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Nutrition: Chloride

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Total 498 results found since Jan 2013.

Polyoxometalate nanoclusters act as broad-spectrum antioxidants to alleviate ischemic stroke by intrathecal injection
Conclusion: Intrathecal injection significantly improved the delivery and efficacy of POM nanoclusters to the brain, resulting in the rapid accumulation of POM nanoclusters in the ischemic penumbra. Due to this, we confirmed that the POM nanoclusters could be used as nano-antioxidants to inhibit oxidative stress as well as inflammatory damage effectively.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Rosenkrans, Z., Li, S., Jiang, D., NI, D., Engle, J., Cai, W. Tags: Center for Molecular Imaging Innovation & amp; Translation (CMIIT) YIA Symposium Source Type: research

Protective Role of Low Ethanol Administration Following Ischemic Stroke via Recovery of KCC2 and p75 NTR Expression
AbstractA striking result from epidemiological studies show a correlation between low alcohol intake and lower incidence for ischemic stroke and severity of derived brain injury. Although reduced apoptosis and inflammation has been suggested to be involved, little is known about the mechanism mediating this effect in vivo. Increase in intracellular chloride concentration and derived depolarizing GABAAR-mediated transmission are common consequences following various brain injuries and are caused by the abnormal expression levels of the chloride cotransporters NKCC1 and KCC2. Downstream pro-apoptotic signaling through p75NTR...
Source: Molecular Neurobiology - February 11, 2021 Category: Neurology Source Type: research

LncRNA-MIAT promotes neural cell autophagy and apoptosis in ischemic stroke by up-regulating REDD1
CONCLUSION: Altogether, MIAT promotes autophagy and apoptosis of neural cells and aggravates IS by up-regulating the expression of REDD1.PMID:33745924 | DOI:10.1016/j.brainres.2021.147436
Source: Brain Research - March 22, 2021 Category: Neurology Authors: Xiaqing Guo Yabo Wang Donglin Zheng Xiangshu Cheng Yuhua Sun Source Type: research

Oxytocin improves ischemic stroke by reducing expression of excitatory amino acid transporter 3 in rat MCAO model
This study investigates the neuroprotective effect of OT in an animal model of middle cerebral artery occlusion (MCAO) and the possible role of EAAT3. Transient MCAO was performed as a model of ischemic stroke in male rats and then OT was administrated intra-nasally. Infarct volume was measured by 2, 3, 5-triphenyl tetrazolium chloride staining. Nissl staining method was performed for the evaluation of neuronal cell morphology. Immunohistochemistry assay was performed to analyze the EAAT3 expression in the ischemic region. OT significantly reduced the infarct volume in the cerebral cortex and striatum after ischemia (P<...
Source: Journal of Immunoassay and Immunochemistry - March 31, 2021 Category: Biochemistry Authors: Parinaz Barahimi Mohammad Karimian Majid Nejati Abolfazl Azami Tameh Mohammad Ali Atlasi Source Type: research

Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats
Ischemic stroke continues to be a major global health problem associated with considerable mortality and morbidity. Thus, it is still targeted by researchers for developing new strategies or drugs to alleviate the lesion of stroke. In the present study, both the permanent occlusion of the middle cerebral artery (MCAO) model and the restoration of cerebral blood flow after middle cerebral artery occlusion (CI/R) model were set up for evaluating the efficiency of salvianolic acid B and ginsenoside Rg1 combination (SalB-Rg1). SalB-Rg1 decreased infarct area through 3,5-triphenyltetrazolium chloride stain and improved neurolog...
Source: NeuroReport - August 16, 2021 Category: Neurology Tags: Degeneration and Repair Source Type: research

Electroacupuncture Regulates Endoplasmic Reticulum Stress and Ameliorates Neuronal Injury in Rats with Acute Ischemic Stroke
This study aimed to determine whether endoplasmic reticulum stress (ERS) could contribute to the protective effects of EA in cerebral ischemia/reperfusion injury (CIRI) to provide a rationale for the widespread clinical use of EA. Rats were divided into the sham-operated (sham) group, the CIRI (model) group, and the EA group. Rats in the model group were subjected to middle cerebral artery occlusion (MCAO) for 2 h followed by 72 h of reperfusion. Rats with CIRI were treated daily with EA at GV20 and ST36 for a total of 3 days. The Longa scoring system and adhesive removal somatosensory test were applied to evaluate neurolo...
Source: Evidence-based Complementary and Alternative Medicine - August 26, 2021 Category: Complementary Medicine Authors: Ya-Min Zhang Hong Xu Su-Hui Chen Hua Sun Source Type: research

Protective effects of Dimethyl malonate on neuroinflammation and blood-brain barrier after ischemic stroke
Conclusions DMM could regulate activation and polarization of microglia to inhibit neuroinflammation and protect BBB.
Source: NeuroReport - September 3, 2021 Category: Neurology Tags: Degeneration and Repair Source Type: research

The neuroprotective effect and RNA ‐sequence analysis of postconditioning on the ischemic stroke with diabetes mellitus tree shrew model
ConclusionsIPOCs have a neuroprotective effect in a DMIS animal model that reduces infarct size and nerve cell injury. This mechanism might be related to reducing inflammation and stress responses that decreases the activity of TNF and NF- κB signaling pathways.
Source: Brain and Behavior - September 24, 2021 Category: Neurology Authors: Ling Zhao, Shufen Tan, Qiwei Liao, Xia Li, Tingyu Ke, Shuqing Li Tags: ORIGINAL RESEARCH Source Type: research

Molecules, Vol. 26, Pages 6365: Lack of Neuroprotective Effects of High-Density Lipoprotein Therapy in Stroke under Acute Hyperglycemic Conditions
Conclusion: We observed a nonsignificant decrease in cerebral infarct size in the HDL group. The deleterious consequences of reperfusion such as hemorrhagic transformation or inflammation were not improved by HDL infusion. In acute hyperglycemia, HDLs are not potent enough to counteract the adverse effects of hyperglycemia. The addition of antioxidants to therapeutic HDLs could improve their neuroprotective capacity.
Source: Molecules - October 21, 2021 Category: Chemistry Authors: David Couret Cynthia Planesse Jessica Patche Nicolas Diotel Brice Nativel Steeve Bourane Olivier Meilhac Tags: Article Source Type: research

Fraxetin protects rat brains from the cerebral stroke via promoting angiogenesis and activating PI3K/Akt pathway
CONCLUSION: Fraxetin has protective effects on the brain ischemia-reperfusion injury and promotes angiogenesis for cerebral repair via phosphorylation of PI3K and Akt.PMID:35285387 | DOI:10.1080/08923973.2022.2052893
Source: Immunopharmacology and Immunotoxicology - March 14, 2022 Category: Allergy & Immunology Authors: Yuhuan Cui Meihong Liu Li Zuo Haiyan Wang Jian Liu Source Type: research