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The devastating effects of humeral nonunion on health-related quality of life
CONCLUSIONS: Humeral nonunions have a devastating effect on a patient's physical and mental health with HRQoL measures lower than patients with other chronic conditions, such as asthma, diabetes, AIDS, and stroke. We found that our patients, on average, would trade approximately 45% of their remaining lifespan for perfect health.PMID:35718254 | DOI:10.1016/j.jse.2022.05.012
Source: Hand Surgery - June 19, 2022 Category: Surgery Authors: Mark R Brinker Christopher M Loftis Justin D Khoriaty Warren R Dunn Source Type: research

Molecules, Vol. 28, Pages 1021: Cyclic Glycine-Proline (cGP) Normalises Insulin-Like Growth Factor-1 (IGF-1) Function: Clinical Significance in the Ageing Brain and in Age-Related Neurological Conditions
ep Singh-Mallah Insulin-like growth factor-1 (IGF-1) function declines with age and is associated with brain ageing and the progression of age-related neurological conditions. The reversible binding of IGF-1 to IGF binding protein (IGFBP)-3 regulates the amount of bioavailable, functional IGF-1 in circulation. Cyclic glycine-proline (cGP), a metabolite from the binding site of IGF-1, retains its affinity for IGFBP-3 and competes against IGF-1 for IGFBP-3 binding. Thus, cGP and IGFBP-3 collectively regulate the bioavailability of IGF-1. The molar ratio of cGP/IGF-1 represents the amount of bioavailable and functional IG...
Source: Molecules - January 19, 2023 Category: Chemistry Authors: Jian Guan Fengxia Li Dali Kang Tim Anderson Toni Pitcher John Dalrymple-Alford Paul Shorten Gagandeep Singh-Mallah Tags: Review Source Type: research

Ensuring medication adherence with direct oral anticoagulant drugs: Lessons from adherence with vitamin K antagonists (VKAs)
Abstract: Medication adherence (taking drugs properly) is uncommon among patients on warfarin. Poor adherence to warfarin leads to an increase in adverse medical events, including stroke in atrial fibrillation (AF). Factors related to patients, physicians and the health system account for poor adherence. Direct oral anticoagulants (DOACs) are easier to use than warfarin, with fewer drug and food interactions and no need for routine blood monitoring. A proper use of DOACs may reduce the risk of stroke in AF. However, in clinical settings where no laboratory monitoring is needed, a poor medication adherence is common and may...
Source: Thrombosis Research - February 12, 2014 Category: Hematology Authors: Alessandro Di Minno, Gaia Spadarella, Antonella Tufano, Domenico Prisco, Giovanni Di Minno Tags: Mini-Reviews Source Type: research

Use of floss/interdental brushes is associated with lower risk for new cardiovascular events among patients with coronary heart disease
ConclusionsThese findings suggest that flossing and brushing of interdental spaces might reduce the risk for new cardiovascular events among patients with CHD. The hypothesis that interdental cleaning per se reduces the risk of new cardiovascular events should be examined in an interventional study.
Source: Journal of Periodontal Research - May 14, 2014 Category: Dentistry Authors: S. Reichert, A. Schlitt, V. Beschow, A. Lutze, S. Lischewski, T. Seifert, T. Dudakliewa, R. Gawe, K. Werdan, B. Hofmann, H.‐G. Schaller, S. Schulz Tags: Original Article Source Type: research

Duration of residence and disease occurrence among refugees and family reunited immigrants: test of the ‘healthy migrant effect’ hypothesis
ConclusionOur analyses of the effect of duration of residence on disease occurrence among migrants imply that, when explaining migrants' advantageous health outcomes, the ruling theory of the HME should be used with caution, and other explanatory models should be included.
Source: Tropical Medicine and International Health - May 30, 2014 Category: Tropical Medicine Authors: Marie Norredam, Charles Agyemang, Oluf K. Hoejbjerg Hansen, Jørgen H. Petersen, Stine Byberg, Allan Krasnik, Anton E. Kunst Tags: Original Article Source Type: research

Assessment of upper extremity function in multiple sclerosis: review and opinion.
Authors: Kraft GH, Amtmann D, Susan E B, Finlayson M, Sutliff MH, Tullman M, Sidovar M, Rabinowicz AL Abstract Upper extremity (UE) dysfunction may be present in up to ~80% of individuals with multiple sclerosis (MS), although its importance may be under-recognized relative to walking impairment, which is the hallmark symptom of MS. Upper extremity dysfunction affects independence and can impact the ability to use walking aids. Under-recognition of UE dysfunction may result in part from limited availability of performance-based and patient self-report measures that are validated for use in MS and that can be readil...
Source: Postgraduate Medicine - November 28, 2014 Category: Internal Medicine Tags: Postgrad Med Source Type: research

CDC's Mission: Protecting the Health of Americans
There is no doubt Ebola will rank as the biggest public health story of 2014, both here in the United States and around the world: more people sickened by Ebola than ever before in history, more people dying, and more understanding of how the health of one nation affects the health of us all. Today, more than 170 of CDC's top health professionals are in West Africa working to stop the current Ebola epidemic and leave behind stronger public health systems. Many hundreds more support their work at home. Leaving behind better capacities to find, stop, and prevent health threats in affected countries will help prevent the ...
Source: Healthy Living - The Huffington Post - December 24, 2014 Category: Consumer Health News Source Type: news

Rethinking Retirement in the 21st Century
Conclusion In the 21st century, many seniors are not retiring from something. Instead, retirement is an opportunity for reinventing, reimagining and reconnecting to one's self, family, friends and community. Robert Browning once wrote, "Grow old along with me! The best is yet to be." By investing in your physical, mental and financial health today, you can help ensure that your best years are just ahead. Rear Admiral Susan Blumenthal, M.D., M.P.A. (ret.) is the Public Health Editor of The Huffington Post. She is a Senior Fellow in Health Policy at New America and a Clinical Professor at Tufts and Georgetown University Sc...
Source: Healthy Living - The Huffington Post - May 1, 2015 Category: Consumer Health News Source Type: news

Can Pet Affection Improve Heart Health?
by Mimi O' Connor An energetic-looking young woman came bouncing down the aisle of the airplane so quickly that I barely had time to read the message on her T-shirt before she plopped down in the seat next to me. It read in bold letters "I LOVE ANIMALS," and underneath in smaller italics, "humans not so much." Being an animal lover myself, her shirt made me smile. I felt compelled to ask her about it. She told me that she was a veterinary medicine student and has cared for an expansive menagerie of critters since she was a little girl. My exposure to animals was modest by comparison. I've lived with and loved just two dogs...
Source: Healthy Living - The Huffington Post - September 29, 2015 Category: Consumer Health News Source Type: news

Medtech approvals: FDA releases August 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in August 2015: Summary of PMA Originals & Supplements Approved Originals: 2 Supplements: 70 Summary of PMA Originals Under Review Total Under Review: 57 Total Active: 28 Total On Hold: 29 Summary of PMA Supplements Under Review Total Under Review: 569 Total Active: 422 Total On Hold: 147 Summary of All PMA Submissions Originals: 5 Supplements: 90 Summary of PMA Supplement PMA Approval/Denial Decision Times Number of Approvals: 70 Number of Denials: 0 Average Days Fr Receipt to Decision (Total Time): 229.0 FDA Time: 130...
Source: Mass Device - October 23, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Pre-Market Approval (PMA) Regulatory/Compliance Source Type: news

Healing through music
The last time I had a mammogram, I got a big surprise — and it was a good one. A string quartet was playing just outside the doors of the breast imaging center, and my thoughts immediately shifted from “What are they going to find on the mammogram?” to “Is that Schubert, or Beethoven?” By the time my name was called, I had almost forgotten why I was there. The unexpected concert was the work of Holly Chartrand and Lorrie Kubicek, music therapists and co-coordinators of the Environmental Music Program at Massachusetts General Hospital. But bringing music to hospital corridors is just a sideline for music therapist...
Source: New Harvard Health Information - November 5, 2015 Category: Consumer Health News Authors: Beverly Merz Tags: Behavioral Health Mental Health Pain Management Surgery Source Type: news

More Than A Third Of Americans Don't Get Enough Sleep
We spend about one-third of our life doing it, but more than one in three Americans still aren’t getting enough sleep, according to a new government report.  In their first study of self-reported sleep length, the U.S. Centers for Disease Control and Prevention found that 34.8 percent of American adults are getting less than seven hours of sleep -- the minimum length of time adults should sleep in order to reduce risk of obesity, diabetes, high blood pressure, stroke, mental distress, coronary heart disease and early death. In total, an estimated 83.6 million adults in the U.S. are sleep deprived, the CDC repor...
Source: Science - The Huffington Post - February 18, 2016 Category: Science Source Type: news

Environmental Pollution: An Under-recognized Threat to Children’s Health, Especially in Low- and Middle-Income Countries
Conclusions Patterns of disease are changing rapidly in LMICs. Pollution-related chronic diseases are becoming more common. This shift presents a particular problem for children, who are proportionately more heavily exposed than are adults to environmental pollutants and for whom these exposures are especially dangerous. Better quantification of environmental exposures and stepped-up efforts to understand how to prevent exposures that cause disease are needed in LMICs and around the globe. To confront the global problem of disease caused by pollution, improved programs of public health monitoring and environmental protecti...
Source: EHP Research - March 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Brief Communication March 2016 Source Type: research

Brain Stimulation After Stroke Aids RecoveryBrain Stimulation After Stroke Aids Recovery
Combined with rehabilitation, transcranial direct-current brain stimulation improved function compared with a sham procedure, a new study shows. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - March 23, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Emerging trends in non-communicable disease mortality in South Africa, 1997 - 2010.
CONCLUSIONS: NCDs contribute to premature mortality in SA, threatening socioeconomic development. While NCD mortality rates have decreased slightly, it is necessary to strengthen prevention and healthcare provision and monitor emerging trends in cause-specific mortality to inform these strategies if the target of 2% annual decline is to be achieved. PMID: 27138667 [PubMed - as supplied by publisher]
Source: South African Medical Journal - May 5, 2016 Category: African Health Tags: S Afr Med J Source Type: research