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Nutrition: Chloride

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Total 498 results found since Jan 2013.

Exercise pretreatment alleviates neuroinflammation and oxidative stress by TFEB-mediated autophagic flux in mice with ischemic stroke
CONCLUSIONS: Exercise pretreatment has the potential to improve the prognosis of ischemic stroke patients, and it can exert neuroprotective effects in ischemic stroke by inhibiting neuroinflammation and oxidative stress, which might be due to the TFEB-mediated autophagic flux. And targeting autophagic flux may be promising strategies for the treatment of ischemic stroke.PMID:36914085 | DOI:10.1016/j.expneurol.2023.114380
Source: Experimental Neurology - March 13, 2023 Category: Neurology Authors: Yun Zhao Zhongqiu Hong Yao Lin Weimin Shen Yuhan Yang Zejie Zuo Xiquan Hu Source Type: research

The long-term effects of hyaluronic acid on hemiplegic shoulder pain and injury in stroke patients: A randomized controlled study
Conclusion: Subacromial HA injections might provide longer HSP reduction and decrease in hyperemia reactions at the long head of biceps tendon and subscapularis tendon in stroke patients with HSP and tendon injury.
Source: Medicine - August 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway.
CONCLUSIONS: We demonstrated that xuesaitong has long-term neuroprotective effects against ischemic stroke, possibly by promoting the polarization of microglia to an M2 phenotype and by inhibiting neuronal cell death via down-regulation of the STAT3 signaling pathway, providing new evidence that xuesaitong might be a promising therapeutic strategy for ischemic stroke. PMID: 30426907 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - November 14, 2018 Category: Drugs & Pharmacology Authors: Li F, Zhao H, Han Z, Wang R, Tao Z, Fan Z, Zhang S, Li G, Chen Z, Luo Y Tags: CNS Neurol Disord Drug Targets Source Type: research

Antioxidative neuroprotective role of iron-gallic acid coordination nanoparticles and PET/MR usage in an ischemia stroke model
Conclusions: Fe-GA CPNs exhibit an impressive antioxidative neuroprotective role in ischemia stroke, which might have the potential to be translated into clinical applications for improved treatment of patients with stroke. PET/MRI is effective and accurate method for ischemic evaluation.
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: KANG, L., Jiang, D., NI, D., Ehlerding, E., Wang, R., Cai, W. Tags: Basic Science I (Neurosciences) Source Type: research

Motor deficit in the mouse ferric chloride-induced distal middle cerebral artery occlusion model of stroke.
In this study, we reproduced the recently developed model and expanded its characterization by thorough evaluation of blood supply, cerebral infarction, and motor function in adult male and female mice up to 14 days after stroke. Our observations indicate near complete interruption of blood flow in the distal MCA shortly after application of 20% ferric chloride over the artery through a cranial window, which remained occluded for at least 4 hours. As expected, infarction of the brain tissue, documented by TTC and hematoxylin stains, was restricted to the cerebral cortex. We also systematically evaluated motor impairment ...
Source: Behavioural Brain Research - December 4, 2019 Category: Neurology Authors: Syeara N, Alamri FF, Jayaraman S, Lee P, Karamyan ST, Arumugam TV, Karamyan VT Tags: Behav Brain Res Source Type: research

Renshen Shouwu extract enhances neurogenesis and angiogenesis via inhibition of TLR4/NF¬κB/NLRP3 signaling pathway following ischemic stroke in rats
ConclusionsRSSW enhances neurogenesis and angiogenesis via inhibition of TLR4/NF¬κB/NLRP3 inflammatory signaling pathway following ischemic stroke in rats. Hence, RSSW may be a promising Chinese Medicine for the treatment of ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Renshen Shouwu extract enhances neurogenesis and angiogenesis via inhibition of TLR4/NF-κB/NLRP3 signaling pathway following ischemic stroke in rats
ConclusionsRSSW enhances neurogenesis and angiogenesis via inhibition of TLR4/NF-κB/NLRP3 inflammatory signaling pathway following ischemic stroke in rats. Hence, RSSW may be a promising Chinese Medicine for the treatment of ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - February 10, 2020 Category: Drugs & Pharmacology Source Type: research

Can the early use of botulinum toxin in post stroke spasticity reduce contracture development? A randomised controlled trial.
CONCLUSION: BoNTA reduced spasticity and contractures after stroke and effects lasted for approximately 12-weeks. BoNTA reduced the need for concomitant contracture treatment and did not interfere with recovery of arm function. TRIAL REGISTRATION: EudraCT (2010-021257-39) and ClinicalTrials.gov-Identifier: NCT01882556. PMID: 33040610 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - October 11, 2020 Category: Rehabilitation Authors: Lindsay C, Ispoglou S, Helliwell B, Hicklin D, Sturman S, Pandyan A Tags: Clin Rehabil Source Type: research

Behavioral and histopathological consequences of transient ischemic stroke in the Flinders Sensitive Line rat, a genetic animal model of depression
Brain Res. 2021 Sep 4:147648. doi: 10.1016/j.brainres.2021.147648. Online ahead of print.ABSTRACTPatients with depression have an increased risk for stroke, higher mortality rates following stroke and worse functional outcomes among survivors. Preclinical studies may help to better understand the underlying mechanisms linking these two diseases, but only a few animal studies have investigated the effects of prestroke depression. The present study investigates whether Flinders Sensitive Line (FSL) rats, a genetic depression model, respond differently to focal ischemic stroke compared to control strains (Flinders Resistant L...
Source: Brain Research - September 7, 2021 Category: Neurology Authors: Denise F Happ Gregers Wegener R Andrew Tasker Source Type: research

Infarct-preconditioning exosomes of umbilical cord mesenchymal stem cells promoted vascular remodeling and neurological recovery after stroke in rats
CONCLUSIONS: Our results demonstrated that infarct-preconditioned exosomes promoted neurological recovery after stroke by enhancing vascular endothelial remodeling, suggested that infarct-preconditioned exosomes could be a novel way to alleviate brain damage following a stroke.PMID:35902882 | DOI:10.1186/s13287-022-03083-9
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Yi-Chao Ye Zhe-Han Chang Peng Wang You-Wei Wang Jun Liang Chong Chen Jing-Jing Wang Hong-Tao Sun Yi Wang Xiao-Hong Li Source Type: research

MicroRNA-193a-5p Rescues Ischemic Cerebral Injury by Restoring N2-Like Neutrophil Subsets
In conclusion, miR-193a-5p protects against cerebral ischemic injury by restoring neutrophil N2 phenotype-associated neuroinflammation suppr ession, likely, in part, via UBE2V2 induction.
Source: Translational Stroke Research - June 29, 2023 Category: Neurology Source Type: research

SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
In this study, electrophysiological properties of chloride current in primary cultured neurons were characterized using low chloride solution, 4,4 ′-diisothiocyano-2,2′-stilbenedisulfonic acid, and SLC26A11-specific siRNA under physiological conditions or ATP-depleted conditions. In vivo effect of SLC26A11 was evaluated on a rat stroke reperfusion model. We found that SLC26A11 mRNA in primary cultured neurons was upregulated as early as 6  h after oxygen glucose deprivation, and later, the protein level was elevated accordingly. Blockade of SLC26A11 activity could reduce chloride entry and attenuate hypoxia-induced ne...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research

Responses of immune organs following cerebral ischemic stroke.
CONCLUSIONS: The present results demonstrated that stroke is a systemic disease, which not only affects the brain, but also induces responses of immune organs. On the basis of these results, a systemic treatment might be a good strategy for clinical stroke care. PMID: 32863340 [PubMed - as supplied by publisher]
Source: Journal of Nippon Medical School - August 30, 2020 Category: Universities & Medical Training Authors: Tan C, Wang Z, Zheng M, Zhao S, Shichinohe H, Houkin K Tags: J Nippon Med Sch Source Type: research