine Authors: Xiaoran Shen Hongliang Guo Guglielmo Mantica Hui Yuan Source Type: research

The effect of ramipril and telmisartan on serum potassium and its association with cardiovascular and renal events: Results from the ONTARGET trial
Conclusions With the precautions stipulated by the protocol of the ONTARGET trial, hypokalemia and hyperkalemia were infrequent events. Nevertheless, both high and low serum potassium were associated with an increased risk of cardiovascular and renal disease.
Source: European Journal of Preventive Cardiology - February 19, 2014 Category: Cardiology Authors: Heerspink, H. J. L., Gao, P., Zeeuw, D. d., Clase, C., Dagenais, G. R., Sleight, P., Lonn, E., Teo, K. T., Yusuf, S., Mann, J. F. Tags: Original scientific papers Source Type: research

Tweaking potassium levels in brain could be a key to fighting Huntington's disease
By boosting the ability of a specific type of cell to absorb potassium in the brain, UCLA researchers were able to improve walking and prolong survival in a mouse model of Huntington's disease.   Their findings, published March 30 in the online edition of the journal Nature Neuroscience, could point to new drug targets for treating the devastating disease, which strikes one in every 20,000 Americans.   Huntington's disease is passed from parent to child through a mutation in the huntingtin gene. By killing brain cells called neurons, the disorder gradually deprives patients of their ability to walk, speak, sw...
Source: UCLA Newsroom: Health Sciences - March 31, 2014 Category: Universities & Medical Training Source Type: news

Potassium in brain could be key to fighting Huntington's disease
By boosting the ability of a specific type of cell to absorb potassium in the brain, UCLA researchers were able to improve walking and prolong survival in a mouse model of Huntington's disease.   Their findings, published March 30 in the online edition of the journal Nature Neuroscience, could point to new drug targets for treating the devastating disease, which strikes one in every 20,000 Americans.   Huntington's disease is passed from parent to child through a mutation in the huntingtin gene. By killing brain cells called neurons, the disorder gradually deprives patients of their ability to walk, speak, swallow, breat...
Source: UCLA Newsroom: Health Sciences - March 31, 2014 Category: Universities & Medical Training Source Type: news

Hemin inhibits the large conductance potassium channel in brain mitochondria: A putative novel mechanism of neurodegeneration.
Abstract Intracerebral hemorrhage (ICH) is a pathological condition that accompanies certain neurological diseases like hemorrhagic stroke or brain trauma. Its effects are severely destructive to the brain and can be fatal. There is an entire spectrum of harmful factors which are associated with the pathogenesis of ICH. One of them is a massive release of hemin from the decomposed erythrocytes. It has been previously shown, that hemin can inhibit the large-conductance Ca(2+)-regulated potassium channel in the plasma membrane. However, it remained unclear whether this phenomenon applies also to the mitochondrial la...
Source: Experimental Neurology - April 30, 2014 Category: Neurology Authors: Augustynek B, Kudin AP, Bednarczyk P, Szewczyk A, Kunz WS Tags: Exp Neurol Source Type: research

The Imbalance of Sodium and Potassium Intake: Implications for Dietetic Practice
Currently, ∼90% of Americans consume excess sodium and virtually everyone consumes inadequate potassium. Randomized control trials and epidemiologic studies have demonstrated that higher sodium intake and lower potassium intake are modifiable risk factors for elevated blood pressure and hypertension, in addition to excess body weight, nonadherence to a Dietary Approaches to Stop Hypertension (DASH) eating plan, lack of physical activity, and excess alcohol consumption. Nonmodifiable risk factors include age and family history. High blood pressure is a leading risk factor for heart disease and stroke, which are both leadi...
Source: Journal of the American Dietetic Association - April 17, 2014 Category: Nutrition Authors: Jessica Lee Levings, Janelle Peralez Gunn Tags: Topics of Professional Interest Source Type: research

Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice.
Conclusion:Chronic administration of dl-PHPB improves learning and memory and promotes LTP in the animal models of Alzheimer's disease, possibly via increasing p-GluN2B expression in the hippocampus. PMID: 24858312 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - May 26, 2014 Category: Drugs & Pharmacology Authors: Li PP, Wang WP, Liu ZH, Xu SF, Lu WW, Wang L, Wang XL Tags: Acta Pharmacol Sin Source Type: research

The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration.
Abstract Potassium channels can fulfill both beneficial and detrimental roles in neuronal damage during ischemic stroke. Earlier studies have characterized a neuroprotective role of the two-pore domain potassium channels KCNK2 (TREK1) and KCNK3 (TASK1). Protective neuronal hyperpolarization and prevention of intracellular Ca(2+) overload and glutamate excitotoxicity were suggested to be the underlying mechanisms. We here identify an unexpected role for the related KCNK5 channel in a mouse model of transient middle cerebral artery occlusion (tMCAO). KCNK5 is strongly upregulated on neurons upon cerebral ischemia, w...
Source: Pflugers Archiv : European Journal of Physiology - October 15, 2014 Category: Physiology Authors: Göb E, Bittner S, Bobak N, Kraft P, Göbel K, Langhauser F, Homola GA, Brede M, Budde T, Meuth SG, Kleinschnitz C Tags: Pflugers Arch Source Type: research

Erythropoietin attenuates loss of potassium chloride co-transporters following prenatal brain injury
Publication date: July 2014 Source:Molecular and Cellular Neuroscience, Volume 61 Author(s): L.L. Jantzie , P.M. Getsy , D.J. Firl , C.G. Wilson , R.H. Miller , S. Robinson Therapeutic agents that restore the inhibitory actions of γ-amino butyric acid (GABA) by modulating intracellular chloride concentrations will provide novel avenues to treat stroke, chronic pain, epilepsy, autism, and neurodegenerative and cognitive disorders. During development, upregulation of the potassium-chloride co-transporter KCC2, and the resultant switch from excitatory to inhibitory responses to GABA guide the formation of essential inhibit...
Source: Molecular and Cellular Neuroscience - November 3, 2014 Category: Neuroscience Source Type: research

Urinary Potassium Excretion and Renal and Cardiovascular Complications in Patients with Type 2 Diabetes and Normal Renal Function.
CONCLUSIONS: Higher urinary potassium excretion was associated with the slower decline of renal function and the lower incidence of cardiovascular complications in type 2 diabetic patients with normal renal function. Interventional trials are necessary to determine whether increasing dietary potassium is beneficial. PMID: 26563378 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - November 12, 2015 Category: Urology & Nephrology Authors: Araki SI, Haneda M, Koya D, Kondo K, Tanaka S, Arima H, Kume S, Nakazawa J, Chin-Kanasaki M, Ugi S, Kawai H, Araki H, Uzu T, Maegawa H Tags: Clin J Am Soc Nephrol Source Type: research