Immunohistochemical analysis of myeloperoxidase expression in cutaneous leucocytoclastic vasculitis
This study aimed to detect MPO in cutaneous leukocytoclastic vasculitis (LCV) using immunohistochemistry. We retrospectively collected 22 confirmed cases of skin LCV diagnosed in our pathology department over 11 years (2012-2023). Immunohistochemistry was performed using anti-myeloperoxidase antibody (Leica clone 59A5) on the LeicaBond MAX automated system, following manufacturer's instructions. Two pathologists assessed immunohistochemical staining, scoring intensity as weak (+), moderate (++), or strong (+++). Patients' mean age was 56.9 years, with a male-to-female ratio of 1.18. Pathologically, vasculitis involved smal...
Source: Journal of Immunoassay and Immunochemistry - January 23, 2024 Category: Biochemistry Authors: Sarra Ben Rejeb Dorsaf Beltaifa Yasmine Ben Romdhane Khadija Bellil Source Type: research

Toll-like receptor 7 and tumor necrosis factor alpha polymorphisms in Egyptian patients with autoimmune thyroid diseases
J Immunoassay Immunochem. 2024 Jan 4:1-19. doi: 10.1080/15321819.2023.2294298. Online ahead of print.ABSTRACTHashimoto's thyroiditis (HT) and Graves' disease (GD) susceptibility depends on a complex interaction between environmental and genetic factors. Genes for tumor necrosis factor alpha (TNF-α) and toll-like receptors (TLRs) have been incorporated into the pathophysiology of autoimmune disorders. Our aim is to assess the association between TLR7 (rs179009) and TNF-α (rs1800629) polymorphisms and susceptibility to autoimmune thyroid disorders. One-hundred ninety-nine individuals, divided into 68 HT patients in group I...
Source: Journal of Immunoassay and Immunochemistry - January 4, 2024 Category: Biochemistry Authors: Marwa Mohammed Ibrahim Mohammed Khalil Manal Monir Mansour Moustafa Bakrey Hamed Ata Shymaa Abdelsattar Elaskary Shaimaa El Sayed Ramadan Genena Source Type: research

Gastric Carcinoma with low ROR alpha, low E- Cadherin and High LAPTM4B Immunohistochemical Profile; is associated with unfavorable prognosis in Egyptian patients
In conclusion, RORα and LAPTM4B may have crucial role in GC aggressiveness. The predominance of low RORα, high LAPTM4B, and heterogeneous or negative E-Cadherin immunohistochemical profile in GC cases with unfavorable pathological parameters suggested that this profile may predict tumor behavior.PMID:38031398 | DOI:10.1080/15321819.2023.2279639 (Source: Journal of Immunoassay and Immunochemistry)
Source: Journal of Immunoassay and Immunochemistry - November 30, 2023 Category: Biochemistry Authors: Shereen Nagib El Mashad Mona Abd El Halim Kandil Taysseer Abd El-Hamid Talab Abd El Naby Saied Abd El Naby Mervat Mahmoud Sultan Ahmed Sohaib Aiat Shaban Hemida Source Type: research