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Total 498 results found since Jan 2013.

Astragaloside IV alleviates stroke-triggered early brain injury by modulating neuroinflammation and ferroptosis via the Nrf2/HO-1 signaling pathway
CONCLUSIONS: Hence, the findings of this research illustrate that AS-IV administration can improve delayed ischemic neurological deficits and decrease neuronal death by modulating nuroinflammation and ferroptosis via the Nrf2/HO-1 signaling pathway.PMID:36995819 | PMC:PMC10041803 | DOI:10.1590/acb380723
Source: Acta Cirurgica Brasileira - March 30, 2023 Category: Surgery Authors: Chunlei Zhang Zhonghua Shi Qinyi Xu Jianqing He Lei Chen Zehua Lu Qiaohua Huan Yuhai Wang Gang Cui Source Type: research

An alternative surgical approach reduces variability following filament induction of experimental stroke in mice RESOURCE ARTICLE
ABSTRACT Animal models are essential for understanding the pathology of stroke and investigating potential treatments. However, in vivo stroke models are associated, particularly in mice, with high variability in lesion volume. We investigated whether a surgical refinement where reperfusion is not reliant on the Circle of Willis reduced outcome variability. Mice underwent 60 min of transient middle cerebral artery occlusion avoiding ligation of the external carotid artery. During reperfusion, the common carotid artery was either ligated (standard approach), or it was repaired to allow re-establishment of blood flow th...
Source: DMM Disease Models and Mechanisms - July 5, 2017 Category: Biomedical Science Authors: Trotman-Lucas, M., Kelly, M. E., Janus, J., Fern, R., Gibson, C. L. Tags: RESOURCE ARTICLE Source Type: research

Inhibition of SNK ‐SPAR signaling pathway promotes the restoration of motor function in a rat model of ischemic stroke
This study aimed to investigate the effects of SPAR signaling pathway on the restoration of motor function in ischemic stroke (IS). Sprague‐Dawley male rats were separated into the control and sham groups, as well as the group for middle cerebral artery occlusion (MCAO) model establishment. Successfully established rat ischemic models were randomly divided into model, SNKMCAO‐del and pcDNA3.1‐SNK groups. The evaluation of motor function among the rats in each group was assessed using a balance beam, a screen test and the Garcia scoring method. CatWalk gait analysis was employed to evaluate the effect of the SNK signa...
Source: Journal of Cellular Biochemistry - July 11, 2017 Category: Biochemistry Authors: Qing ‐Yu Fan, Jing‐Jie Liu, Gui‐Lian Zhang, Hai‐Qin Wu, Ru Zhang, Shu‐Qin Zhan, Na Liu Tags: Article Source Type: research

Effects of High- Versus Moderate-Intensity Training on Neuroplasticity and Functional Recovery After Focal Ischemia Basic Sciences
Conclusions—Low-volume HIT based on lactate threshold seems to be more effective after cerebral ischemia than work-matched MOD to improve aerobic fitness and grip strength and might promote cerebral plasticity.
Source: Stroke - September 25, 2017 Category: Neurology Authors: Caroline Pin–Barre, Annabelle Constans, Jeanick Brisswalter, Christophe Pellegrino, Jerome Laurin Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke.
This study underlines a key role of CCR2- and CX3CR1-expressing immune cells in the neuropathology associated with ischemic injuries. PMID: 29545116 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - March 12, 2018 Category: Neurology Authors: Cisbani G, Le Behot A, Plante MM, Préfontaine P, Lecordier M, Rivest S Tags: Brain Behav Immun Source Type: research

A Novel Model for Studying Voltage-Gated Ion Channel Gene Expression during Reversible Ischemic Stroke.
In conclusion, to our knowledge, this is the first report of the successful evaluation of voltage-gated ion channel gene expression in TIA and RIND animal models. This model will aid future studies in investigating pathophysiological mechanisms, and in developing new therapeutic compounds for the treatment of TIA and RIND. PMID: 30662329 [PubMed - in process]
Source: International Journal of Medical Sciences - January 22, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Stable isotope labeling derivatization and magnetic dispersive solid phase extraction coupled with UHPLC-MS/MS for the measurement of brain neurotransmitters in post-stroke depression rats administrated with gastrodin.
Abstract Synchronous measurement of brain neurotransmitters and blood drug metabolism by dual sites in vivo microdialysis can provide very important information for several neurological disorders such as post-stroke depression (PSD). In this work, d0/d3-6-N-methyl-rhodamine 6G-N-hydroxysuccinimidyl formate (d0/d3-MRSF) were firstly designed, synthesized and used as stable isotope labeling derivatization reagents for the determination of multiple neurotransmitters by ultra-high performance liquid chromatography-tandem mass spectrometry. The light d0-MRSF was used to label neurotransmitters in real samples and the ...
Source: Analytica Chimica Acta - January 23, 2019 Category: Chemistry Authors: Zhao XE, He Y, Zhu S, Xu Y, You J, Bai Y, Liu H Tags: Anal Chim Acta Source Type: research

Nitrogen-doped carbon nanocages and human umbilical cord mesenchymal stem cells cooperatively inhibit neuroinflammation and protect against ischemic stroke
This study aimed to explore the synergistic effects of nitrogen-doped carbon nanocages (NCNCs) and human umbilical cord mesenchymal stem cells (HUC-MSCs) on ischemic stroke and investigate the potential underlying mechanisms.Main methodsThe properties of NCNCs were analyzed by transmission electron microscopy, and the markers of HUC-MSCs were detected by flow cytometry. The cell toxicity of NCNCs was evaluated by MTT. Mice were induced cerebral infarction by transient middle cerebral artery occlusion (MCAO). NCNCs or HUC-MSCs or HUC-MSCs-NCNCs were intravenously injected thirty minutes after reperfusion. The infarct volume...
Source: Neuroscience Letters - June 21, 2019 Category: Neuroscience Source Type: research

Polyacrylic acid-coated nanoparticles loaded with recombinant tissue plasminogen activator for the treatment of mice with ischemic stroke.
Abstract Nanoparticle-based thrombolysis is a potential new treatment for stroke. The aim of this study was to investigate the efficacy of targeted thrombolysis using recombinant tissue plasminogen activator (rtPA). The rtPA was covalently bound to magnetic nanoparticles (MNP) and maintained at the target site using an external magnet. Polyacrylic acid (PAA)-coated MNP were synthesized and rtPA was then bound to the resultant PAA-MNP via carbodiimide-mediated amide bonds. For the in vitro tests, blood clots were formed in plastic centrifuge tubes with anti-coagulated plasma, thrombin and calcium chloride. For the...
Source: Biochemical and Biophysical Research communications - June 20, 2019 Category: Biochemistry Authors: Huang L, Wang J, Huang S, Siaw-Debrah F, Nyanzu M, Zhuge Q Tags: Biochem Biophys Res Commun Source Type: research

Longitudinal investigation of ischemic stroke using magnetic resonance imaging: Animal model.
CONCLUSIONS: The MCAO animal model was successfully established on SD rats using the microsurgery to assess arterial embolization of intracranial tissue injury. PMID: 31306147 [PubMed - as supplied by publisher]
Source: Journal of X-Ray Science and Technology - July 16, 2019 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Astragaloside IV regulates the HIF/VEGF/Notch signaling pathway through miRNA-210 to promote angiogenesis after ischemic stroke.
CONCLUSIONS: AS-IV promotes cerebral protection following angiogenesis and ischemic brain injury. The specific mechanism was activating the HIF/VEGF/Notch signaling pathway via miRNA-210. PMID: 32417803 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - May 19, 2020 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research