Electrophysiological effects of non-vitamin K antagonist oral anticoagulants on atrial repolarizing potassium channels

Conclusion  Apixaban, dabigatran, edoxaban, and rivaroxaban did not exhibit direct functional interactions with human atrial K+ channels underlyingIKr,IKur,Ito,IK1, andIK2P currents that could account for beneficial clinical outcome associated with the drugs. Indirect or chronic effects and potential underlying signalling mechanisms remain to be investigated.
Source: Europace - Category: Cardiology Source Type: research