Caveolin-1's dual impact on endometrioid endometrial carcinoma: a histopathological and immunohistochemical study
The objectives of this study are to evaluate caveolin-1 expression in endometrioid endometrial cancer and its correlation with clinicopathological parameters. Forty-four cases of endometrioid endometrial carcinomas underwent radical hysterectomy. The archived paraffin sections that were stained for caveolin-1 by immunohistochemistry, caveolin-1 expression were detected in cancerous epithelial cells in 18.2% of the cases, and stromal caveolin-1 was detected in 65.9% of the cases. Caveolin-1 expression in the epithelium showed a significant positive association with the T stage and the FIGO stage. Positive caveolin-1 express...
Source: Journal of Immunoassay and Immunochemistry - April 17, 2024 Category: Biochemistry Authors: Rania Mohamed Sabry Samira Abdallah Mahmoud Mona SalahEldin Abdelmagid Somia Abdellatif Mahmoud Yasmine Yassin Ahmed Source Type: research

Prognostic significance of E-Cadherin and B-Catenin in non-muscle invasive bladder cancer
J Immunoassay Immunochem. 2024 Apr 1:1-10. doi: 10.1080/15321819.2024.2335154. Online ahead of print.ABSTRACTNon muscle invasive bladder cancer (NMIBC) has unpredictable outcomes with a variable risk of recurrence and progression. Many clinic-pathological prognostic factors have been identified but remain insufficient, raising the need to investigate new biomarkers. The aim of our study was to assess the prognostic value of the immunohistochemical (IHC) markers E-Cadherin and B-Catenin in NMIBC. All cases of NMIBC were collected between 2008 and 2013. IHC analysis was performed using E-Cadherin and B-Catenin. Reduced or lo...
Source: Journal of Immunoassay and Immunochemistry - April 2, 2024 Category: Biochemistry Authors: Sarra Ben Rejeb Nadia Kouki Dorra Ben Ghachem Hassen Khouni Khadija Bellil Source Type: research

Mutations at the conserved N-Terminal of the human Rhinovirus capsid gene VP4, and their impact on the immune response
J Immunoassay Immunochem. 2024 Mar 29:1-21. doi: 10.1080/15321819.2024.2323460. Online ahead of print.ABSTRACTRhinoviruses (RV) are the major cause of chronic obstructive pulmonary disease and are associated with exacerbation development as well as community-acquired pneumonia in children, leading to substantial morbidity, mortality, and hospital admission. Here we have examined how changes at the amino terminal of the conserved VP4 epitope of different RV serotypes may affect pulmonary cytokine and chemokine responses and disease severity. Samples positive for rhinovirus were used for genetic characterization, followed by...
Source: Journal of Immunoassay and Immunochemistry - March 29, 2024 Category: Biochemistry Authors: Asif Naeem Haitham S Alkadi Muhammad U Manzoor Imran Yousaf Maaweya Awadalla Wael Alturaiki Ahmad S AlYami Adnan Zafar Bandar Alosaimi Source Type: research