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Condition: Hypertension
Nutrition: Calcium

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Total 337 results found since Jan 2013.

Association between the high risk for obstructive sleep apnea and intracranial carotid artery calcification in patients with acute ischemic stroke.
CONCLUSIONS: This study showed that the presence of calcium in symptomatic intracranial ICA was related to high risk for OSA in patients with acute ischemic stroke. PMID: 32562170 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - June 18, 2020 Category: Sleep Medicine Authors: Woo HG, Song TJ, Jung JS, Oh SW, Lee SC, Seok JM, Yang KI Tags: Sleep Breath Source Type: research

Risk Prediction of Coronary Flow Reserve is Strongly Influenced by the Burden of Coronary Calcification
Conclusions: Coronary flow reserve helps to risk stratify patients with CAC &gt 10. These findings have significant clinical implications but will need confirmation in larger studies.
Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Khan, M., Bravo, P., Vidula, M., Selvaraj, S., De Feria Alsina, A. E., Wiener, P., Szapary, H., Julien, H., Litt, H., Pryma, D., Dubroff, J., Guerraty, M. Tags: Technical Considerations and Clinical Application of Absolute Myocardial Blood Flow Source Type: research

Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress
This study explored the effect of pterostilbene (PTS) complexed with hydroxypropyl- β-cyclodextrin (HPβCD) on right heart function, glutathione and glutaredoxin systems, and the expression of redox-sensitive proteins involved with regulation calcium levels in the experimental model of pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). After 7 days of PAH induct ion, rats received daily doses of the PTS:HPβCD complex (corresponding to 25, 50, or 100 mg·kg−1 of PTS) or vehicle (control group, CTR0) (an aqueous solution containing HPβCD; CTR0 and MCT0 (MCT group that did not receive PTS treatment)) v...
Source: Applied Physiology, Nutrition, and Metabolism - March 18, 2020 Category: Physiology Authors: Denise Lacerda Patrick T ürck Cristina Campos-Carraro Alexandre Hickmann Vanessa Ortiz Sara Bianchi Adriane Bell ó-Klein Alexandre Luz de Castro Valquiria Linck Bassani Alex Sander da Rosa Araujo Source Type: research

Association of visit-to-visit variability in blood pressure and first stroke risk in hypertensive patients with chronic kidney disease
Conclusion: In hypertensive adults with mild-to-moderate CKD, visit-to-visit variability in BP was significantly associated with the risk of subsequent first stroke.
Source: Journal of Hypertension - March 6, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research

Trends of antihypertensive agents in patients with hypertension and coronary artery disease in a tertiary hospital of China
Conclusion The compliance to guidelines is overall well for patients with hypertension and coronary artery disease, but improvements is needed for patients with type 2 diabetes. Multi-center studies with large-scale data are required to further assess the usage of antihypertensive agents in patients.
Source: International Journal of Clinical Pharmacy - February 19, 2020 Category: Drugs & Pharmacology Source Type: research

Influence of dual ‐specificity protein phosphatase 5 on mechanical properties of rat cerebral and renal arterioles
In this study, we found that KO ofDusp5 did not alter body weights, kidney and brain weights, plasma glucose, and HbA1C levels. The expression of pERK is higher in the nucleus of primary VSMC isolated fromDusp5 KO rats.Dusp5 KO rats exhibited eutrophic vascular hypotrophy with smaller intracerebral parenchymal arterioles and renal interlobular arterioles without changing the wall ‐to‐lumen ratios. These arterioles fromDusp5 KO rats displayed higher myogenic tones, better distensibility, greater compliance, and less stiffness compared with arterioles from WT control rats. VSMC ofDusp5 KO rats exhibited a stronger contra...
Source: Physiological Reports - January 19, 2020 Category: Physiology Authors: Huawei Zhang, Chao Zhang, Yedan Liu, Wenjun Gao, Shaoxun Wang, Xing Fang, Ya Guo, Man Li, Ruen Liu, Richard J. Roman, Peng Sun, Fan Fan Tags: ORIGINAL RESEARCH Source Type: research

Effects of Blood Pressure Lowering Agents on Cardiovascular Outcomes in Weight Excess Patients: A Systematic Review and Meta-analysis
ConclusionsIn hypertensive subjects with excess weight, diuretics are more effective for preventing HF and stroke than CCB and ACEI, respectively. CCB are a good first-line choice for prevention of cardiovascular disease, except HF.
Source: American Journal of Cardiovascular Drugs - January 2, 2020 Category: Cardiology Source Type: research

Meta-analysis Evaluating Calcium Channel Blockers and the Risk of Peripheral Arterial Disease in Patients with Hypertension
Peripheral arterial disease (PAD) is associated with significant morbidity and mortality. It affects 8.5 million Americans aged 40 years and above, and 202 million people worldwide.1 Given the significant burden and resource utilization associated with PAD, strategies for preventing the development of PAD could have an enormous impact. Hypertension is an established risk factor for the development of atherosclerotic vascular disease including PAD. Over the past two decades, several randomized controlled trials (RCTs) have examined the efficacy of various antihypertensive agents in reducing mortality and other major adverse...
Source: The American Journal of Cardiology - December 26, 2019 Category: Cardiology Authors: Suchith Shetty, Aaqib H. Malik, Herman Feringa, Ramzi El Accaoui, Saket Girotra Source Type: research

Anti-hypertensive agents in Alzheimer's disease: beyond vascular protection.
Authors: Lebouvier T, Chen Y, Duriez P, Pasquier F, Bordet R Abstract INTRODUCTIONMidlife hypertension has been consistently linked with increased risk of cognitive decline and Alzheimer's disease (AD). Observational studies and randomized trials show that the use of antihypertensive therapy is associated with a lesser incidence or prevalence of cognitive impairment and dementia. However, whether anti-hypertensive agents specifically target the pathological process of AD remains elusive.AREAS COVEREDThis review of literature provides an update on the clinical and preclinical arguments supporting anti-AD properties of ...
Source: Expert Review of Neurotherapeutics - December 24, 2019 Category: Neurology Tags: Expert Rev Neurother Source Type: research

The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature
Publication date: Available online 7 November 2019Source: Food Research InternationalAuthor(s): Samad Ghaffari, Neda RoshanravanAbstractHypertension (HTN) is a worldwide epidemic in both developed and developing countries. It is one of the leading causes of major health problems such as cardiovascular disease, stroke, and heart attack. In recent years, several studies have reported associations between specific dietary ingredients and improving HTN. Nutraceuticals are natural food components with pharmacological properties. Reports suggest that functional foods and nutraceutical ingredients might support patients to obtain...
Source: Food Research International - November 8, 2019 Category: Food Science Source Type: research

Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis
Publication date: Available online 24 October 2019Source: The LancetAuthor(s): Marc A Suchard, Martijn J Schuemie, Harlan M Krumholz, Seng Chan You, RuiJun Chen, Nicole Pratt, Christian G Reich, Jon Duke, David Madigan, George Hripcsak, Patrick B RyanSummaryBackgroundUncertainty remains about the optimal monotherapy for hypertension, with current guidelines recommending any primary agent among the first-line drug classes thiazide or thiazide-like diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, dihydropyridine calcium channel blockers, and non-dihydropyridine calcium channel blockers, in ...
Source: The Lancet - October 26, 2019 Category: General Medicine Source Type: research

Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts.
CONCLUSIONS: There was no significant difference in mortality among A+C, A+D, and C+D combination treatment in patients without previous CVD. This finding was consistent across multi-national heterogeneous cohorts in real-world practice. PMID: 31642211 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - October 25, 2019 Category: Cardiology Tags: Korean Circ J Source Type: research

Force Sensing by Piezo Channels in Cardiovascular Health and Disease.
Abstract Mechanical forces are fundamental in cardiovascular biology, and deciphering the mechanisms by which they act remains a testing frontier in cardiovascular research. Here, we raise awareness of 2 recently discovered proteins, Piezo1 and Piezo2, which assemble as transmembrane triskelions to combine exquisite force sensing with regulated calcium influx. There is emerging evidence for their importance in endothelial shear stress sensing and secretion, NO generation, vascular tone, angiogenesis, atherosclerosis, vascular permeability and remodeling, blood pressure regulation, insulin sensitivity, exercise per...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 18, 2019 Category: Cardiology Authors: Beech DJ, Kalli AC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China.
Conclusions: Among patients with incident PD, a higher serum Lp(a) level may predict a lower risk of hemorrhagic stroke. PMID: 31498021 [PubMed - in process]
Source: Renal Failure - September 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research