Xuesaitong may protect against ischemic stroke by modulating microglial phenotypes and inhibiting neuronal cell apoptosis via the STAT3 signaling pathway.

CONCLUSIONS: We demonstrated that xuesaitong has long-term neuroprotective effects against ischemic stroke, possibly by promoting the polarization of microglia to an M2 phenotype and by inhibiting neuronal cell death via down-regulation of the STAT3 signaling pathway, providing new evidence that xuesaitong might be a promising therapeutic strategy for ischemic stroke. PMID: 30426907 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30426907?dopt=Abstract

Source: CNS and Neurological Disorders Drug Targets - November 14, 2018 Category: Drugs & Pharmacology Authors: Li F, Zhao H, Han Z, Wang R, Tao Z, Fan Z, Zhang S, Li G, Chen Z, Luo Y Tags: CNS Neurol Disord Drug Targets Source Type: research