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Nutrition: Potassium

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Total 378 results found since Jan 2013.

Loop Diuretics Inhibit Ischemia-Induced Intracellular Ca2+ Overload in Neurons via the Inhibition of Voltage-Gated Ca2+ and Na+ Channels
One consequence of ischemic stroke is disruption of intracellular ionic homeostasis. Intracellular overload of both Na+ and Ca2+ has been linked to neuronal death in this pathophysiological state. The etiology of ionic imbalances resulting from stroke-induced ischemia and acidosis includes the dysregulation of multiple plasma membrane transport proteins, such as increased activity of sodium-potassium-chloride cotransporter-1 (NKCC-1). Experiments using NKCC1 antagonists, bumetanide (BMN) and ethacrynic acid (EA), were carried out to determine if inhibition of this cotransporter affects Na+ and Ca2+ overload observed follow...
Source: Frontiers in Pharmacology - September 15, 2021 Category: Drugs & Pharmacology Source Type: research

Urinary element profiles and associations with cardiometabolic diseases: A cross-sectional study across ten areas in China
CONCLUSION: In China, the urinary levels of several toxic metals were significantly associated with the consumption of specific food groups and the risk of cardiometabolic diseases including diabetes and stroke.PMID:34896320 | DOI:10.1016/j.envres.2021.112535
Source: Environmental Research - December 13, 2021 Category: Environmental Health Authors: Lijiao Xu Yunan Liu Qianyu Zhao Huaidong Du Ying Gao Meijuan Bai Jun Lv Yu Guo Liming Li Liang Sun Xu Lin Zhengming Chen Yan Chen Geng Zong Source Type: research

How Heat Waves Could Have Long-Term Impacts on Your Health
Health officials from the U.S., the U.K., Europe, and Japan have been warning residents to stay out of the sun as the northern hemisphere experiences some of the highest early summer temperatures ever recorded. It’s not just to prevent heat-stroke, but to prevent the long-term consequences as well. As climate change drives summer temperatures even higher than usual, medical researchers are starting to find links between sustained heat exposure and chronic health conditions ranging from diabetes to kidney stones, cardiovascular disease and even obesity. “While increased risk for heat stroke is an obvious manifes...
Source: TIME: Health - July 13, 2022 Category: Consumer Health News Authors: Aryn Baker Tags: Uncategorized climate change Climate Is Everything Evergreen healthscienceclimate Londontime overnight Source Type: news

Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women
CONCLUSIONS: When compared to regular salt, LSSS probably reduce blood pressure, non-fatal cardiovascular events and cardiovascular mortality slightly in adults. However, LSSS also probably increase blood potassium slightly in adults. These small effects may be important when LSSS interventions are implemented at the population level. Evidence is limited for adults without elevated blood pressure, and there is a lack of evidence in pregnant women and people in whom an increased potassium intake is known to be potentially harmful, limiting conclusions on the safety of LSSS in the general population. We also cannot draw firm...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Amanda Brand Marianne E Visser Anel Schoonees Celeste E Naude Source Type: research

LncRNA KCNQ1OT1 predicts further cerebral events in patients with transient ischemic attack
Transient ischemic attack (TIA) poses a great threat of cerebrovascular diseases to a large number of patients, despite its reversible neurological dysfunction. Long non-coding RNAs (lncRNAs) have been proven to play critical roles in the pathophysiological development of cerebrovascular events. Exploring the function of lncRNAs in modulating TIA prognosis would help to develop individualized therapeutics. A total of 231 participants with the first onset of TIA were recruited in the study, including 65 subsequent stroke patients. The expression of lncRNA potassium voltage-gated channel subfamily Q member 1 opposite strand ...
Source: Frontiers in Pharmacology - October 7, 2022 Category: Drugs & Pharmacology Source Type: research

Reducing Salt And Increasing Potassium Will Have Major Global Health Benefits
Results have helped develop first WHO guidelines on potassium intake Cutting down on salt and, at the same time, increasing levels of potassium in our diet will have major health and cost benefits across the world, according to studies published on bmj.com today. Such a strategy will save millions of lives every year from heart disease and stroke, say experts. Much evidence shows that reducing salt intake lowers blood pressure and thereby reduces the risk of stroke and heart disease...
Source: Health News from Medical News Today - April 5, 2013 Category: Consumer Health News Tags: Nutrition / Diet Source Type: news

Effect of increased potassium intake on cardiovascular risk factors and disease: systematic review and meta-analyses
Salt seems to get the most press, but potassium is an important player in the prevention of vascular disease. This systematic review of 22 RCTs and 11 cohort studies shows that systolic blood pressure was reduced by 7.16 (1.91 to 12.41) mm Hg when the potassium intake was 90-120 mmol/day, without any dose response. Furthermore, there was a 24% lower risk of stroke. The results suggest that patients without impaired renal excretion of potassium would potentially see the most benefit with respect to hypertension and stroke prevention with increased potassium intake. : Effect of lower sodium intake on health: systematic revi...
Source: Nephrology Now - July 15, 2013 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: General Nephrology Hypertension Source Type: research

Dietary potassium: A key mediator of the cardiovascular response to dietary sodium chloride
Abstract: Potassium and sodium share a yin/yang relationship in the regulation of blood pressure (BP). BP is directly associated with the total body sodium and negatively correlated with the total body potassium. Epidemiologic, experimental, and clinical studies have shown that potassium is a significant regulator of BP and further improves cardiovascular outcomes. Hypertensive cardiovascular damage, stroke, and stroke-related death are accelerated by salt intake but might be curbed by increasing dietary potassium intake. The antihypertensive effect of potassium supplementation appears to occur through several mechanisms t...
Source: Journal of the American Society of Hypertension - June 3, 2013 Category: Cardiology Authors: Mehmet Kanbay, Yeter Bayram, Yalcin Solak, Paul W. Sanders Tags: Review Articles Source Type: research

Neuroprotective effects of potassium channel openers on cerebral ischemia –reperfusion injury in diabetic rats
Conclusion Treatment of ischemic stroke with potassium channel openers in T1DR is neuroprotective. Inhibition of apoptosis may contribute to their neuroprotective effects after stroke in T1DR.
Source: Bulletin of Faculty of Pharmacy, Cairo University - October 20, 2016 Category: Drugs & Pharmacology Source Type: research

This diet advice could kill you
The American Heart Association says sodium in salt raises blood pressure. They say it increases the risk for heart disease and stroke.  But the latest science says otherwise… A British review of 34 clinical trials showed that cutting down on salt reduced blood pressure only slightly for people with hypertension.1  And a new study in The Lancet found that some low-salt diets could put you at GREATER risk of heart disease and death.2 Researchers analyzed data from 133,118 people. They wanted to see if there was a link between high sodium and heart attack, stroke and death The results were startling. People on “he...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Randall Hall Tags: Health Heart Health Men's Health Nutrition Women's Health Source Type: news

Invited Commentary: Can Estimation of Sodium Intake Be Improved by Borrowing Information From Other Variables?
AbstractEstimation of dietary sodium intake is problematic. The most accurate measure is average sodium excretion from multiple 24-hour urine collections, but such an approach is impractical. Using data from the Women's Health Initiative, Prentice et al. (Am J Epidemiol. 2017;186(9):1035 –1043) assessed the relationship of calibrated estimates of sodium and potassium excretion with cardiovascular outcomes. The calibrated estimates were a function of self-reported sodium-to-potassium ratio from a food frequency questionnaire, age, body mass index, race, supplement use, smoking stat us, educational level, income, and aspir...
Source: American Journal of Epidemiology - June 14, 2017 Category: Epidemiology Source Type: research

The yin and yang of KV channels in cerebral small vessel pathologies
This article is protected by copyright. All rights reserved.
Source: Microcirculation - December 15, 2017 Category: Research Authors: Masayo Koide, Arash Moshkforoush, Nikolaos M. Tsoukias, David C. Hill ‐Eubanks, George C. Wellman, Mark T. Nelson, Fabrice Dabertrand Tags: Invited Reviews Source Type: research

Condition-specific transcriptional regulation of neuronal ion channel genes in brain ischemia.
The objective of this study is to identify ion channel genes that are differentially regulated under different brain ischemic conditions, as a mean to identify those ion channels that are associated with ischemic brain injury and ischemic tolerance. In mice in vivo, transient focal cerebral ischemia was induced by middle cerebral artery occlusion. In cultured neuronal cells in vitro, simulated ischemia was modeled by oxygen-glucose deprivation. For both in vivo and in vitro studies, three principal ischemic conditions were included: ischemic-preconditioned, injured and tolerant, respectively, plus appropriate controls. In ...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 21, 2018 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research