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Optimization of biochip assay for illegal substances on drug abusers' whole blood: Randox Evidence vs LC-MS/MS
J Immunoassay Immunochem. 2023 Mar 15:1-13. doi: 10.1080/15321819.2023.2189451. Online ahead of print.ABSTRACTImmunoassay tests are used in clinical and forensic toxicology laboratories to determine illicit drug use in biological samples. Therefore, this study aims to optimize the cutoff concentrations of DOA I Plus in the blood and compare the LC-MS/MS results. 680 authentic forensic whole blood specimens with Randox Evidence DOA I Plus array were screened for drug of abuse and confirmed by LC-MS/MS. Regarding the manufacturer recommended threshold values, 139 out of 680 authentic blood samples were positive for one or mo...
Source: Journal of Immunoassay and Immunochemistry - March 15, 2023 Category: Biochemistry Authors: Pinar Efeoglu Ozseker Sevinc Puren Yucel Nebile Daglioglu Source Type: research

Assessment of cytochrome P450 1A1 gene polymorphism and vitamin A serum level in psoriasis vulgaris
J Immunoassay Immunochem. 2023 Mar 15:1-14. doi: 10.1080/15321819.2023.2189471. Online ahead of print.ABSTRACTPsoriasis is characterized by cutaneous hyperproliferation, secondary to immune system dysregulation. Vitamin A regulates the immune response and sustains epithelial tissue hemostasis. The CYP1A1 gene, has many biological actions, including vitamin A metabolism. To evaluate CYP1A1 gene polymorphism and serum vitamin A level in patients with psoriasis vulgaris, a case-control study involving two groups was conducted: group 1 (45 patients with psoriasis vulgaris) served as the cased group and group 2 (45 healthy part...
Source: Journal of Immunoassay and Immunochemistry - March 15, 2023 Category: Biochemistry Authors: Heba A S Bazid Alaa Marae Nermin Tayel Etab Serag Hadeer Selim Mohammed I Mostafa Eman Abd El Gayed Source Type: research

Microarray expression results of VEGF, YAP1 and PTEN immunostains in preeclampsia cases
J Immunoassay Immunochem. 2023 Mar 4;44(2):204-212. doi: 10.1080/15321819.2023.2182219. Epub 2023 Feb 23.ABSTRACTWe aimed to evaluate the expression of YAP1, PTEN, VEGF in the placentas of patients with preeclampsia and placentas of healthy pregnant women for trophoblast invasion, which is similar to cancer etiopathogenesis. The placentas of 70 women who gave birth, including 30 preeclampsia and 40 healthy controls, were evaluated. YAP1, PTEN and VEGF immunohistochemical staining were performed using the microarray method on placental tissue. The mean ± standard deviation for YAP1, PTEN and VEGF intensity were; 1.57 ± 0....
Source: Journal of Immunoassay and Immunochemistry - February 23, 2023 Category: Biochemistry Authors: Ayhan Atigan Yeliz Arman Karakaya Derya Kili ç Omer Tolga Guler Source Type: research